Clinical trials: Methodology Study
Aortic Aneurysm, Abdominal
NExT ERA: National Expertise Based Trial of Elective Repair of Abdominal Aortic Aneurysms: A Pilot Study
Objectives. To study the feasibility of an expertise-based randomized controlled trial (RCT) testing the role of traditional surgery (OPEN) versus endovascular repair (EVAR) for abdominal aortic aneurysms (AAA). Study design.
- Trial name
- NCT00358085
- Testing
- Endovascular Repair of Abdominal Aortic Aneurysm, Conventional open repair of Abdominal Aortic Aneurysm
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Hamilton Health Sciences Corporation
Neuralgia, Postherpetic, Diabetic Neuropathy
Neuropathic Pain Syndrome Patient Study (MK-0000-072)
The purpose of this study is to determine the best way to conduct clinical trials in patients with neuropathic pain (nerve pain). This study will see if generic pregabalin has any effect on neuropathic pain.
- Conditions
- Neuralgia, Postherpetic, Diabetic Neuropathy, Painful Small-Fiber Neuropathy, Idiopathic Distal Sensory Polyneuropathy
- Trial name
- NCT00570310
- Testing
- Comparator: pregabalin
- Volunteers
- 104 people
- Sponsor
- Merck Sharp & Dohme LLC
Pulmonary Disease, Chronic Obstructive
A Study To Investigate The Ability To Use 18FDG PET Scanning To Monitor The Effectiveness Of New Drugs In COPD Patients
It is hypothesised that there is a difference between the uptake of a radioactive substance ([18F]fluorodeoxyglucose (FDG)) in the lungs of patients with Chronic Obstructive Pulmonary Disease (COPD) and healthy volunteers.
- Trial name
- NCT00472264
- Testing
- PET imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pfizer
Chronic Pain
A New Approach in Chronic Pain; Acceptance & Commitment Therapy-Exposure & Perspective Taking (ACT-EPT)
Background: Chronic pain is a highly prevalent phenomenon with a large impact on the individual's wellbeing. Acceptance and Commitment Therapy (ACT) can be used to help patients relate to chronic pain in a way that helps improve…
- Trial name
- ACT-EPT (NCT03481504)
- Testing
- Acceptance & Commitment Therapy-Exposure and Perspective Taking
- Where
- Netherlands
- Volunteers
- 3 people
- Sponsor
- Maastricht University Medical Center
Healthy
GI Interlab 2 Study: Measuring the Glycaemic Index (GI) of Foods
The purpose of this study is to assess the extent of and sources of variation in the glycaemic index values of foods measured by different laboratories around the world.
- Trial name
- NCT00260858
- Testing
- Test Meal: Reference food (glucose or white bread), Test Meal: Pirate's Booty, Test Meal: Ceaprove wafer
- Where
- 28 sites in United States, Australia and 15 more
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Glycaemic Index Testing, Inc.
Pain
Reduction of Pain in Childhood Vaccination in the Primary Care Nurse Vaccination Consultation
Non-randomized study with control group (CG) with the objective of analyzing the non-pharmacological analgesic efficacy of the "Painless Vaccine" protocol for the reduction of pain during vaccination in the population aged 2…
- Trial name
- NoVacPain (NCT06004258)
- Testing
- Painless Vaccination
- Where
- Spain
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Virgen Macarena
Infertility, Hysterosalpingography
Clinical Trial on the Methodology of Hysterosalpingography: a Comparative Study
Different techniques have been developed to optimize hysterosalpingography (HSG) methodology. Our aim is to compare the advantages and disadvantages of these three different techniques in terms of both patient satisfaction and…
- Trial name
- MethodHSG (NCT07583758)
- Testing
- Hysterosalpingography - Metal Cannula Method, Hysterosalpingography - Active Balloon Method, Hysterosalpingography - Passive Balloon Method
- Where
- Turkey (Türkiye)
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Medipol University
Depressive Disorder, Major
Study for Evaluating Different Methods of Measuring Depression Treatment Response
Purpose of the study is to evaluate use of electronic diaries and voice acoustics for use in future depression clinical trial. Focus is on increased precision of measurement.
- Trial name
- NCT00406952
- Testing
- electronic diary, Sertraline, voice acoustics
- Where
- 12 sites in United States
- Volunteers
- 165 people
- Sponsor
- Pfizer
Normal Children
Rehacom or Wechsler Assessment Methodology in Cognitive Abilities of Normal Children: Correlation Study
The purpose of this study is to investigate the relationship between a computerized cognitive assessment tool (Rehacom) and a traditional intelligence scale (Wechsler Intelligence Scale for Children) in assessing cognitive…
- Trial name
- NCT07819006
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cairo University
Head and Neck Cancer
Hypofractionated Preoperative Radiation for Head and Neck Cancers (HyPR-HN)
This is a phase 1 study to determine the safety of a condensed preoperative radiation regimen (10, 7, or 5 fractions) for the management of head and neck squamous cell carcinoma.
- Trial name
- NCT05538533
- Testing
- 46 Gy Radiation Therapy, 40 Gy Radiation Therapy, 35 Gy Radiation Therapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical College of Wisconsin
Oral Health
A Study to Evaluate the Effect of a Stannous Fluoride Toothpaste on the Oral Microbiome
The aim of this study is to evaluate the effect of a toothpaste containing stannous fluoride (SnF2) over time on the oral bacterial composition and activity and to explore its effect in comparison to a regular fluoride toothpaste.
- Trial name
- NCT06048809
- Testing
- Stannous Fluoride Toothpaste (Sensodyne Repair and Protect), Regular Fluoride Toothpaste (Colgate Cavity Protection)
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- HALEON
Severe Combined Immunodeficiency Due to ADA Deficiency
Methodology Study of Retroviral Insertion Site Analysis in Strimvelis Gene Therapy
This study is a post approval commitment to evaluate the accuracy and precision of retroviral insertion site (RIS) analysis and its utility for investigating and predicting the potential for insertional oncogenesis in subjects…
- Trial name
- NCT04959890
- Testing
- Strimvelis
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Fondazione Telethon
Mental Health Disorder
CoCo-20: a Longitudinal Follow-up Study of the French Paediatric Population During and After the Coronavirus Pandemic COVID-19
In the context of a viral outbreak and of widespread quarantine measures, a significant increase in psychological disorders, such as stress or fear behaviours, had previously been observed.
- Trial name
- CoCo-20 (NCT04498416)
- Testing
- Quantitative and qualitative assessments of mental health
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Lenval
Attention Deficit/Hyperactivity Disorder, Emotional Dysfunction
Optimizing Research With Diverse Families - Feasibility and Acceptability Study (FAST)
Evaluate feasibility and acceptability of recruiting Black and Hispanic families for an open label clinical trial of multinutrients while collecting real-time parent-reported child behavior data and collecting at-home…
- Conditions
- Attention Deficit/Hyperactivity Disorder, Emotional Dysfunction, Irritable Mood
- Trial name
- FAST (NCT06133231)
- Testing
- Multinutrients; a 36-ingredient blend of vitamins, minerals, amino acids, and antioxidants
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Oregon Health and Science University
Pelvic Floor Disorders
Anovaginal Distance, Interobserver Agreement
Interobserver variation in measuring the anovaginal distance (AVD) with perineal ultrasound
- Trial name
- NCT02943018
- Testing
- anovaginal distance variation
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ostergotland County Council, Sweden
Methodology Study
Effect Of Treatment With Oral Zolpidem On Polysomnography And Actigraphy Measures In Healthy Volunteers
This study will assess the feasibility of conducting sleep studies in a clinical research unit environment. In addition, the sensitivity of polysomnography and mobile actigraphy technologies will be compared for evaluating sleep…
- Trial name
- NCT00716521
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
Neoplasm Metastasis, Locoregional Neoplasm
Do Patients Want to Engage in Discussions Dedicated to Anticipating (DDA) Their Preferences of Care in the Event of Worsening Health Status?
Context: In people concerned by serious illness, how to anticipate the aggravation of the disease according to the patient's preferences is a challenging clinical question and an ethical key-issue to improve end-of-life care and…
- Conditions
- Neoplasm Metastasis, Locoregional Neoplasm, Advanced Cancer
- Trial name
- ESOP (NCT04308356)
- Testing
- Dedicated Discussions on Anticipating preferences of care in the event of Aggravation (DDA), Autonomy Preference Index (API ) questionnaire - Information, anxiety and depression (HADS) questionnaire
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Surgery-associated Acute Kidney Injury
A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries.
- Trial name
- NCT06772025
- Testing
- No investigational study intervention
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Bayer
Healthy
Study of Body Composition Methodology in Young Children (InfantPod)
The InfantPod study is a cross-sectional study designed to determine how practical and precise a body composition method is for measuring body fat and lean tissue in infants and children ages 5 months to 3 years.
- Trial name
- NCT00730587
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
HIV Infections, Tuberculosis
A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin
To evaluate the methodology for rapidly determining the early bactericidal activity (EBA), tolerance, and pharmacokinetics of isoniazid and levofloxacin in the treatment of pulmonary tuberculosis (TB).
- Trial name
- NCT00000778
- Testing
- Isoniazid, Pyridoxine hydrochloride, Levofloxacin
- Where
- 10 sites in United States
- Volunteers
- 44 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)