Clinical trials: Microcirculatory Dysfunction
Coronary Artery Disease, Acute Kidney Injury
Endothelial Glycocalyx Damage in Acute Kidney Injury
Abstract Significance: Cardiac surgery-associated acute kidney injury (CSA-AKI) is common and has serious immediate and long-term sequelae.
- Trial name
- NCT05471583
- Testing
- Main group
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- King's College London
Hemodyalysis
Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients
Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population.
- Trial name
- PRE-COCO (NCT07608679)
- Testing
- Transthoracic ultrasound at rest, Cardiological stress test, Coronary angiography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris
A Multi-center, Real-World Clinical Trial of caIMR on Two Specific Kinds of Patients.
The coronary angiography-derived index of microcirculatory resistance (caIMR) can be used to provide a binary assessment whether patients（with stable angina, unstable angina, suspected myocardial ischemia, or coronary artery…
- Conditions
- Coronary Microvascular Dysfunction (CMD), Stable Angina Pectoris, Unstable Angina Pectoris, Myocardial Ischemia, Angina Pectoris
- Trial name
- FlashV (NCT06945094)
- Testing
- caIMR
- Volunteers
- 508 people
- Sponsor
- Ge Junbo
Coronary Heart Disease
Ticagrelor Versus Clopidogrel for CMD in Patients With AMI: A Retrospective Study Based on the Angio-IMR
Coronary microvascular dysfunction (CMD) is increasingly recognized as an important indicator for long-term prognosis in patients with acute myocardial infarction (AMI).
- Trial name
- NCT05978726
- Testing
- Dual antiplatelet therapy with aspirin and either ticagrelor or clopidogrel
- Where
- China
- Volunteers
- 325 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Circulatory Shock, Cardiovascular Shock
Physiologic Effect of Topical Nitroglycerin on Microcirculation Capacity in Patients With Circulatory Shock.
This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery.
- Trial name
- NCT05102734
- Testing
- Nitroglycerin Topical Product
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease, Microvascular Angina
Coronary Thermo-dilution Derived Flow-indices in Chronic Coronary Syndrome
Patients scheduled for elective coronary angiography due to chronic coronary syndrome are recruited at admission to hospital before the coronary anatomy is known.
- Conditions
- Coronary Artery Disease, Microvascular Angina, Coronary Microvascular Dysfunction
- Trial name
- NCT06306066
- Where
- Sweden
- Volunteers
- 505 people
- Sponsor
- Karolinska Institutet
Endothelial Dysfunction, Coronary Microvascular Disease
Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial)
A total of 50 patients with ST-elevation myocardial infarction (STEMI) undergoing primary-percutaneous coronary intervention (PPCI) will be randomized to two different coronary stents: BIOFREEDOM vs. COMBO stent.
- Conditions
- Endothelial Dysfunction, Coronary Microvascular Disease, Myocardial Infarction
- Trial name
- FUNCOMBO (NCT04202172)
- Testing
- Stent implantation in the infart-related artery in patients with ST elevation myocardial infarction
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
Coronary Artery Disease, Coronary Microvascular Dysfunction
Multimodal Epicardial and Endocardial COronary PHYsiological Evaluation in Pathological Situations (PHYCO)
When performing coronary angiography in a stable situation, the identification of an intermediate coronary lesion (between 50 and 70%) is common, and requires additional functional evaluation.
- Trial name
- PHYCO (NCT06008041)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Brest
Heart Failure With Preserved Ejection Fraction, Coronary Microvascular Dysfunction
Distribution and Clinical Implication of CMD in Patients With HFpEF Without Significant CAD
To evaluate the incidence of coronary microvascular dysfunction (CMD) and its' prognostic implication in patients who have diagnosed as heart failure with preserved ejection fraction (HFpEF) confirmed by HFA-PEFF scoring system…
- Trial name
- HFpEF-CMD (NCT04788576)
- Testing
- Invasive physiologic evaluation (fractional flow reserve, coronary flow reserve, index of microcirculatory resistance)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Samsung Medical Center
Endothelial Dysfunction, Hemolysis
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
Acute microcirculatory perfusion disturbances is common in critical illness and associated with increased morbidity and mortality.
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME part II (NCT05647200)
- Testing
- Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Sepsis
Randomized Trial of Inhaled Nitric Oxide to Augment Tissue Perfusion in Sepsis
The purpose of this study is to determine whether inhaled nitric oxide is an effective treatment for microcirculatory dysfunction and acute organ system failure in the early stage of sepsis therapy.
- Trial name
- NCT00608322
- Testing
- Inhaled nitric oxide
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease
For Patients With Myocardial Infarction and Multiple Vessel: Testing if Ultrasound (UFR) Can Guide All Needed Treatment in One Procedure, Avoiding a Return Hospital Visit for a Second Operation.
Brief Summary The Purpose of the Study : The purpose of this study is to find a safe and reliable "one-stop" solution for treating heart attack patients who have multiple blocked arteries.
- Conditions
- Microvascular Obstruction (MVO), Multivessel Coronary Artery Disease, ACS (Acute Coronary Syndrome), ST Elevation Myocardial Infarction (STEMI)
- Trial name
- ACT-EVOLVE (NCT07264881)
- Testing
- IVUS-based Fractional Flow Reserve (UFR), Invasive Coronary Physiology Measurement (FFR/RFR/IMR), Cardiac Magnetic Resonance (CMR)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Calcification, Intravascular Lithotripsy
Prognostic Impact of Coronary Microvascular Dysfunction After IVL Versus RA in Patients With Severe Coronary Calcification Undergoing PCI
The goal of this observational study is to lean that whether the distinct mechanisms by which intravascular lithotripsy (IVL) and rotational atherectomy (RA) treat severe coronary calcification differentially affect the…
- Conditions
- Coronary Artery Calcification, Intravascular Lithotripsy, Coronary Microcirculation Dysfunction
- Trial name
- NCT07699965
- Where
- China
- Volunteers
- 590 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Sclerosis, Multiple
Exploration of Microcirculatory Alteration and Endothelial Dysfunction by Adaptive Optics in Multiple Sclerosis
It's a pilot, interventional prospective monocentric study. It aims to compare the wall / lumen ratio (WLR) of retinal arterioles (common marker of microangiopathies) between patients with multiple sclerosis and controls using…
- Trial name
- MS-EYE (NCT03508089)
- Testing
- Ocular fundus on patient with Multiple Sclerosis, Ocular Fundus on voluntary person
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Versailles Hospital
Critical Illness, Septic Shock
Microcirculatory Alterations in Critical Disease: New Ultrasound Technology
Aim of this study is (1) to test and further develop a new non-invasive ultrasound method, and (2) to gain new insight into microcirculatory alterations during critical disease, particularly in critical septic shock patients.
- Trial name
- SepCease (NCT03311568)
- Testing
- ultrasound for microcirculatory assessment
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Endothelial Dysfunction, Hemolysis
CPB Prime Fluid Strategies to Preserve Mcirocirculatory Perfusion
Acute microcirculatory perfusion disturbances is common in critical illness and associated with higher morbidity and mortality. Recent findings by the investigators' group showed that microcirculatory perfusion is disturbed…
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME (NCT05647057)
- Testing
- A: gelofusine + ringers, B: albumine + ringers, C: ringers + retrograde autologous priming
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Amsterdam UMC, location VUmc
End Stage Liver Disease
Study of Peripheral Tissue Oxygenation in End-stage Liver Disease Patients During Liver Transplantation
End - stage liver disease can cause many problems to the patients including fatigue, weakness,jaundice, confusion, abdominal pain and distension. Another important problem is the cardiovascular system (heart and blood vessels).
- Trial name
- NCT01794637
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Microcirculatory Dysfunction, Tissue Hypoperfusion
Submental Tissue Oxygenation and Arterial Lactate in Major Surgery
During major surgical procedures performed under general anesthesia, changes in blood flow and oxygen delivery to tissues may occur due to blood loss, hemodynamic fluctuations, and anesthesia-related physiological effects.
- Conditions
- Microcirculatory Dysfunction, Tissue Hypoperfusion, Microcirculatory Status, Microvascular Circulation
- Trial name
- NCT07399275
- Testing
- No intervention. This is a prospective observational study. Near-infrared spectroscopy measurements are performed for monitoring purposes only and do not influence clinical management.
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Bursa Sevket Yilmaz Training and Research Hospital
Non-ST Segment Elevation Myocardial Infarction, ST Segment Elevation Myocardial Infarction
Comparison of Clopidogrel and Ticagrelor on Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction
Ticagrelor is a non-thienophyridine, direct P2Y12 blocker that is more potent than clopidogrel and is associated with less interindividual variability.
- Trial name
- NCT02026219
- Testing
- Clopidogrel, Ticagrelor
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Inha University Hospital