Clinical trials: Microbiome Composition
Human Microbiome
Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge
Changes in the gut microbiomes of healthy volunteers who followed a gluten-free diet (GFD) for four weeks were studied. Per participant, nine stool samples were collected: one at baseline, four during the GFD period, and four…
- Trial name
- NCT02731976
- Testing
- Dietary intervention
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Breastfeeding
Effects of 5-Methyltetrahydrofolic Acid Supplementation on Maternal Health and One-Carbon Metabolism During Lactation
This double-blind, randomized, placebo-controlled parallel trial evaluates the effects of maternal 5-methyltetrahydrofolate (5-MTHF) supplementation during breastfeeding.
- Trial name
- OCMS (NCT07508917)
- Testing
- 5-MTHF Supplementation
- Where
- 2 sites in Spain
- Volunteers
- 36 people
- Sponsor
- Fundació Sant Joan de Déu
Healthy Diet, Gastrointestinal Microbiome
Study the Effect of Water Kefir Consumption on the Gut Microbiome in Healthy Adults
The goal of this intervention study is to analyse the microbiota composition after the water kefir consumption. The main questions are to evaluate the potential probiotic drink can have beneficial effect on the gut microbiota.
- Conditions
- Healthy Diet, Gastrointestinal Microbiome, Probiotics
- Trial name
- NCT05657730
- Testing
- Water Kefir beverage
- Where
- Sweden
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Lund University
Healthy, Healthy Nutrition
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Double-blinded Intervention Trial
The goal of The BEGIN Study, a randomized controlled double-blinded intervention trial, is to learn if probiotics, with Bifidobacterium longum subspecies infantis Bifin02 (B.
- Trial name
- BEGIN (NCT06452199)
- Testing
- B. infantis
- Where
- 2 sites in Denmark
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Focus: Healthy Skin Microbiome
The Effect of Surfactants on the Bacterial Composition of the Layers of the Skin
Recent research in the investigator's lab has shown that bacteria are present not only on the outer surface of our skin, but also in the deeper components as well.
- Trial name
- NCT02057055
- Testing
- Soap 300000027003, Soap 300000029240
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metabolism, Gut Microbiota
The Impact of Plant-Based Protein-rich Food Products With Varying Degree of Processing on the Human Gut Microbiome Composition and Human Metabolome
It is observed that replacing meat with protein-rich plant-based food products are associated with lower mortality and obesity prevention.
- Conditions
- Metabolism, Gut Microbiota, Inflammation
- Trial name
- NCT05885750
- Testing
- Unprocessed, Mildly processed, Heavily refined
- Where
- Finland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Turku
Overweight or Obesity
Modified Atkins Diet for Overweight and Obesity
The aim of the study is to investigate dynamic changes in biochemical metabolism, gut microbiome and its metabolites among overweight and obese participants while they are on a modified Atkins Diets.
- Trial name
- NCT04207879
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Hebei Medical University Third Hospital
Sleep, Gut Microbiome
Impact of Nutritional Supplementation on Sleep Quality and Gut Microbiome Composition in Older Adults
The aim of this study is to assess the impact of 5-hydroxytryptophan (5-HTP) supplementation on sleep quality and gut microbiome composition in older adults with normal cognition vs.
- Trial name
- NCT04078724
- Testing
- 5-HTP, Without 5-HTP
- Where
- 2 sites in Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Antimicrobial Resistance (AMR), Oral Microbiota
Salivary Microbiota and Antimicrobial Resistance in Relation to Chlorhexidine Use
This study evaluated the ecological effects of 0.06% chlorhexidine toothpaste on the salivary microbiota of healthy individuals, focusing on taxonomic composition, functional shifts, and prevalence of predicted antimicrobial…
- Conditions
- Antimicrobial Resistance (AMR), Oral Microbiota, Oral Microbiome Health, Chlorhexidine
- Trial name
- SMARCH (NCT07570927)
- Testing
- 0.06% Chlorhexidine Digluconate Toothpaste
- Where
- 2 sites in Czechia
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Masaryk University
Microbiome, Metabolic Syndrome
Dietary Fibers Effect on the Gut Microbiota Composition
The randomized double-blinded placebo-controlled multicenter study will be held in parallel groups. During 5 weeks the efficacy of different endpoints as a measure of response to the daily intake of dietary fibers (8 g of either…
- Conditions
- Microbiome, Metabolic Syndrome, Cardiovascular Risk Factor, Inflammation
- Trial name
- NCT04114513
- Testing
- Maltodextrin, Inulin, Pectin
- Where
- Russia
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlas Biomed
Obesity
Dairy Intervention in People With Obesity
Obesity is associated with increased morbidity and mortality, but weight reduction is difficult to achieve. In this randomized controlled trial we will include 120 obese subjects.
- Trial name
- DIPO (NCT04154475)
- Testing
- yogurt diet, dairy diet, standard diet
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Biliary Atresia, Intrahepatic Cholestases
Intestinal Microbiome Composition in Infants With Biliary Atresia (BA)
A prospective observational study in infants with biliary atresia and controls to determine whether the composition of the intestinal microbiome is specific for biliary atresia will be conducted.
- Conditions
- Biliary Atresia, Intrahepatic Cholestases, Normal Controls
- Trial name
- BA (NCT03890536)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colorectal Cancer, Colon Cancer
MIMICC Study in Patients With Colorectal Cancer
This multicenter prospective interventional study will evaluate stool and saliva microRNA expression and microbiome composition in patients with histologically confirmed colon or rectal cancer during key phases of the diagnostic…
- Conditions
- Colorectal Cancer, Colon Cancer, Rectal Cancers
- Trial name
- MIMICC (NCT07494201)
- Testing
- Prospective Biological Sample Collection and Longitudinal Molecular Profiling, Diet and Lifestyle Assessment
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Fondazione del Piemonte per l'Oncologia
Colorectal Polyp, Inflammation
Impact of Dietary Intervention on Inflammation and Microbiome Composition Post-Colonoscopy
This study aims to investigate the impact of various healthy diets, specifically a modified plant-based Mediterranean diet, on the gut microbiome and overall well-being post-colonoscopy.
- Conditions
- Colorectal Polyp, Inflammation, Dietary Intervention, Microbiota
- Trial name
- NCT06603519
- Testing
- Modified Plant-Based Mediterranean Diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Gut Microbiota
Impact of Soylent Consumption on Human Microbiome Composition
Soylent 2.0 is a popular meal replacement drink that is used to supplement or replace one's regular diet. Soylent is designed to fully fulfill one's nutritional needs, but its impact on the human microbiome remains unknown.
- Trial name
- NCT03203044
- Testing
- Soylent and water diet
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Dysbiosis
Association Between Fecal Microbiota Composition, Metabolite Concentrations, and Indoxyl Sulfate Levels
Gut dysbiosis is frequently characterized by decreased microbial diversity and alterations in the abundance of certain microbial species.
- Trial name
- NCT06877585
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Pilot Study
How Differences in the Composition of Microorganisms in the Soil Affect the Microorganisms in the Human Gut, Through the Vegetables That Grow in it: a Process Pilot Study With Healthy Participants
There are two objectives for this clinical trial. The first is to test whether, with the current logistics and study setup it is possible to perform the study well and see where there might be bottlenecks we couldn't predict.
- Trial name
- HUMANITAS (NCT07742319)
- Testing
- Low diversity vegetable smoothie, High diversity vegetable smoothie
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure
Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure
The purpose of the study is to determine the effectiveness of wild blueberries on cardiovascular health, cognitive function, and gut microbiota composition in non-Hispanic Black and White adults with elevated blood pressure.
- Conditions
- Hypertension (Without Type 2 Diabetes Mellitus), High Blood Pressure, Male, Female
- Trial name
- NCT06735599
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Georgia State University
Obesity, Childhood, Obesity, Adolescent
PROBESITY-2: Synbiotics in Pediatric Obesity
The global obesity epidemic presents an unprecedented challenge to the public health worldwide. The factors associated with obesity are complex, and include health behaviours, such as eating habits and daily physical activity…
- Trial name
- PROBESITY-2 (NCT05162209)
- Testing
- Synbiotic
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Obesity (Disorder)
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.
The goal of this clinical trial is to understand how gallotannin-rich (GT-rich) mangoes can reduce the inflammatory markers in obese individuals in vitro.
- Trial name
- NCT07505212
- Testing
- Gallotannin-rich mango, Lactiplantibacillus pentosus (probiotic), No Treatment Added
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prairie View A&M University