Clinical trials: Miscarriage in First Trimester
Cesarean Scar Pregnancy
Surgery Alone Versus Methotrexate Before Surgery in Cesarean Scar Pregnancy
There are no universal treatment guidelines available. The ultimate purpose of the management of CSP is to simultaneously remove the pregnancy and successfully preserve the woman's fertility (Gonzalez \& Tulandi, 2017).
- Trial name
- NCT04379219
- Testing
- Methotrexate
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Mansoura University
Recurrent Miscarriage
Habitual Abortion Study: Oral Dydrogesterone Treatment During Pregnancy in Women With Recurrent Miscarriage
The purpose of this clinical study is to demonstrate the shift from inflammatory cytokines to non-inflammatory cytokines in women suffering from habitual abortion treated with dydrogesterone (Duphaston).
- Trial name
- NCT00193674
- Testing
- Dydrogesterone
- Where
- 3 sites in Austria, Poland
- Volunteers
- 71 people
- Sponsor
- Abbott Products
Missed Abortion
Letrozole Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
- Trial name
- NCT04217265
- Testing
- Letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
Missed Abortion, Medical; Abortion, Fetus
Gemeprost Versus Dinoprostone in First Trimester Miscarriages
Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.
- Conditions
- Missed Abortion, Medical; Abortion, Fetus, Incomplete Abortion
- Trial name
- NCT05342467
- Testing
- Gemeprost 1 Mg Vaginal Pessary, Dinoprostone 3 mg
- Where
- 2 sites in Malaysia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Effect of Drug
Analgesia From Conscious Sedation Versus Paracervical Block for Manual Vacuum Aspiration
Miscarriage is one of the major causes of early pregnancy losses. Incomplete miscarriage is a major cause of maternal morbidity and mortality.
- Trial name
- NCT06539143
- Testing
- Lidocaine
- Where
- Nigeria
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Darlington-Peter Chibuzor Ugoji
Spontaneous Abortion in First Trimester
Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss
First trimester miscarriages are common. When the failed pregnancy does not pass spontaneously on its own, it is called a missed abortion.
- Trial name
- NCT02141555
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Miscarriage
Misoprostol for Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks gestation, that is, before fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated with abdominal pain and cramping.
- Trial name
- NCT05088720
- Testing
- misoprostol 800 µg, misoprostol 400 µg
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
IUCD Complication
Isonicotinic Acid Hydrazide (INH) Pretreatment With Misoprostol Versus Misoprostol Alone in Missed Abortion
The primary endpoint was the success rate of adjuvant isonicotinic acid hydrazide (INH) and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy.
- Trial name
- NCT04500002
- Testing
- Isonicotinic Acid Hydrazide, Misoprostol
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Aswan University Hospital
Abortion Threatened
Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage
Threatened miscarriage occurs in about one-fifth of pregnancies with an estimated miscarriage rate of 3-16% after successful demonstration of fetal cardiac activity.
- Trial name
- NCT03797508
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Ain Shams University
Miscarriage
Comparison Between Letrozole and Mifepristone in Medical Termination of First Trimester Miscarriages
Prospective interventional study where participants with non-viable pregnancy at 1st trimester will be randomized into two arms, one group will receive conventional treatment with oral mifepristone followed by misoprostol…
- Trial name
- NCT05304273
- Testing
- Mifepristone, Letrozole
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Calcutta National Medical College and Hospital
Miscarriage in First Trimester
Machine Learning Miscarriage Management Clinical Decision Support Tool Study
Machine learning used to develop an algorithm to determine chance of success with expectant or medical management for an individual patient.
- Trial name
- MLMM (NCT06384144)
- Testing
- Expectant Management of First Trimester Miscarriage, Medical Management of First Trimester Miscarriage
- Where
- United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Miscarriage, Missed Abortion
Letrozole Pretreatment With Misoprostol fInduction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first trimester pregnancy.
- Trial name
- NCT03628625
- Testing
- Letrozole 2.5mg, Misoprostol
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Miscarriage
Serum Kisspeptin: a Predictive Marker of Miscarriage or Not?
This is a prospective observational study. Eligible women undergo ART treatment in our centre will be recruited for the study and each woman will only be included in the study once. Informed written consent will be obtained.
- Trial name
- NCT03940495
- Where
- China
- Volunteers
- 182 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Miscarriage
Management of Women With an Incomplete Miscarriage
Miscarriage is defined as the spontaneous loss of a pregnancy before 24 weeks' gestation, that is, before the fetal viability. The clinical signs of miscarriage are usually vaginal bleeding associated abdominal pain and cramping…
- Trial name
- NCT03148561
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Assiut University
Miscarriage in First Trimester
Misoprostol 400 µg Versus 200 µg for Cervical Ripening in 1st Trimester Miscarriage
Local current protocol for cervical ripening in 1st trimester miscarriage recommends 400 µg of misoprostol intravaginally 3 hours before uterine evacuation. This regime has been recommended by some international guidelines .
- Trial name
- MISO200 (NCT02957305)
- Testing
- Misoprostol 400mcg Tab, Misoprostol 200mcg Tab
- Where
- Brazil
- Volunteers
- 211 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Recurrent Spontaneous Abortion
Difference Between Mean Gestational Sac Diameter and Crown-rump Length as a Marker of First-trimester Pregnancy Outcome in Patients With Recurrent Spontaneous Abortion
Objective: To determine the effect and predictive value of the difference between the mean gestational diameter (mGSD) sac and crown-rump length (CRL) of the first trimester on the pregnancy outcomes of patients with recurrent…
- Trial name
- mGSD-CRL& RSA (NCT06081556)
- Testing
- ultrasonic testing
- Where
- China
- Volunteers
- 256 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Pregnancy
Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage
The aim of this study is to determine whether the dydrogesterone therapy is associated with reduction in miscarriage in women with first trimester threatened miscarriage.
- Trial name
- NCT02128685
- Testing
- Dydrogesterone
- Where
- 3 sites in Hong Kong
- Volunteers
- 406 people
- Sponsor
- The University of Hong Kong
Missed Abortion
Letrozole Pretreatment With Misoprostol Induction of Abortion In First-Trimester Missed Miscarriage
This study compares the success rate of letrozole and misoprostol versus misoprostol alone for medical termination of first-trimester pregnancy among women with one or more previous cesarean deliveries.
- Trial name
- NCT04215835
- Testing
- letrozole then misoprostol
- Volunteers
- 200 people
- Sponsor
- Cairo University
Early Pregnancy Loss, Miscarriage in First Trimester
Letrozole and Misoprostol for Early Pregnancy Loss Management
A pilot cohort study to preliminarily investigate the efficacy of pretreatment with letrozole 10 mg daily for three consecutive days followed by treatment with misoprostol 800 mcg vaginally for medical management of early…
- Conditions
- Early Pregnancy Loss, Miscarriage in First Trimester, Miscarriage
- Trial name
- LeMi (NCT06452719)
- Testing
- Letrozole, Misoprostol
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Pennsylvania
Miscarriage, Misoprostol
Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage
The miscarriage is one of the adverse outcomes of pregnancy and is responsible for stress and anxiety of the couple. there are different types of miscarriages.missed miscarriage also known as early fetal demise is one of the type…
- Trial name
- NCT04604366
- Testing
- misoprostol
- Where
- Pakistan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Islamabad Medical and Dental College