Clinical trials: Modic Changes
Low Back Pain
Epigenetic and Molecular Biomarkers in Chronic Low Back Pain and Modic Changes
In the present study the investigators aim to examine the presence of bacteria in the disc and Modic Changes (MCs) (bone). A prospective study with 1-year follow-up of two patient populations undergoing elective spinal surgery…
- Trial name
- NCT03406624
- Testing
- Biopsy
- Where
- 4 sites in Norway
- Volunteers
- 200 people
- Sponsor
- Oslo University Hospital
Chronic Pain
Efficacy of Lumbar Immobilisation by Rigid Brace for Chronic Low Back Pain Patients With Modic 1 Changes (DICO)
Chronic low back pain may be associated with active discopathy. This subset of individuals are defined by a clinical and radiological syndrome with specific MRI signals, known as MODIC changes.
- Trial name
- DICO (NCT04191161)
- Testing
- Wearing the rigid brace
- Where
- France
- Volunteers
- 2 people
- Sponsor
- University Hospital, Clermont-Ferrand
Brucella Spondylitis
Can Hematological Inflammatory Indexes be Used to Differentiate Type 1 Modic Changes From Brucella Spondylodiscitis
Hematological inflammatory indices (Table 2) are currently very popular and have diagnostic, prognostic, and predictive, roles in various diseases.
- Trial name
- NCT06432530
- Testing
- C-Reactive Protein (CRP), Erythrocyte Sedimentation Rate (ESR), Complete Blood Count (CBC) values, and indexes derived from the CBC.
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Yuzuncu Yil University
Low Back Pain, Modic Changes Type I or II Seen on MRI
Antibiotics In Modic Changes
Low-back pain (LBP) is the single leading cause for disability worldwide, affects all age groups and has increased from 58 million years lived with disability (YLDs) in 1990 to 83 million YLDs in 2010.
- Trial name
- AIM (NCT02323412)
- Testing
- Amoxicillin (Amoksicillintrihydrat)
- Where
- Norway
- Volunteers
- 180 people
- Sponsor
- Oslo University Hospital
Intervertebral Disc Degeneration, Modic I Discopathy
Efficiency and Safety Study of Pamidronate in Inflammatory Back Pain Due to Degenerative Disk Disease
The purpose of this study is to determine whether pamidronate is effective and well-tolerated in the treatment of painful degenerative disk disease, also known as Modic type 1 changes
- Conditions
- Intervertebral Disc Degeneration, Modic I Discopathy, Back Pain, Low Back Pain
- Trial name
- NCT01799616
- Testing
- Pamidronate
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Clermont-Ferrand
Low Back Pain
Probiotics for Modic Changes in Low Back Pain Patients
Probiotics for spinal inflammatory end-plate changes, so-called Modic changes, a randomised controlled study Modic changes are inflammatory end-plate changes primarily affecting the lower lumbar levels.
- Trial name
- NCT03100266
- Testing
- Probiotic, Inactive capsules
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Ole Kudsk Jensen
Low Back Pain, Bone Marrow Edema
Lumbar Bracing for People With Type I Modic Changes
Despite the high prevalence of low back pain, little is still known about its underlying pathology. Only a small proportion of people (~1%) have a diagnosable pathoanatomical entity causing low back pain.
- Conditions
- Low Back Pain, Bone Marrow Edema, Brace, Modic Changes
- Trial name
- NCT03829644
- Testing
- Horizon 627 Lumbar Brace, Aspen Medical Company, Oak Canyon, Irvine, CA 92618
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Alberta
Disc Degeneration
Low-grade Infections of the Intervertebral Discs
The purpose of this prospective, observational study was to evaluate frequency and characteristics of low-grade infections of the intervertebral discs in an unselected real-life patient population undergoing surgery for…
- Trial name
- NCT04712487
- Testing
- Microbiological culture, viral PCR, histopathological analysis
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Kepler University Hospital
Brucellosis, Spinal Degeneration
Brucella Serology and History of Brucellosis in Patients With Modic Changes Type 1
Objective: This study aims to examine Brucella serology and history of brucellosis in patients with lumbar Modic changes (MCs) type 1, considering results from cross-sectional and case-control comparisons.
- Trial name
- NCT04911283
- Testing
- Brucella serology test, Medical history for brucellosis
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Veysel Delen
Modic Changes
Complete Blood Count-derived Indexes in Inflammatory Modic Changes
Some indicators generated from hemogram such as neutrophil/lymphocyte (NLR) have been suggested as biomarkers of systemic inflammation.
- Trial name
- NCT06440096
- Testing
- hemogram
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Veysel Delen, MD
Low Back Pain
The Efficacy of Zoledronic Acid in Modic Changes-related Low Back Pain (LBP)
Modic changes are associated with low back pain (LBP) both in clinical and general population-based samples. Type I changes are regarded as more likely to be painful than type II changes.
- Trial name
- NCT01330238
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- University of Oulu
Low Back Pain
Association of Lumbar MODIC Changes With Chronic Low Back Pain in Southern European Subjects
In this case-control study, cases were chronic LBP patients aged 30-50 in whom a lumbar MRI had been prescribed. Controls were subjects aged 30-50 in whom a cranial MRI had been prescribed for headache, who did not suffer from…
- Trial name
- MODIC 2 (NCT00479063)
- Where
- Spain
- Volunteers
- 304 people
- Sponsor
- Kovacs Foundation
Low Back Pain
Rehabilitation of Patients With Modic Changes in the Lumbar Spine
The purpose of this study is to compare patients with low back pain (LBP) and Modic Changes from The Backcenter Funen, Ringe: 1. To compare the effect of two types of non-operative treatments: A.
- Trial name
- NCT00454792
- Testing
- Exercise, Restitution
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- The Back Research Center, Denmark
MSK Conditions, Chronic Low Back Pain (CLBP)
Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial
The goal of this clinical trial is to learn if antibiotics (amoxicillin) work to treat chronic low back pain in adults. In some patients, this type of back pain may be caused by bacteria in the vertebrae, resulting in a condition…
- Conditions
- MSK Conditions, Chronic Low Back Pain (CLBP), Modic Changes
- Trial name
- ABBA (NCT06771492)
- Testing
- Amoxicillin
- Where
- Netherlands
- Volunteers
- 144 people
- Sponsor
- Bart Koes
Degenerative Disc Disease, Low Back Pain
Lumbar Transforaminal Anterior Epidural Steroid Injections in Discogenic Low Back Pain
Modic changes have been associated with low back pain in many clinical studies and are often considered a part of the disc degeneration process. Modic type 1 change is considered an inflammatory process.
- Trial name
- NCT04930211
- Testing
- Dexamethasone-Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Low Back Pain
BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes
Low-Back Pain (LBP) is the leading cause of disability worldwide. Even though LBP relates to different underlying pathologies, there are a substantial number of patients with chronic complaints that have vertebral bone marrow…
- Trial name
- NCT03704363
- Testing
- Biosimilar Infliximab
- Where
- 6 sites in Norway
- Volunteers
- 128 people
- Sponsor
- Oslo University Hospital
Low Back Pain, Chronic Low Back Pain (CLBP)
Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain
The goal of this clinical trial is to learn whether the Spinery® RF Generator and its sterile single-use accessories can safely lower disability and pain in adults with long-term low back pain that is thought to come from changes…
- Trial name
- BASILEA (NCT07696507)
- Testing
- Single Bipolar Ablation, Double Parallel Bipolar Ablation, Double Cross Bipolar Ablation
- Where
- 3 sites in Italy
- Volunteers
- 69 people
- Sponsor
- Axon srl
Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain
SPINE-RISK VE: Multimodal Predictive Model for Failed Back Surgery Syndrome in Venezuelan Surgical Patients
SPINE-RISK VE is a prospective multicenter cohort study designed to develop and internally validate a multimodal preoperative predictive model for Failed Back Surgery Syndrome (FBSS), now classified as Persistent Spinal Pain…
- Conditions
- Persistent Spinal Pain Syndrome Type 2 (PSPS-T) Lower Spine, Chronic Low Back Pain, Postoperative Pain, Lumbar Spine Surgery
- Trial name
- SPINE-RISK VE (NCT07693517)
- Testing
- SPINE-RISK VE multimodal preoperative assessment
- Where
- Venezuela
- Volunteers
- 150 people
- Sponsor
- juan jose valero quintero,MD
Back Pain
Antibiotic Treatment to Patients With Low Back Pain
A large proportion of patients with Low Back Pain (LBP) (80 %) are classified as "non-specific", due to the lack of a patho-anatomical diagnosis.
- Trial name
- NCT00302796
- Testing
- Bioclavid
- Where
- Denmark
- Volunteers
- 162 people
- Sponsor
- The Back Research Center, Denmark
Low Back Pain
Modic Changes and Associated Features in Southern European Chronic Low Back Pain Patients
To assess: a) The prevalence of Modic changes and other findings on lumbar magnetic resonance imaging (MRI), among Spanish adult chronic LBP patients, b) Patient characteristics and radiological findings associated with Modic…
- Trial name
- MODIC (NCT00478868)
- Where
- Spain
- Volunteers
- 487 people
- Sponsor
- Kovacs Foundation