Clinical trials: Mood Lability
Emotional Lability, PTSD
Yoga Based Psychotherapy Group Feasibility and Efficacy Study
This preliminary study will examine the feasibility of conducting a randomized clinical trial of Yoga Based Psychotherapy (YBPG) and standard care mental health (SCMH) treatment compared to SCMH for children ages 8-12 years who…
- Trial name
- NCT01524172
- Testing
- Yoga Based Psychotherapy Group, Standard Mental Health Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Depression, Multiple Sclerosis
The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to…
- Trial name
- NCT00151294
- Testing
- escitalopram oxalate antidepressant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Depressive Disorder, Major, Depression
Pilot Study: Investigating Mood Changes After Slow-wave Enhancement
The aim of this pilot project proposal is to test the hypothesis that decreased sleep slow-wave activity (SWA) observed in individuals with major depressive disorder (MDD) is related to mood dysfunction, and that manipulating SWA…
- Conditions
- Depressive Disorder, Major, Depression, Depression, Unipolar, Depressive Disorder
- Trial name
- SWE (NCT05146427)
- Testing
- Slow-wave enhancement
- Sponsor
- University of Pennsylvania
Chronic Pain, Opioid Use Disorder
The Acupuncture for Pain, Opioid Use Disorder and Mood
The goal of this study is to determine how patients with chronic pain and opioid use disorder will respond to treatment with acupuncture, including whether there will be any changes in mood (as an exploratory outcome).
- Conditions
- Chronic Pain, Opioid Use Disorder, Mood Change, Opioid Misuse
- Trial name
- AcuPOM (NCT06543355)
- Testing
- Modified Battlefield Acupuncture + National Acupuncture Detoxification Association protocol
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Albert Einstein College of Medicine
Bipolar Disorder (BD)
The PEDAL Intervention - Reducing Affective Lability in Bipolar Disorder
PEDAL is a group-based intervention for patients with bipolar disorder that builds on the traditional group psychoeducational program (GPP) by adding digital tools and specific strategies to help manage rapid fluctuations between…
- Trial name
- PEDAL (NCT07239778)
- Testing
- Traditional group psychoeducation for bipolar disorder, Group psychoeducation with digital elements and focus on affective lability
- Where
- 4 sites in Norway
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Menopausal Syndrome
The Effect of Internet- and Mobile-based Group Treatment in Menopausal Women
Background: Menopause syndrome generally occurs with and is related to psychological problems. However, Internet- and mobile-based group treatment (imGT) may improve women's physiological and psychological conditions.
- Trial name
- IMGTMP (NCT03948269)
- Testing
- group behavioral cognitive therapy
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Depression
Behavioral Study of Effects of Low-Level Light Therapy on Mood and Reaction Time
The goal of this project is to use low-level light therapy (LLLT) to enhance neural metabolism in the prefrontal cortex of humans, and measure the effects of LLLT on attentional bias change following a single session of attention…
- Trial name
- NCT02390076
- Testing
- Left Low Level Light Therapy, Attention bias modification, Right Low Level Light Therapy
- Volunteers
- 51 people
- Sponsor
- Seth Disner
Inflammatory Bowel Disease 11
Steroid-induced Mood Changes in Patients With Inflammatory Bowel Disease
Steroid is commonly used to treat autoimmune disorders such as rheumatoid arthritis, lupus, and inflammatory bowel disease (Crohn's Disease and Ulcerative Colitis).
- Trial name
- NCT01981889
- Testing
- Prednisone
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- University of British Columbia
Alcohol Craving, Mood Changes
A Dose Response Effect of Atomoxetine to the Acute Effects of Alcohol
This two-stage study will examine the effects of a 5 day course of atomoxetine (placebo, 40, 60 or 80 mg/day; Strattera) (a selective NE transporter (NET) inhibitor) on alcohol-elicited craving and sensitivity to alcohol.
- Trial name
- ATX_COMT (NCT01408589)
- Testing
- Atomoxetine, Strattera
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Alzheimer's Disease
Study of the Effects of Current Drug Treatments on Levels of Certain Brain Chemicals in Alzheimer's Disease
Alzheimer's disease is a medical illness that damages the brain and causes problems with memory, mood and behavior. A substance called acetylcholine (ACh), which is naturally produced in the body, plays an important role in the…
- Trial name
- NCT00104442
- Testing
- Rivastigmine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Novartis
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Mood Swings
Effect of Moderate Alcohol Consumption on Postprandial Mood
Rationale: Food choice is influenced by postprandial mood; the feelings of well-being after a meal. Postprandial mood can be measured by subjective responses.
- Trial name
- NCT01426022
- Testing
- Nutrition, mood manipulation
- Where
- Netherlands
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- TNO
Women's Health
Evaluating the Effect of a Supplement on Symptoms of Hormonal Imbalance.
This is a virtual single-group trial lasting 12 weeks to evaluate the effects of Perelel Health's hormonal balance support on symptoms of hormonal imbalance and overall menstrual health.
- Trial name
- NCT06535698
- Testing
- Perelel Health Hormonal Balance Support
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Perelel Inc.
Insomina, Mood Change
Integrating Smart Wearable Device Into Digital Insomnia Treatment Application: Exploration of Combining Emotional and Lifestyle Records
Emotions, behavior, and cognition are the main factors contributing to insomnia. Insomnia not only affects sleep quality but also harms health, quality of life, and daytime functioning.
- Trial name
- NCT07600840
- Testing
- Personalized Experience Sampling Method, Non-personalized Experience Sampling Method
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Technology
Contraception, Mood Change
Stress Hormones and IUDs
Determine what kind of side effects women experience in the first year after they start using an intrauterine device.
- Trial name
- NCT03499379
- Testing
- Mirena, Paraguard
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Major Depressive Disorder, Sexual Behavior
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling
Large register based work has shown that starting on oral contraceptives (OCs) is associated with an increased risk of developing depressive episodes.
- Conditions
- Major Depressive Disorder, Sexual Behavior, Mood Disturbance, Mood Change
- Trial name
- NCT05212389
- Testing
- Femicept
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mood Change, Depressive Symptoms
Mind-Body Skills Group for Graduate Students
Integrative-Mind-Body Skills Group (I-MBS-G) is an 8-week group that teaches skills to build inner resources for effective mood management.
- Conditions
- Mood Change, Depressive Symptoms, Anxiety Generalized
- Trial name
- NCT05447689
- Testing
- Integrative-Mind-Body Skills Group
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Bipolar Disorder, Mood Swing
Seeing the Light: Early Intervention in People at Risk for Bipolar Disorder
In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated.
- Conditions
- Bipolar Disorder, Mood Swing, Prodromal Symptoms
- Trial name
- NCT06282250
- Testing
- Bright light therapy + Psycho-education + Imagery focused Cognitive Therapy, Blue-light blocking glasses + Psycho-education + Imagery focused Cognitive Therapy, Psycho-education + Imagery focused Cognitive Therapy
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Geestelijke Gezondheidszorg Eindhoven (GGzE)
Memory Deficits, Mood Change
The Effects of Microbiological Spectrum Changes to Improve Cognitive Health in Aging Population
The goal of this project is to develop probiotic dietary supplements intended for the elderly, which can modify the composition of the intestinal microbiota typically occurring in the aging population.
- Conditions
- Memory Deficits, Mood Change, Gut Health, Aging Problems
- Trial name
- CleverAgeBiota (NCT05051501)
- Testing
- Probiotics C2P
- Where
- 2 sites in Czechia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health, Czech Republic
Attention Deficit Hyperactivity Disorder
Imaging the Effects of Stimulant Medication on Emotional Lability in Patients With ADHD
The aim of this study is to examine the mechanisms by which stimulant medications reduce symptoms in patients with Attention Deficit Hyperactivity Disorder (ADHD).
- Trial name
- NCT01415440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute