Clinical trials: Military Exposure
Post-Traumatic Stress Disorder
Virtual Reality (VR) Therapy for Post-Traumatic Stress Disorder (PTSD)
It is proposed that using Virtual Reality as part of therapy will result in improvements in Post Traumatic Stress Disorder for Service Members with PTSD related to service in Iraq and/or Afghanistan.
- Trial name
- NCT00992953
- Testing
- Treatment as Usual, Virtual Reality Exposure with Stimulus Control
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- Office of Naval Research (ONR)
Post Traumatic Stress Disorder, Written Exposure Therapy
Behavioral Health Technician Delivered Written Exposure Therapy
This study has two main goals. First, it aims to test a treatment called written exposure therapy to see if it can help military service members who have posttraumatic stress disorder (PTSD).
- Trial name
- NCT06789887
- Testing
- Written Exposure Therapy, Treatment as Usual (TAU)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Prolonged Grief Disorder
Treatment of Prolonged Grief Disorder in Combat Veterans
The purpose of this study is to compare the efficacy of an experimental treatment (termed BATE-G) for Prolonged Grief Disorder (PGD) in Veterans compared to the current, VA-approved standard of care treatment.
- Trial name
- PGD (NCT02283333)
- Testing
- BATE-G, Standard Treatment
- Where
- 2 sites in United States
- Volunteers
- 155 people
- Sponsor
- VA Office of Research and Development
Spine Health, Spine Injuries and Disorders
Occupational Exposure to Whole Body Vibration Among U.S. Military Veterans: Acute and Chronic Contributions to Musculoskeletal Disorders and Spine-Area Pain
Significance to VA: There is a lack of prospective longitudinal studies investigating the relationship between risk factors to Veterans and development and progression of musculoskeletal (MSK) spine injury and pain.
- Conditions
- Spine Health, Spine Injuries and Disorders, Spine Degeneration, Whole Body Vibration
- Trial name
- NCT07367139
- Testing
- Water
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Milwaukee VA Medical Center
Pulmonary Function
Service and Health Among Deployed Veterans
The purpose of the study is to better understand the health, including lung health, of Veterans who deployed in support of Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), or Operation New Dawn (OND) and other…
- Trial name
- SHADE (NCT02825654)
- Where
- 6 sites in United States
- Volunteers
- 6,200 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Burn Pit Exposure
Tele-Exercise for MERP
During Operations Desert Shield and Desert Storm, Veterans in combat were exposed to a variety of airborne hazards, including oil well fire smoke, emissions from burn pits, and other substances associated with negative health…
- Trial name
- TEMPO (NCT07018466)
- Testing
- Tele-exercise, Standard of Care
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
PTSD
Implementation of Prolonged Exposure in the Military
This randomized study examines how prolonged exposure (PE) therapy, an evidence-based treatment for posttraumatic stress disorder (PTSD), can be successfully disseminated and implemented in the Army.
- Trial name
- NCT02982538
- Testing
- Extended Training in Prolonged Exposure Therapy for PTSD, Standard Training in Prolonged Exposure Therapy for PTSD
- Where
- 3 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Posttraumatic Stress Disorder, Combat Disorders
An Open-Trial of Web-Prolonged Exposure (Web-PE) Among Active-Duty Military
It is urgent to make evidence-based treatments (EBTs) for military personnel readily accessible in order to meet the growing demand for effective and efficient treatment for posttraumatic stress disorder (PTSD) in a timely…
- Trial name
- NCT03337750
- Testing
- Web-PE Therapy
- Where
- 2 sites in United States
- Volunteers
- 34 people
- Sponsor
- University of Pennsylvania
Posttraumatic Stress Disorders, Combat Disorders
Integrated Treatment of OEF/OIF Veterans With PTSD & Substance Use Disorders
In comparison to the general population, U.S. military and Veterans are at an increased risk for developing both substance use disorders (SUD) and Post Traumatic Stress Disorder (PTSD).
- Conditions
- Posttraumatic Stress Disorders, Combat Disorders, Alcohol Dependence, Drug Dependence
- Trial name
- COPE (NCT01338506)
- Testing
- Concurrent Treatment with Prolonged Exposure (COPE)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Medical University of South Carolina
Post-Traumatic Stress Disorder
Brief Cognitive Behavioral Treatment of Deployment-Related PTSD Symptoms in Primary Care Settings
A significant number of veterans of the wars in Iraq and Afghanistan are affected by posttraumatic stress disorder (PTSD). The limited reach of effective treatments for PTSD into the veteran population is at least partially due…
- Trial name
- NCT02290639
- Testing
- Brief Cognitive Behavioral Treatment, Minimal Contact
- Where
- 2 sites in United States
- Volunteers
- 74 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorder
Couple HOPES and COVID-19
Posttraumatic Stress Disorder (PTSD) will be a severe problem in Canada in the wake of COVID-19, especially for Military Members, Veterans, First Responders, and Healthcare Workers (MVFH).
- Trial name
- HOPES (NCT04763681)
- Testing
- Couple HOPES Guided, Internet-Delivered, Self-Help Intervention
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- York University
Iraq and Afghanistan Era Veterans
Service and Health During the Iraq and Afghanistan Era
The primary objective of CSP #595, "Service and Health During the Iraq and Afghanistan Era," is to characterize the impact of deployment to Iraq and Afghanistan on the respiratory health of Veterans.
- Trial name
- CSP #595 Pilot (NCT01987401)
- Where
- 2 sites in United States
- Volunteers
- 1,242 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Posttraumatic Stress Disorders, Combat Disorders
A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel
The purpose of this randomized controlled trial is to compare the efficacy and potential biological mechanisms of action of 10 sessions of a web-version of Prolonged Exposure (PE), "Web-PE," delivered over 8-weeks to 10 sessions…
- Trial name
- NCT02556645
- Testing
- Web-PE Therapy, Therapist-Delivered Present-Centered Therapy
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Military Sexual Trauma, Intimate Partner Violence
Multifaceted Intervention to Restore Resilience and Overcome Risk
The MIRROR study will compare the effectiveness of two interventions in improving emotion regulation and reducing PTSD symptoms in female Veterans with military sexual trauma (MST) and/or intimate partner violence (IPV) and…
- Conditions
- Military Sexual Trauma, Intimate Partner Violence, Brain Injury, Post Traumatic Stress Disorder
- Trial name
- MIRROR (NCT06988787)
- Testing
- webSTAIR, ExpoTx, PsychoEd
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
PFAS, Environmental Exposures
Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study
The goal of this study is to test the efficacy and feasibility of Colesevelam administration (50% of the recommended dose) to reduce serum PFAS concentration in the Veteran population who have serum PFAS levels that exceed the…
- Conditions
- PFAS, Environmental Exposures, Occupational Exposure to Chemicals, Military Exposure
- Trial name
- PAVERS (NCT07592858)
- Testing
- Colesevelam
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Rhode Island
Burn Pit Exposure, Airborne Hazard Exposure
Project PHOENIX: Molecular Signatures of Burn Pit Exposure
Project PHOENIX is an observational clinical research study designed to characterize molecular, genomic, cellular, and functional features in blood specimens from former U.S.
- Conditions
- Burn Pit Exposure, Airborne Hazard Exposure, Veteran Health, Deployment-Related Toxic Exposure
- Trial name
- PHOENIX (NCT07562243)
- Testing
- Prior Burn Pit Exposure, No Known Burn Pit Exposure
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Creative Medical Technology Holdings Inc
PTSD, Stress Disorders, Post - Traumatic
Innovative Delivery of Evidence Based Psychotherapy to Women With Military Sexual Trauma
The purpose of this study is to determine whether a scientifically validated treatment for Posttraumatic Stress Disorder (PTSD) called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma…
- Conditions
- PTSD, Stress Disorders, Post - Traumatic, Anxiety Disorders, Mental Disorders
- Trial name
- NCT02417025
- Testing
- PE
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Medical University of South Carolina
Posttraumatic Stress Disorder
Predicting Treatment Outcomes With Intensive Outpatient Treatment for PTSD
The open-label clinical study explores potential modifiable predictors of treatment outcomes in a sample of 55 military service members and veterans with clinically significant PTSD symptoms who receive Intensive Outpatient…
- Trial name
- PTSD (NCT04307498)
- Testing
- Intensive Outpatient Program - Prolonged Exposure
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Posttraumatic Stress Disorders, Combat Disorders
Prolonged Exposure for Post Traumatic Stress Disorder (PTSD) Among Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Personnel
The purpose of this study is 1) to evaluate whether massing 10 PE sessions in 2 weeks (massed trials; M-PE) is more efficacious than Minimal Contact control (MCC); 2) whether the massed sessions format retains the efficacy of…
- Trial name
- STRONG STAR (NCT01049516)
- Testing
- Prolonged Exposure Therapy - Massed, Prolonged Exposure Therapy - Spaced, Minimal Contact Control
- Where
- 3 sites in United States
- Volunteers
- 366 people
- Sponsor
- University of Pennsylvania
Trauma, Post-Traumatic Stress Disorder
BraveMind: Advancing the Virtual Iraq/Afghanistan PTSD Exposure Therapy
The proposed study is designed to test the clinical efficacy of the BRAVEMIND military sexual trauma (MST) system in an initial feasibility and wait list clinical trial of 45 users. The following hypotheses will be tested: 1.
- Trial name
- NCT02246972
- Testing
- Virtual Reality Exposure Therapy (VRET)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Emory University