Clinical trials: Mood Instability
Autism
Oxcarbazepine Versus Placebo in Childhood Autism
The proposed study is designed to assess the effectiveness of treatment with Oxcarbazepine vs. placebo in childhood/adolescent autism.
- Trial name
- NCT00467753
- Testing
- Oxcarbazepine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Schizophrenia, Bipolar Disorder
Can Neural Network Instability in Schizophrenia be Improved With a Very Low Carbohydrate Ketogenic Diet?
Wide ranging cognitive deficits are major drivers of functional decline and poor outcomes in people with schizophrenia (SZ) and bipolar disorder (BD).
- Trial name
- NCT05268809
- Testing
- Ketogenic diet
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Northern California Institute of Research and Education
Emotional Distress, Impulsive Behavior
Neurobehavioral Affective Control Training
The goal of this clinical trial is to test a new cognitive training program to improve emotion regulation in adults. The investigators' primary aim is to determine whether participating in this program addresses two key features…
- Conditions
- Emotional Distress, Impulsive Behavior, Mood Lability, Mood Instability
- Trial name
- N-ACT (NCT06226467)
- Testing
- Neurobehavioral Affective Control Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Berkeley
Attention Deficit Hyperactivity Disorder, ADHD
Female Experiences and Brain Activity
The Female Experiences and Brain Activity study will investigate how different groups of people process information in different ways.
- Conditions
- Attention Deficit Hyperactivity Disorder, ADHD, Bipolar Disorder
- Trial name
- FEBA (NCT01395160)
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Depression, Premenstrual Dysphoric Disorder (PMDD)
Neurofeedback Treatment of Affective Instability in Premenstrual Dysphoric Disorder(PMDD)
Premenstrual Dysphoric Disorder (PMDD) is characterized by affective instability and irritability, diagnosed in 5% of reproductive-age women.
- Trial name
- NCT01945372
- Testing
- EEG NeuroFeedback
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Emotion Regulation, Mood Disorders
Neurostimulation Versus Therapy for Problems With Emotions
The primary goal of this clinical trial is to evaluate the unique neural and behavioral effects of a one-session training combining emotion regulation skills training, with excitatory repetitive transcranial magnetic stimulation…
- Conditions
- Emotion Regulation, Mood Disorders, Stress Disorder, Anxiety Disorders
- Trial name
- NCT05712057
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), electrical scalp stimulation, Cognitive Restructuring
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Duke University
Parkinsons Disease
First-in-Human Study of ALN-SNCA in Adult Participants With Early Parkinson's Disease (PD)
This study is researching an experimental drug called ALN-SNCA (called "study drug"). The study is focused on people with early Parkinson's disease, a disorder of the nervous system that affects movement.
- Trial name
- NCT07216066
- Testing
- ALN-SNCA
- Where
- 3 sites in Canada, Netherlands
- Volunteers
- 46 people
- Sponsor
- Regeneron Pharmaceuticals
Bipolar Disorder, Cyclothymia
Calling for Care: Cell Phones for Mood Telemetry in Teens
We will modify our existing VMQ/VADIS mood telemetry software to run on a Motorola platform, and enhance it to collect information on both mood symptoms (currently covered by the VMQ/VADIS) as well as daily life stressors…
- Conditions
- Bipolar Disorder, Cyclothymia, Borderline Personality Disorder
- Trial name
- NCT01083823
- Testing
- Mental health telemetry (MHT)
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Gastrointestinal Symptoms, Bloating
A Clinical Trial to Evaluate the Effects of Super Liver Liquid Drops on Gut Health, Digestive Comfort, and Daily Energy Levels
This is a decentralized (fully virtual), single-group, open-label, prospective clinical trial evaluating the effects of Super Liver Liquid Drops, a liquid botanical dietary supplement, on gut health, digestive comfort, energy…
- Conditions
- Gastrointestinal Symptoms, Bloating, Digestive Discomfort, Low Energy Levels
- Trial name
- NCT07742657
- Testing
- Super Liver
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- SuperBonsai Inc.
Bipolar Disorder I or II, Healthy (Controls)
Decoding Emotional Dynamics in Bipolar Disorder
The goal of this neuroimaging study is to investigate how emotional states fluctuate in people with bipolar disorder (BD) compared to healthy controls, and to understand the neural mechanisms driving mood instability.
- Trial name
- NCT07221864
- Testing
- Think and Regulate Affective State Task
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Bipolar Disorder, Bipolar I Disorder
Children's Bipolar Network Treatment Trial I
This is a naturalistic treatment and follow-up study of youth with bipolar spectrum disorders (BSDs) across four US sites of The Childhood Bipolar Network (CBN).
- Conditions
- Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder, Other Specified Bipolar and Related Disorder
- Trial name
- CBN (NCT05427123)
- Testing
- Medication or psychosocial treatment
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Bipolar Disorder
MAPP: Imagery-focused Therapy for Bipolar Disorder
Bipolar Disorder (BD) (previously known as "manic depression") is a severe mental health illness affecting at least 1% of the population and with annual NHS cost estimated at £342 million.
- Trial name
- MAPP (NCT01981018)
- Testing
- Imagery-focused Cognitive Therapy (ImCT - psychotherapy based on CBT principles)
- Where
- 4 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Bipolar Disorder
Group Dialectical Behavioural Therapy for Mood Instability Within Bipolar Disorder: An Open Trial
Bipolar Disorders (BD) typically involve repeated episodes of both depression and excessively high mood or irritability (hypomania or mania).
- Trial name
- NCT02637401
- Testing
- Dialectical Behaviour Therapy
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Exeter
Unipolar Depression, Anxiety Disorders
Effects of Mindfulness Based Cognitive Therapy on Emotional Processing
Background: In the last 30 years mindfulness-based approaches have been extensively used for a variety of mental disorders, including affective disorders characterized by emotional instability.
- Conditions
- Unipolar Depression, Anxiety Disorders, Adjustment Disorders, Emotional Instability
- Trial name
- MESI (NCT03358056)
- Testing
- Mindfulness-Based Cognitive Therapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Parc de Salut Mar