Clinical trials: Metabolism
Type 2 Diabetes Mellitus
Return of First-phase Insulin Secretion in Type 2 Diabetes is Associated With Depletion of Pancreas Lipid
The hypothesis for this study is that pancreas lipid will be more closely associated with first-phase beta-cell response in African-Americans than in European-Americans, both at baseline and in response to treatment.
- Trial name
- NCT03430310
- Testing
- Low Glycemic Diet, Control Diet
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Atherosclerosis Cardiovascular Disease
Lipoprotein (a) and Vascular Regenerative Cell Content
Lp(a)-VRCE is an observational, cross sectional study looking at vessel reparative stem cell content in people with and without elevated lipoprotein (a) [Lp(a)].
- Conditions
- Cardiovascular Diseases, Atherosclerosis Cardiovascular Disease, Ischemic Heart Disease, Dyslipidemia
- Trial name
- Lp(a)-VRCE (NCT06626659)
- Where
- 2 sites in Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group
Gestational Diabetes
Visualizing Beta Cells in Patients With a History of Gestational Diabetes
In order to evaluate the difference in beta cell mass in women with and without a history of gestational diabetes mellitus (GDM), investigators aim to compare quantitative PET imaging of the pancreas between these groups.
- Trial name
- NCT03182296
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Iron Deficiency
Cereals as a Source of Iron for Breastfed Infants
The purpose of this research study is to determine whether the type of iron in infant cereals makes a differance in how well the cereal helps infants remain free of iron deficiency.
- Trial name
- Bfe03B (NCT00841061)
- Testing
- electrolytic iron, ferrous fumarate
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health (NIH)
Type 2 Diabetes, PreDiabetes
Recreational Basketball to Increase Participation in Diabetes Prevention
The purpose of this study is to assess the efficacy of adapting the National Diabetes Prevention Program (NDPP) to include recreational sports in effort to increase physical activity (PA) and promote lifestyle changes that can…
- Trial name
- DPPHoops (NCT05066542)
- Testing
- NDPP + Basketball (BB), NDPP Standard of Care SOC
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity
A Study to Determine the Effectiveness of a Self-regulation Program to Treat Pediatric Obesity
The objective of this study is to pilot test, evaluate and compare the effects of Cue Reactivity and Sensitivity Training (CRST) and Children's Appetite Awareness Training (CAAT) in 48 children aged 8-12 years old.
- Trial name
- ROC (NCT01442142)
- Testing
- CAAT: Appetite Awareness, CRST: Volcravo, Combined CAAT and CRST program
- Where
- United States
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Fed
Bioequivalence Study of Etodolac Tablet USP 500 mg Under Fed Condition
This is a open Label, balanced, randomized, single dose, two-treatment, two-sequence, two-period, crossover pivotal study. The purpose of this study is to assess the bioequivalence between Test Product and the corresponding…
- Trial name
- NCT01735383
- Testing
- Etodolac Tablets USP 500mg, Etodolac Tablets USP 500 mg
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- IPCA Laboratories Ltd.
Sleep, Body Composition
Nutrition, Body Composition, and Sleep
The purpose of the research is to determine if protein and omega-3 fatty acid supplementation improve sleep, improve body composition, and improve markers of metabolic health in postmenopausal women.
- Conditions
- Sleep, Body Composition, Strength, Insulin Sensitivity
- Trial name
- SHAPE (NCT03603041)
- Testing
- Whey protein, Omega-3 fatty acids
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Type II Diabetes, Primary Health Care
INTEGRATE-D: A Pilot Test to Support Integration of Medical and Psychosocial Care for People With Type II Diabetes
In 2016, the American Diabetes Association (ADA) published its first-ever recommendations for integrating medical and psychosocial care for patients with Type II Diabetes Mellitus (DMII) and common mental and behavioral health…
- Conditions
- Type II Diabetes, Primary Health Care, Behavioral Health
- Trial name
- NCT04461405
- Testing
- INTEGRATE-D
- Where
- United States
- Volunteers
- 294 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Bone Loss
Bone Mineral Density Changes Among Clinical Subtypes of Parkinson's Disease
The bone loss in Parkinson's disease (PD) emerges as a non-motor symptom with motor and non-motor outcomes, such as fracture and musculoskeletal pain.
- Trial name
- NCT03806517
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ordu University
Iron-deficiency
Effect of Vitamin D3-fortified Fruit Juice on Iron Status in Women
The present study is designed to utilise vitamin D3 supplements that may potentially act as an iron absorption enhancer to improve iron status in the Malaysian child-bearing aged women with low iron stores.
- Trial name
- NCT04618289
- Testing
- Vitamin D3-fortified fruit juice supplement
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Osteoporosis
Osteoporosis Prevention: Changes to Exercise and Diet in Children
The purpose of this study is to determine whether educating parents about health and behavior management techniques will increase physical activity, calcium intake, fitness, and bone density in their children.
- Trial name
- NCT00063050
- Testing
- Physical activity and nutrition intervention
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Obesity, Adolescent, Stress
Ethnic Influences on Stress, Energy Balance and Obesity in Adolescents
The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females.
- Conditions
- Obesity, Adolescent, Stress, Physical Activity
- Trial name
- NCT03369691
- Where
- United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Cardiometabolic Health, Pregnancy Related
Cardiometabolic Health in First Time Pregnancy
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth…
- Conditions
- Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction
- Trial name
- POPPY (NCT05856318)
- Where
- 7 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hyperbilirubinemia, Jaundice
Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia
The purpose of this study is to compare the demographic, metabolic, and genomic characteristics of patients who develop severe hyperbilirubinemia to patients who never developed a significant bilirubin level.
- Trial name
- NCT00383318
- Testing
- Gene mutation sample
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Osteoporosis
A Single-Dose Study of the Safety, Tolerability, and Pharmacokinetics of Odanacatib (MK0822) in Healthy Volunteers
This study assessed the safety, tolerability, and pharmacokinetics of single-dose odanacatib (MK0822) with and without food.
- Trial name
- NCT00863590
- Testing
- odanacatib, Comparator: odanacatib (Panel B), Comparator: odanacatib (Panel C)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Insulin Resistance, Type 2 Diabetes
Alpelisib Challenge Test (ACT)
The goal of this study is to test a potentially easier method for measuring how much insulin a person is capable of producing than the current gold-standard method, the "hyperglycemic clamp." Participants will come in for a…
- Conditions
- Insulin Resistance, Type 2 Diabetes, Obesity & Overweight, Healthy Adult Participants
- Trial name
- NCT07778524
- Testing
- Alpelisib 300 mg, Alpelisib Challenge Test (ACT): Mixed Meal Tolerance Test (MMTT) after taking alpelisib, Hyperglycemic clamp
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Columbia University
Hepatitis C, Chronic, Hepatitis C
Monotherapy Versus Placebo Over 14 or 17 Days in Healthy and Hepatitis C Infected Adults
This study represents the first administration of GSK625433 in humans. The study is designed to evaluate initial safety and tolerability in healthy adults as well as anti-viral activity in Hepatitis C(HVC) infected adults.
- Trial name
- NCT00439959
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Prader-Willi Syndrome
Gut Derived Hormones, Body Composition and Metabolism in Prader-Willi Syndrome
The purpose of this study is to investigate the effects of a GLP-1 agonist on satiety hormones in patients with Prader-Willi Syndrome (genetic defect causing obesity).
- Trial name
- NCT00551343
- Testing
- Exenatide
- Where
- Australia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Diabetes
Body Composition, Fitness, and Thermoregulation in Young Boys With Type I Diabetes vs. Healthy Soccer Players
The study aims to assess differences in body composition, exercise capacity, and thermoregulation between young soccer players with type 1 diabetes and their healthy peers.
- Trial name
- BCFTYR (NCT06676878)
- Testing
- Incremental exercise
- Where
- Poland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Paweł Korman
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