Clinical trials: Model Disease
Cerebral Palsy
Strength Training in Children With Cerebral Palsy
This study was set out to assess the effect of stretch-shortening (SSC) exercises on gait-symmetry and balance in children with unilateral cerebral palsy (UCP).
- Trial name
- NCT04892576
- Testing
- Physical Therapy
- Where
- Saudi Arabia
- Volunteers
- 42 people
- Sponsor
- Cairo University
Chronic Lymphocytic Leukemia (CLL), Splenic Marginal Zone Lymphoma
Innovative 3D Preclinical Models for Mature B-cell Malignancies to Advance Personalized Immuno and Combination Therapies
Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of…
- Conditions
- Chronic Lymphocytic Leukemia (CLL), Splenic Marginal Zone Lymphoma, Hairy Cell Leukemia (HCL)
- Trial name
- IMPACT (NCT07759661)
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- IRCCS San Raffaele
Acute Myeloid Leukemia, Myelodysplastic Syndromes
A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy
This research study is evaluating the impact a collaborative palliative care and oncology team will have on end-of-life outcomes, quality of end-of-life care, and the quality of life, symptoms, and mood of patients with acute…
- Trial name
- NCT03310918
- Testing
- Palliative Care, Standard Leukemia care
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Massachusetts General Hospital
Acute Kidney Injury, Liver Transplantation
Development and Validation of a Clinical Risk Prediction Model for Early Acute Kidney Injury Within 48 Hours After Liver Transplantation
Acute kidney injury (AKI) is a common complication after liver transplantation, with an incidence of 12.7-95%. The occurrence of acute kidney injury after transplantation is related to the poor prognosis of patients, which…
- Conditions
- Acute Kidney Injury, Liver Transplantation, Model
- Trial name
- NCT06750770
- Testing
- KDIGO CRITERIA
- Where
- China
- Volunteers
- 453 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Breast Cancer, Perimenopause
AMH Dynamic Changes to Predict Ovarian Reserve in Perimenopausal Breast Cancer
This study is a prospective observational cohort study aimed at developing a clinical model based on dynamic changes in anti-Müllerian hormone (AMH) to predict ovarian reserve in perimenopausal women with hormone…
- Conditions
- Breast Cancer, Perimenopause, Ovarian Reserve
- Trial name
- NCT07497191
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
TSC, Tuberous Sclerosis Complex
Long-term, Prospective Study Evaluating Clinical and Molecular Biomarkers of Epileptogenesis in a Genetic Model of Epilepsy - Tuberous Sclerosis Complex
The primary objective of clinical part of EPISTOP project is to identify the clinical and molecular biomarkers of epileptogenesis in a prospective clinical study of patients with TSC.
- Conditions
- TSC, Tuberous Sclerosis Complex, Epilepsy
- Trial name
- EPISTOP (NCT02098759)
- Testing
- epilepsy early diagnosis protocol
- Where
- 9 sites in Austria, Belgium and 6 more
- Volunteers
- 100 people
- Sponsor
- Sergiusz Jozwiak
Ventricular Tachycardia, Ventricular Fibrillation
Impact of Ventricular Pacing in Unselected ICD/CRT-D Patients
Observational study is evaluating Ventricular Tachycardia (VT)/Ventricular Fibrillation (VF) thérapies as a function of ventricular pacing
- Trial name
- FIRST (NCT01169896)
- Where
- France
- Volunteers
- 616 people
- Sponsor
- LivaNova
Osteoarthritis, Care Model
The Effect of Continuous Care Counseling Based on the Roy Adaptation Model on Comfort and Quality of Life in Patients Undergoing Total Knee Arthroplasty
Osteoarthritis is a common joint disease that leads to problems such as pain, restricted mobility, and decreased quality of life in the knee joint, especially among elderly individuals.
- Conditions
- Osteoarthritis, Care Model, Quality of Life, Nursing Interventions
- Trial name
- RAM-TKA (NCT07015879)
- Testing
- Continuous Care Counseling Based on the Roy Adaptation Model
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Cyprus International University
HIV/AIDS, Sexually Transmitted Infection
GPS: Adaptation Trial of an HIV Prevention Counselling Program for HIV-positive and HIV-negative Gay and Bisexual Men
GPS is a sexual health promotion and HIV prevention peer-delivered counselling program. The GPS program has 4 parts: information provision about HIV and sexually transmitted infections, motivational interviewing counselling…
- Conditions
- HIV/AIDS, Sexually Transmitted Infection, Health Behavior
- Trial name
- NCT03186183
- Testing
- GPS program
- Where
- 6 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Toronto Metropolitan University
Stroke
New Model of Stroke Education
The main goal of this study is to reorganize how stroke educational materials are given to patients from written delivery of information to using verbal delivery of information.
- Trial name
- NCT05614882
- Testing
- Written Stroke Education, Verbal Stroke Education
- Where
- United States
- Sponsor
- Yale University
Liver Cancer
Development of a Risk Prediction Model for Immune-Targeted Therapy-Related Diarrhea in Patients With Hepatocellular Carcinoma Based on TCM Constitutional Types: A Prospective Cohort Study
Immune checkpoint inhibitors combined with anti-angiogenic targeted agents have become the first-line standard therapeutic regimen for advanced hepatocellular carcinoma (HCC).
- Trial name
- NCT07741903
- Volunteers
- 500 people
- Sponsor
- Affiliated Hospital of Chengde Medical University
Osteoarthritis
Acute Osteoarthritis Experimental Model Study.
This is a methodological study designed to investigate a new model for testing pain agents in the treatment of patients with osteoarthritis (OA).
- Trial name
- NCT01231490
- Testing
- Naproxen
- Where
- 3 sites in United Kingdom
- Volunteers
- 53 people
- Sponsor
- GlaxoSmithKline
Sjögren's Disease
a Salivary Cell-free RNA Liquid Biopsy Model for Non-invasive Diagnosis in Sjögren's Disease
The goal of this observational study is to learn whether salivary cell-free RNA (cfRNA) can be used as a non-invasive liquid biopsy test to help diagnose Sjögren's disease (SjD) and understand disease-related changes in the…
- Trial name
- cell-free RNA (NCT07824440)
- Where
- China
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Schizophrenia
The Effect of a Community-based LAT-treated Management Model on the Violence Risk of Patients With Schizophrenia
This is a 49 weeks open-label randomized controlled study. Patients with schizophrenia and violence risk will be enrolled in the study.
- Trial name
- NCT03434210
- Testing
- LAT-treated Community Model, care as usual
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Yi Li MD, PhD
Food Allergy
Adherence to Self-care Regimens for Young People With Food Allergy
Anaphylaxis is a severe and potentially life threatening allergic reaction which can affect the airway, breathing and/or circulation.
- Trial name
- NCT01006382
- Where
- 4 sites in United Kingdom
- Volunteers
- 275 people
- Sponsor
- Brighton & Sussex Medical School
Type 1 Diabetes
The International Diabetes Closed Loop (iDCL) Trial: Protocol 4
The investigators aim to compare the efficacy and safety of an AID system using an adaptive MPC algorithm versus SAP (which may or may not include PLGS; to be referred to as SAP) in people with type 1 diabetes.
- Trial name
- DCLP4 (NCT04436796)
- Testing
- interoperable Artificial Pancreas System (iAPS), Sensor-Augmented Pump (SAP)/Predictive Low Glucose Suspend (PLGS)
- Where
- 5 sites in United States
- Volunteers
- 35 people
- Sponsor
- Sansum Diabetes Research Institute
Anabolic Androgenic Steroid Use, Substance-Related Disorders
Anabolic-Androgenic Steroid Use Among Gym-Goers
This randomized controlled trial will evaluate the efficacy of a Transtheoretical Model (TTM)-based behavior-change intervention, delivered through stage-matched counseling sessions, on anabolic-androgenic steroid (AAS) use among…
- Trial name
- TTM - AAS (NCT07702110)
- Testing
- TTM-Based Intervention for AAS Use Reduction A structured, multi-session counseling intervention grounded in the Transtheoretical Model. Content and techniques (e.g., consciousness raising, decisional
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- Alaa Yousif Ayed Ahmed
Thoracic Diseases, Lung Diseases
AI-Based Assessment of Chest Diseases on Chest X-ray Imaging Using DenseNet-121 and a CheXpert-Trained Model
Chest X-rays are widely used to detect thoracic and lung conditions, but reviewing high volumes of radiographs can lead to workload strain and variation between interpreters.
- Trial name
- NCT07834879
- Volunteers
- 100 people
- Sponsor
- Assiut University
Tooth Discoloration
Safety and Efficacy of the ToothWave Powered Toothbrush for Extrinsic Stain Reduction (Texas)
This study is a single blind, prospective study aimed to evaluate the safety and efficacy of the Silk'n ToothWave Powered Toothbrush for stains reduction and improvement of teeth shade.
- Trial name
- NCT04092062
- Testing
- ToothWave, powered toothbrush
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Home Skinovations Ltd.
Dental Erosion, Acid Wear
Evaluation of Efficacy of Experimental Gel to Foam Dentifrices in Dental Erosion
The purpose of this study is to compare and evaluate the ability of two European Union (EU) regulated gel to foam toothpaste formulations versus a non-fluoride toothpaste using a modified in-situ model of dental erosion and…
- Trial name
- NCT01657903
- Testing
- Sodium Fluoride, Potassium nitrate
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline