Clinical trials: Microfractures
Cartilage Injury, Osteoarthritis
Study to Compare Efficacy and Safety of Cartistem and Microfracture in Patients With Knee Articular Cartilage Injury
The purpose of the study is to assess and compare the safety and efficacy of the allogeneic-unrelated umbilical cord blood-derived mesenchymal stem cell product (Cartistem®) to that of a microfracture treatment in patients with…
- Trial name
- NCT01041001
- Testing
- Cartistem, Microfracture treatment
- Where
- 8 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Medipost Co Ltd.
Rupture of the Rotator Cuff
Microfracture in Rotator Cuff Injury Repair
The hypothesis is that microfractures in the footprint of the humerus will aid to improve the tendon healing to the bone. The aim of the study is to investigate whether the use of microfractures at the footprint of the rotator…
- Trial name
- NCT02097901
- Testing
- Microfracture, NO microfracture
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Zealand University Hospital
Chondral Defect, Articular Cartilage Defect
A Comparison of JointRep® and Microfracture in Repair of Cartilage Lesions on the Femoral Condyle or Trochlea,
The aim of the study is to compare whether JointRep® plus microfracture is more effective than microfracture alone when treating symptomatic focal articular cartilage lesions in the knee (femoral condyles or trochlea).
- Conditions
- Chondral Defect, Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- JMAC (NCT04840147)
- Testing
- JointRep®, Microfracture
- Where
- 8 sites in Australia, Canada
- Volunteers
- 185 people
- Sponsor
- Oligo Medic Pty Ltd
Focal Cartilage Lesions of the Knee
Management of Focal Cartilage Lesions of the Knee: The Benefits of an Autograft Procedure
Cartilage is a tissue whose primary function is to transmit and distribute loads when joints are under stress. It acts as a buffer between bones at the joints.
- Trial name
- CART-MCI Knee (NCT07641868)
- Testing
- Management of focal cartilage lesions of the knee: micro-fracture, Minced Cartilage Implantation (MCI)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Louis Pasteur Santé Lorraine
Rotator Cuff Tears, Micro Fracture
Microfracture at Proximal Humerus Lateral to Footprint Could Enhance the Rotator Cuff Healing
The goal of this clinical trial is to test whether there is any effect on rotator cuff healing by making microfracture at the lateral side of the footprint.
- Trial name
- NCT05624164
- Testing
- Lateralised microfracture
- Where
- 2 sites in China
- Volunteers
- 88 people
- Sponsor
- Affiliated Hospital of Nantong University
Tear; Knee, Cartilage, Articular
Arthroscopic Autologous Chondrocyte Implantation Versus Microfractures
This is a phase III, randomised controlled trial of matrix-encapsulated chondrocyte implantation procedure compared to the microfracture procedure in the repair of symptomatic cartilage lesions of the knee.
- Trial name
- NCT01947374
- Testing
- Matrix encapsulated chondrocyte implantation, Microfracture awl
- Where
- Mexico
- Volunteers
- 48 people
- Sponsor
- Instituto Nacional de Rehabilitacion
Defect of Articular Cartilage
Smith & Nephew's European Trufit Study
The purpose of this clinical study is to demonstrate the effectiveness and safety of the Trufit CB (Cartilage Bone) implant for the treatment of single, isolated cartilage defects of the knee compared to Microfracture.
- Trial name
- NCT01246635
- Testing
- Trufit CB (Cartilage Bone) Implant, Microfracture if the knee
- Where
- 14 sites in Belgium, Denmark and 6 more
- Volunteers
- 153 people
- Sponsor
- Smith & Nephew, Inc.
Knee Chondral, Osteochondral Defect
Comparison of Microfracture Treatment and CARTIPATCH® Chondrocyte Graft Treatment in Femoral Condyle Lesions
CARTIPATCH® is an Autologous Chondrocyte Implantation product including functional cells in a matrix, indicated for the treatment of isolated osteocartilaginous lesions.
- Trial name
- NCT00945399
- Testing
- CARTIPATCH® procedure, Microfracture
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- TBF Genie Tissulaire
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Femoroacetabular Impingement, Cartilage Damage
Cartilage Repair Using a Hyaluronic Acid-Based Scaffold With Bone Marrow Aspirate Compared With Microfracture for Focal Articular Cartilage Damage of the Hip
Femoroacetabular impingement (FAI) is a hip disorder resulting from a mismatch of the hip joint, resulting in hip pain and can potentially cause osteoarthritis.
- Trial name
- CHASE (NCT04875767)
- Testing
- HA-based scaffold with BMA (Hyalofast®; Anika Therapeutics, Bedford, MA, USA)
- Sponsor
- McMaster University
Chondral or Osteochondral Lesion of Talus
Efficacy and Safety of Allogenic Stem Cell Product(CARTISTEM®) for Osteochondral Lesion of Talus
The purpose of this study is to evaluate the efficacy and safety of adding CARTISTEM®(allogenic umbilical cord blood-derived stem cell product) on microfracture, a currently standard treatment for OLT, in patients with talar…
- Trial name
- NCT04310215
- Testing
- CARTISTEM®, Microfracture
- Where
- 6 sites in South Korea
- Volunteers
- 102 people
- Sponsor
- Hyundai Bioland Co., Ltd.
Hip Osteoarthritis, Hip Impingement Syndrome
Losartan to Improve Hip Microfracture
Phase I/IIA randomized, double-blind, placebo-controlled clinical trial to assess safety and efficacy of oral losartan for improving cartilage repair following microfracture to treat focal cartilage defects during hip arthroscopy.
- Conditions
- Hip Osteoarthritis, Hip Impingement Syndrome, Cartilage Damage, Fibrosis
- Trial name
- NCT04212650
- Testing
- Losartan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Steadman Philippon Research Institute
Articular Cartilage Lesion of the Knee
Study to Assess the Efficacy and Safety of Treatment of Articular Cartilage Lesions With CartiLife®
The purpose of this study is to assess the safety and efficacy of implanting bead-type autologous chondrocyte (CartiLife®) obtained by culturing expanded costal chondrocytes of the patient with a chondral defect in the knee.
- Trial name
- NCT03545269
- Testing
- CartiLife®, Microfracture
- Volunteers
- 30 people
- Sponsor
- Biosolution Co., Ltd.
Cartilage Injury, Osteochondritis Dissecans
A Randomized Controlled Trial Comparing Chondro-Gide® to Microfracture Alone for Treatment of Knee Cartilage Defects.
The purpose of this study is to evaluate the safety and effectiveness of using Chondro-Gide® collagen membrane either sutured or glued compared to microfracture alone in the treatment of symptomatic cartilage defects of the knee.
- Trial name
- NCT02993510
- Testing
- Microfracture, Chondro-Gide sutured, Chondro-Gide glued
- Where
- 7 sites in Germany
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Geistlich Pharma AG
Articular Cartilage Defect Grade III or IV of the Knee
Use of Cell Therapy to Enhance Arthroscopic Knee Cartilage Surgery
The purpose of this study is to assess the potential benefit of enhancing knee surgery for cartilage injury using some of the patient's own cells, taken from fat tissue, that may be able to help cartilage to regenerate.
- Trial name
- NCT01799876
- Testing
- Autologous Cell, Standard microfracture arthroscopic surgery
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Fondren Orthopedic Group L.L.P.
Knee Injury, Cartilage Injury
Norwegian Cartilage Project - Microfracture
114 patients between 18 and 50 years with an isolated focal cartilage defect in the knee will be randomized to either receive arthroscopic microfracture or arthroscopic debridement.
- Trial name
- NCT02637505
- Testing
- Arthroscopic microfracture (MF), Arthroscopic debridement (AD)
- Where
- Norway
- Volunteers
- 66 people
- Sponsor
- University Hospital, Akershus
Articular Cartilage Defect, Articular Cartilage Degeneration
Phase 3 Clinical Trial of CartiLife® in Korea
To evaluate the safety and efficacy of pellet-type extracellular matrix-associated autologous chondrocytes (CartiLife®) obtained by cultivating costal chondrocytes of the subject implanted into articular cartilage defects of the…
- Trial name
- NCT05051332
- Testing
- Autologous Chondrocyte Implantation (CartiLife®), Microfracture Surgery
- Where
- 18 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Biosolution Co., Ltd.
Knee Injuries
Follow-Up Study Evaluating The Long Term Safety and Efficacy of BST-CarGel and Microfracture Repair of the Knee
This follow-up study will evaluate the effects of BST-CarGel® application to a microfractured lesion (investigational) and microfracture alone (control) for up to 5 years from treatment in subjects, treated under Protocols…
- Trial name
- NCT01246895
- Testing
- Microfracture with BST-CarGel, Microfracture without BST-CarGel
- Where
- 16 sites in Canada, Spain
- Volunteers
- 67 people
- Sponsor
- Piramal Healthcare Canada Ltd
Degenerative Lesion of Articular Cartilage of Knee
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the…
- Trial name
- NCT02090140
- Testing
- ADSC Application, Microfracture
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Cartilage Defects of the Knee
Long-term Safety and Efficacy of CartiFill After Microfracture Surgery in Knee Cartilage Defects
The purpose of this clinical trial is to evaluate the safety and efficacy of CartiFill implanted at the site of knee joint cartilage defect in a 6-year, long-term, follow-up investigation.
- Trial name
- NCT07621172
- Testing
- CartiFill, Microfracture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Cellontech Co., Ltd.