Clinical trials: Mono
Chronic Hepatitis C (Disorder)
Dynamic Changes of Monocytes and NK Cells of CHC Patient Treated by DAAs
Recently,surprisingly and unexpectedly increased aggressiveness and high rates of HCC recurrence (28%(16/58) and 29%(17/59), respectively) have been reported in patients who cleared HCV with DAAs after achieving a complete…
- Trial name
- NCT03063723
- Testing
- Ledipasvir-Sofosbuvir, Daclatasvir-Sofosbuvir
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Multiple Myeloma
Study of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in Advanced Multiple Myeloma
This is a Phase Ib, open-label, multicenter, global study designed to assess the safety and tolerability of RO6870810 as monotherapy and in combination with daratumumab in participants with relapsed/refractory multiple myeloma.
- Trial name
- NCT03068351
- Testing
- RO6870810, daratumumab
- Where
- 12 sites in United States, Australia and 1 more
- Volunteers
- 24 people
- Sponsor
- Hoffmann-La Roche
Epilepsy
First Add-on vs. Mono-therapy Study of Topiramate in Neuro-Surgical Patients
The purpose of this study is to examine seizure control and tolerability of Topiramate after either transitioning from previous antiepileptic drug (AED) or adding on to previous AED.
- Trial name
- TEAMS (NCT01627860)
- Testing
- Topiramate add-on therapy, Topiramate monotherapy
- Volunteers
- 55 people
- Sponsor
- Johnson & Johnson Taiwan Ltd
Nocturnal Enuresis
A New Check-list Method for Nocturnal Enuresis
The study is aimed to demonstrate the benefits of newly formed written check-list of behavioral instructions and investigate its effects on parent's awareness, consciousness and motivation toward MNE.
- Trial name
- NCT03510975
- Testing
- desmopressin melt form 120 μg, Verbal behavioral therapy, Behavioral therapy with written check-list
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Tumor, Solid
BDB001-101: Clinical Study of BDB001 as a Mono-therapy or in Combination With Pembrolizumab
Phase 1 Open-Label Dose Escalation Study of BDB001 as a Single Agent and in combination with Pembrolizumab in Subjects with Advanced Solid Tumors
- Trial name
- EIK1001 (NCT03486301)
- Testing
- BDB001 (EIK1001), Pembrolizumab
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- Eikon Therapeutics
Lupus Erythematosus, Cutaneous
Efficacy and Safety of Fumaric Acid Esters (Fumaderm®) in the Treatment of Patients With Cutaneous Lupus Erythematosus
The purpose of this study is to evaluate the therapeutic effect of fumaric acid esters (Fumaderm®) in the treatment of Cutaneous Lupus Erythematosus with respect to proportion of responders based on the Revised Cutaneous Lupus…
- Trial name
- FumaCLE (NCT01352988)
- Testing
- Fumaric acid esters
- Where
- Germany
- Volunteers
- 11 people
- Sponsor
- University Hospital Muenster
Healthy
Study of ESBA105 Eye Drops in Healthy Subjects
Objectives: To evaluate the safety, tolerability and pharmacokinetics of ESBA105 administered topically to the eye for up to 28 days in healthy volunteers.
- Trial name
- NCT00671619
- Testing
- ESBA105
- Where
- Switzerland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- ESBATech AG
Hypertension
Blood Pressure Control of Nifedipine GITS 60mg Treatment in Chinese Hypertensive Subjects Uncontrolled on Starting-dose Mono-therapyo-therapy.
To evaluate antihypertensive efficacy and tolerability of Nifedipine GITS 60mg treated for 8 weeks in Chinese hypertensive subjects who failed to achieve BP control with the starting-dose antihypertensive monotherapy.
- Trial name
- ADEPT (NCT02413515)
- Testing
- Nifedipine (Adalat GITS, BAY1040)
- Where
- 14 sites in China
- Volunteers
- 278 people
- Sponsor
- Bayer
Bone Atrophy, Alveolar
Piezo-assisted Expansion of Narrow Ridges
the goal of the study was the evaluation of the clinical and histological performance of delayed inserted implants in augmented sites with a shaped solid graft inserted in an originally narrow alveolar edentulous ridge.
- Trial name
- PRIDE (NCT07401238)
- Testing
- Alveolar Ridge Reconstruction
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Coronary Heart Disease
CD16+ Monocytes in Coronary Heart Disease (CHD)
Monocytes may be separated into phenotypically and functionally distinct cell types by the presence or absence of the lipopolysaccharide receptor CD14 and the Fcγ-receptor CD16.
- Trial name
- PHAMOS (NCT01442948)
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Age-Related Macular Degeneration
Genetic Study of Age-Related Macular Degeneration
This study will examine skin and blood cells for genetic changes related to the development of age-related macular degeneration, an eye disease that can significantly impair the ability to read, drive, and carry out daily…
- Trial name
- NCT00357578
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Immune System, Nutrition
Postprandial Monocyte Study
The purpose of this research is to determine the role of a type of immune cell in blood, called a non-classical monocytes (NCMs), following consumption of a high-fat meal.
- Conditions
- Immune System, Nutrition, Inflammation
- Trial name
- PPMS (NCT05792137)
- Testing
- High saturated fat challenge meal, High mono unsaturated fat challenge meal
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Nocturnal Enuresis
The Safety and Efficacy of Fluoxetine for Refractory Primary Mono-symptomatic Nocturnal Enuresis in Children
To determine whether there is a role for the selective serotonin reuptake inhibitors, fluoxetine, as therapy in the treatment of refractory primary monosymptomatic nocturnal enuresis in children , and whether there are side…
- Trial name
- NCT04676139
- Testing
- Fluoxetine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Dynamic Wrinkles
ANTI-DYNAMIC LINE Test for Cream
The goal of this clinical trial is to find out whether a new cream (Formula# 899675 44A) can help reduce dynamic facial and neck wrinkles in young Chinese women.
- Trial name
- NCT07067073
- Testing
- Anti-Dynamic Line Cream
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Proximal Humeral Fracture
A Clinical Trial Investigating Iloprost as Medication to Improve Bone Healing in Patients With Proximal Humeral Fracture
The main objective of this study is to establish the safety as well as the efficacy of local insertion of Iloprost at the fracture site for bone healing of the proximal humeral fracture.
- Trial name
- Ilobone (NCT04543682)
- Testing
- 0.125 ng/kg/min Iloprost, 0.25 ng/kg/min Iloprost, open reduction and internal fixation with an angular stable plate (PHILOS)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Charite University, Berlin, Germany
Pulmonary Fibrosis, Interstitial Lung Disease
The MONACO Cell Therapy Study: Monocytes as an Anti-fibrotic Treatment After COVID-19
Up to a third of patients who recovered from SARS coronavirus (SARS-CoV) had a 20% decline in lung function with a long term reduction in exercise capacity and SF-36 health status a year after infection.
- Conditions
- Pulmonary Fibrosis, Interstitial Lung Disease, Covid19
- Trial name
- MONACO (NCT04805086)
- Testing
- MON002
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Immunotoxicity, Anesthesia
Anesthetic Depth Effects Upon Immune Competent Cells
Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients.
- Conditions
- Immunotoxicity, Anesthesia, Inert Gas Narcosis
- Trial name
- BIS-MA (NCT02794896)
- Testing
- High dose propofol, fentanyl and sevoflurane, Low dose propofol, fentanyl and sevoflurane
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Heidelberg University
Tumor, Cancer
Transcriptomal and Molecular Characterization of Tumor Associated Monocytes/Macrophages in Human Cancers
Recent studies from both human and mice cancer models have demonstrated a crucial role for monocytes/macrophages in contributing to cancer progression and disease prognosis.
- Trial name
- NCT00979277
- Where
- Singapore
- Sponsor
- National University Hospital, Singapore
Myeloproliferative Neoplasm
Exploring the Impact of Monocytes in Myeloproliferative Neoplasia (EMYNEM)
Impact of monocytes on Myeloproliferative Neoplasm hematopoietic stem cell growth and differentiation in vitro
- Trial name
- EMYNEM (NCT06462664)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Brest
Hematological Malignancies
Immunological Impact of a Post Cell Therapy Treatment With FLT3 Inhibitors
Allogeneic hematopoietic stem cell transplantation (aHSCT) is the only curative option for many hematological maligancies. The main cause of death following HSCT is the relapse of the original disease.
- Trial name
- TARGETALLO (NCT06992934)
- Testing
- Gilteritinib
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice