Clinical trials: Multimodal General Anesthesia
General Anesthesia
Cerebral Perfusion Variation During Blood Pressure Changes Under General Anesthesia
The risk associated with arterial hypotension during general anesthesia for surgery has been demonstrated , but the threshold at which consequences for perfusion of one or more organs appear varies according to the mechanism of…
- Trial name
- DELTAPAMAG (NCT05803876)
- Testing
- Diagnostic test - monitoring
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Electroencephalographic Density Spectrum Array Analysis, Density Spectrum Array
Machine-learning Algorithm to Differentiate Intraoperative Ketamine Dosing Based on Electroencephalographic Density Spectrum Array Analysis
Ketamine is widely used in the setting of multimodal general anesthesia, and the Electroencephalographic density spectral array (DSA) monitoring has been implemented in the practice of anesthesia.
- Conditions
- Electroencephalographic Density Spectrum Array Analysis, Density Spectrum Array, Ketamine, Multimodal General Anesthesia
- Trial name
- NCT05256264
- Testing
- Ketamine
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Post Operative Pain
Efficacy of Parecoxib Combined With Paracetamol in Mastectomy
Patients undergoing breast cancer surgery experience persistent pain after surgery and subsequent development of chronic pain. Parecoxib or paracetamol has been reported to reduce postoperative pain in mastectomy.
- Trial name
- NCT05757388
- Testing
- Parecoxib + paracetamol, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Spine Fusion, Locoregional Anaesthesia
PeriOPerative Spine Surgery COntrol Pain (POPSSCOP) Study: Intrathecal Morphine vs Erector Spinae Plane Block for Postoperative Pain Management in Spinal Fusion
This is a prospective observational study conducted at the trauma center of Città della Salute e della Scienza of Turin. The aim of the study is to compare two local regional anesthesia techniques in multimodal analgesia for…
- Conditions
- Spine Fusion, Locoregional Anaesthesia, Intrathecal Anesthesia, Erector Spina Plan Block
- Trial name
- POPSSCOP (NCT07245524)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Analgesics，Opioid, Bariatric Surgery
Multimodal Analgesic Management of Naborphine Combined With Opioid Free Anesthesia in OSA Patients Undergoing Bariatric Surgery
Comparative study to explore the effect of opioid free anesthesia technology in perioperative analgesia management, clarify the effect of naborphine instead of opioids on perioperative analgesia management in morbid obesity…
- Trial name
- NCT05386979
- Testing
- Opioid free anesthesia technology
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
Uterine Bleeding, Uterine Neoplasms
Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies
The main goal of this randomised double-blinded controlled trial is to assess whether adding anterior quadratus lumborum block preoperatively can reduce intraoperative and postoperative opioid consumption, reduce pain after…
- Conditions
- Uterine Bleeding, Uterine Neoplasms, Uterine Diseases, Uterine Fibroids
- Trial name
- NCT07046949
- Testing
- ANTERİOR QUADRATUS LUMBORUM BLOCK, Parenteral administration of analgesics, General Anesthesia (GA)
- Where
- Ukraine
- Volunteers
- 56 people
- Sponsor
- Yuri Semenyuk Rivne Regional Clinical Hospital
Scoliosis, Spinal Deformity
Bilateral Bi-level Erector Spine Plane Block as a Component of General Anesthesia in Surgical Correction of Spinal Deformations
Improving the anesthesiology management for surgical correction of spinal deformations with introducing the diagnostic methods and treatment strategy of acute pain, preventing the evolution of chronic pain.
- Conditions
- Scoliosis, Spinal Deformity, Acute Pain, Chronic Pain
- Trial name
- BBESPB (NCT04697498)
- Testing
- Bilateral bi-level Erector spine plane block, General anaesthesia
- Where
- Ukraine
- Volunteers
- 150 people
- Sponsor
- Lviv National Medical University
Postoperative Delirium, Hemodynamic Instability
Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies
In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1.
- Conditions
- Postoperative Delirium, Hemodynamic Instability, Pain, Neurocognitive Dysfunction
- Trial name
- PATHFINDERII (NCT05279898)
- Testing
- EEG Monitoring, Ropivacaine, Ketamine
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Beth Israel Deaconess Medical Center
Postoperative Pain, Recovery
Methadone for Enhanced Postoperative Analgesia in Intermediate-Risk Noncardiac Surgery (MELODY)
Postoperative pain control remains suboptimal for a large proportion of surgical patients and is frequently associated with slower recovery and higher reliance on opioids after surgery.
- Trial name
- MELODY (NCT07565870)
- Testing
- Intravenous Methadone, Short-acting Opioids Intraoperative analgesia
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Alexandre P. Joosten
Lumbar Spine Fusion Surgery
Multimodal GA for Lumbar Spine Surgery
To evaluate the effects of multimodal general anesthesia on the recovery profile of elder patients undergoing lumbar spine fusion surgery.
- Trial name
- NCT05247177
- Testing
- dexmedetomidine, ketamine co-administration with sevoflurane for general anesthesia, Conventional general anesthesia by administration of sevoflurane alone
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Craniotomy
EEG Spectrogram-guided vs. Index-guided Anesthesia for Craniotomy
In this trial, investigators aimed to compared the clinical effects between the electroencephalographic (EEG) spetrogram-guided and processed EEG index-guided multimodal general anesthesia using the combination of propofol…
- Trial name
- NCT06244017
- Testing
- EEG spectrogram, Bispectral index
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Anesthesia, General Anesthesia
Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery
The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel…
- Conditions
- Anesthesia, General Anesthesia, Analgesics, Opioid, Opioid Free Anesthesia
- Trial name
- RUMBLE (NCT04144933)
- Testing
- Acetaminophen, Gabapentin, Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine, Dexamethasone, Ondansetron
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Saskatchewan
Analgesia
IPACK or Selective Tibial Nerve Block for ACL Reconstruction With an Adductor Canal Block
The purpose of this study is to compare the analgesic efficacy of the combination of an adductor canal and selective tibial nerve blocks versus adductor canal block and IPACK after ACL reconstruction under general anaesthesia.
- Trial name
- TIPACK (NCT05303233)
- Testing
- Selective tibial nerve block, IPACK
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Postoperative Sore Throat, Nasal Obstruction
Pharyngeal Mucosal Conditioning to Prevent Postoperative Sore Throat in Septoplasty Patients With Severe Nasal Obstruction
Postoperative sore throat (POST) affects 21-65% of patients after endotracheal intubation and is among the most common complaints after general anesthesia.
- Conditions
- Postoperative Sore Throat, Nasal Obstruction, Septoplasty
- Trial name
- POST-MUCOSAL R (NCT07870252)
- Testing
- Nebulized 0.9% Normal Saline, Water-Soluble Lubricant Gel on Endotracheal Tube
- Where
- Saudi Arabia
- Volunteers
- 105 people
- Sponsor
- Mansoura University
Regional Anesthesia
A Randomized Clinical Trial
Acute postoperative pain is a common problem faced by the patient after surgery, most frequently occurring in first 24 hours. Our primary objective was to assess pain score in first 24 hours in PECS block group undergoing…
- Trial name
- NCT03947463
- Testing
- PECS block
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
General Anesthesia
Multimodal Monitoring During General Anesthesia in ENT Surgery
This study evaluated whether using several monitoring methods together during general anesthesia could improve patient safety and help anesthesiologists adjust medication doses in adults undergoing ear, nose, and throat (ENT)…
- Trial name
- NCT07895836
- Testing
- Multimodal Anesthesia Monitoring (BIS, SPI, TOF), Standard Anesthesia Monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Barbara Verro
Anesthesia, General, Major Abdominal Surgeries
The Impact of Multimodal Brain Monitoring on Postoperative Outcomes in Elderly Patients Undergoing Major Abdominal Surgery
The purpose of this clinical trial is to investigate the effect of multimodal brain monitoring under general anesthesia on postoperative outcomes in elderly patients undergoing abdominal surgery.The research hypothesis is that…
- Trial name
- NCT07713355
- Testing
- Multimodal brain monitoring guided anesthesia, Bispectral Index(BIS) monitoring guided anesthesia
- Where
- 4 sites in China
- Volunteers
- 368 people
- Sponsor
- Xuanwu Hospital, Beijing
Nephrolithiasis, Postoperative Pain
Effect of a Low-Dose Ketamine-Dexmedetomidine-Based Opioid-Sparing Anesthesia Protocol on Postoperative Quality of Recovery After Percutaneous Nephrolithotomy
Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure used to remove large or complex kidney stones. Although effective, dilation of the surgical tract and the placement of a nephrostomy tube cause…
- Conditions
- Nephrolithiasis, Postoperative Pain, Quality of Recovery
- Trial name
- NCT07855068
- Testing
- Ketamine and Dexmedetomidine, Fentanyl
- Volunteers
- 100 people
- Sponsor
- Assiut University