Clinical trials: Mitochondrial Alteration
Menopause, Exercise Adaptation
The Effects of Menopausal Status, Isoflavone Supplementation and Training on Cardiometabolic Function Women
The goal of this clinical trial is to investigate the role of estrogen and isoflavone supplementation in exercise-induced cellular signaling and cardiometabolic adaptations in premenopausal and postmenopausal women.
- Conditions
- Menopause, Exercise Adaptation, Mitochondrial Alteration, Vascular Function in Healthy Volunteers
- Trial name
- EXISO (NCT07878741)
- Testing
- Red Clover Isoflavone Supplementation, Supervised exercise training
- Where
- 2 sites in Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Schizophrenia and Related Disorders, Mitochondrial Alteration
MitoQ for Early-phase Schizophrenia-spectrum Disorder and Mitochondrial Dysfunction
The goal of this double-blind, placebo-controlled randomized clinical trial is to test the effect of 12 weeks of orally administered MitoQ (mitoquinol mesylate) supplementation on cognition in 50 people with early phase…
- Conditions
- Schizophrenia and Related Disorders, Mitochondrial Alteration, Cognitive Impairment
- Trial name
- NCT06191965
- Testing
- MitoQ
- Where
- 3 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- Mclean Hospital
Heart Failure，Congestive, Heart Failure New York Heart Association Class IV
Nicotinamide Riboside in LVAD Recipients
While preliminary data show that oral nicotinamide riboside (NR) supplementation increases myocardial levels of oxidized nicotine-adenine dinucleotide (NAD+) levels in mice, there has been no direct evidence that suggests oral NR…
- Conditions
- Heart Failure，Congestive, Heart Failure New York Heart Association Class IV, Mitochondrial Alteration
- Trial name
- PilotNR-LVAD (NCT03727646)
- Testing
- Nicotinamide riboside
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Mitochondrial Alteration
National CounterACT Initiative
The purpose of the study is to determine in vitro effects on mitochondrial function of selected chemical agents in human cells, and assess the capability of a cell-permeable succinate prodrug to attenuate toxic effects The…
- Trial name
- NCT03597438
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Infertility, Female, Polycystic Ovary Syndrome
Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort
Enrolling of 150 female patients of fertile age diagnosed with PCOS, insulin resistance, infertility, or mitochondrial disease, and the same number of age- and sex-matched controls are planned.
- Conditions
- Infertility, Female, Polycystic Ovary Syndrome, Insulin Resistance, Primary Ovarian Insufficiency
- Trial name
- POMODORI (NCT06167135)
- Where
- Hungary
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Pulmonary Disease, Chronic Obstructive, Mitochondrial Alteration
High Intensity Interval Training and Muscle Adaptations During PR
Pulmonary rehabilitation (PR) is a validated treatment in patients with Chronic Obstructive Pulmonary Disease (COPD), improving exercise tolerance, quality of life and dyspnea.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Mitochondrial Alteration, Oxygen Deficiency
- Trial name
- MITOXITRAIN (NCT05858463)
- Testing
- Modality of exercise training
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Covid19, Muscle Loss
The Impact of Covid-19 on Skeletal Muscle
With the recent worldwide outbreak of the COVID-19 infection and the huge impact it has had upon lives in the UK, it is key to increase knowledge on the impact of the virus on the body.
- Conditions
- Covid19, Muscle Loss, Mitochondrial Alteration
- Trial name
- NCT04756674
- Testing
- No intervetion will be used
- Where
- United Kingdom
- Sponsor
- University of Nottingham
Multiple Sclerosis, Mitochondrial Alteration
Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients.
- Trial name
- MS-MIDY (NCT03052595)
- Testing
- Oral glucose tolerance test, Testing of autonomous nervous system function, Stroop test
- Where
- Slovakia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Subclinical Hypothyroidism, Autoimmune Thyroid Disease
NeoThyr - the Role of Mitochondria-dysfunction in Newborns of Mothers With Autoimmune Thyroid Disease
Previously, studies have shown that children of women with thyroid autoantibodies experience more birth complications and poorer health in their first days.
- Conditions
- Subclinical Hypothyroidism, Autoimmune Thyroid Disease, Alteration of Mitochondrial Membrane
- Trial name
- NCT02061111
- Where
- Denmark
- Volunteers
- 77 people
- Sponsor
- Naestved Hospital
HIV/AIDS, Antiviral Toxicity
Relative Mitochondrial Toxicity of Tenofovir Alafenamide (TAF) vs. Tenofovir Disoproxil Fumarate (TDF)
Increased comorbidities such as cardiovascular disease (CVD), are emerging problems in HIV infection but the mechanisms are unclear.
- Conditions
- HIV/AIDS, Antiviral Toxicity, Antiviral Drug Adverse Reaction, Mitochondrial Alteration
- Trial name
- UCLACAREMITO (NCT03251144)
- Testing
- Switch to E/C/FTC/TAF daily
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Nephropathy, Hypoxia
Acute Effects of SGLT2 Inhibition on Renal Oxygenation and Autonomic Function in Type 1 Diabetes
Background: Inhibiting the sodium-glucose cotransporter-2 (SGLT2) has been observed to reduce risk of cardiovascular events and kidney failure in type 2 diabetes.
- Conditions
- Nephropathy, Hypoxia, Mitochondrial Alteration, Type 1 Diabetes
- Trial name
- Astronaut (NCT04193566)
- Testing
- Forxiga
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Metabolism Disorder, Mitochondrial Alteration
Mitochondrial Energy Metabolism in Obese Women
Considering that the failure of the treatment of obesity is justified by the multifactorial pathophysiology of this morbidity, the present project has the following hypotheses: 1.
- Conditions
- Metabolism Disorder, Mitochondrial Alteration, Physical Activity, Obesity
- Trial name
- NCT03119350
- Testing
- Physical Training
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- University of Sao Paulo
Alteration of Mitochondrial Membrane, Type2 Diabetes
Mitochondrial Effects of C18:0 Supplementation in Humans
The purpose of this crossover study is to determine whether nutritional supplementation of C18:0 in humans has mitochondrial effects as shown in Drosophila and human cell culture.
- Conditions
- Alteration of Mitochondrial Membrane, Type2 Diabetes, Fatty Acid Deficiency
- Trial name
- NCT02957838
- Testing
- C18:0, mock
- Where
- Germany
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg