Clinical trials: Microbiome
Ageing
Microbiome of the Ageing Gut and Its Effect on Human Gut Health and Cognition.
The investigators aim to undertake a 49-month longitudinal study in a cohort of 360 healthy individuals of 60 years and older, living in East Anglia to understand the role of gut microbes (the microbiome) in healthy ageing.
- Trial name
- MOTION (NCT04199195)
- Where
- United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Overactive Bladder
Bacterial Genomic Sequencing in Overactive Bladder
No one really knows what causes overactive bladder syndrome (OAB). Urinary tract infection (UTI)causes similar symptoms to OAB with the difference being the presence of bacteria, as evidenced by routine microbiology cultures.
- Trial name
- NCT01642277
- Testing
- Solifenacin
- Where
- United States
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Loyola University
Growth Failure, Adiposity
Optimal Growth of Preterm Infants With Growth Restriction
In this prospective randomized controlled multi center trial the investigators stratify "Very Low Birthweight " (VLBW)-infants with growth retardation in small for gestational age (SGA) or intrauterine growth restricted (IUGR) …
- Conditions
- Growth Failure, Adiposity, Diabetes, Neurologic Deficits
- Trial name
- OPTIGROW (NCT02999945)
- Testing
- SGA-enhanced nutrients, IUGR-enhanced nutrients, SGA-standard nutrients
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Blood Pressure
Salt and HMB Study
Hypertension affects one-third of adults in the US. High salt diet is a key risk factor for elevated blood pressure (BP). The associations of gut microbiome with high salt diet and hypertension have been established in both…
- Trial name
- NCT05515900
- Testing
- Sodium, HMB
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Augusta University
Stress Disorders, Post-Traumatic
Alterations of Gut Microbiome in the Frontline Medical Staff Under the Stress
With the outbreak of 2019 novel coronavirus (2019-nCoV), the frontline medical workers faced enormous stress, including a high risk of infection and inadequate protection from contamination, isolation, patients with negative…
- Trial name
- AGMFMSS (NCT04443075)
- Testing
- faecal sample collector
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diet Habit, Microbial Colonization
Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity
Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship.
- Conditions
- Diet Habit, Microbial Colonization, Activity, Motor
- Trial name
- PerOME (NCT04766528)
- Testing
- 3 maximal aerobic tests
- Where
- Canada
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Laval University
Open GI Surgery
Surgical Site Infections and the Microbiome: Understanding the Pathogenesis of Surgical Site Infections
This is a prospective, observational study of patients undergoing open GI surgery. At the time of operation, samples will be collected from the incision site and GI tract.
- Trial name
- NCT06300892
- Testing
- No intervention
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Minnesota
Parkinson Disease
The Parkinson's Disease Case-Control Study
The Parkinson's Disease Case-Control Study is a study of healthy volunteers and patients with Parkinson's disease aged 50-75 years living in Hangzhou, China.
- Trial name
- NCT06848192
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Westlake University
Mild Cognitive Impairment (MCI)
Relationship Between Gut Microbiome, Probiotics, and Mild Cognitive Impairment
This study is to evaluate whether the consumption of probiotics can improve the symptoms of patients with mild cognitive impairment; also evaluate the effects of probiotics on patients' blood, oxidation and stress related…
- Trial name
- NCT04971096
- Testing
- PS23 live, PS23 heat-treated
- Where
- Taiwan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Microbiome, Immune Function
SWAP-MEAT: Study With Appetizing Plant Food - Meat Eating Alternatives Trial
This study aims to investigate the impact of replacing meat consumption with plant-based meat alternative consumption on cardiovascular health, the gut microbiome, and metabolic status.
- Conditions
- Microbiome, Immune Function, Cardiovascular Diseases
- Trial name
- SWAP-MEAT (NCT03718988)
- Testing
- Meat products, Plant Alternative products
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Stanford University
Nutritional and Metabolic Diseases
FaibaLite - Reduce Weight, One Bite at a Time
This study aims to evaluate the suitability of a fiber-enriched chewing gum as a practical and accessible approach to support healthy body weight management.
- Trial name
- NCT07045766
- Testing
- FibreGum chewing gum
- Sponsor
- University of Bern
Diet, Healthy, Breath Analysis
Why Calories Are Not the Same - a Gut Explanation?
The aim of this study is to understand how the gut microbiome influences how much dietary energy humans excrete via feces. This study is based on the hypothesis that levels of methane in exhaled breath represent two different gut…
- Trial name
- GutEnergy (NCT06932666)
- Testing
- Diet A group, Diet B group
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Protein Digestion, Gastrointestinal Microbiome
Effect of Probiotics on Amino Acid Absorption
The goal of this clinical trial is to test effects of consuming probiotics in healthy adults. The main question it aims to answer is: Do consuming probiotics affect a healthy adult's ability to absorb amino acids from plant…
- Trial name
- NCT05752266
- Testing
- AMILI Probiotic pills
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore Institute of Technology
COVID-19
Intestinal Microbiota of Patients Hospitalized With Sars-CoV-2
The study investigators hypothesize that SARS-Cov2 infection alters the composition of the digestive microbiota and its functionality, resulting in changes in intestinal permeability and consequently in microbial digestive…
- Trial name
- MICRODIGCOV (NCT05178238)
- Testing
- Fecal sample
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Healthy
Building an AI to Infer/Predict an Estimated Stool Microbiome Profile
This is a study to collect data to build, evaluate and validate (test) a tool to infer/predict an estimated microbiome (community of microorganisms such as bacteria, fungi and viruses that exists in a particular environment)…
- Trial name
- Poobiome (NCT05847543)
- Testing
- Stool diaper data and sample collection
- Where
- 4 sites in Malaysia, Singapore and 1 more
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Impacted Third Molar Tooth
Impact of Antibiotic Treatment and Extraction on the Oral Micro Biome
This is a prospective, longitudinal, observational, cohort study investigating young adults undergoing surgical extraction of a wisdom tooth with and without antibiotics post-operatively.
- Trial name
- NCT02951676
- Testing
- Extraction
- Where
- China
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Infant Development, Stress
Multisensory Early Oral Administration of Human Milk in Preterm Infants
The aims of this pilot are to determine the feasibility and acceptability of the Multisensory early oral administration of human milk (M-MILK) intervention, recruitment, retention, and obtain data for sample size estimation.
- Trial name
- M-MILK (NCT06230848)
- Testing
- Multisensory Early Oral Administration of Human Milk (M-MILK)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Loyola University
Sepsis, Septic Shock
Molecular Diagnosis and Risk Stratification of Sepsis in India
Background: Globally, sepsis is common with an estimated population incidence of 437 cases per 100, 000 person-years and acute mortality of 26%, one of the few major medical conditions whose incidence and resulting mortality…
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome
- Trial name
- MARS-India (NCT03727243)
- Where
- India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Dandruff
Antidandruff Lotion Mediating Microbiome Rebalance
Edit Brief Summary: To evaluate the NaP lotion effect to decrease dandruff scoring and microbiome rebalance. Detailed Description: Dandruff is a common scalp disorder affecting almost half of the population of any gender and…
- Trial name
- NCT06813521
- Testing
- NaP1%+VitCG3% leave-on lotion (formula 1256103), vehicle (formula 1256145), reference Octopirox 0.25% (formula 1256149).
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University