Clinical trials: Morbid Obesity, open to volunteers
Obesity, Morbid, Bariatric Surgery Candidate
Cognitive Impairment, Obesity, and the Effects of Bariatric Surgery
Study is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.
- Trial name
- NCT05215886
- Testing
- Surgery
- Where
- United States
- Volunteers
- 9,500 people
- Sponsor
- University of California, Davis
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Obesity, Obesity, Morbid
Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body.
- Conditions
- Obesity, Obesity, Morbid, Metabolic Disease, Weight, Body
- Trial name
- NCT06299644
- Testing
- Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain
Effect of Lidocaine-Dexmedetomidine on Pain, Inflammation, and Oxidative Stress After Bariatric Surgery.
The goal of this randomized clinical trial is to find out whether giving an intravenous lidocaine + dexmedetomidine combination (LIDEX) during laparoscopic bariatric surgery can lower post-operative pain, inflammation, and…
- Conditions
- Morbid Obesity Requiring Bariatric Surgery, Postoperative Pain, Postoperative Pain Management, Postoperative Analgesia
- Trial name
- NCT07073846
- Testing
- Intravenous Lidocaine infusion + Standard Anesthesia, Intravenous Dexmedetomidine infusion + Standard Anesthesia, Lidocaine + Dexmedetomidine Combination (LIDEX) + Standard Anesthesia
- Where
- 2 sites in Mexico
- Volunteers
- 104 people
- Sponsor
- Instituto Mexicano del Seguro Social
Obesity, Morbid
Bariatric Surgery Registry
Periodic analyses of our extensive database with regards to different surgical procedures for severe obesity and different obesity co-morbidities will be of benefit to our severely obese patients as well as to others world-wide.
- Trial name
- NCT01055054
- Where
- United States
- Volunteers
- 8,000 people
- Sponsor
- Virginia Commonwealth University
Bariatric Surgery Candidate, Cardiovascular Diseases
Gut Microbiota in Metabolic Surgery
Metabolic surgery is an emerging option to treat obesity-related metabolic diseases (e.g., type 2 diabetes) and prevent cardiovascular disease (CVD).
- Conditions
- Bariatric Surgery Candidate, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidemias
- Trial name
- NCT05000996
- Testing
- Bariatric Surgery
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Vanderbilt University Medical Center
Childhood Obesity, Morbid Obesity
Whole Transcriptome Profiling and Metabolic Phenotyping in Children With ROHHAD Syndrome
Rapid onset Obesity, Hypoventilation, Hypothalamic dysfunction and Autonomic Dysregulation (ROHHAD) is a syndrome named in 2007. The hallmark of the syndrome is the rapid onset obesity and dysregulation of central ventilation.
- Trial name
- NCT02602769
- Testing
- Transcriptome profiling
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Obesity, Morbid
Bariatric Surgery and Modulation of Perceived Satiety
Bariatric surgery is the ideal therapeutic strategy for patients with severe obesity when lifestyle interventions have failed. Unfortunately, weight recovery after surgery affects one third of patients and is due to several…
- Trial name
- BAR_SAZ (NCT05777928)
- Testing
- Sleeve gastrectomy, OverStitch™ Endoscopic Suturing System
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Istituto Auxologico Italiano
Gastroesophageal Reflux Disease, Morbid Obesity
Effect of Laparoscopic Sleeve Gastrectomy Versus Roux-en-Y Gastric Bypass on Gastroesophageal Reflux Disease: An 8-Year Prospective Cohort Study
This study represents a long-term observational follow-up of patients who had previously undergone bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) in the context of an earlier interventional trial…
- Trial name
- NCT03692455
- Where
- Brazil
- Volunteers
- 75 people
- Sponsor
- Clinica Gastrobese
Gastro Esophageal Reflux, Severe Obesity
Comparison of Nissen-Sleeve and Gastric Bypass for GERD in Obese Patients
This randomized clinical trial aims to compare two surgical techniques for the treatment of obesity in patients who also have symptoms of gastroesophageal reflux disease (GERD).
- Conditions
- Gastro Esophageal Reflux, Severe Obesity, Bariatric Surgery
- Trial name
- SLEEVE-GERD (NCT07158008)
- Testing
- Nissen-Sleeve Gastrectomy (N-SG), Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG)
- Where
- Poland
- Volunteers
- 560 people
- Sponsor
- Jagiellonian University
Morbid Obesity
Cost-Effectiveness and Outcome of Robot-assisted Vs Laparoscopic Roux-en-Y Gastric Bypass
The objective of this randomized controlled trial is to compare perioperative outcomes between laparoscopic and robotic approaches in patients with severe obesity who are candidates for RYGB.
- Trial name
- LvRRYGB (NCT07153419)
- Testing
- Laparoscopic and robotic (DaVinci) RYGB
- Where
- Italy
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Severe Obesity
Mazdutide as Adjuvant Therapy Following Sleeve Gastrectomy in Severe Obesity
The SMART study is a 96-week, multicenter, randomized, double-blind, placebo-controlled superiority clinical trial. A total of 256 severe obesity patients are randomized 1:1 to either receive the bariatric surgery plus GCG/GLP-1…
- Trial name
- SMART (NCT07135141)
- Testing
- Sleeve gastrectomy plus early mazdutide initiation
- Where
- 14 sites in China
- Volunteers
- 256 people
- Sponsor
- Beijing Friendship Hospital
Obesity; Drug, Obesity, Morbid
Improving Efficacity of Sleeve Gastrectomy With Naltrexone/Bupropion Extended-release Tablet
The goal of this clinical trial is to assess the impact of combination therapy with Naltrexone-Bupropion (NB) in the post-operative period of sleeve gastrectomy (SG).
- Trial name
- NCT06620562
- Testing
- Naltrexone/Bupropion
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Laval University
Hemorrhage, Bariatric Surgery
Role of Tranexamic Acid in Reducing Hemorrhagic Events in Bariatric Surgery
The goal of this clinical trial is to learn if tranexamic acid (TXA) helps reduce bleeding during bariatric surgery, such as laparoscopic sleeve gastrectomy (LSG) and mini gastric bypass (MGB).
- Conditions
- Hemorrhage, Bariatric Surgery, Obesity, Morbid
- Trial name
- NCT07098780
- Testing
- Tranexamic Acid
- Where
- Pakistan
- Volunteers
- 140 people
- Sponsor
- Patel Hospital, Pakistan
Obesity, Bariatric Surgery
Establishment of a Classification System and Postoperative Risk Warning Model for Patients Undergoing Bariatric Metabolic Surgery for Severe Obesity
This study aims to establish a classification system for patients undergoing metabolic surgery for severe obesity by constructing a prospective cohort of 2,000 patients and collecting clinical and biological data at multiple time…
- Conditions
- Obesity, Bariatric Surgery, Bariatric Surgery (Sleeve Gastrectomy )
- Trial name
- NCT07093502
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Morbid Obesity, PCA
Dual-chamber Patient-controlled Analgesia for Postoperative Recovery
Postoperative nausea and vomiting (PONV) are the most common complications that can occur after general anesthesia. Postoperative use of opioids and morbid obesity have been reported as risk factors of PONV.
- Conditions
- Morbid Obesity, PCA, Analgesia, PONV
- Trial name
- NCT07051109
- Testing
- multimodal analgesia via dual-chamber PCA, single regimen (only fentanyl)
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Seoul National University Bundang Hospital
Obesity, Morbid Obesity
The Effect of Cognitive Function Level in Morbidly Obese Patients
Obesity is a disease caused by many factors, such as lifestyle, eating habits, lack of physical activity, hormonal and genetic influences. These different factors make treatment planning difficult.
- Trial name
- NCT07032415
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Kocaeli City Hospital
Morbid Obesity
Dairy Lipids and Cardiometabolic Risk
It is a randomized parallel arm intervention study in adults with severe obesity. The objective is to demonstrate that within a dietary handling for weight loss, the daily ingestion during 3 months of whole dairy products…
- Trial name
- DAILICATE (NCT05783466)
- Testing
- Low-fat dairy products, Whole-fat dairy products, Milk polar lipid enriched whole-fat dairy products
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Hospices Civils de Lyon
Bariatric Surgery, Bone Health
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population.
- Conditions
- Bariatric Surgery, Bone Health, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- BODI (NCT03455868)
- Testing
- Bariatric surgery
- Where
- 3 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Bariatric Surgery, Bone Health
Bone and Muscle Health Following Sleeve Gastrectomy in Men, Premenopausal and Postmenopausal Women
Background: Bariatric surgery is gaining in popularity. While it's health benefits are undisputed, the older malabsorptive bariatric procedures (Roux-in-Y gastric bypass - RYGB and biliopancreatic diversion - BPD) are associated…
- Conditions
- Bariatric Surgery, Bone Health, Severe Obesity, Muscle Health
- Trial name
- BONUS (NCT06547515)
- Testing
- Bariatric surgery
- Where
- Canada
- Volunteers
- 156 people
- Sponsor
- CHU de Quebec-Universite Laval