Clinical trials: Metformin
Jaw Cysts, Metformin
Osteogenic Potential of Topical Metformin Gel on Cystic Jaw Defects
Evaluate the osteogenic effect of locally applied 1% metformin gel on bone volume formation after jaw cystic defects enucleation
- Conditions
- Jaw Cysts, Metformin, Inflammatory Cyst, Cyst Enucleation
- Trial name
- NCT07867236
- Testing
- For the Experimental Arm: 1% Metformin Gel
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fayoum University
Polycystic Ovary Syndrome, Metformin
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOS
The aim of this study is to see the associations of metabolic responses of metformin with single nucleotide polymorphisms (SNPs) (rs628031 and rs2282143) of solute carrier family 22 member 1 (SLC22A1) gene in women with…
- Trial name
- NCT05680805
- Testing
- Metformin Hydrochloride
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Diabete Type 2, Muscle Strength
Metformin in Elderly Patients With Type 2 Diabetes and Muscle Strength, Muscle Mass, and Physical Function: Positive or Negative Correlation?
With the accelerating aging process in China, sarcopenia has drawn increasing attention. Sarcopenia is an age-related geriatric syndrome characterized by reductions in muscle mass, muscle strength, and/or physical function.
- Conditions
- Diabete Type 2, Muscle Strength, Muscle Mass, Physical Function
- Trial name
- NCT07788378
- Testing
- Metformin
- Where
- China
- Volunteers
- 290 people
- Sponsor
- Fudan University
Fragile X Syndrome, Metformin
Metformin in Children With Fragile X Syndrome
This study is a controlled trial of metformin in children with fragile X syndrome(FXS). The age of FXS children range from 2 to 16 years old.
- Trial name
- NCT05120505
- Testing
- Metformin
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Children's Hospital of Fudan University
Metformin Gel, Bone Healing
Effect of Metformin Gel on Guided Bone Regeneration Around Immediate Dental Implant at Posterior Maxillary Region
To evaluate, by standardized radiographic follow-up, whether locally delivered 1% metformin gel improves bone healing around immediately placed dental implants augmented with GBR.
- Conditions
- Metformin Gel, Bone Healing, Guided Bone Regeneration, Crestal Bone Loss
- Trial name
- MET-GBR (NCT07770087)
- Testing
- Metformin 1% Topical Gel, immediate Dental Implant Placement With Guided Bone Regeneration
- Where
- 2 sites in Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Exercise Capacity, Metformin
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity
Metformin is the most prescribed blood sugar (glucose)-lowering medication for patients diagnosed with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06638671
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sepsis, Septic Shock
Safety and Feasibility of Metformin for Sepsis Induced AKI
Acute kidney injury (AKI) is an independent risk factor for death that affects 10-15% of hospitalized patients and more than 50% of patients admitted to the intensive care unit.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury, Metformin
- Trial name
- NCT05900284
- Testing
- Metformin low dose, Metformin high dose
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hernando Gomez
Males, Females
Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes
This study is examining whether short-term supplementation with inorganic nitrate, in the form of beetroot juice, can enhance blood vessel health, insulin sensitivity, and exercise capacity in individuals with prediabetes.
- Conditions
- Males, Females, Sedentary, Metformin
- Trial name
- NO3-PreDM (NCT07131384)
- Testing
- Dietary Supplement: Inorganic Nitrate (Beetroot juice)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Virginia
Kidney Transplantation, Metabolic Disorder
Ameliorating Metabolic Profiling After Kidney Transplantation (AMPKT)
Advances in patient selection, organ procurement and preservation, surgical technique, immunosuppression, and infection prevention have conferred significant decrease in rejection, infection, and subsequently improve…
- Conditions
- Kidney Transplantation, Metabolic Disorder, Metformin, Empagliflozin
- Trial name
- NCT05013112
- Testing
- SGLT2 inhibitor, Metformin
- Where
- China
- Volunteers
- 105 people
- Sponsor
- West China Hospital
Metformin Gel, Bone Graft
Adding 1% Metformin Gel to Bone Graft in Association With Immediate Dental Implants
This study aimed to investigate whether combining xenografts with Metformin Gel gel enhances bone regeneration and improves implant outcomes.
- Conditions
- Metformin Gel, Bone Graft, Immediate Dental Implants
- Trial name
- NCT07469254
- Testing
- Metformin gel-xenograft, Xenograft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Mitochondria, Metformin
Mitochondrial Redox Modulation in Newly Diagnosed Type 2 Diabetes: A Randomized Controlled Trial Comparing Imeglimin vs. Metformin Monotherapy
he goal of this clinical trial is to compare the mitochondrial redox effects of imeglimin versus metformin monotherapy in adults with newly diagnosed Type 2 diabetes mellitus who are treatment-naive.
- Trial name
- MIRROR-DM (NCT07436182)
- Testing
- Imeglimin, Metformin 1000 mg Oral Tablet
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Mansoura University
Metformin, Prediabetes
Metformin and Molecular Aging in Prediabetes
The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing globally. The global prevalence of diabetes has nearly doubled since 1980, rising from 4.7% to 8.5% in the adult population.
- Trial name
- NCT07302932
- Testing
- Metformin treatment, Analyzed by qPCR for T/S ratio.
- Where
- India
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Prediabetic State, Atherosclerosis
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes
This research will help us to learn if the medicine called metformin reduces the risk of death, heart attacks, and/or strokes in Veterans who have pre-diabetes and heart or blood vessel problems.
- Conditions
- Prediabetic State, Atherosclerosis, Metformin
- Trial name
- VA-IMPACT (NCT02915198)
- Testing
- Metformin XR
- Where
- 40 sites in United States
- Volunteers
- 7,410 people
- Sponsor
- VA Office of Research and Development
Diabetes Type 2, Diabetes Mellitus, Experimental
Phase-III Clinical Studies on Poly Herbal Anti-Diabetic Formulation
The goal of this clinical trial to learn the clinical efficacy and safety of standardized polyherbal capsule weighing around 500 mg, containing Syzygium cumini, Momordica charantia, Wrightia tinctoria, and Gymnema sylvestre in…
- Conditions
- Diabetes Type 2, Diabetes Mellitus, Experimental, HbA1c, Urinary Glucose
- Trial name
- NCT07279909
- Testing
- DIAB-PHC1, Metformin
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Hamdard University
Steinert's Disease, Myotonic Dystrophy 1
Evaluation of the Efficacy and Safety of Metformin in the Myotonic Dystrophy Type 1 (Steinert's Disease)
The study team hypothesize that non-diabetic patients with Myotonic dystrophy type I (DM1) will improve their symptoms, especially their motor deficit which is the main feature of the disease, because of the splicing defect…
- Conditions
- Steinert's Disease, Myotonic Dystrophy 1, Metformin
- Trial name
- METFORMYO (NCT05532813)
- Testing
- Treatment taken
- Where
- France
- Volunteers
- 142 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Drug Overdose, Metformin
Clinical and Biological Signs of Dapagliflozin Overdose in ICU Patients With Metformin Poisoning
This study looks at patients admitted to intensive care for drug poisoning involving metformin, a common diabetes medication. Researchers will compare two groups: patients who overdosed on metformin alone and those who took both…
- Conditions
- Drug Overdose, Metformin, Dapagliflozin, Lactic Acidosis
- Trial name
- NCT07193069
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Glioblastoma, IDH-wildtype, Metformin
Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma
About 75% of CNS malignant tumors are classified as gliomas and the IDH-wildtype glioblastoma (GBM) represents the most aggressive form among CNS malignancies.
- Conditions
- Glioblastoma, IDH-wildtype, Metformin, Malignancies
- Trial name
- NCT05929495
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milano Bicocca
Polycystic Ovary Syndrom, Metformin
PCOS Patients' Immune Alterations
In this study, the investigators will include PCOS patients and healthy women who meet the trial criteria from the clinical research centers of 3 hospitals, introduce the content of this study to participants, and invite…
- Conditions
- Polycystic Ovary Syndrom, Metformin, Immune Function
- Trial name
- NCT06325969
- Testing
- Detect the immune function of peripheral blood samples
- Where
- China
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Metformin, Aging
Pilot Study on Evaluating the Geroprotective Effect of Metformin
The objective of this research is to assess the efficacy of oral metformin in mitigating the aging process in middle-aged and elderly males, to pinpoint sensitive indicators of human senescence, and to offer innovative frameworks…
- Trial name
- AGE-M (NCT06459310)
- Testing
- Metformin Hydrochloride tablet
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Rectal Cancer, Metformin
DataBase for Analysis of Rectal Cancer Oncological Results
The data will be obtained from 10 tertiary centers located in Poland (Cracow - coordinating center, Warsaw - 3 centers, Sosnowiec, Szczecin, Bydgoszcz, Lublin, Gdansk, Poznan) and 5 foreign centers.
- Conditions
- Rectal Cancer, Metformin, Overall Survival, Lymph Node Metastases
- Trial name
- BARO (NCT04947020)
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 2,443 people
- Sponsor
- Jagiellonian University