Clinical trials: Multi-antibiotic Resistance
Infection Control
Enhanced Room Cleaning in Intensive Care Units to Reduce Gown and Glove Contamination With Multi-drug-resistant Bacteria
The purpose of this study is to determine whether extra cleaning of frequently-contaminated surfaces in intensive care rooms is effective in preventing contamination of disposable isolation gowns and gloves with multi-drug…
- Trial name
- NCT01481935
- Testing
- Enhanced cleaning of surfaces in ICU rooms
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- University of Maryland, Baltimore
Multi-Drug Resistant Organism Colonization
Response to Emerging Antimicrobial Resistance With Containment Microbiota Therapy (REACT)
REACT is a phase two, open-label, randomized, controlled trial of microbiota therapy (MT) to reduce colonization with multi-drug resistant organisms (MDRO).
- Trial name
- NCT06321536
- Testing
- Allogeneic Microbiota in Glycerol (9%) (AMG)
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Emory University
Lung-transplant Recipients, Antibiotic Prophylaxis
Antibiotic Prophylaxis in Lung-Transplant Recipients
Retrospective, monocentric observational pharmacological cohort study including all adult patients who underwent lung transplantation at IRCCS Azienda Ospedaliero-Universitaria di Bologna from 1st January 2002 to 31st August 2023.
- Trial name
- PRO-LUNG (NCT06760143)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bacteremia, Healthcare-associated Pneumonia
Randomized-controlled Trial (RCT) on Combination Antibiotic for Infections Caused by Gram-negative Bacteria
Background and rationale: Antimicrobial resistance is a global public health threat. An increasing number of Gram-negative bacteria isolates worldwide are resistant to virtually all antibiotics including carbapenems.
- Conditions
- Bacteremia, Healthcare-associated Pneumonia, Ventilator-associated Pneumonia
- Trial name
- XDR-GNB (NCT02134106)
- Testing
- Polymyxin B, Polymyxin B + Doripenem
- Where
- 2 sites in Singapore
- Sponsor
- Tan Tock Seng Hospital
Nasopharyngeal Carriage of Streptococcus Pneumoniae
Pneumococcal Carriage, Serotypes, and Antibiotic Resistance in Malaysian Children: A Multi-Centre Study
The goal of this observational study is to determine the prevalence, serotype distribution, and antimicrobial resistance patterns of nasopharyngeal carriage of Streptococcus pneumoniae in Malaysian children aged ≤5 years…
- Trial name
- MY-PNEUMO2 (NCT07545876)
- Where
- 4 sites in Malaysia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Gram-negative Bacteremia, Microbial Colonization
Antimicrobial Resistant Organism Decolonization After Microbiome Perturbation
ARO-DECAMP is a multi-centre, placebo-controlled, pilot and feasibility randomized controlled trial for the microbial consortium Microbial Ecosystem Therapeutic-2.
- Conditions
- Gram-negative Bacteremia, Microbial Colonization, Antibiotic Resistant Infection
- Trial name
- ARO-DECAMP (NCT06214403)
- Testing
- MET-2
- Where
- 4 sites in Canada
- Sponsor
- University Health Network, Toronto
Gastritis, Gastric Ulcer
A Multi-center Study for Individual Treatment of Helicobacter Pylori Infection
Since the discovery of Helicobacter pylori (H. pylori), many studies have been carried out with the goal of improving H. pylori eradication and therapies have changed from single-antibiotic treatments to the current…
- Trial name
- NCT02689583
- Testing
- Antibiotic selection based on the antibiotic susceptibility testing, PPI selection based on the CYP2C19 gene polymorphism, Probiotics usage based on the 16SrRNA sequencing
- Volunteers
- 3,000 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Bacterial Infections
A Multiple Dose Study of Debio 1450 [Intravenous (IV) and Oral] in Healthy Volunteers
Debio 1450-103 is a trial to study the pharmacokinetics (PK) of an experimental drug called Debio 1450 in healthy adult volunteers. Originally, Part A was registered separately (in NCT02214355).
- Trial name
- NCT02214433
- Testing
- Debio 1450 IV Solution, Debio 1450 Tablet, Debio 1450 Capsule
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Debiopharm International SA
Healthy Volunteers, Anti-Bacterial Agents
A Study to Evaluate the Safety, PK, PD, Immunogenicity of N-Rephasin® SAL200 in Healthy Male Volunteers
To evaluate the safety, pharmacokinetics, pharmacodynamics and immunogenicity of N-Rephasin® SAL200 following single and multiple ascending doses in healthy male volunteers after continuous intravenous infusion over 60 minutes.
- Conditions
- Healthy Volunteers, Anti-Bacterial Agents, Methicillin-Resistant Staphylococcus Aureus, Methicillin-Sensitive Staphylococcus Aureus Infection
- Trial name
- NCT03446053
- Testing
- N-Rephasin® SAL200
- Where
- South Korea
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Intron Biotechnology, Inc.
Bacterial Sensitivity Tests, Antimicrobial Drug Resistance
AMR-DetecTool for the Diagnostic of MDR Bacterial Infections
The fight against bacteria is one of the greatest challenges faced by societies, especially with the spread of multi drug resistant (MDR) bacteria.
- Trial name
- AMR DetecTool (NCT05378217)
- Testing
- AMR LFIA Assay
- Where
- 3 sites in France, Hungary and 1 more
- Volunteers
- 167 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Endophthalmitis
Endophthalmitis Cultures
The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin…
- Trial name
- PROSPER (NCT01496794)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Vanderbilt University
Multiple Myeloma
Fluoroquinolone Resistance Prevalence Study
This is an exploratory study to determine the prevalence of fluoroquinolone resistance in patients receiving dose-intense melphalan with autologous peripheral blood stem cell (PBSC) transplantation in the treatment of multiple…
- Trial name
- FRE (NCT05824689)
- Where
- 2 sites in United States
- Volunteers
- 124 people
- Sponsor
- Hackensack Meridian Health
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Ventilator Associated Pneumonia by Multi-Drug Resistant Organism
Ventilator-associated pneumonia (VAP) is an infection of the pulmonary parenchyma in patients exposed to invasive mechanical ventilation for at least 48 h and is part of ICU-acquired pneumonia.
- Trial name
- VAP-MDR (NCT05549427)
- Testing
- Ventilation
- Where
- Oman
- Volunteers
- 319 people
- Sponsor
- Sultan Qaboos University
E. Coli Infection, Multi-antibiotic Resistance
Perinatal Transmission of MDR Bacteria
The investigators aim to conduct a prospective surveillance study of mothers and their infants born vaginally or by scheduled C-section and who are admitted to Northwestern Medicine Prentice Women's Hospital to determine the…
- Trial name
- ACQUIRE (NCT06148480)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Bacterial Pneumonia
Comparative Study of Ceftaroline vs. Ceftriaxone in Adult Subjects With Community-Acquired Pneumonia
The purpose of this study is to determine whether ceftaroline is effective and safe in the treatment of Community-Acquired Pneumonia
- Trial name
- CAP (NCT00621504)
- Testing
- Ceftaroline fosamil for Injection, IV Ceftriaxone, Clarithromycin
- Where
- 168 sites in United States, Argentina and 21 more
- Volunteers
- 606 people
- Sponsor
- Forest Laboratories
Multi-antibiotic Resistance
Fecal Transplant for MDR Pathogen Decolonization
This is a proof-of-principle research study designed to determine whether fecal microbiota transplantation (FMT) can eliminate highly drug-resistant bacteria from the intestinal tract of renal transplant patients.
- Trial name
- NCT02906774
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- University of British Columbia
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Use of Aaerosol Combined With Intravenous Antibiotics for the Treatment of Multidrug Resistant GNB Pneumonia
To investigate use of aerosol combined with intravenous antibiotics for the treat of multi-drug resistance gram negative bacterias diagnosed ventilator-associated pneumonia in intensive care unit in a hospital.
- Trial name
- ACAMP (NCT03921645)
- Testing
- aerosol antibiotics
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Urinary Tract Infections, Recurrent UTI
Probiotics and Multi-Drug Resistant Urinary Tract Infection
This pilot study is a single-site randomized, double blinded placebo-controlled in females with recurrent multi-drug resistant (MDR) urinary tract infections(UTI).
- Conditions
- Urinary Tract Infections, Recurrent UTI, Antibiotic Resistant Infection
- Trial name
- NCT03644966
- Testing
- Bifidobacterium infantis, Antibiotics
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ochsner Health System
Urinary Tract Infection
Nosocomial Bacteriuria in Geriatric Internal Medicine Services and Follow-up Care and Geriatric Rehabilitation of the Strasbourg University Hospitals
This thesis is a comparative study of the epidemiological characteristics of health-care associated bacteriuria in short and medium term of geriatrics wards in Strasbourg's University Hospital, between 2003 and 2017, in the…
- Trial name
- NCT03577769
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Urinary Tract Infection Complicated, Acute Pyelonephritis
CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) Compared to Meropenem in Complicated Urinary Tract Infections (cUTIs) Caused by ESBL Producing Gram Negative Bacteria
The purpose of this study is to evaluate the effects of CSE-1034 (Ceftriaxone+ Sulbactam+ EDTA) compared to Meropenem for treating hospitalized patients with complicated urinary tract infections, including acute pyelonephritis…
- Trial name
- PLEA (NCT03477422)
- Testing
- CSE-1034 (Ceftriaxone + Sulbactam + EDTA), Meropenem
- Where
- 17 sites in India
- Volunteers
- 230 people
- Sponsor
- Venus Remedies Limited