Clinical trials: Microcirculatory Dysfunction
Sclerosis, Multiple
Exploration of Microcirculatory Alteration and Endothelial Dysfunction by Adaptive Optics in Multiple Sclerosis
It's a pilot, interventional prospective monocentric study. It aims to compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between patients with multiple sclerosis and controls using…
- Trial name
- MS-EYE (NCT03508089)
- Testing
- Ocular fundus on patient with Multiple Sclerosis, Ocular Fundus on voluntary person
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Versailles Hospital
Critical Illness, Septic Shock
Microcirculatory Alterations in Critical Disease: New Ultrasound Technology
Aim of this study is (1) to test and further develop a new non-invasive ultrasound method, and (2) to gain new insight into microcirculatory alterations during critical disease, particularly in critical septic shock patients.
- Trial name
- SepCease (NCT03311568)
- Testing
- ultrasound for microcirculatory assessment
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Septic Shock
Assessment of Microcirculatory Dysfunction in Septic Shock Patients by OCTA
Purpose and rationale: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis and septic shock are major public health problems killing one in every three patients.
- Trial name
- SshOCTA (NCT04593212)
- Testing
- Optical Coherence Tomography Angiography
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospital da Luz, Portugal