Clinical trials: Mitral Valve Prolapse
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Mitral Valve Prolapse Arrhythmic Risk
Mitral valve prolapse (MVP) is common with a 2-3 % prevalence in the general association and generally associated with a favorable prognosis.
- Trial name
- MVP-Risk (NCT07830888)
- Testing
- Risk prediction model
- Where
- Norway
- Volunteers
- 500 people
- Sponsor
- Oslo University Hospital
Mitral Valve Prolapse
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
This is a multicenter, observational prospective and retrospective study which aims are: 1) to compute a scoring model potentially predictive for the diagnosis of fibrosis by CMR in patients with MVP; 2) to identify specific…
- Trial name
- SCIMITAR (NCT06341166)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Centro Cardiologico Monzino
Mitral Valve Prolapse, Left Ventricular Fibrosis
PRIMARY Ancillary Substudy
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological…
- Conditions
- Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
- Trial name
- NCT07103733
- Testing
- Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Annetine Gelijns
Mitral Valve Prolapse, Ventricular Arrythmia
Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring
Mitral valve prolapse (MVP) affects up to 3% of the general population and a small subset of patients is at risk for ventricular arrhythmias.
- Trial name
- ALARM-PILOT (NCT06378996)
- Testing
- 14-day rhythm monitoring
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Mitral Valve Prolapse
STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2
Mitral valve prolapse (MVP) is a frequent affection of the mitral valve with a prevalence of 2-3% in the general population. This valvular disease is generally considered as benign, but may at term evolve toward mitral valve…
- Trial name
- STAMP-2 (NCT04852731)
- Testing
- Cardiac MRI, Blood collection, Prolongation of the MRI examination
- Where
- France
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Mitral Valve Prolapse, Mitral Regurgitation
The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation
Mitral regurgitation (MR) is the second most frequent valvular heart disease and the second most frequent indication for valve surgery in Europe.
- Trial name
- INTEGRATE (NCT07366723)
- Testing
- mitral valve surgery, Clinical Follow up
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Centro Cardiologico Monzino
Mitral Valve Prolapse, Myxomatous Mitral Valve Degeneration
AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound
This study aims to develop and validate a fully automated imaging and modeling pipeline for the analysis of mitral valve prolapse (MVP) using real-time three-dimensional transesophageal echocardiography (RT3DE).
- Trial name
- AI4MVP (NCT07384871)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Policlinico S. Donato
Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse
Mitro-annular Disjunction in Cardiac Magnetic Resonance
Mitral annular disjunction (MAD) is an abnormal atrial displacement of the mitral valve leaflet hinge point. MAD is gaining clinical importance for several studies reporting its association to mitral valve prolapse (MVP), complex…
- Conditions
- Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse, Mitral Valve Disorder
- Trial name
- NCT06436573
- Where
- Italy
- Volunteers
- 4,000 people
- Sponsor
- IRCCS San Raffaele
Mitral Regurgitation, Mitral Valve Prolapse
Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Study objectives: To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline…
- Conditions
- Mitral Regurgitation, Mitral Valve Prolapse, Ventricular Tachycardia
- Trial name
- Mitra-VT (NCT06255457)
- Testing
- Mitral valve surgery
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest
Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse
FLECAPRO is a randomized controlled crossover trial assessing the effect and safety of adding flecainide to standard beta-blocker therapy to reduce the burden of ventricular arrhythmias in patients with arrhythmic mitral valve…
- Trial name
- FLECAPRO (NCT05631730)
- Testing
- Flecainide, Metoprolol
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Heart Valve Diseases, Aortic Valve Stenosis
Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice
Valvular heart disease (VHD) is a growing public health concern globally, with increasing disease burden and rising interest in advanced treatment strategies such as transcatheter interventions.
- Conditions
- Heart Valve Diseases, Aortic Valve Stenosis, Aortic Valve Insufficiency, Mitral Valve Insufficiency
- Trial name
- NCT07068633
- Where
- South Korea
- Volunteers
- 30,000 people
- Sponsor
- Yonsei University
Mitral Valve Posterior Leaflet Prolapse
Triangular Exclusion Technique in Isolated Posterior Mitral Valve Leaflet Prolapse for Mitral Valve Repair
The goal of this clinical trial is to learn if surgical method done to repair one of the heart valve called mitral valve disease during open heart surgery The main questions aims to answer is: Does this method is safe and…
- Trial name
- NCT06778369
- Testing
- traingular exclusion technique in mitral valve repair
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Zagazig University
Mitral Valve Prolapse, Mitral Valve Insufficiency
A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk
This study investigates the characteristics and prevalence of mitral annular disjunction in patients with mitral valve prolapse with severe mitral regurgitation (MR) at Assiut University Heart Hospital.
- Trial name
- NCT06741709
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Mitral Valve Prolapse
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
This is a qualitative and quantitative study that seeks to obtain information from patients with degenerative mitral valve prolapse and providers regarding factors important in deciding between surgical mitral valve repair (MVR)…
- Trial name
- PRIMARY SDM (NCT06738537)
- Testing
- Focus Groups/Quantitative Survey for Patients, Focus Group/Quantitative Survey for HCPs, Qualitative Focus Group
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- Northwell Health
Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM)
Multimodal and Multidisciplinary Approach to Optimize Diagnostic, Prognostic, and Therapeutic Management of Patients with Non-ischemic Cardiomyopathies and Arrhythmogenic-inflammatory Phenotypes: a Multicenter, Observational, Retrospective and Prospective Registry Study.
Non-ischemic cardiomyopathies (NICM) represent a heterogeneous group of pathologies characterized by absence of obstructive disease of the epicardial coronary vessels and distinct structural and functional changes of the…
- Conditions
- Non-ischemic Cardiomyopathy, Dilated Cardiomyopathy (DCM), Hypertrophic Cardiomyopathy (HCM), Restrictive Cardiomyopathy
- Trial name
- AINICM (NCT06607471)
- Testing
- Support treatment, cardiac medical treatment, aetiology-specific treatment, device implant, arrhythmia ablation, Support treatment, cardiac medical treatment, aetiology-specific treatment
- Where
- Italy
- Volunteers
- 15,000 people
- Sponsor
- Scientific Institute San Raffaele
Severe Degenerative Mitral Regurgitation Due to Mid-segment Posterior Leaflet Prolapse
Observational Registry on the HARPOON Device
To collect data on the HARPOON™ Mitral Valve Repair System for use in patients with severe degenerative mitral regurgitation due to posterior leaflet prolapse.
- Trial name
- REPLICATE (NCT04393779)
- Testing
- HARPOON Beating Heart Mitral Valve Repair System (MVRS)
- Where
- 7 sites in Germany, Spain and 1 more
- Volunteers
- 26 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Regurgitation, Mitral Valve Prolapse
CE Mark Study for the Harpoon Medical Device in Poland
The purpose of this study is to evaluate the safety and performance of the Harpoon Medical TSD-5. The Harpoon device will provide many significant advantages over current surgical interventions including: 1) a small minimally…
- Conditions
- Mitral Valve Regurgitation, Mitral Valve Prolapse, Mitral Valve Insufficiency
- Trial name
- NCT02432196
- Testing
- Harpoon Medical Device
- Where
- 2 sites in Poland
- Volunteers
- 26 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Regurgitation, Mitral Valve Prolapse
Safety and Early Feasibility Study of the Harpoon Medical Device (EFS)
The purpose of this study is to evaluate the safety and performance of the Harpoon Medical TSD-5. The Harpoon device will provide many significant advantages over current surgical interventions including: 1) a small minimally…
- Conditions
- Mitral Valve Regurgitation, Mitral Valve Prolapse, Mitral Valve Insufficiency
- Trial name
- EFS (NCT02771275)
- Testing
- Harpoon Medical Device
- Where
- 2 sites in Poland
- Volunteers
- 13 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Regurgitation, Mitral Valve Prolapse
CE Mark Study for the Harpoon Medical Device
The purpose of this study is to evaluate the safety and performance of the Harpoon Medical device. It is anticipated, that the Harpoon Medical device will provide advantages over current surgical interventions including: 1) a…
- Conditions
- Mitral Valve Regurgitation, Mitral Valve Prolapse, Mitral Valve Insufficiency
- Trial name
- TRACER (NCT02768870)
- Testing
- Harpoon Artificial ePTFE Chords
- Where
- 4 sites in Italy, United Kingdom
- Volunteers
- 26 people
- Sponsor
- Edwards Lifesciences
Mitral Valve Prolapse
Genetic Basis of Mitral Valve Prolapse
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions.
- Trial name
- MVP (NCT01719211)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Massachusetts General Hospital