Clinical trials: Metabolomics
Biological Markers, Diet, Healthy
Dietary Biomarkers Intervention Core
The purpose of this controlled feeding trial is to establish an Intervention Core, equipped to perform tightly controlled pharmacokinetic (PK) and dose-response (DR) feeding studies.
- Conditions
- Biological Markers, Diet, Healthy, Metabolomics, Nutrition, Healthy
- Trial name
- NCT05616585
- Testing
- Pharmacokinetic (PK)- Controlled Feeding Diet, Dose Response (DR)- Controlled Feeding Diet
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Obesity in Diabetes, Obesity/Therapy
Semaglutide Treatment in Type 1 Diabetes
The goal of this clinical trial is to investigate the efficacy of semaglutide on body weight, insulin dose requirements and improvements in glucose control and safety aspects in regards to risk of hypoglycemia and diabetic…
- Conditions
- Obesity in Diabetes, Obesity/Therapy, Type 1 Diabetes Mellitus (T1DM), Insulin Sensitivity/Resistance
- Trial name
- OBES1TY (NCT06909006)
- Testing
- Semaglutide 2.4mg
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Nordsjaellands Hospital
Metabolomics, Cord Blood
Effect of Delivery Method on Umbilical Cord Metabolomic Analysis
Birth type is closely linked to fetal and maternal stress responses. In this study, we aimed to examine the effects of delivery method on the stress response in newborns at the metabolite level.
- Trial name
- NCT07093957
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Fibromyalgia, Primary, Pain
Bio-significance of LPC16:0 in Fibromyalgia
Fibromyalgia (FM) is a very common but mysterious pain disorder characterized by chronic widespread muscular pain. Fatigue, anxiety and depression are common comorbidities.
- Conditions
- Fibromyalgia, Primary, Pain, Soreness, Muscle, Oxidative Stress
- Trial name
- NCT04832100
- Testing
- Pregabalin 150mg, imipramine 25mg
- Where
- Taiwan
- Volunteers
- 245 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Pulmonary Embolism, Venous Thromboembolism
Supplemental Oxygen in Pulmonary Embolism (SO-PE)
A study of how supplemental oxygen helps patients with acute pulmonary embolism (PE). Hypothesis: Oxygen affects right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE) primarily by relieving hypoxic…
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Metabolomics, Oxygen Inhalation Therapy
- Trial name
- SO-PE (NCT05891886)
- Testing
- Oxygen Therapy, Non-rebreather mask
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Metabolic Effects, Immunosuppressive Agents
Impact of SCFA Supplementation on Metabolic Profiles in Serum and Urine of Kidney Transplant Recipients.
This is a randomized, double-blind, placebo-controlled clinical trial evaluating the impact of short-chain fatty acid (SCFA) supplementation on the serum and urinary metabolome in stable kidney transplant recipients.
- Conditions
- Metabolic Effects, Immunosuppressive Agents, Adverse Events, Imunological Effects
- Trial name
- METAKID (NCT06951581)
- Testing
- Short Chain Fatty Acid
- Where
- Slovakia
- Volunteers
- 41 people
- Sponsor
- University Hospital, Martin
Energy Expenditure, Metabolic Syndrome
The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome
During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.
- Conditions
- Energy Expenditure, Metabolic Syndrome, Anthropometry, Body Composition
- Trial name
- 12OATS (NCT06951386)
- Testing
- with short-chain fatty acids enriched drink, unenriched oat drink
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- KU Leuven
Lactate, Sports Performance
Association Between Training Load and Lactate and Other Metabolites Analyzed by Metabolomic and Proteomic Techniques
Physical exercise induces numerous changes in the body in a complex signalling network caused by or in response to increased metabolic activity of contracting skeletal muscles.
- Conditions
- Lactate, Sports Performance, Metabolomics, Proteomics
- Trial name
- PROTEOMET (NCT06365320)
- Testing
- Single basketball training
- Where
- 2 sites in Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Lung Cancer, Lung
Establishing a Longitudinal Cohort Study of Lung Cancer Using Tissue and Peripheral Blood Metabolomics.
This study will utilize tissue and peripheral blood samples for metabolomics analysis and establish a longitudinal metabolomics cohort at multiple critical treatment time points to comprehensively investigate the role of…
- Conditions
- Lung Cancer, Lung, Lung Cancer (NSCLC), Metabolomics
- Trial name
- NCT06843707
- Testing
- Monitoring serum metabolites in lung cancer patients using tissue and peripheral blood samples.
- Where
- China
- Volunteers
- 2,500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Premature Ovarian Insufficiency, Metabolomics
Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics
1. Identify differential metabolites in POI patients. 2. Analysis of differential metabolites and their involved mechanism pathways.
- Conditions
- Premature Ovarian Insufficiency, Metabolomics, Traditional Chinese Medicine, Mechanism
- Trial name
- JJGS and POI (NCT06102655)
- Testing
- Jiajian Guishen Formulation
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Shi Yun
Metabolomics
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome Radical Resection of Colorectal Cancer
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with colorectal cancer complicated with metabolic syndrome…
- Trial name
- NCT06710314
- Testing
- Colorectal cancer patients with hypertension, Colorectal cancer patients with diabetes, Colorectal cancer patients with fatty liver
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Dong Peng
Esophagus Adenocarcinoma, Esophagus Cancer
Oncometabolome and MALDI-MSI in Upper GI Carcinomas - Chemosensitivity in Esophageal Carcinoma
Locally advanced adenocarcinoma of the esophagus is a leading cause of death from malignant disease in Germany and has been characterized on a molecular level in recent years.
- Conditions
- Esophagus Adenocarcinoma, Esophagus Cancer, Metabolome, Mass Spectrometry
- Trial name
- NCT06642506
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Colorectal Cancer, Imaging
Metabolism Imaging-genomics for Predicting the Surgical Outcomes of Colorectal Cancer
In this study, the investigators constructed an imaging-metabolism prediction model for colorectal cancer by analysing the imaging and metabolomics features of colorectal cancer, in order to further adjust and guide the treatment…
- Conditions
- Colorectal Cancer, Imaging, Metabolomics, Prognosis
- Trial name
- NCT06614660
- Testing
- Metabolism genomics and imaging genomics
- Where
- China
- Volunteers
- 800 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile
Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities
The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1)…
- Conditions
- Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile, Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities
- Trial name
- 3X (NCT05365334)
- Testing
- Low intensity exercise session, Moderate intensity exercise session, High intensity exercise session
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Metabolomics; Retinopathy; Etiology
Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was…
- Trial name
- NCT06408571
- Testing
- etiology
- Where
- China
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Adiposity, Insulin Resistance
PREterM FOrmula Or Donor Breast Milk for Premature Babies
In order to address this crucial question, central to preterm newborn care, a multicentre United Kingdom (UK) -wide study randomising 4000 preterm babies would be necessary to achieve sufficient power to evaluate the impact on…
- Conditions
- Adiposity, Insulin Resistance, Metabolomic Profile, microRNA Profile
- Trial name
- PREMFOOD (NCT01686477)
- Testing
- Unfortified Human donor Milk used to make up any shortfall in mother's own milk, Fortified Human donor Milk used to make up any shortfall in mother's own milk, Preterm Formula used when there is a shortfall in mother's own milk
- Where
- United Kingdom
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Methylphenidate, Metabolomics
Metabolic Mechanisms of the Electrophysiological Biomarkers for Response to Methylphenidate Treatment in Children With ADHD
To explore the relationship of treatment-related changes in electrophysiology and those in metabolomics for identification of the underlying metabolic mechanisms for the electrophysiological effects of methylphenidate in children…
- Trial name
- NCT06073470
- Testing
- methylphenidate
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Microbial Disease, Metabolomics
Foot-skin Microbiome and Metabolomics of Pitted Keratolysis
This study aimed to investigate the skin microbiome and metabolomics of patients with pitted keratolysis.
- Trial name
- Foot-skin M&M (NCT04781036)
- Testing
- 4%Chlorhexidine
- Where
- 2 sites in Thailand
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Metabolomic
Metabolomic in Critical Ill Patients
Analysis of blood, urinary, and intrathecal metabolites of critical ill patients will be checked for possible correlations between metabolomics patterns and patients' outcomes.
- Trial name
- NCT01506674
- Where
- Italy
- Volunteers
- 94 people
- Sponsor
- Università Vita-Salute San Raffaele
Embryo Culture Media, Metabolomics
Targeted Metabolomics and Spent Embryo Culture Medium
More than 8 million babies have been born through in vitro fertilization (IVF). Non-invasive observation of embryos in vitro to better understand their development is becoming increasingly important.
- Trial name
- NCT06094439
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- gyn-medicum Göttingen