Clinical trials: Monitored Anaesthesia Care, active
Dexmedetomidine, Sedation
Safety Exploration and Evaluation of Dexmedetomidine Hydrochloride Nasal Spray for Pre-anesthesia Sedation in Low-Monitoring Settings
The goal of this clinical trial is to assess the viability of dexmedetomidine hydrochloride nasal spray under minimal or no supervision and to further investigate novel clinical applications for this medication.
- Conditions
- Dexmedetomidine, Sedation, Safety, Preanesthetic Medication
- Trial name
- NCT07298525
- Testing
- Dexmedetomidine hydrochloride nasal spray
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Aortic Valve Stenosis
RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation
Open-label, 2 x 2 factorial, prospective, randomized, national, multicenter study to compare latest-generation self-expanding valves and a minimalist approach versus standard of care in transcatheter aortic valve implantation.
- Trial name
- DOUBLE-CHOICE (NCT05036018)
- Testing
- ACURATE neo2, minimalist approach, CoreValve Evolut Pro, Pro+ and FX
- Where
- 10 sites in Germany
- Volunteers
- 836 people
- Sponsor
- Leipzig Heart Science gGmbH
Respiratory, Monitored Anaesthesia Care
The PneumoRator Study
Healthcare workers measure heart rate, blood pressure, temperature, oxygen levels and breathing rate to monitor how unwell a patient is. All these apart from breathing rate are now normally measured by machines.
- Conditions
- Respiratory, Monitored Anaesthesia Care, Perioperative
- Trial name
- NCT07293299
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Anesthesia, Sedation
The Million Anesthesia Cases Study (MACS) - a Cohort Study of Preoperative Fasting and Perioperative Outcomes
Perioperative fasting has historically been viewed as a low-risk intervention. However, preliminary data indicate that perioperative loss of nutrition and fluids is likely harmful.
- Conditions
- Anesthesia, Sedation, Monitored Anesthesia Care, Procedure
- Trial name
- MACS (NCT07022951)
- Testing
- Preoperative fasting
- Where
- United States
- Volunteers
- 1,200,000 people
- Sponsor
- Massachusetts General Hospital
Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia
qNOX Response to Nociceptive Motor Events During Procedural Sedation
The goal of this observational study is to evaluate whether the CONOX monitor can detect pain during sedation in patients undergoing urological procedures.
- Conditions
- Monitoring Noxious Events Using EEG-Derived Pain Indices, Procedural Sedation and Analgesia, Monitored Anesthesia Care
- Trial name
- MO-NOX (NCT07413848)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara University
Patients Undergoing Endoscopic Submucosal Dissection
A Comparison of High-flow Nasal Oxygen and Conventional Nasal Cannula in Monitored Anesthesia Care for Endoscopic Submucosal Dissection
Sedation for endoscopic submucosal dissection places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk.
- Trial name
- NCT06688019
- Testing
- conventional oxygenation (nasal cannula), high-flow humidified oxygen-delivery system (OptiFlow THRIVE)
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice
Supraglottic Oxygenation Via Oral Transtracheal Catheter for Reducing the Incidence of Hypoxemia During ERCP Under Sedation
Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used for the diagnosis and treatment of pancreatobiliary diseases.
- Conditions
- Choledocholithiasis With Cholecystitis With Obstruction, Obstructive Jaundice, Pancreatitis, Cholelithiasis
- Trial name
- NCT07637721
- Testing
- The Supraglottic Oxygenation Via Oral Transtracheal Catheter Group, The Regular Nasal Cannula
- Where
- 3 sites in China
- Volunteers
- 410 people
- Sponsor
- Zhejiang University
Minor Surgical Procedures With Monitored Anesthesia Care, Driving Performance After Minor Ambulatory Surgery
Safety of Driving After Minor Surgery With Monitored Anesthesia Care
Patients are currently advised to refrain from driving motor vehicles or using public transportation unescorted for a 24 hour period if they undergo any minor ambulatory surgical procedure with monitored anesthesia care…
- Trial name
- MACDrive (NCT00577200)
- Testing
- Midazolam, Sufentanil, Propofol
- Where
- United States
- Volunteers
- 625 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Breast Cancer, Mastectomy
Same-Day Awake Mastectomy With Immediate Breast Reconstruction for Patients With Breast Cancer
The goal of this clinical trial is to learn if the AMADeuS care pathway is as safe as usual hospital care and works as well for pain control in women having mastectomy with immediate prepectoral breast reconstruction.
- Conditions
- Breast Cancer, Mastectomy, Prepectoral Breast Reconstruction, ERAS Programmes
- Trial name
- AMADeuS (NCT07510698)
- Testing
- AMADeuS Perioperative Pathway, Usual Perioperative Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Rome Tor Vergata
Chronic Subdural Hematoma
Propofol Target-Controlled Infusion Versus Dexmedetomidine for Sedation During Chronic Subdural Hematoma Surgery Under Local Anesthesia
Chronic subdural hematoma is a collection of old blood on the surface of the brain that mainly affects older adults. It is often treated by draining the blood through a small hole in the skull (burr hole), under local anesthesia…
- Trial name
- NCT07912203
- Testing
- Dexmedetomidine, Propofol (Astra-Zeneca)
- Volunteers
- 60 people
- Sponsor
- National Institute of Neurology, Tunisia
Lung Cancer
Prospective Study to Evaluate High Flow Nasal Cannula With Monitored Anesthesia Care During EBUS Bronchoscopy
Our objective is to assess whether the use of high flow nasal cannula (Vapotherm, Exeter, NH) with monitored anesthesia care (MAC) during an endobronchial ultrasound (EBUS) bronchoscopy procedure will lead to less procedure…
- Trial name
- NCT05203328
- Testing
- Vapotherm, Regular nasal canula
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Cooper Norcross Health
Hip Fracture Surgeries, Intertrochanteric Fracture
Monitored Anesthesia Care and Soft Tissue Infiltration With Local Anesthesia Feasibility Trial
The purpose of this study is to establish preliminary efficacy of Monitored Anesthesia Care and Soft Tissue Infiltration with Local Anesthesia (MAC-STILA) on severity of post operative delirium and secondary outcomes in patients…
- Conditions
- Hip Fracture Surgeries, Intertrochanteric Fracture, Femoral Hip Fracture
- Trial name
- MAC-STILA (NCT07897656)
- Testing
- Monitored Anesthesia Care (MAC), Soft Tissue Infiltration with Local Anesthetic (STILA), General Anesthesia
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- NYU Langone Health
Intrauterine Polyp, Intrauterine Synechiae
Study on the Effective Dose and Safety of Esketamine in Hysteroscopic Surgery Under Monitored Anesthesia Care
Cervical dilation-induced somatic responses remain a critical challenge in ambulatory hysteroscopic surgery. Esketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, exhibits unique analgesic and sedative properties that…
- Trial name
- NCT07034963
- Testing
- Determine the ED50 and ED95 of esketamine, Intravenous the dose of esketamine ED95, Intravenous remifentanil 1μg∙kg-1
- Where
- China
- Volunteers
- 95 people
- Sponsor
- The First Affiliated Hospital of Xiamen University