Stroke, IschemicIMPreSTNCT04035746
Microcirculation and Plasticity After Stroke
An observational study of Stroke, Ischemic, run by University of Zurich at 1 site in Switzerland.
Trial summary
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours where risk of hemorrhage outweighs the benefit. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Stroke, Ischemic
- What is being tested?
- Observation of microcirculation and plasticity of the brain
- How many people
- 49 participants
- Where
- 1 siteSwitzerland
- Study dates
- 7 Oct 2019to 31 Jan 2022
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Consecutively admitted to the hospital
Who may be able to join
- ≤72h First-ever clinical ischemic stroke at hospital admission
- Occlusion of M1-segment of the middle cerebral artery, and/ or intracranial internal carotid artery, and perfusion deficits with cortical involvement
- 18 years or above
- Living independent before stroke (mRS ≤3)
- Written informed consent of the patient or the when the patient is not able to participate in the consenting procedure, the written authorization of an independent doctor who is not involved in the research project to safeguard the interests of the patient; in that case, post-hoc written informed consent of the patient is needed, or when the patient remains unable to participate in the informed consent procedure, written informed consent of a next of kind
Who cannot join
- Major cardiac, psychiatric and/ or neurological diseases
- Early seizures
- Known or suspected non-compliance, drug and/ or alcohol abuse
- Contra-indications for Magnetic Resonance Imaging and Transcranial Magnetic Stimulation, such as a history of seizure, prior electroconvulsive therapy, deep brain stimulators or other metal in the head, skull defect, pacemaker; neuroleptic medication; known allergic reaction to contrast material
- Documented evidence that the patient does not want to participate in any scientific study or, in case of lack of documented evidence, no behavior and/or expression(s) that indicate(s) refusal of the patient to participate in research
Trial locations and contacts
1 site in 1 country.
Switzerland1 site, 1 recruiting
- Recruiting
University Hospital Zurich
Zurich, 8091
Andreas R. Luft, Prof. MD, +41 (0)44 255 54 00, andreas.luft@uzh.ch
About this study
Official title: The Interplay of Microcirculation and Plasticity After Ischemic Stroke
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours where risk of hemorrhage outweighs the benefit. Recently, this cutoff has been put into perspective using standardized perfusion measurements by magnetic resonance imaging (MRI) or computed tomography (CT). Two trials have shown that revascularization is beneficial up to 24 hours after stroke onset if patient selection is based on perfusion imaging. This suggests interindividual differences in the temporal evolution of an infarction. One explanation for interindividual differences is the variability of the collateral blood supply to the brain, which in turn can maintain different perfusion pressures around the infarct core, also called the penumbra region. Insufficient recruitment of these collateral pathways is an independent negative predictor of poor outcome; the insufficiency may in part be explained by insufficient dilatation of arterioles ("low dilator reserve"). So far, interventions to improve collateral perfusion, e.g., induced hypertension, have not demonstrated effectiveness, likely because our understanding of collateral perfusion, demand-dependent dilatation of arteries (cerebrovascular reserve, CVR) and their effect on microcirculation is insufficient.
Functional recovery after a brain lesion is based on plasticity. Plasticity involves the creation of new synapses, fibers (axons and dendrites) and lasting modification to synaptic strength as well as the formation and migration of new neurons. In the cortex surrounding an infarct, plasticity is facilitated by ischemia via modification of gene expression, i.e. a certain time window after stroke, and is stimulated by activity and training. Tissue microcirculatory status and perfusion surrounding the stroke lesion may play a role in the formation of this plasticity. The investigators will analyze the contributions of pre-existing vascular networks, the impact of stroke-affected vessels, timing and degree of recanalization success, brain excitability, and short-term intra-cortical inhibition to better understand how these factors relate to functional recovery after stroke.
- Conditions
- Stroke, Ischemic
- Being tested
- Observation of microcirculation and plasticity of the brain
- Keywords
- Microcirculation, Plasticity, Cohort studies
- Medical subject headings
- Ischemic Stroke
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Observation of microcirculation and plasticity of the brainOther
Assessment of microcirculation, brain plasticity and clinical function
| Study group | Role | What they receive |
|---|---|---|
| Single-group study | Assessment of microcirculation, brain plasticity and clinical function Receives: Other: Observation of microcirculation and plasticity of the brain |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in brain microcirculation
Change in microcirculation of the brain as measured by magnetic resonance imaging (MRI)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Change in brain plasticity
Change in plasticity of the brain as measured by transcranial magnetic stimulation (TMS)
Measured: 7, 45 and 90 days after stroke onset
Secondary outcomes (13)
National Institutes of Health Stroke Scale
Neurological impairments (scale range 0-42, higher values represent a worse outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Fugl-Meyer Motor Assessment - Upper Extremity Subscale
Upper limb motor function (scale range 0-66, higher values represent a better outcome)
Measured: 7, 45 and 90 days after stroke onset
Fugl-Meyer Motor Assessment - Lower Extremity Subscale
Lower limb motor function (scale range 0-34, higher values represent a better outcome)
Measured: 7, 45 and 90 days after stroke onset
Finger extension 1
Ability to extend the fingers (scale range 0-2, higher values represent a better outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Finger extension 2
Ability to extend the fingers (scale range 0-10, higher values represent a better outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Finger extension 3
Ability to extend the fingers (scale range 0-3, higher values represent a worse outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Trunk Control Test
Trunk ability (scale range 0-100, higher values represent a better outcome)
Measured: 7 and 90 days after stroke onset
Functional Ambulation Categories
Walking ability (independence) (scale range 0-5, higher values represent a better outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Ten-Meter Walk Test
Gait speed and cadence (scale range is time in seconds, higher values represent a worse outcome)
Measured: 7, 45 and 90 days after stroke onset
Modified Rankin Scale
Global disability (scale range 0-5, higher values represent a worse outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Mobilization
Amount of mobilization (scale range is time in minutes, higher values represent a better outcome)
Measured: <72 hours; 7 days
Concomitant movement therapy
Intensity of therapy based on charts (scale range is time in minutes, higher values represent a better outcome)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Related Serious Events
Serious Events (1. death; 2. life-threatening illness or injury; 3. in-patient or prolonged hospitalization; 4. medical or surgical intervention to prevent life threatening illness; 5. led to fetal distress, death or a congenital abnormality or birth defect)
Measured: <72 hours; 7, 45 and 90 days after stroke onset
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Jul 2019
- Study start7 Oct 2019
- Primary completion31 Jan 2022 (estimated)
- Study completion31 Jan 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (11)Papers the sponsor has linked to this study.
- Other trials for Stroke, IschemicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 49 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Zurich
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Andreas R Luft, Prof. MD, Study chair, University of Zurich, University Hospital Zurich
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04035746
- Sponsor's protocol ID
- BASEC-Nr. 2019-00750
- Acronym
- IMPreST
- Status last verified
- Nov 2019
- First submitted
- 15 Jul 2019
- Last updated
- 25 Aug 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, McTaggart RA, Torbey MT, Kim-Tenser M, Leslie-Mazwi T, Sarraj A, Kasner SE, Ansari SA, Yeatts SD, Hamilton S, Mlynash M, Heit JJ, Zaharchuk G, Kim S, Carrozzella J, Palesch YY, Demchuk AM, Bammer R, Lavori PW, Broderick JP, Lansberg MG; DEFUSE 3 Investigators. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N Engl J Med. 2018 Feb 22;378(8):708-718. doi: 10.1056/NEJMoa1713973. Epub 2018 Jan 24.
PubMed 29364767Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH. Molecular, cellular and functional events in axonal sprouting after stroke. Exp Neurol. 2017 Jan;287(Pt 3):384-394. doi: 10.1016/j.expneurol.2016.02.007. Epub 2016 Feb 10.
PubMed 26874223Cortes JC, Goldsmith J, Harran MD, Xu J, Kim N, Schambra HM, Luft AR, Celnik P, Krakauer JW, Kitago T. A Short and Distinct Time Window for Recovery of Arm Motor Control Early After Stroke Revealed With a Global Measure of Trajectory Kinematics. Neurorehabil Neural Repair. 2017 Jun;31(6):552-560. doi: 10.1177/1545968317697034. Epub 2017 Mar 16.
PubMed 28506149El Amki M, Wegener S. Improving Cerebral Blood Flow after Arterial Recanalization: A Novel Therapeutic Strategy in Stroke. Int J Mol Sci. 2017 Dec 9;18(12):2669. doi: 10.3390/ijms18122669.
PubMed 29232823Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, Davalos A, Majoie CB, van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millan M, Davis SM, Roy D, Thornton J, Roman LS, Ribo M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD, Jovin TG; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016 Apr 23;387(10029):1723-31. doi: 10.1016/S0140-6736(16)00163-X. Epub 2016 Feb 18.
PubMed 26898852Ginsberg MD. Expanding the concept of neuroprotection for acute ischemic stroke: The pivotal roles of reperfusion and the collateral circulation. Prog Neurobiol. 2016 Oct-Nov;145-146:46-77. doi: 10.1016/j.pneurobio.2016.09.002. Epub 2016 Sep 13.
PubMed 27637159Mostany R, Chowdhury TG, Johnston DG, Portonovo SA, Carmichael ST, Portera-Cailliau C. Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex. J Neurosci. 2010 Oct 20;30(42):14116-26. doi: 10.1523/JNEUROSCI.3908-10.2010.
PubMed 20962232Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P, Veznedaroglu E, Hellinger FR, Feng L, Kirmani JF, Lopes DK, Jankowitz BT, Frankel MR, Costalat V, Vora NA, Yoo AJ, Malik AM, Furlan AJ, Rubiera M, Aghaebrahim A, Olivot JM, Tekle WG, Shields R, Graves T, Lewis RJ, Smith WS, Liebeskind DS, Saver JL, Jovin TG; DAWN Trial Investigators. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018 Jan 4;378(1):11-21. doi: 10.1056/NEJMoa1706442. Epub 2017 Nov 11.
PubMed 29129157Wahl AS, Omlor W, Rubio JC, Chen JL, Zheng H, Schroter A, Gullo M, Weinmann O, Kobayashi K, Helmchen F, Ommer B, Schwab ME. Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke. Science. 2014 Jun 13;344(6189):1250-5. doi: 10.1126/science.1253050.
PubMed 24926013Dufour JP, Inauen C, Hobner L, Bellomo J, Schubert T, Sebok M, Fierstra J, Colombo E, van Niftrik CHB, Piccirelli M, Globas C, Kulcsar Z, Luft A, Wegener S, Regli L, Esposito G. Serial Intracranial Flow Rate Measurements Using Quantitative Magnetic Resonance Angiography Following Large-Vessel Occlusion Stroke. Brain Sci. 2026 Jan 31;16(2):171. doi: 10.3390/brainsci16020171.
PubMed 41750172Barbagallo M, Zahn M, Zimmermann J, Klovekorn R, Held J, Nemeth B, Reolon B, Bellomo J, Schwarz A, Veerbeek JM, Van Niftrik CHB, Sebok M, Piccirelli M, Michels L, Luft AR, Kulcsar Z, Regli L, Esposito G, Fierstra J, Thurner P, Schubert T, Wegener S. Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence. Front Neurol. 2025 Aug 22;16:1639880. doi: 10.3389/fneur.2025.1639880. eCollection 2025.
PubMed 40917674
Study at a glance
From the registry record, last updated by the sponsor on 25 Aug 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Interplay of Microcirculation and Plasticity After Ischemic Stroke
- ClinicalTrials.gov ID
- NCT04035746
- Acronym / sponsor ID
- IMPreST / BASEC-Nr. 2019-00750
- Conditions
- Stroke, Ischemic
- Keywords
- Microcirculation, Plasticity, Cohort studies
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 49 participants (estimated)
- Lead sponsor
- University of ZurichUniversity, hospital or other
- Study start
- 7 Oct 2019 (actual)
- Primary completion
- 31 Jan 2022 (estimated)
- Study completion
- 31 Jan 2022 (estimated)
- First posted
- 29 Jul 2019 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statistical cutoff of 4.5 hours where risk of hemorrhage outweighs the benefit. Recently, this cutoff has been put into perspective using standardized perfusion measurements by magnetic resonance imaging (MRI) or computed tomography (CT). Two trials have shown that revascularization is beneficial up to 24 hours after stroke onset if patient selection is based on perfusion imaging. This suggests interindividual differences in the temporal evolution of an infarction. One explanation for interindividual differences is the variability of the collateral blood supply to the brain, which in turn can maintain different perfusion pressures around the infarct core, also called the penumbra region. Insufficient recruitment of these collateral pathways is an independent negative predictor of poor outcome; the insufficiency may in part be explained by insufficient dilatation of arterioles ("low dilator reserve"). So far, interventions to improve collateral perfusion, e.g., induced hypertension, have not demonstrated effectiveness, likely because our understanding of collateral perfusion, demand-dependent dilatation of arteries (cerebrovascular reserve, CVR) and their effect on microcirculation is insufficient.
Functional recovery after a brain lesion is based on plasticity. Plasticity involves the creation of new synapses, fibers (axons and dendrites) and lasting modification to synaptic strength as well as the formation and migration of new neurons. In the cortex surrounding an infarct, plasticity is facilitated by ischemia via modification of gene expression, i.e. a certain time window after stroke, and is stimulated by activity and training. Tissue microcirculatory status and perfusion surrounding the stroke lesion may play a role in the formation of this plasticity. The investigators will analyze the contributions of pre-existing vascular networks, the impact of stroke-affected vessels, timing and degree of recanalization success, brain excitability, and short-term intra-cortical inhibition to better understand how these factors relate to functional recovery after stroke.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Single-group study | – | Other: Observation of microcirculation and plasticity of the brainAssessment of microcirculation, brain plasticity and clinical function |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Consecutively admitted to the hospital
Key inclusion criteria (5 listed)
- ≤72h First-ever clinical ischemic stroke at hospital admission
- Occlusion of M1-segment of the middle cerebral artery, and/ or intracranial internal carotid artery, and perfusion deficits with cortical involvement
- 18 years or above
- Living independent before stroke (mRS ≤3)
- Written informed consent of the patient or the when the patient is not able to participate in the consenting procedure, the written authorization of an independent doctor who is not involved in the research project to safeguard the interests of the patient; in that case, post-hoc written informed consent of the patient is needed, or when the patient remains unable to participate in the informed consent procedure, written informed consent of a next of kind
Key exclusion criteria (5 listed)
- Major cardiac, psychiatric and/ or neurological diseases
- Early seizures
- Known or suspected non-compliance, drug and/ or alcohol abuse
- Contra-indications for Magnetic Resonance Imaging and Transcranial Magnetic Stimulation, such as a history of seizure, prior electroconvulsive therapy, deep brain stimulators or other metal in the head, skull defect, pacemaker; neuroleptic medication; known allergic reaction to contrast material
- Documented evidence that the patient does not want to participate in any scientific study or, in case of lack of documented evidence, no behavior and/or expression(s) that indicate(s) refusal of the patient to participate in research
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Observation of microcirculation and plasticity of the brainAssessment of microcirculation, brain plasticity and clinical function | Other | Single-group study |
Primary outcome
Change in brain microcirculation
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Change in microcirculation of the brain as measured by magnetic resonance imaging (MRI)
Change in brain plasticity
Time frame: 7, 45 and 90 days after stroke onset
Change in plasticity of the brain as measured by transcranial magnetic stimulation (TMS)
13 secondary outcomes
National Institutes of Health Stroke Scale
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Fugl-Meyer Motor Assessment - Upper Extremity Subscale
Time frame: 7, 45 and 90 days after stroke onset
Fugl-Meyer Motor Assessment - Lower Extremity Subscale
Time frame: 7, 45 and 90 days after stroke onset
Finger extension 1
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Finger extension 2
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Finger extension 3
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Trunk Control Test
Time frame: 7 and 90 days after stroke onset
Functional Ambulation Categories
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Ten-Meter Walk Test
Time frame: 7, 45 and 90 days after stroke onset
Modified Rankin Scale
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Mobilization
Time frame: <72 hours; 7 days
Concomitant movement therapy
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Related Serious Events
Time frame: <72 hours; 7, 45 and 90 days after stroke onset
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 25 Aug 2020.
- Background: PubMed 29364767Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, McTaggart RA, Torbey MT, Kim-Tenser M, Leslie-Mazwi T, Sarraj A, Kasner SE, Ansari SA, Yeatts SD, Hamilton S, Mlynash M, Heit JJ, Zaharchuk G, Kim S, Carrozzella J, Palesch YY, Demchuk AM, Bammer R, Lavori PW, Broderick JP, Lansberg MG; DEFUSE 3 Investigators. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging. N Engl J Med. 2018 Feb 22;378(8):708-718. doi: 10.1056/NEJMoa1713973. Epub 2018 Jan 24.
- Background: PubMed 26874223Carmichael ST, Kathirvelu B, Schweppe CA, Nie EH. Molecular, cellular and functional events in axonal sprouting after stroke. Exp Neurol. 2017 Jan;287(Pt 3):384-394. doi: 10.1016/j.expneurol.2016.02.007. Epub 2016 Feb 10.
- Background: PubMed 28506149Cortes JC, Goldsmith J, Harran MD, Xu J, Kim N, Schambra HM, Luft AR, Celnik P, Krakauer JW, Kitago T. A Short and Distinct Time Window for Recovery of Arm Motor Control Early After Stroke Revealed With a Global Measure of Trajectory Kinematics. Neurorehabil Neural Repair. 2017 Jun;31(6):552-560. doi: 10.1177/1545968317697034. Epub 2017 Mar 16.
- Background: PubMed 29232823El Amki M, Wegener S. Improving Cerebral Blood Flow after Arterial Recanalization: A Novel Therapeutic Strategy in Stroke. Int J Mol Sci. 2017 Dec 9;18(12):2669. doi: 10.3390/ijms18122669.
- Background: PubMed 26898852Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, Davalos A, Majoie CB, van der Lugt A, de Miquel MA, Donnan GA, Roos YB, Bonafe A, Jahan R, Diener HC, van den Berg LA, Levy EI, Berkhemer OA, Pereira VM, Rempel J, Millan M, Davis SM, Roy D, Thornton J, Roman LS, Ribo M, Beumer D, Stouch B, Brown S, Campbell BC, van Oostenbrugge RJ, Saver JL, Hill MD, Jovin TG; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016 Apr 23;387(10029):1723-31. doi: 10.1016/S0140-6736(16)00163-X. Epub 2016 Feb 18.
- Background: PubMed 27637159Ginsberg MD. Expanding the concept of neuroprotection for acute ischemic stroke: The pivotal roles of reperfusion and the collateral circulation. Prog Neurobiol. 2016 Oct-Nov;145-146:46-77. doi: 10.1016/j.pneurobio.2016.09.002. Epub 2016 Sep 13.
- Background: PubMed 20962232Mostany R, Chowdhury TG, Johnston DG, Portonovo SA, Carmichael ST, Portera-Cailliau C. Local hemodynamics dictate long-term dendritic plasticity in peri-infarct cortex. J Neurosci. 2010 Oct 20;30(42):14116-26. doi: 10.1523/JNEUROSCI.3908-10.2010.
- Background: PubMed 29129157Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P, Veznedaroglu E, Hellinger FR, Feng L, Kirmani JF, Lopes DK, Jankowitz BT, Frankel MR, Costalat V, Vora NA, Yoo AJ, Malik AM, Furlan AJ, Rubiera M, Aghaebrahim A, Olivot JM, Tekle WG, Shields R, Graves T, Lewis RJ, Smith WS, Liebeskind DS, Saver JL, Jovin TG; DAWN Trial Investigators. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018 Jan 4;378(1):11-21. doi: 10.1056/NEJMoa1706442. Epub 2017 Nov 11.
- Background: PubMed 24926013Wahl AS, Omlor W, Rubio JC, Chen JL, Zheng H, Schroter A, Gullo M, Weinmann O, Kobayashi K, Helmchen F, Ommer B, Schwab ME. Neuronal repair. Asynchronous therapy restores motor control by rewiring of the rat corticospinal tract after stroke. Science. 2014 Jun 13;344(6189):1250-5. doi: 10.1126/science.1253050.
- Derived from this study: PubMed 41750172Dufour JP, Inauen C, Hobner L, Bellomo J, Schubert T, Sebok M, Fierstra J, Colombo E, van Niftrik CHB, Piccirelli M, Globas C, Kulcsar Z, Luft A, Wegener S, Regli L, Esposito G. Serial Intracranial Flow Rate Measurements Using Quantitative Magnetic Resonance Angiography Following Large-Vessel Occlusion Stroke. Brain Sci. 2026 Jan 31;16(2):171. doi: 10.3390/brainsci16020171.
- Derived from this study: PubMed 40917674Barbagallo M, Zahn M, Zimmermann J, Klovekorn R, Held J, Nemeth B, Reolon B, Bellomo J, Schwarz A, Veerbeek JM, Van Niftrik CHB, Sebok M, Piccirelli M, Michels L, Luft AR, Kulcsar Z, Regli L, Esposito G, Fierstra J, Thurner P, Schubert T, Wegener S. Reperfusion failure after successful thrombectomy of large vessel occlusion stroke: clinical and imaging evidence. Front Neurol. 2025 Aug 22;16:1639880. doi: 10.3389/fneur.2025.1639880. eCollection 2025.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Andreas R Luft, Prof. MD study chair
University of Zurich, University Hospital Zurich
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Stroke, Ischemic, run by University of Zurich at 1 site in Switzerland.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 25 Aug 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Switzerland. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Andreas R Luft, Prof. MD (+41 (0)44 255 54 00, andreas.luft@uzh.ch), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in brain microcirculation (time frame: <72 hours; 7, 45 and 90 days after stroke onset). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04035746, which also lists 11 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Aug 2020.