Clinical trials: Methotrexate
Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors
Perioperative Durvalumab With Neoadjuvant ddMVAC in Patients With Muscle-Invasive Bladder Cancer (NIAGARA-2)
The Phase II NIAGARA-2 study aims to expand on the data from the Phase III NIAGARA study by investigating perioperative durvalumab in combination with cisplatin based neoadjuvant chemotherapy in a clinical practice setting.
- Conditions
- Urinary Bladder Neoplasms, Immune Checkpoint Inhibitors, Methotrexate, Vinblastine
- Trial name
- NCT06960577
- Testing
- Durvalumab, Methotrexate, Vinblastine
- Where
- 59 sites in Australia, Brazil and 5 more
- Volunteers
- 150 people
- Sponsor
- AstraZeneca
Methotrexate, Polyarthritis; Rheumatoid
Evaluation of the Impact of 3 Methods of Communication on the Adherence of Methotrexate in Patients With Rheumatoid Arthritis
Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA). Poor adherence of this treatment decreases the control of the disease and the effectiveness of the associated treatments.
- Trial name
- METHO-PR (NCT03107299)
- Testing
- Communication methods to encourage adherence
- Where
- France
- Volunteers
- 98 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Investigate the Effect(s) of Methotrexate Treatment on Arthritis Disease Severity
Methotrexate Treatment of Arthritis Caused by Chikungunya Virus (MARCH)
MARCH is the first randomized, double-blind, placebo-controlled evaluation of the efficacy and pathologic mechanism determined by synovial biopsy of 6 months of methotrexate (n=100) versus placebo (n=50) therapy for chronic…
- Trial name
- NCT04483466
- Testing
- Methotrexate
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- George Washington University
Vitiligo - Evaluation of Methotrexate Iontophoresis and Topical Methotrexate Gel as Localized Treatment Approache
Methotrexate Iontophoresis Versus Methotrexate 1% Gel on Depigmentation in Vitiligo Patients
Vitiligo is a common autoimmune depigmenting disorder characterized by selective destruction of melanocytes. Methotrexate (MTX) has shown potential in stabilizing disease activity and promoting repigmentation; however, systemic…
- Trial name
- NCT07208890
- Testing
- Methotrexate Iontophoresis/a low-intensity electric current
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Osteo Arthritis of the Knee, Synovitis of Knee
Role of Methotrexate in Ultrasound Proven Synovitis in Primary Knee OA
Background: Osteoarthritis (OA) is a leading cause of disability worldwide, with limited treatment options and many patients suffering from chronic pain.
- Conditions
- Osteo Arthritis of the Knee, Synovitis of Knee, Methotrexate
- Trial name
- MTX in knee OA (NCT07161336)
- Testing
- Methotrexate (MTX)
- Where
- Bangladesh
- Volunteers
- 70 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Methotrexate Adverse Reaction, Advantage of Using Subcutaneous Route for Methotrexate
Subcuteous Methotrexate in Rheumatoid Arthritis
Methotrexate use is important for the treatment of Rheumatoid arthritis. Some patients can not tolerate oral methotrexate. So subcutaneous may help to overcome it.
- Trial name
- SCMTXRA (NCT07094880)
- Testing
- Tab. Methotrexate 25mg/week, Inj. Methotrexate 25mg/week
- Volunteers
- 45 people
- Sponsor
- Bangladesh Medical University
Rheumatic Arthritis, Rheumatoid Arthritis (RA) Prevention
Efficacy and Safety of Resveratrol in Patients With Rheumatoid Arthritis.
The aim of the current study is to evaluate the effects of resveratrol on the clinical outcome(s) of patients with moderate rheumatoid arthritis. Objectives : 1.
- Conditions
- Rheumatic Arthritis, Rheumatoid Arthritis (RA) Prevention, Inflamation, Antioxidant
- Trial name
- NCT07089381
- Testing
- Resveratrol 1 gm., Methotrexate
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Ain Shams University
Crohn Disease, Azathioprine
Comparison of Azathioprine to Methotrexate in Combination Therapy With Adalimumab in Crohn's Disease: an Open-label Randomized Controlled Trial
Combination therapy, the association of an anti-Tumor Necrosis Factor (TNF) to an immunosuppressant, is recognized as the most effective treatment during Crohn's disease (CD).
- Conditions
- Crohn Disease, Azathioprine, Methotrexate
- Trial name
- COMET (NCT05040464)
- Testing
- AZA capsules, MTX, blood sample
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Methotrexate Spermatotoxicity
Impact of Selenium on Methotrexate Induced Spermatotoxicity; A Comparative Study
The aim of this study is to assess the potential protective role of selenium on semen parameters and its effect on seminal glutathione peroxidase level in patients on MTX therapy
- Trial name
- NCT06951282
- Testing
- Selenium, Methotrexate
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Rheumatoid Arthritis, Insufficient Response to Methotrexate or Leflunomide
Clinical Trial Evaluating Methotrexate or Leflunomide + Targeted Therapy Versus Methotrexate or Leflunomide + Sulfasalazine + Hydroxychloroquine in Patients With Rheumatoid Arthritis and Insufficient Response to Methotrexate or Leflunomide
Approximately, 40 to 50% of patients with rheumatoid arthritis (RA), the most frequent inflammatory arthritide, are non responders to the consensual 1st line of treatment : methotrexate.
- Trial name
- BIO3 (NCT02714634)
- Testing
- Methotrexate + targeted therapy administration, methotrexate or leflunomide + sulfasalazine + hydroxychloroquine administration
- Where
- France
- Volunteers
- 286 people
- Sponsor
- University Hospital, Strasbourg, France
Rheumatoid Arthritis (RA), Methotrexate Induced Nephrotoxicity
The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate
The primary aim of this clinical trial is to Evaluate the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate.
- Conditions
- Rheumatoid Arthritis (RA), Methotrexate Induced Nephrotoxicity, Methotrexate Adverse Reaction
- Trial name
- NCT06641128
- Testing
- MTX SC or IM, Empagliflozin 25mg tab
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Local, Systemic
Local vs Systemic Methotrexate in Management of Uterine Ectopic Pregnancy
This study aims to compare local and systemic methotrexate in the management of uterine ectopic pregnancy regarding the duration of beta human chorionic gonadotropin (hCG) clearance and need for further management options.
- Conditions
- Local, Systemic, Methotrexate, Uterine Ectopic Pregnancy
- Trial name
- NCT06554470
- Testing
- Systemic Methotrexate, Local Methotrexate
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Tanta University
Methotrexate Toxicity
Evaluation of High Dose Methotrexate Toxicity
This study aims to: 1. Evaluation of high dose methotrexate related toxicities among children admitted to Sohag Oncology Centre. 2. Role of methotrexate blood level in prediction of high dose methotrexate related toxicities. 3.
- Trial name
- NCT06123403
- Testing
- blood methotrexate level and Cystatin C level
- Volunteers
- 100 people
- Sponsor
- Sohag University
Low Dose Methotrexate in Severe Chronic Asthma
Low-dose Methotrexate for Change in Global Initiative for Asthma Step 5 Medications in Chronic Severe Asthma
Patients with chronic severe asthma (CSA) have a crippling disease and current available treatments are not satisfactory. Thus, management of CSA remains a major unmet need.
- Trial name
- NCT02124226
- Testing
- Methotrexate
- Volunteers
- 102 people
- Sponsor
- University of Catania
Psoriasis, Methotrexate
Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis
Psoriasis is a chronic relapsing dermatological disease which often necessitates a long-term therapy and occurs in a significant percent of the population . It affects the skin and sometimes the nails and joints of patients .
- Trial name
- NCT04971239
- Testing
- topical methotrexate micoemulsion, Excimer light, Narrow band ultraviolet B
- Volunteers
- 30 people
- Sponsor
- Assiut University
Methotrexate Adverse Reaction, Oral Mucositis
Stratification of Oral Ulcers in Rheumatoid Arthritis Patients Kept on Methotrexate
This study included rheumatoid arthritis patients receiving Methotrexate as monotherapy. All eligible patients were subjected to thorough clinical examination and full history to identify oral events.
- Trial name
- NCT04540250
- Testing
- questionnaire
- Volunteers
- 804 people
- Sponsor
- Beni-Suef University
Takayasu Arteritis, Methotrexate
Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients
Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy.
- Conditions
- Takayasu Arteritis, Methotrexate, Inhibition, Treatment
- Trial name
- NCT04299971
- Testing
- Methotrexate Tablets, Tofacitinib tablet
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Shanghai Zhongshan Hospital
Inflammatory Bowel Diseases, Liver Fibroses
Dose Effect Relationship of MTX and IBD
Currently there are no guidelines for monitoring hepatic fibrosis associated with long term MTX use. Routine liver biopsies are not being done as a part of surveillance due to potential complications like bleeding and…
- Conditions
- Inflammatory Bowel Diseases, Liver Fibroses, Methotrexate
- Trial name
- NCT03531593
- Testing
- Ultrasound Elastography
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's Mercy Hospital Kansas City
Rheumatoid Arthritis, Influenza
2-week dc of MTX and Influenza Vaccination in RA
To investigate whether a transient discontinuation of methotrexate MTX for 2 weeks improves the vaccination response to a seasonal influenza.
- Conditions
- Rheumatoid Arthritis, Influenza, Methotrexate
- Trial name
- 2 wk MTX (NCT02897011)
- Testing
- Methotrexate
- Where
- 3 sites in South Korea
- Volunteers
- 318 people
- Sponsor
- Seoul National University Hospital
Alopecia, Rheumatoid Arthritis
Hair Fall in Patients on Low Dose Methotrexate
Low dose methotrexate used in rheumatoid arthritis is considered very safe and has a side effect profile very different from that seen with high dose methotrexate used in oncology.
- Conditions
- Alopecia, Rheumatoid Arthritis, Methotrexate Adverse Reaction
- Trial name
- NCT02591823
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Columbia Asia