Clinical trials: Metagenome
Community Acquired Pneumonia, Respiration Failure
A Molecular Toolkit for the Microbial Investigation of Severe Community Acquired Pneumonia
Severe community acquired pneumonia is common and associated with high mortality. Conventional microbiological diagnostics identify pathogens in approximately half of cases, which is inadequate for both clinical and…
- Conditions
- Community Acquired Pneumonia, Respiration Failure, Pneumonia
- Trial name
- S-CAP (NCT02963142)
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gingivitis, Oral Disease
Metagenome Resilience in Experimental Gingivitis
This study aims to identify new biomarkers that indicate the resilience of individuals to developing oral disease. An 'experimental gingivitis' model will be employed in which subjects will refrain from oral hygiene in one…
- Trial name
- NCT05389124
- Testing
- Partial abstinence from oral hygiene
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Parkinson Disease, Genetic Predisposition
Study of the Genome, Gut Metagenome and Diet of Patients With Incident Parkinson's Disease
A case-control study to identify microbiome and genetic differences between healthy subjects and patients with incident Parkinson's disease.
- Trial name
- NCT04119596
- Testing
- 16S rRNA gene sequencing, DNA-microarray genotyping
- Where
- Russia
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Atlas Biomed
Microbial Colonization, Microbial Superinvasion
Metagenomic Analysis of Gut Microbiome in Preterm
This is single center study. The investigators will try to know that relationships between intestinal microbiome and mortality in preterm infants and what relationships is between intestinal microbiome in preterm infants and…
- Conditions
- Microbial Colonization, Microbial Superinvasion, Microbial Substitution, Newborn Morbidity
- Trial name
- MAGMP (NCT03235635)
- Where
- South Korea
- Volunteers
- 120 people
- Sponsor
- Wonju Severance Christian Hospital
Stem Cell Transplantation
Pipeline Integrating Gut Metagenome Data, Host Immunogenetic Characteristics and Clinical Gut Inflammatory Biomarkers
The combined analysis of microbiome, immunological parameters and host genetics in patients has potential for applying personalized approaches of prevention, diagnostics or therapy in the future.
- Trial name
- ImMiGeNe (NCT02940093)
- Testing
- Stem cell transplantation
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Sepsis, Acute Kidney Injury
Gut Microbiota and Sepsis-associated Acute Kidney Injury
Sepsis has emerged as one of the important life-threatening infectious diseases with high morbidity and mortality. Sepsis-associated kidney injury (SAKI) is one of the most common and serious complications of sepsis.
- Trial name
- GMASAKI (NCT05718804)
- Testing
- Whether renal injury occurred and differences in intestinal flora
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Diabetes Mellitus, Type 2, Metagenome
Study of the Genome, Gut Metagenome and Lifestyle of Patients With Incident Type 2 Diabetes Mellitus
A case-control study to identify microbiome and genetic differences between healthy people and patients with incident type 2 diabetes mellitus.
- Conditions
- Diabetes Mellitus, Type 2, Metagenome, Genetic Predisposition
- Trial name
- NCT04113239
- Testing
- 16S rRNA gene sequencing, DNA-microarray genotyping
- Where
- Russia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Atlas Biomed
Obesity
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA).
The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions.
- Trial name
- IRONmiRNA (NCT05345106)
- Testing
- Bariatric Surgery
- Where
- Spain
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Aging
A Model for Healthy Aging: Moscow Centenarians (AGE-100)
This study evaluates the associations between biomarkers of ageing, comprehensive geriatric status, telomere length and progerin level, the composition of the gut microbiota, 16sRNA metagenome sequencing in Moscow centenarians.
- Trial name
- AGE-100 (NCT02876809)
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Pirogov Russian National Research Medical University
Melanoma, Healthy Volunteers
Polish Microbiome Map
Knowledge about the correlations between the composition of the gut microbiome and a wide range of diseases has substantially increased in recent years.
- Conditions
- Melanoma, Healthy Volunteers, Microbiome, Metagenome
- Trial name
- NCT04169867
- Testing
- Collection of stool samples
- Where
- Poland
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Ardigen
Obesity, Sarcopenia
Pilot Study of the Human Metagenome in Metabolic Diseases
This is a cohort study to understand the role of the human metagenome, and associated metabolites, in health and in various diseased states, in particular obesity as well as sarcopenia.
- Conditions
- Obesity, Sarcopenia, Sarcopenic Obesity, Chronic Inflammation
- Trial name
- NCT06363253
- Testing
- No specific intervention
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Constipation
Metagenome Analysis of Gut Microbiota in CC Patients
Constipation is a heterogeneous and multifactorial disease, influenced by a number of different genetic and environmental factors.
- Trial name
- NCT02395484
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Irritable Bowel Syndrome, Abdominal Pain
Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS
The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS).
- Trial name
- NCT04315714
- Testing
- Yoga Program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Respiratory Syncytial Virus Infection
Molecular and Microbiome/Metagenome Correlates of Recurrent Wheeze in RSV Infected Infants
The goal of this observational study is to learn about further wheezing in infants with RSV infection.. The main question it aims to answer is: If infant factors, the infant immune response in the nose and the bacteria that…
- Trial name
- NCT06424795
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Rochester
Microbiota, Antibiotic Disruption
Antibiotic-induced Disruption of the Microbiota
The use of antibiotics causes profound changes in the microbiota. However, the magnitude of the effect of intrapartum and early-life antibiotics on the breast milk and the infant oral and intestinal microbiota, and whether…
- Trial name
- ABERRANT (NCT04091282)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Infectious Disease
Developing Metagenomic Approaches to Identify the Causes of Pediatric Infectious Diseases
Infectious diseases remain leading causes of mortality and morbidity in children. Rapid and accurate diagnosis of infectious diseases in children is important for developing an effective treatment and management strategy.
- Trial name
- NCT04320810
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Children's Hospital of Fudan University
Diabetic Foot Osteomyelitis, Diabetic Foot Infection
Studying on the Difference Between Two Kinds of Osteomyelitis
To explore the microbial differences of diabetic foot osteomyelitis and osteomyelitis without diabetes.
- Conditions
- Diabetic Foot Osteomyelitis, Diabetic Foot Infection, Microbiome
- Trial name
- NCT04240964
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Crohn Disease, Pediatric Crohns Disease
Personalized AZithromycin/metronidAZole Therapy in Pediatric Crohn's Disease (CD)
This is a multi-center, randomized, controlled open-label add-on design trial pilot study to evaluate the efficacy of personalized adjunctive antibiotic (azithromycin + metronidazole) therapy in pediatric subjects with mild to…
- Trial name
- PAZAZ (NCT04186247)
- Testing
- Azithromycin, Metronidazole, Standard of Care
- Where
- 5 sites in United States, Canada and 2 more
- Volunteers
- 13 people
- Sponsor
- University of North Carolina, Chapel Hill
Non Small Cell Lung Cancer, Microbiome
BioForte Technology for in Silico Identification of Candidates for a New Microbiome-based Therapeutics and Diagnostics
The goal of the project is to develop and validate the BioForte technology. Its main functionality should be to in silico determine candidates for novel microbiome-based therapeutics and diagnostics.
- Conditions
- Non Small Cell Lung Cancer, Microbiome, Metagenome, Immunotherapy
- Trial name
- NCT04136470
- Testing
- Collection of stool, blood (PBMC) and biopsy (FFPE)
- Where
- 10 sites in Poland
- Volunteers
- 130 people
- Sponsor
- Ardigen
Hyperglycemia, Insulin Sensitivity
Investigating Inter-individual Variability in Glycemic and Insulin Responses
This study aims to test the following hypothesis in healthy lean young men: There are differences in glycemic response (GR) and insulin response (IR) between Chinese, Malay and Asian-Indian There are differences in GI values to…
- Trial name
- NCT01804738
- Testing
- Jasmine rice, Parboiled basmati rice
- Where
- Singapore
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore