Clinical trials: Microvascular Circulation
Peripheral Arterial Disease, Diabetes Mellitus
Evaluation of Compression Therapy in Patients With Mild to Moderate PAD or Diabetes Mellitus
Aim of this prospective clinical study is the Evaluation of the Effect of Compression Therapy on the Microcirculation in Patients With Leg Edema and Mild to Moderate PAD or Diabetes Mellitus.
- Conditions
- Peripheral Arterial Disease, Diabetes Mellitus, Leg Edema
- Trial name
- NCT03384758
- Testing
- Compression Therapy
- Where
- Germany
- Volunteers
- 94 people
- Sponsor
- University Hospital Erlangen
Brain Tumors
A Comparison of the Effect of 1.5 Versus 3% NaCl on Brain Relaxation and Microcirculation
Hyperosmotic solutions of 1.5% and 3% NaCl are equally effective for brain relaxation and microcirculation during brain surgery. The effect of 1.5% NaCl on postoperative natremia and natriuresis is less pronounced.
- Trial name
- NCT02537106
- Testing
- 1.5% NaCl, 3% NaCl
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Hradec Kralove
Hypotension, Poor Peripheral Perfusion
Effect of Vasopressin on Tissue Oxygen Saturation in Cardiac Surgery Patients During Cardiopulmonary Bypass
The objective of this research is to compare the effect of a low dose Vasopressin infusion or placebo during cardiopulmonary bypass on vasopressor requirements, hemodynamics and tissue oxygen saturation and its recovery using…
- Trial name
- NCT01532505
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Mohamed Ismail
ST-elevation Myocardial Infarction (STEMI)
The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI
This study aims to assess the impact of NC balloon post-dilatation on coronary microcirculation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- POSTDILSTEMI (NCT02788396)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Septic Shock
Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock
Sepsis is defined as a life-threatening event due to a dysregulated immune response to an host. Blood purification techniques may be considered as a therapeutic weapon to front sepsis and septic shock.
- Trial name
- NCT03456180
- Testing
- Haemoadsorption with Cytosorb cartridge
- Volunteers
- 10 people
- Sponsor
- Università Politecnica delle Marche
Stroke, Ischemic
Microcirculation and Plasticity After Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours…
- Trial name
- IMPreST (NCT04035746)
- Testing
- Observation of microcirculation and plasticity of the brain
- Where
- Switzerland
- Volunteers
- 49 people
- Sponsor
- University of Zurich
Microcirculation; Biomarkers; Myocardial Ischemia
Endothelial and Microvascular Functions in Patients With Myocardial Ischemia
Cardiovascular diseases (CVD) are responsible, throughout the world, for high mortality rates and cardiovascular morbidity. Endothelial dysfunction is the earliest marker of clinical atherosclerosis development.
- Trial name
- NCT03243968
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Septic Shock
The Effect of Increasing the Mean Arterial Pressure on the Microcirculation and the Prognosis of Patients With Septic Shock
Background： The mean arterial pressure（ MAP） is a key pressure index to improve tissue perfusion. At present, there are no surprising results of large-scale clinical studies on sublingual microcirculation.
- Trial name
- NCT04136080
- Testing
- vasopressors
- Volunteers
- 752 people
- Sponsor
- Fujian Provincial Hospital
Complication of Hemodialysis
Microcirculation During Haemodialysis
SDF is validated by measuring changes in microcirculation in sepsis patients with MOF (Boerma studies). SDF is validated by measuring changes in microcirculation in stable chronic hemodialysis patients (NDT 2009 Bemelmans).
- Trial name
- NCT01396980
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Frisius Medisch Centrum
Refractory Angina Pectoris
IMR Evaluation in Patients with Coronary Sinus Reducer Implantation (INROAD Study)
The INROAD is an investigator-driven, prospective, study in which patients undergoing coronary sinus reducer implantation (Reducer) for chronic refractory angina undergo evaluation of the index of microcirculatory resistance…
- Trial name
- INROAD (NCT05174572)
- Testing
- IMR
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Consorzio Futuro in Ricerca
Spinal Cord Injury, Insulin Resistance
IR and Microvascular Blood Flow in SCI
Persons with spinal cord injury (SCI) are at an increased risk for metabolic disorders, including that of insulin resistance. As a result of neurological injury, they often have impaired mechanisms that regulate blood vessel…
- Trial name
- NCT02034331
- Testing
- Insulin iontophoresis, Acetylcholine Iontophoresis, Heat application
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Blood Flow
Microvascular Blood Flow During Passive Heating
Determine whether passive heating intervention effects microvascular blood flow as measured with near-infrared spectroscopy
- Trial name
- NCT06565221
- Testing
- Heat and negative pressure
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Burn Injury, Acute Wound
Cutaneous Microcirculation After Plasma Therapy
In plastic and reconstructive surgery, treatment strategies of second-degree burns, superficial wounds, burn scars, flaps and chronic wounds aim at reducing infection and improving microcirculation.
- Conditions
- Burn Injury, Acute Wound, Chronic Wound, Burn Scar
- Trial name
- NCT02417818
- Testing
- Plasma Therapy (PlasmaDerm), Repetitive Plasma Therapy (repetitive PlasmaDerm)
- Where
- Germany
- Volunteers
- 240 people
- Sponsor
- University Hospital Schleswig-Holstein
End-stage Renal Disease
The Microcirculation, Dialysis Modality and Sequestered Salt
The aim of this clinical trial is to investigate the effect of 5 different dialysis treatments (combinations of dialysis mode and dialysis fluid sodium content) on the microcirculation (MC) and sequestered sodium content (SSC) in…
- Trial name
- MIMOSA (NCT06327750)
- Testing
- Hemodialysis (DNa = PNa), Hemodialysis (DNa<PNa), Hemodialysis after isolated ultrafiltration (DNa=PNa)
- Where
- 2 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam UMC, location VUmc
Hypertension
Neural Mechanism of Aldosterone-induced Insulin Resistance
Patients with high aldosterone hormone have higher blood glucose than normal people. This study is being done to understand how aldosterone hormone affects the nerve activity that controls blood flow in the muscles and blood…
- Trial name
- NCT02102243
- Testing
- DEFINITY® infusion, Human Recombinant Regular Insulin infusion, Dextrose infusion
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wanpen Vongpatanasin
Septic Shock
Study on the Improvement of Microcirculation in Patients With Sepsis by Vitamin B6, Vitamin B12 and Vitamin C
Sepsis is a kind of disease with high morbidity and mortality in ICU. At present, there is no specific treatment, and its pathogenesis is mainly excessive oxidative stress.
- Trial name
- NCT06749756
- Testing
- vitamin B6+ Vitamin B12 +vitamin C, vitamin B6+ Vitamin B12, vitamin C
- Where
- China
- Volunteers
- 296 people
- Sponsor
- Fan Zeng
Hepatitis B Virus Related Cirrhosis, Portal Hypertension Related to Cirrhosis
Hepatic and Splenic Microcirculatory Perfusion for Ruling Out High-Risk Varices in Patients With Hepatitis B-Related Cirrhosis
Background: Chronic hepatitis B (CHB)-related cirrhosis is a common cause of portal hypertension, which leads to the development of gastroesophageal varices (EGVs).
- Conditions
- Hepatitis B Virus Related Cirrhosis, Portal Hypertension Related to Cirrhosis, Esophagogastric Varices
- Trial name
- NCT07450651
- Volunteers
- 150 people
- Sponsor
- Beijing Friendship Hospital
Myocardial Infarction [C14.907.585.500]
Influence of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment
The aim of this study was to measure the effect of low- and high-dose lipid-lowering treatment with rosuvastatin on the coronary physiology parameters.
- Trial name
- NCT01245894
- Testing
- Low-dose Rosuvastatin, High-dose Rosuvastatin
- Where
- Denmark
- Volunteers
- 87 people
- Sponsor
- Odense University Hospital
Acute Kidney Injury, Renal Artery Blood Flow
Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance
To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical…
- Conditions
- Acute Kidney Injury, Renal Artery Blood Flow, Renal Venous Return, Renal Microcirculation
- Trial name
- NCT06090773
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Peking Union Medical College Hospital
Liver Failure, Critical Care
Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment
Background: In patients undergoing hemodialysis or hemofiltration will suffer from the injury of reactive oxidative species. Oxidative stress will affect cell membrane, protein, and DNA.
- Trial name
- NCT00772252
- Testing
- liver support treatment
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital