Clinical trials: Methotrexate
Methotrexate Adverse Reaction
Pharmacokinetic Analysis of High Dose Methotrexate in Pediatric Lymphoblastic Malignancies
The pharmacokinetics of MTX were assessed with regards to the relevance of several different patient specific factors in 291 pediatric patients, who were administered with high dose of MTX.
- Trial name
- HDMTX (NCT02011022)
- Testing
- 3g MTX, 5g MTX
- Where
- China
- Volunteers
- 291 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methotrexate
A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Methotrexate
The purpose of this study is to assess the effect of multiple doses of isavuconazole on the pharmacokinetics of a single dose of methotrexate.
- Conditions
- Pharmacokinetics of Isavuconazole, Pharmacokinetics of Methotrexate, Pharmacokinetics of 7-hydroxymethotrexate, Healthy Subjects
- Trial name
- NCT01884636
- Testing
- isavuconazole, methotrexate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Global Development, Inc.
Methotrexate Induced Nephrotoxicity
Prevention of Methotrexate Induced Nephrotoxicity and Prolonged Drug Elimination Time With 12 Hours Prehydration
Infusions with high-dose methotrexate 5 g/m2 or 8 g/m2 are used to treat children with acute lymphoblastic leukemia (ALL), non-Hodgkin's lymphoma, medulloblastoma and ependymoma.
- Trial name
- NCT00570817
- Testing
- 12 hours of prehydration
- Where
- Denmark
- Volunteers
- 47 people
- Sponsor
- University of Aarhus
Methotrexate, Vasodilation
The Influence of Methotrexate on the Metabolism and Vascular Effects of Adenosine in Humans
In this study we aim to determine whether methotrexate influences the metabolism and vascular effects of adenosine in humans in vivo. Adenosine is an endogenous purine-nucleoside with potent anti-inflammatory effects.
- Trial name
- NCT00184886
- Testing
- Methotrexate 15 mg/week for 12 weeks
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Radboud University Medical Center