Clinical trials: Motor Activity
Healthy
A Study to Test the Effectiveness of Different Interventions to Improve Physical Activity in Adults.
During the initial months of the COVID-19 pandemic, physical activity (PA) engagement levels declined worldwide. Despite the overwhelming adoption of wearable fitness tracker (WFT) devices, it continues to be unclear as to their…
- Trial name
- NCT04902014
- Testing
- Motivational Interviewing, Education, Wearable Fitness Trackers
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Facioscapulohumeral Muscular Dystrophy
Safety, Tolerability, Pharmacokinetics (PK), and Activity of ATYR1940 in Participants With Muscular Dystrophy - Study Extension
The purpose of this study is to assess the safety and tolerability profile of ATYR1940 in the treatment of adult participants with molecularly defined genetic muscular dystrophies.
- Trial name
- NCT02531217
- Testing
- ATYR1940
- Where
- 3 sites in United States, Italy and 1 more
- Volunteers
- 9 people
- Sponsor
- aTyr Pharma, Inc.
Cognitive Dysfunction, Breast Cancer Survivors
Physical Activity and Neuropsychological Outcomes in a Cancer Population
Many cancer survivors experience treatment-related impairments in mental abilities such as memory, attention, and concentration (known as cognition).
- Trial name
- NCT02332876
- Testing
- Exercise, Control
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of California, San Diego
V600-mutated BRAF Unresectable Melanoma, V600-mutated BRAF Metastatic Melanoma
A Phase 1b Open Label, Dose Escalation Study of PLX3397 in Combination With Vemurafenib in V600-mutated BRAF Melanoma
The purpose of this research study is to test the safety of an investigational new drug called PLX3397 when used in combination with Vemurafenib (Zelboraf™) at different dose levels.
- Conditions
- V600-mutated BRAF Unresectable Melanoma, V600-mutated BRAF Metastatic Melanoma, Stage III or Stage IV Metastatic Melanoma That Has Not Been Previously Treated With a Selective BRAF Inhibitor
- Trial name
- NCT01826448
- Testing
- PLX3397, vemurafenib
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 13 people
- Sponsor
- Daiichi Sankyo
Obesity
Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects
This study will evaluate the effect of semaglutide on eating behavior, appetite (hunger/fullness), and food liking in the long-term, as compared to placebo.
- Trial name
- STABLE Wt Loss (NCT05548647)
- Testing
- Behavioral Treatment, Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Pennsylvania
Stress, Psychological, Social Isolation
Stay Healthy In Nature Everyday: Family Nature Outings in a Low Income Population
The SHINE study is a randomized controlled study of the effect of a park-based family support group on multiple outcomes (including stress and physical activity) in a low income population.
- Conditions
- Stress, Psychological, Social Isolation, Physical Activity
- Trial name
- SHINE (NCT02623855)
- Testing
- Family outings, Park prescription, Pedometry
- Where
- United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Rheumatoid Arthritis
Follow-up of Rheumatoid Arthritis (RA) Moderate to Low Disease Activity Study
To continue to assess the clinical safety and efficacy of Certolizumab Pegol as add-on therapy with stable-dose Disease Modifying Anti-Rheumatic Drugs (DMARDs)
- Trial name
- CERTAIN 2 (NCT00843778)
- Testing
- Certolizumab Pegol
- Where
- 25 sites in Austria, France and 3 more
- Volunteers
- 131 people
- Sponsor
- UCB Pharma
COPD
COPD Access to Pulmonary Rehabilitation Intervention
Persons with COPD have significant functional disability but cannot access rehabilitative treatment at hospital-based conventional pulmonary rehabilitation (PR) programs.
- Trial name
- CAPRI (NCT03794921)
- Testing
- Every Step Counts
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- VA Office of Research and Development
Ulcerative Colitis
Study of ABBV-668 Oral Capsules to Assess Adverse Events and Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- NCT05570006
- Testing
- ABBV-668
- Where
- 30 sites in United States, Belgium and 2 more
- Volunteers
- 30 people
- Sponsor
- AbbVie
Peripheral Arterial Disease, Intermittent Claudication
Pain Management and Patient Education for Physical Activity in Intermittent Claudication (PrEPAID)
Peripheral Arterial disease is a common condition which causes narrowing of the arteries. The most common symptom that patients with PAD experience is Intermittent Claudication (IC), pain in the lower limb(s) on exertion, which…
- Trial name
- PrEPAID (NCT03204825)
- Testing
- Active TENS, Patient-Centred Education
- Where
- United Kingdom
- Volunteers
- 95 people
- Sponsor
- Glasgow Caledonian University
Frailty
Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study
The Supporting Habit Formation to Attenuate Prefrailty in Elders (SHAPE) Pilot Study is a randomized control study. The main objective of this pilot study is to determine the feasibility of using Habit Formation (HF) treatment to…
- Trial name
- SHAPE (NCT04140890)
- Testing
- Habit Formation, Education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wayne State University
Osteoarthritis, Pain
Effectiveness of Tailored Activity Pacing for Symptomatic Osteoarthritis
The primary objective of this project is to examine effectiveness of a tailored pacing intervention on fatigue, pain, and physical function compared to general pacing intervention and usual care groups.
- Trial name
- AIM (NCT01192516)
- Testing
- Tailored Activity Pacing, General Activity Pacing
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- US Department of Veterans Affairs
PreDiabetes, Hyperglycemia
Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs
The purpose of this research study is to compare the effectiveness of a fully automated digital diabetes prevention program to standard of care human coach-based diabetes prevention programs for promoting clinically meaningful…
- Conditions
- PreDiabetes, Hyperglycemia, Glucose, High Blood, Overweight
- Trial name
- NCT05056376
- Testing
- Digital Diabetes Prevention Program (dDPP), Human Coach-based Diabetes Prevention Program (hDPP)
- Where
- 2 sites in United States
- Volunteers
- 368 people
- Sponsor
- Johns Hopkins University
Healthy Volunteers
A Study of LY2484595 on the Electrical Activity of the Heart
The purpose of this study is to evaluate the effect on the electrical activity of the heart as measured by an electrocardiogram (ECG) after dosing with 10 days of LY2484595 compared to 10 days of placebo in relation to a single…
- Trial name
- NCT01537887
- Testing
- LY2484595, Moxifloxacin
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Delirium, Agitation
Randomized Controlled Trial of Dexmedetomidine for the Treatment of Intensive Care Unit (ICU) Delirium
The purpose of the research is to see if dexmedetomidine (a drug that has a calming effect - a sedative) is effective for the treatment of acute delirium
- Trial name
- NCT00351299
- Testing
- Dexmedetomidine, Standard of Care
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Sedentary Behavior, Screen Time
StandUPTV: Reducing Sedentary Screen Time in Adults
The goal of this study is to develop an optimized intervention for reducing leisure sedentary screen time (SST) in middle-aged adults with overweight or obesity.
- Conditions
- Sedentary Behavior, Screen Time, Physical Activity, Sleep
- Trial name
- StandUPTV (NCT04464993)
- Testing
- Device-based feedback, self-monitoring, and education: CORE, Sedentary Screen Time lockout: LOCKOUT, Context-based prompts: TEXT
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Malaria
Safety, Tolerability and Antimalarial Activity of Single Doses of OZ439 and PQP
A single-centre Phase 1b study to assess the safety, tolerability, pharmacokinetic profile, and antimalarial activity of single doses of coadministered artefenomel (OZ439) and piperaquine phosphate (PQP) against early Plasmodium…
- Trial name
- NCT03542149
- Testing
- 480 mg Piperaquine phosphate, 640 mg Piperaquine phosphate, 200 mg OZ 439
- Where
- Australia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
HIV Infections
Comparative Efficacy and Safety Study of Dolutegravir and Lopinavir/Ritonavir in Second-line Treatment
For treatment of human immunodeficiency virus type 1(HIV-1), publicly funded programmes tend to follow World Health Organization (WHO) guidelines to use a non-nucleoside reverse transcriptase inhibitor (NNRTI) combined with two…
- Trial name
- NCT02227238
- Testing
- DTG, LPV/RTV, Two NRTIs
- Where
- 59 sites in Argentina, Brazil and 11 more
- Volunteers
- 627 people
- Sponsor
- ViiV Healthcare
Psychiatric Emergency, Aggression
TREC-Lebanon: A Trial for Rapid Tranquilisation for Agitated Patients in the Emergency Setting
This is a randomised controlled trial comparing haloperidol + promethazine versus haloperidol + promethazine + chlorpromazine for agitated patients in the emergency department.
- Conditions
- Psychiatric Emergency, Aggression, Agitation
- Trial name
- TREC (NCT03639558)
- Testing
- Haloperidol + Promethazine + Chlorpromazine, Haloperidol + Promethazine
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Joseph Dib
Bronchospasm, Activity/Exercise Induced Bronchospasm
A Study Measuring Asthma Control In Pediatric And Adolescent Subjects Whose Asthma Is Worsened By Activity Or Exercise
During this study, your child will need to attend up to 5 office visits and maintain regular telephone contact with the clinic. Certain office visits will include physical exams, medical history review, exercise challenge test…
- Trial name
- NCT00118716
- Testing
- Fluticasone propionate/salmeterol, Fluticasone Propionate
- Where
- 50 sites in United States
- Volunteers
- 248 people
- Sponsor
- GlaxoSmithKline
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