Clinical trials: Motility Disorder
Bronchiectasis, Cystic Fibrosis
Natural History of Bronchiectasis
Background: Bronchiectasis is a disease characterized by airways that are inflamed, abnormally dilated, and chronically infected. Individuals with bronchiectasis have a history of chronic and recurring respiratory infections.
- Conditions
- Bronchiectasis, Cystic Fibrosis, Autoimmune Disease, Common Variable Immunodeficiency
- Trial name
- NCT00943514
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Achalasia
Endoscopic Versus Laparoscopic Myotomy for Treatment of Idiopathic Achalasia
Achalasia is a rare neurodegenerative esophageal motility disorder characterized by incomplete lower esophageal sphincter (LES) relaxation, increased LES tone, and aperistalsis of the esophagus leading to dysphagia…
- Trial name
- POEMrct (NCT01601678)
- Testing
- Peroral Endoscopic Myotomy (POEM), Laparoscopic Heller Myotomy (LHM)
- Where
- 8 sites in Belgium, Czechia and 4 more
- Volunteers
- 240 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Esotropia
The Prism Adaptation Study (PAS)
To determine whether the preoperative use of prisms in eyeglasses can improve the outcome of surgery for acquired esotropia, a type of strabismus.
- Trial name
- NCT00000121
- Testing
- Prisms in Eyeglasses
- Sponsor
- National Eye Institute (NEI)
Progressive Supranuclear Palsy
Clinical Trial to Evaluate Bone Marrow Stem Cell Therapy for PSP, a Rare Form of Parkinsonism
There is evidence suggesting that stem cells harvested from the bone marrow and transplanted into the brain may be effective in slowing down the progression of parkinsonism.
- Trial name
- NCT01824121
- Testing
- stem cell therapy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Exotropia, Exophoria
A-eyedrops on Ocular Alignment and Binocular Vision
Atropine is a non-selective muscarinic acetylcholine (M) receptor antagonist that paralyzes the ciliary muscle, dilates the pupil, and reduces the power of accommodation.
- Conditions
- Exotropia, Exophoria, Myopia
- Trial name
- NCT05379855
- Testing
- 0.01% atropine eye drops, 0.05% atropine eye drops
- Where
- China
- Volunteers
- 339 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Convergence Insufficiency
Effect of Oculomotor Therapy in Individuals With Convergence Insufficiency
The aim of this study is to investigate the effect of oculomotor therapy in individuals with ocular convergence insufficiency.
- Trial name
- NCT07036263
- Testing
- Oculomotor therapy, No Treatment Added
- Volunteers
- 70 people
- Sponsor
- University of Nove de Julho
Paraesophageal Hernia, Gastro Esophageal Reflux
Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.
Short-term follow up after surgery of para-esophageal hernia comparing two different types of fundoplication
- Trial name
- NCT04436159
- Testing
- Addition of 360 fundoplication after crural closure, Addition of 180 posterior fundoplication after crural closure
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital
Strabismus
Peribulbar Block for Prevention of Oculocardiac Reflex
Strabismus is a common ophthalmic problem in Egypt that usually requires surgical correction. This surgery primarily aims to improve alignment of visual axis but may be required only for cosmetic reasons.
- Trial name
- NCT04549844
- Testing
- Bupivacaine
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Non-erosive Gastroesophageal Reflux Disease, Functional Dyspepsia
Functional Gastrointestinal Disorder Screening Program - A Randomized Controlled Trial
Background: Functional gastrointestinal disorder (FGID) is the most common gastrointestinal disease in daily clinical practice. The disease is symptomatic but has no identifiable cause by standard diagnostic tests such as…
- Conditions
- Non-erosive Gastroesophageal Reflux Disease, Functional Dyspepsia, Irritable Bowel Syndrome
- Trial name
- FGISP-RCT (NCT01047800)
- Testing
- Counseling
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Chinese University of Hong Kong
Esophageal Disease
Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
This is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal…
- Trial name
- NCT04001400
- Testing
- Rabeprazole 20mg bid, Rabeprazole 20mg qd
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Esophageal Motility Disorders
Changes in Esophageal Motility and Swallowing Symptoms After Thyroid Surgery
The pronounced effect of goiter on the esophagus needs further exploration, as the mechanisms by which goiter leads to swallowing difficulties are unknown.
- Trial name
- NCT03100357
- Testing
- Thyroidectomy
- Volunteers
- 39 people
- Sponsor
- University of Southern Denmark
Oesophageal Reflux, Gastric Reflux
Efficacy and Speed of Action of a Product to Control Gastric Hydration and Gastroesophageal Reflux
A Randomised, Placebo-Controlled Clinical Trial off the Efficacy and Rapidity of Action of a Product Containing Sodium Alginate, Calcium and Magnesium Salts, Hyaluronic Acid and Aloe Vera to Control Oesophageal-Gastric pH and…
- Conditions
- Oesophageal Reflux, Gastric Reflux, Hyperactivity; Stomach
- Trial name
- AQUAA (NCT05060744)
- Testing
- Antacid, Control
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Uriach Consumer Healthcare
Laryngopharyngeal Reflux, Laryngopharyngitis Chronic
Method of Early Diagnosis of Laryngopharyngeal Reflux
The investigator will issue a Patient Information Consent for the participant in the study. 1.Patients will be asked to complete the Reflux Symptom Index questionnaire. Clinical survey, medical history. 2.
- Conditions
- Laryngopharyngeal Reflux, Laryngopharyngitis Chronic, Gastro Esophageal Reflux, Laryngitis
- Trial name
- LPR (NCT04771221)
- Testing
- pH metry, Filling out the questionnaire, Endoscopic laryngoscopy
- Where
- 2 sites in Kazakhstan
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Kazakh Medical University of Continuing Education
Gastroesophageal Reflux, Esophageal Atresia
Rectal and Oral Omeprazole Treatment of Reflux Disease in Infants.
The purpose of this study is to compare the efficacy of oral and rectal omeprazole treatment in infants with gastroesophageal reflux due to esophageal atresia or congenital diaphragmatic hernia.
- Conditions
- Gastroesophageal Reflux, Esophageal Atresia, Hernia, Diaphragmatic
- Trial name
- NCT00226044
- Testing
- Omeprazole rectally 1mg/kg
- Where
- Netherlands
- Volunteers
- 17 people
- Sponsor
- Rijnstate Hospital
Symptomatic Gastroesophageal Reflux Disease (sGERD)
Comparing the Efficacy, Safety, and Tolerability of Rabeprazole ER 50 mg With Placebo in Subjects With Symptomatic Gastroesophageal Reflux Disease (sGERD)
The purpose of this study is to compare the efficacy, safety and tolerability of rabeprazole extended release (ER) 50 mg with placebo in subjects with symptomatic gastroesophageal reflux disease (sGERD).
- Trial name
- NCT00911534
- Testing
- rabeprazole sodium
- Where
- 98 sites in United States
- Volunteers
- 305 people
- Sponsor
- Eisai Inc.
Laryngopharyngeal Reflux
Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment
This study proposes to investigate prospectively, the presence of molecular markers for inflammation in laryngopharyngeal reflux (LPR) patients and to study the effect of a proton pump inhibitor (Aciphex) on these molecular…
- Trial name
- NCT00204698
- Testing
- Aciphex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Utah
Acne Vulgaris, Allergic Rhinitis
MedlinePlus Health Prescriptions: Developing a Pragmatic Approach for Clinic Use
The specific aim of this proposed pilot study is to compare two standardized processes (paper and electronic) to deliver a customized MedlinePlus health information prescription.
- Conditions
- Acne Vulgaris, Allergic Rhinitis, Anxiety, Asthma
- Trial name
- NCT01050465
- Testing
- health information prescription
- Volunteers
- 907 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Gastric Motility Disorder
Effect of Methylnaltrexone on GI Transit in Healthy Volunteers
This is a single-center, randomized, double blind, placebo-controlled study evaluating the effects of placebo, codeine, methylnaltrexone and codeine with methylnaltrexone on gastrointestinal motility and colonic transit of solids…
- Trial name
- NCT01055704
- Testing
- Methylnaltrexone only, Codeine only, Methylnaltrexone + codeine
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Parkinson Disease, Multiple System Atrophy
Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism
The purpose of this study is to determine the efficacy of Droxidopa for the treatment of fatigue in patients with Parkinsonism by the Visual Analog Fatigue Scale (VAFS).
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT03446807
- Testing
- Droxidopa
- Where
- United States
- Sponsor
- Loma Linda University
Cataract, Glaucoma
Potential Research Participants for Future Studies of Inherited Eye Diseases
This study will evaluate potential candidates for future clinical research studies related to diagnosed or undiagnosed genetic eye disorders or diseases.
- Conditions
- Cataract, Glaucoma, Retinitis Pigmentosa, Macular Degeneration
- Trial name
- NCT00559234
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Eye Institute (NEI)