Clinical trials: Monitoring, Intraoperative
Head and Neck Disorder, Head and Neck Cancer
Bevonescein for Improved Intraoperative Nerve Visualization to Improve Voice Outcomes in Thyroidectomy Patients
Bevonescein (ALM-488) is a novel fluorescein-containing peptide that is intended as a visualization adjunct for the real-time enhanced structural delineation of major nerves during Head and Neck surgery to potentially improve…
- Trial name
- NCT07631650
- Testing
- Bevonescein (ALM 488) Infusion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Matthew Spector
Spine Injuries and Disorders
Evaluation Of Intra-Operative Neuro-Monitoring Alarm During Complex Spine Surgery
Iatrogenic spinal cord injury is the most feared complication of complex spine surgery. The incidence of neurological complications for spinal deformity surgery has been estimated by the Scoliosis Research Society as 1%, except…
- Trial name
- NCT05710016
- Volunteers
- 64 people
- Sponsor
- Assiut University
Burst Suppression, General Anesthesia
Interrater Variability for the Identification of Anesthetic-induced Burst Suppression EEG
Burst suppression describes a specific EEG pattern that can generally indicate a too deep general anesthesia. The pathophysiology of anesthetic-induced Burst Suppression may be distinctly different from the pathophysiology of…
- Conditions
- Burst Suppression, General Anesthesia, Electroencephalogram
- Trial name
- NCT05508386
- Testing
- MATLAB-based interface, showing 50 EEG traces, classification of the EEG-pattern as Burst Suppression possible, yes, no.
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Focal Epilepsy, Intraoperative Monitoring
High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT
What's the clinical value of high-density flexible microelectrocorticography (μECoG) for guiding the resection of epileptogenic zone (EZ) in epilepsy surgery?
- Trial name
- Epi-PRECISE (NCT07656857)
- Testing
- Using High-density Flexible microElectrocorticography for intraoperative monitoring
- Where
- China
- Volunteers
- 85 people
- Sponsor
- Beijing Tiantan Hospital
Peripheral Vascular Diseases, Blood Pressure
Intraoperative Simultaneous Pressure Guided Revascularization Study
This study aims to determine whether intraoperative physiologic measurements of blood flow to the leg during endovascular treatment of Peripheral Arterial Disease (PAD) can predict future clinical outcomes.
- Conditions
- Peripheral Vascular Diseases, Blood Pressure, Monitoring, Intraoperative, Clinical Decision-Making
- Trial name
- INSTANT (NCT03875846)
- Testing
- Intraoperative Hemodynamic Pressures, Contrast Flow Rate
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Mark Rockley
Hemodynamic Instability, General Anesthesia
End-eXpiratory Occlusion Test to Predict fluId REsponsiveness in the Operating Room (EXPIRE)
The purpose of the study is to evaluate the influence of different durations of the end-expiratory occlusion test to predict fluid responsiveness in mechanically ventilated patients in the operating room.
- Conditions
- Hemodynamic Instability, General Anesthesia, Surgery, Protective Mechanical Ventilation
- Trial name
- EXPIRE (NCT04399278)
- Testing
- Diagnostic Test: end-expiratory occlusion (EEO) test
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Type 1 Diabetes Mellitis
Diathermy On Diabetes Glucose Monitoring Effectiveness
The goal of this observational study is to investigate if diathermy (a surgical tool that uses electrical energy to control bleeding) has any affect on the accuracy and functioning of continuous glucose monitoring systems in…
- Trial name
- DODGE (NCT07583238)
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- University of Nottingham
Craniosynostoses, Hypovolemia
Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic…
- Conditions
- Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability
- Trial name
- CRASY-PRAM (NCT06263075)
- Testing
- Intraoperative monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Placenta Previa
Non-invasive Hemoglobin Monitoring in Cesarean Section
Non-invasive hemoglobin monitoring will be performed in patients who underwent cesarean section with placenta previa and this will be compared with actual laboratory findings.
- Trial name
- NCT03409822
- Testing
- Masimo SpHb™ monitor
- Where
- South Korea
- Volunteers
- 39 people
- Sponsor
- Seoul National University Bundang Hospital
Spine Condition
Evaluating MIONM Effectiveness in Predicting Postoperative Neurological Deficits Using Combined Modalities
Objective: This study aimed to integrate findings from spinal and cranial surgeries with existing literature, emphasizing the role of Intraoperative Neurophysiological Monitoring (IONM) in improving surgical outcomes through best…
- Trial name
- MIONM (NCT06712069)
- Testing
- Multimodal Intraoperative Neurophysiologic Monitoring (MIONM)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Analyse Neuromuscular Monitoring for Developing a Model to Predict TOF Ratio During Anesthesia
Predictive Modelling of the Intraoperative Train-of-Four (TOF) Ratio
Neuromuscular Blocking Agents (NMBAs) are routinely administered to patients in a multiplicity o anaesthetic settings in order to paralyze and impede (re)active muscular contraction.
- Trial name
- NCT04518761
- Testing
- Elective surgery
- Where
- 2 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Anesthesia
The Comparability of Bispectral Index and Neurosense During Anesthesia
The assessment of anesthesia depth was based, until recently, on the evolution of hemodynamic parameters. Nowadays it can be evaluated by several monitoring methods, derived from electroencephalogram analysis, namely the…
- Trial name
- NCT00910416
- Testing
- propofol, remifentanil, atracurium, propofol, remifentanil, atracurium, sevoflurane, EEG monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Foch
Bispectral Index and Neurmuscular Monitoring Data in Anesthetized Patients
Analysis and Record Intraoperative Bispectral Index of Patients of Thoracic Surgeries
Bispectral index(BIS) is commonly used to monitor the depth of anesthesia. The electroencephalographic signal is collected and analyzed by the device, resulting a number related to the awareness of the patient.
- Trial name
- NCT04394364
- Testing
- Bispectral index
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Continuous Glucose Monitoring
Effects of Intraoperative Glycemic Management Strategies Assisted With RT-CGM on TIR and Postoperative Recovery
The purpose of this study is to investigate the effect of intraoperative blood glucose management based on real-time continuous glucose monitoring ( RT-CGM) on time in range (TIR) and postoperative recovery during…
- Trial name
- NCT06755788
- Testing
- RT-CGM, Control
- Where
- China
- Volunteers
- 246 people
- Sponsor
- Peking Union Medical College Hospital
Nociception, NOL Index
Nociception Monitoring During Cardiac Surgery
Cardiac surgery is frequently a source of acute or chronic pain. According to the International Association for the Study of Pain (IASP), nociception is defined as "the neural mechanisms of encoding and processing harmful…
- Conditions
- Nociception, NOL Index, Cardiac Surgery
- Trial name
- MoNOLcard (NCT06817005)
- Testing
- Intervention arm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Strasbourg, France
Hernia, Ventral, Hernia Incisional
Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair
People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed.
- Conditions
- Hernia, Ventral, Hernia Incisional, Postoperative Complications, Respiratory Insufficiency
- Trial name
- CLOSE-STAT (NCT07422441)
- Testing
- Compliance-Guided Abdominal Wall Closure Decision Strategy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Swissmed Hospital
Anesthesia, General, Gynecologic Surgical Procedures
DSA vs. BIS for Anesthesia and Analgesia Management
The purpose of this study is to compare two different methods of monitoring brain activity (anesthesia depth) during gynecological surgeries.
- Conditions
- Anesthesia, General, Gynecologic Surgical Procedures, Intraoperative Monitoring, Anesthesia Depth Monitoring
- Trial name
- DSA-PRECISION (NCT07502261)
- Testing
- Density Spectral Array (DSA) Monitoring, Bispectral Index (BIS) Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Liver Transplantation
Physiological Data Analysis of Patients Undergoing Anesthesia for Liver Transplantation
To record the intra-operative digital data from the standard monitoring instruments containing cardiovascular system information, and from depth-of-anesthesia monitoring modules (Bispectral index, Entropy module, Surgical…
- Trial name
- NCT03694301
- Volunteers
- 40 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Remimazolam, Anesthesia Awareness
The Effect of Wavelet Index in Monitoring the Sedation Depth of Remimazolam Besylate
To explore the sedative effect of remimazolam in patients undergoing spinal anesthesia without pain stimulation. Both the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) and the Wavelet index (WLi) were used to…
- Conditions
- Remimazolam, Anesthesia Awareness, Sedative, Hypnotic, or Anxiolytic Withdrawal
- Trial name
- NCT06427785
- Testing
- Remimazolam besylate
- Volunteers
- 30 people
- Sponsor
- Beijing Chao Yang Hospital
Hemodynamics, Fluid Therapy
Observation of Principal Hemodynamic Variables After Spinal Anesthesia With Non Invasive Hemodynamic Monitoring
The study is aimed at observe how spinal anesthesia modifies the hemodynamic state of the patient after optimization to preload independence with a Goal Directed Therapy algorithm guided by non invasive hemodynamic monitoring…
- Conditions
- Hemodynamics, Fluid Therapy, Anesthesia, Spinal, Monitoring, Intraoperative
- Trial name
- NCT03086603
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli