Clinical trials: Microbial Colonization
Microbial Colonization, Eye Diseases
Assessment of the Ocular Microbiome in Health and Disease
The objective of this application is to illustrate the core constituents of the ocular surface microbiome, describe factors that promote colonization, and assess the ocular microbiome's role in the health of the anterior segment.
- Conditions
- Microbial Colonization, Eye Diseases, Ophthalmopathy
- Trial name
- NCT05414994
- Testing
- Eye swab
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Microbial Colonization
Restoration of the Gut Microbiome After Cesarean Section
This study aims to develop a therapy for restoring the gut microbiome in infants born via CS. The Study will conduct a randomized, placebo-controlled feasibility trial to assess the ability of microbiome restoration by FMT and…
- Trial name
- RestoreGut (NCT06264219)
- Testing
- Microbiome restoration - FMT, Microbiome restoration - FVT, Vaginal birth, untreated control
- Where
- 2 sites in Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jakob Stokholm
Minimal Flow Anesthesia, General Anaesthesia
Minimal Flow Anesthesia and Infection Risk
This study is being done to find out if the heat and moisture that build up during minimal flow anesthesia can lead to the growth of germs (microorganisms) inside the anesthesia equipment.
- Conditions
- Minimal Flow Anesthesia, General Anaesthesia, Inhalation Anesthesia, Infection Risk
- Trial name
- NCT07092046
- Testing
- Sevoflurane (Volatile Anesthetic), Propofol 1%, Remifentanil 2 MG
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Microbial Colonization, Dysbiosis
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
The aim of this study is to determine the efficacy of an oral nutraceutical with probiotics in restore vaginal health.
- Conditions
- Microbial Colonization, Dysbiosis, Fertility Issues
- Trial name
- PROSALVAG (NCT05176535)
- Testing
- FertyBiotic Balance
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Fertypharm
Bacterial Vaginosis, Microbial Colonization
The Genital Microbiome of Male Partners of Women With Recurrent BV Undergoing Vaginal Microbiome Transplantation
There is strong observational evidence that sexual activity plays a key role in Bacterial Vaginosis (BV) acquisition and recurrence.
- Trial name
- NCT05963711
- Testing
- chlorhexidine gluconate 4%
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Prematurity; Extreme, Feeding Disorder Neonatal
Early Protein Supplementation in Extremely Preterm Infants Fed Human Milk
The central hypothesis of this clinical trial is that, in extremely preterm infants, protein-enriched human milk diets compared to usual human milk diets during the first 2 weeks after birth increase fat-free mass (FFM)-for-age Z…
- Conditions
- Prematurity; Extreme, Feeding Disorder Neonatal, Breast Milk Expression, Growth Failure
- Trial name
- NCT04325308
- Testing
- Protein-enriched human milk diet, Usual human milk diet
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Microbial Colonization, Burns
Understanding the Burn Wound Microbiome: Comparing Traditional Wound Cultures to Next Generation Sequencing Technology
The purpose of this investigation is to better understand the wound microbiome in burn wounds and the role it plays in outcomes and complications related to treatment.
- Trial name
- NCT05275335
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Evaluation of Microbial Colonization Around Implants and Overdenture Surfaces Using MK1 and Clip Attachments
Microbial Evaluation of MK1 and Clip Attachments in Implant Overdentures
This crossover clinical trial aims to compare the microbial colonization associated with double-structure bar implant-supported mandibular overdentures retained by either MK1 or conventional clip attachments.
- Trial name
- NCT07817498
- Testing
- MK1 Attachment System, Bar-Clip Attachment System
- Where
- Egypt
- Volunteers
- 7 people
- Sponsor
- Mansoura University
Staphylococcus Aureus, Microbial Colonization
Comparing Single Versus Repeat NMT on the Diversity of the Neonatal Nasal Microbiome
This study aims to determine whether a parent-to-child nasal microbiota transplant (NMT) can seed and engraft parental organisms into the neonatal microbiome and increase the neonatal microbiome diversity.
- Conditions
- Staphylococcus Aureus, Microbial Colonization, Neonatal Infection
- Trial name
- NCT06283355
- Testing
- Nasal Microbiota Transplant (NMT)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Lung Infection, Microbial Colonization
FMT for Lung and Associated-organ Rescue Efficacy in MDRO-infected Ventilated Patients
Multidrug-resistant organism (MDRO)-infection represents a substantial global health burden. In the intensive care unit (ICU), the concurrent administration of antibiotics, opioids, proton pump inhibitors (PPIs)…
- Conditions
- Lung Infection, Microbial Colonization, Food Intolerance Syndromes
- Trial name
- FLARE-MV (NCT06970262)
- Testing
- Fecal suspension
- Where
- China
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Staphylococcal Aureus Infection, Microbial Colonization
Administering NMT to Reestablish Infant Nasal Microbiome Diversity Following Intranasal Mupirocin Treatment
This protocol aims to evaluate how NMT affects pediatric nasal microbiome diversity following intranasal mupirocin treatment
- Conditions
- Staphylococcal Aureus Infection, Microbial Colonization, Pediatric Infection, S. Aureus Colonization
- Trial name
- NMT Protocol 3 (NCT06805994)
- Testing
- Nasal Microbiota Transplant (NMT)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Edentulous Mouth, Periodontal Diseases
Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in…
- Conditions
- Edentulous Mouth, Periodontal Diseases, Periodontitis, Adult, Microbial Colonization
- Trial name
- NCT06149585
- Testing
- Microbial Sampling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Microbial Colonization
The Influence of Endurance Sports Activity on the Oral Microbiota of Young Adults.
The oral cavity is an easily accessible anatomical site that accurately reflects the health of the individual. The mouth is considered an early indicator of biological aging, leading to the identification of oral biomarkers…
- Trial name
- ORAMICAP (NCT05765422)
- Testing
- salivar and gum sampling
- Where
- France
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Preterm Infant, Growth Delay
The Milk, Growth and Microbiota Study
Late preterm infants, who are born at 34, 35 or 36 weeks gestation, often have difficulty feeding, establishing growth, and fighting off infection.
- Conditions
- Preterm Infant, Growth Delay, Microbial Colonization, Breastfeeding
- Trial name
- MGM (NCT03220282)
- Testing
- Donor milk, Preterm infant formula
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of California, San Francisco
Microbial Colonization, Ventilator Associated Pneumonia
Frequent Standardized Oral Care to Improve Health Outcomes in Premature Infants in the Neonatal Intensive Care Unit
Premature very low birth weight (VLBW) infants are susceptible to complications related to infrequent and non-standardized oral care.
- Trial name
- NCT05167318
- Testing
- frequent standardized oral care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Florida
Microbial Colonization, Preterm Birth
Matching Donor Human Milk On Maternal Secretor Status (MMOMSS) Study
This study will evaluate the impact of matching donor human milk to the maternal secretor status of very preterm infants (<34 weeks gestation) on the gut microbiome.
- Trial name
- MMOMSS (NCT04130165)
- Testing
- Matched donor human milk
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- University of Manitoba
Microbial Colonization, Peri-Implantitis
Microbiome Modulation by PEMF on Plaque Induced Mucositis in Human Jaws
To evaluate the impact of Pulsed Electromagnetic Field (PEMF) on mucositis induced in humans around dental implants and correlate these possible effects with the proteomic profile of implants with and without PEMF and teeth.
- Trial name
- NCT07045636
- Testing
- Teeth wih gingivits
- Where
- Brazil
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Jamil awad shibli
Microbial Colonization
Microbiome Derived Metabolism and Pharmacokinetics
The investigators will perform single-dose pharmacokinetic (PK) studies in humans following administration of drugs with known microbiome derived metabolism (MDM) in parallel with preclinical studies.
- Trial name
- MDM-PK (NCT05065671)
- Testing
- Tolcapone 100 MG, Duloxetine 20 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Vagus Nerve Autonomic Disorder, Heart Rate
Balance, Autonomic Response, and Sensory Modulation to Dosage of Mechanical Vagal Stimulation in Healthy Adults
The vagus nerve (VN) plays a crucial role in regulating vital functions (heart rate, blood pressure, digestion, and immune response) and maintaining communication between internal organs and the brain.
- Conditions
- Vagus Nerve Autonomic Disorder, Heart Rate, Pain, Equilibrium; Disorder, Labyrinth
- Trial name
- BARVANS (NCT06541808)
- Testing
- mechanical Vagus Nerve Stimulation (Low Intensity), mechanical Vagus Nerve Stimulation (Intermediate Intensity), mechanical Vagus Nerve Stimulation (High Intensity)
- Where
- Austria
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Pregnancy Related, Pregnancy Loss
Microbiome and Malnutrition in Pregnancy
This study is being conducted to investigate how a mother's nutritional status and her gut microbiome during pregnancy contribute to the birth outcomes and health of her baby.
- Conditions
- Pregnancy Related, Pregnancy Loss, Pregnancy Complications, Pregnancy; Parasitic Disease
- Trial name
- MMIP (NCT04992104)
- Where
- 2 sites in Canada
- Volunteers
- 800 people
- Sponsor
- The Hospital for Sick Children