Clinical trials: Microplastics, active
Colorectal Cancer (MSI-H), Microplastic Exposure
Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer
The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and…
- Trial name
- NCT07063550
- Testing
- exposure to microplastic
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Dong Peng
Urolithiasis
Assessment of Urinary Microplastic Concentration in Patients With Urolithiasis: A Prospective Case-Control Study
This prospective observational case-control study aims to evaluate the presence and burden of microplastic particles in urine samples from patients with kidney and ureteral stones and to compare these findings with healthy…
- Trial name
- Microplastics (NCT07841834)
- Testing
- No Intervention
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Konya City Hospital
Cirrhosis, Microplastics
Microplastics, Cirrhosis and Portal Hypertension
Cirrhosis and portal hypertension are associated with an hyperdynamic circulation and hepatic inflammation, leading to complications like ascites, variceal bleeding, acute kidney injury, and higher infection risk.
- Conditions
- Cirrhosis, Microplastics, Portal Hypertension Related to Cirrhosis, Nanoplastics
- Trial name
- NCT07280390
- Testing
- Assessment of microplastics in tissue
- Where
- 2 sites in India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Obesity and Overweight
Identification of Microplastics in Liver, Stomach, Blood, and Feces of Obese Patients and Their Association Analysis with Macrogenomics and Metabolomics.
The aim of this study was to identify and quantify microplastics in the stomach, liver, feces, and blood of obese patients to be treated with bariatric surgery by using a variety of advanced analytical techniques to explore the…
- Trial name
- NCT06826586
- Testing
- Measuring the microplastics
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Intracerebral Hemorrhage, Brain Hematoma
Microplastics in Brain Hematomas and Neurological Outcomes After Intracerebral Hemorrhage
This observational study investigates the presence of micro- and nanoplastics in surgically removed intracerebral hematomas and their association with neurological outcomes in patients with spontaneous intracerebral hemorrhage.
- Trial name
- PARTENOPE (NCT07580326)
- Testing
- Observational Analysis
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Pancreatic Diseases, Pancreatic Neoplasms
Microplastics in Pancreas: Oncologic and Metabolic Impact
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants that have been detected in several human tissues, raising concerns about their potential impact on human health.
- Trial name
- PAN-Plastic (NCT07486128)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Infertility, Microplastics Exposure
Fertility Impact of Microplastics - Advancing Countermeasures and Tracking
FERTIMPACT is a prospective clinical study based on the hypothesis that exposure to micro- and nanoplastics (MNPs) is associated with impaired reproductive function.
- Conditions
- Infertility, Microplastics Exposure, Fertility
- Trial name
- FERTIMPACT (NCT07562958)
- Volunteers
- 1,000 people
- Sponsor
- University of Kragujevac
Crohns Disease, Pregnancy
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as…
- Conditions
- Crohns Disease, Pregnancy, Inflammatory Bowel Disease
- Trial name
- PLANET (NCT06001450)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Microvascular Dysfunction (CMD), Microplastic Exposure
Micro-nanoplastic Exposure and Coronary Microcirculatory Dysfunction as Well as Cardiovascular Outcomes
With strict quality control procedures applied throughout microplastic testing, this study will assess the association between baseline circulating micro-nanoplastic exposure and coronary microvascular dysfunction, as well as…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Microplastic Exposure, Nanoplastics, MACE
- Trial name
- NCT07748767
- Testing
- micro-nanoplastic examination, Microvascular Function Examination
- Volunteers
- 184 people
- Sponsor
- Beijing Anzhen Hospital
Head and Neck Cancer, Microplastic Exposure
Impact of Chronic MICROplastic Exposure on RADiotherapy of Head and Neck Cancer Patients: Clinical and Translational Oncology Study:
MICRORAD is a pioneering 48-month translational research project that investigates the potential health and environmental impacts of micro- and nanoplastics (MNPs) released from medical devices when exposed to ionizing radiation.
- Trial name
- MICRORAD (NCT07690631)
- Volunteers
- 500 people
- Sponsor
- University of Kragujevac
Carotid Artery Stenosis, Glioma
Detection of Microplastics and Nanoplastics in Neurosurgery Patients (DT-MiNi)
Plastic particles are a ubiquitous pollutant in the living environment and food chain, so far, plenty of studies have reported the internal exposure of microplastics and nanoplastics in human tissues and enclosed body fluids.
- Conditions
- Carotid Artery Stenosis, Glioma, Intracranial Aneurysm, Intracranial Hemorrhages
- Trial name
- DT-MiNi (NCT05968053)
- Testing
- biological samples analysis
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Tiantan Hospital
Infant Development, Breast Feeding
Developmental Impacts of Microplastics Exposure in Early Life
The goal of this observational study is to characterize and evaluate micro- and nano-plastic (MNP) exposures among mothers and infants in mother-infant dyads 1 or 3 months postpartum living in Baltimore, Maryland.
- Conditions
- Infant Development, Breast Feeding, Environmental Exposure
- Trial name
- DIMPLE (NCT06107933)
- Testing
- Observational only
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Female Infertility, Environmental Exposure
Detection of Microplastics in Human Granulosa Cells and in the Follicular Fluid of Women Undergoing ICSI Treatment
Plastic products have been used ubiquitously in the modern world for many decades - for example as packaging materials, textile fibers or molded parts.
- Trial name
- MP2021 (NCT05179993)
- Testing
- Microplastics
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Infertility Treatment Center Dortmund
Atopic Dermatitis
Prenatal Exposure to Emerging Contaminants and Children's Atopic Dermatitis
This prospective cohort study aims to investigate the association between prenatal blood levels of Emerging Contaminants and the five-year incidence of atopic dermatitis (AD) in offspring.
- Trial name
- PECCAD (NCT06316609)
- Testing
- Gestational Exposure to Emerging Contaminants (ECs)
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Children's Hospital of Fudan University
ST-elevation Myocardial Infarction (STEMI), Microplastics
Microplastics and Nanoplastics (MNPs) in Patients With ST-elevation Myocardial Infarction (STEMI)
Air pollution and microplastics pose major public health threats. Emerging data have shown that micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants accumulating in human tissues, triggering inflammation and…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Microplastics, Nanoplastics, Pollution Exposure
- Trial name
- STEMI-Plastics (NCT06965023)
- Where
- 10 sites in Italy
- Volunteers
- 130 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Gastric Cancers
The Association Between Microplastics and Macrogenomics and Metabolomics in Gastric Cancer
The aim of this study was to identify and quantify microplastics in blood, stool, and tumor surgical specimens from gastric cancer patients by analyzing the nature, type, and abundance of microplastics using laser direct infrared…
- Trial name
- NCT06856382
- Testing
- gastric cancer
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Dong Peng
Chronic Coronary Syndrome, Microplastics
Microplastics and Nanoplastics in Patients With Chronic Coronary Syndromes
The CCS-plastics is an investigator-initiated, prospective, multicenter study of patients undergoing coronary CT angiography (CCTA) for suspected or known chronic coronary syndromes (CCS) referred to invasive coronary angiography…
- Conditions
- Chronic Coronary Syndrome, Microplastics, Nanoplastics, Coronary Artery Disease
- Trial name
- CCS-Plastics (NCT07291609)
- Where
- 6 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Microplastic and Nanoplastic Particle Burden in Peripheral Blood, Double-Filtration Plasmapheresis
Evaluating DFPP for Microplastic and PFAS Reduction
This prospective, non-interventional, within-subject paired biomarker study will evaluate whether circulating microplastic and nanoplastic-associated particle concentrations and PFAS concentrations in peripheral blood change…
- Trial name
- DFPP-MNP (NCT07658443)
- Testing
- Double-Filtration Plasmapheresis With the IN300 Apheresis Device
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 20 people
- Sponsor
- Proxima Health, Inc.
Gastric Carcinoma, Gastritis Chronic
Association Between Microplastic Exposure and the Pathological Progression of Gastric Carcinogenesis
The objective of this clinical trial is to explore the correlation between the level of microplastic exposure and the risk of gastric mucosal carcinogenesis, and to evaluate the strength of its effect as an independent risk…
- Conditions
- Gastric Carcinoma, Gastritis Chronic, Intestinal Metaplasia, Gastric Precancerous Lesions
- Trial name
- NCT07542652
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Yongquan Shi
Lung Cancer
Investigation of MP Pollution in the Human Respiratory System and Its Relationship to Lung Cancer
This project will study and characterize Microplastic (MP) burden in the lungs of patients undergoing Bronchoalveolar Levage (BAL) in thoracic clinics at Moffitt.
- Trial name
- NCT06530615
- Testing
- Bronchoalveolar Lavage (BAL) during Bronchoscopy
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute