Clinical trials: Methamphetamine Use
Methamphetamine Use Disorder
Accelerated Development of Additive Pharmacotherapy Treatment (ADAPT-2) for Methamphetamine Use Disorder
This is a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy of extended-release naltrexone plus bupropion as a combination pharmacotherapy for methamphetamine use disorder.
- Trial name
- ADAPT-2 (NCT03078075)
- Testing
- Naltrexone: Vivitrol®, Bupropion: Wellbutrin XL®
- Where
- 8 sites in United States
- Volunteers
- 403 people
- Sponsor
- University of Texas Southwestern Medical Center
Substance Use Disorders, Substance Use
Ketamine for Methamphetamine Use Disorder
This study aims to determine whether treatment response with IV ketamine is superior to treatment response with IV midazolam in adults with moderate to severe MUD.
- Conditions
- Substance Use Disorders, Substance Use, Methamphetamine Abuse
- Trial name
- KMD (NCT06496750)
- Testing
- Ketamine Hydrochloride, Midazolam Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Use Disorder, Substance Use Disorder
Closed-loop TBS Targeting rPO for the Core Clinical Features of Methamphetamine Use Disorder
The goal of this clinical trial is to evaluate whether closed-loop theta-burst stimulation (TBS) targeting the right parietal-occipital cortex (rPO) can improve core clinical symptoms in individuals with methamphetamine use…
- Conditions
- Methamphetamine Use Disorder, Substance Use Disorder, Cue-reactivity, Craving
- Trial name
- NCT07775807
- Testing
- Closed-loop Theta-Burst Stimulation (TBS) Targeting rPO
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shanghai Mental Health Center
Methamphetamine Use Disorder
Randomized Controlled Trial of Tirzepatide for Methamphetamine Use Disorder
This is a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial evaluating the tolerability, safety, and preliminary efficacy of tirzepatide for the treatment of individuals with moderate or severe…
- Trial name
- T-STEM (NCT07825857)
- Testing
- Tirzepatide
- Where
- 4 sites in United States
- Volunteers
- 228 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Use, Heart Failure
Rural Community Peer Partnerships for Improving Methamphetamine-Associated Heart Failure Screening and Engagement
The goal of PEER-Heart is to implement and assess feasibility and preliminary effectiveness of a community peer-facilitated screening for methamphetamine-associated heart failure (MAHF) and linkage to evidence-based cardiology…
- Trial name
- PEER-Heart (NCT06461962)
- Testing
- Treatment as Usual, Telehealth-Cardiology
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Oregon Health and Science University
Stress Physiology, Stress Reaction
The Human Stress Response in a Simulated ED Setting
Stress is important for health. As emergency departments (EDs) are often stressful places, a better understanding of the human stress response is important for understanding how and why patients respond as they do when they come…
- Conditions
- Stress Physiology, Stress Reaction, Substance Use Disorders, Methamphetamine-dependence
- Trial name
- NCT04317482
- Testing
- Standard social stress task, Stressful experience in the ED
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Contingency Managment, Methamphetamine Use Disorder
Implementing a Contingency Management Program Addressing Methamphetamine Use For and With the People of Hawaii
The goal of this clinical trial is to use contingency management (CM) as an intervention tool to address methamphetamine use. The main objectives are to: Gather effectiveness data on a pilot a CM program for participants in…
- Trial name
- NCT06532370
- Testing
- Contingency Managment
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Queen's Medical Center
Methamphetamine Use Disorder
Intranasal Oxytocin for Methamphetamine Withdrawal in Women
Methamphetamine use disorder (MUD) is a significant public health concern with burden to individuals, families and health systems estimated to cost over $5 billion annually in Australia.
- Trial name
- mOXY (NCT05760807)
- Testing
- Oxytocin nasal spray
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Turning Point
Methamphetamine Use Disorder, Pregnancy
Transcranial Magnetic Stimulation for Methamphetamine Use Disorder During Pregnancy
The goal of this clinical trial is to learn whether transcranial magnetic stimulation, also called TMS, is a practical and acceptable treatment option for methamphetamine use disorder during pregnancy.
- Trial name
- NCT07849530
- Testing
- 4- Week Dual-Target Transcranial Magnetic Stimulation (TMS), Accelerated Dual-Target Transcranial Magnetic Stimulation (aTMS), Treatment as Usual (TAU)
- Volunteers
- 45 people
- Sponsor
- University of Utah
Opioid-use Disorder, Cocaine Use Disorder
Encouraging Abstinence Behavior in a Drug Epidemic: Optimizing Dynamic Incentives
Combatting the rise of the opioid epidemic is a central challenge of U.S. health care policy. A promising approach for improving welfare and decreasing medical costs of people with substance abuse disorders is offering incentive…
- Conditions
- Opioid-use Disorder, Cocaine Use Disorder, Opioid Use, Cocaine Use
- Trial name
- NCT04927143
- Testing
- App-Based Contingency Management
- Where
- 2 sites in United States
- Volunteers
- 206 people
- Sponsor
- Wake Forest University Health Sciences
Obesity, Methamphetamine Use Disorder
Tirzepatide for Obesity and Meth Use Disorder
This is an open-label pilot study to evaluate the feasibility and preliminary efficacy of using tirzepatide when prescribed for its United States (US) Food and Drug Administration (FDA)-approved weight-related indication in…
- Trial name
- NCT06745128
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Texas Southwestern Medical Center
Methamphetamine Use Disorder
A Pilot Study of Transcranial Magnetic Stimulation Plus Episodic Future Thinking for Methamphetamine Use Disorder
The purpose of this study is to assess impact of repetitive transcranial magnetic stimulation (rTMS)+Episodic Future Thinking (EFT) vs.
- Trial name
- NCT06712446
- Testing
- EFT, high frequency rTMS
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- The University of Texas Health Science Center, Houston
Methamphetamine Abuse, Substance Use Disorders
rTMS for Craving in Methamphetamine Use Disorder
The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine…
- Conditions
- Methamphetamine Abuse, Substance Use Disorders, Stimulant Dependence, Methamphetamine-dependence
- Trial name
- NCT03470480
- Testing
- Real Repetitive transcranial magnetic stimulation, Methamphetamine visual cues, Neutral visual cues
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Methamphetamine Use Disorder
Psilocybin for Methamphetamine Use Disorder
This trial tests whether psilocybin-assisted treatment can help adults stop using methamphetamine. Participants receive a single oral dose of psilocybin during a supervised session, paired with brief cognitive behavioral therapy…
- Trial name
- NCT07774702
- Testing
- Psilocybin (single oral capsule administered at one of two dose levels, Dose A or Dose B; specific doses withheld during conduct)., Manualized cognitive behavioral therapy platform (2 preparation + 2 integration sessions).
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Peter Hendricks
Contingency Management, Methamphetamine Use Disorder
Implementing a Contingency Management Program Addressing Methamphetamine Use for and With the People of Hawai'i
This clinical trial is to implement contingency management (CM) as an intervention tool to address methamphetamine use and will be initiated during inpatient acute hospitalization in trauma injured patients.
- Trial name
- NCT06931197
- Testing
- Contingency management
- Where
- United States
- Sponsor
- Queen's Medical Center
Methamphetamine Use, Common Mental Disorders (CMD)
Friendship Bench for Women Who Use Methamphetamine in Vietnam
The high comorbidity of mental health issues and meth use in women worsens both their mental health and meth use outcomes. The study team proposes to evaluate the potential of Friendship Bench to be used as a low-threshold…
- Trial name
- FB-WWUM (NCT06789523)
- Testing
- Friendship Bench, Usual psychiatric care
- Where
- Vietnam
- Volunteers
- 100 people
- Sponsor
- Hanoi Medical University
Methamphetamine Use Disorder
Screen, Treat and Retain People With Primary Meth Use Disorder at MMT Clinics
This study is built upon the STAR-OM study (R01 DA050486) to assess if providing psycho-behavioral interventions and medications for people with primary methamphetamine use disorder (MUD) and without opioid use disorder (OUD) at…
- Trial name
- STAR-OM+ (NCT07121296)
- Testing
- Contingency management for substance use, Contingency management for attendance, Group-based Matrix counseling
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Hanoi Medical University
Methamphetamine Use Disorder, Theta Burst Stimulation
Theta Burst Stimulation in the Management of Methamphetamine Use Disorder in Indonesia
Methamphetamine use disorder (MUD) remains a major public health concern in Indonesia, with limited effective treatment options and high relapse rates.
- Conditions
- Methamphetamine Use Disorder, Theta Burst Stimulation, Transcranial Magnetic Stimulation
- Trial name
- NCT07399431
- Testing
- Theta Burst Stimulation, Cognitive Behavioral Therapy
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Opioid Use Disorder, Medication Adherence
MHealth Incentivized Adherence Plus Patient Navigation
Polysubstance use involving opioids and methamphetamine is emerging as a new public health crisis. Patients with opioids and methamphetamine use often experience serious medical complications requiring hospitalization, which…
- Conditions
- Opioid Use Disorder, Medication Adherence, Polysubstance Drug Use (Indiscriminate Drug Use), Methamphetamine-dependence
- Trial name
- MIAPP (NCT06027814)
- Testing
- Patient Navigation and mHealth (PN+mHealth)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Washington
Methamphetamine Use Disorder, Methamphetamine-induced Psychosis
LRFN5 and OLFM4 in Methamphetamine-Induced Psychosis
This cross-sectional observational case-control study aimed to examined serum levels of leucine-rich repeat and fibronectin type III domain-containing protein 5 (LRFN5) and olfactomedin-4 (OLFM4) levels in methamphetamine use…
- Trial name
- NCT07450027
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Elazığ Mental Health and Diseases Hospital