Clinical trials: Metabolic Response to Dietary Modification
Obesity, Metabolically Healthy Obesity
Exercise and Diet Responses in Adult Men With Obesity by MC4R Genotype and Metabolic Health
This study evaluated whether differences in the MC4R rs17782313 gene variant and metabolic health status were associated with different responses to a 12-week exercise and dietary intervention in adult men with obesity.
- Conditions
- Obesity, Metabolically Healthy Obesity, Metabolically Unhealthy Obesity
- Trial name
- NCT07750197
- Testing
- Supervised Aerobic and Resistance Exercise
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Harbin Sport University
Cardiovascular Diseases
Fat Metabolism in Response to Acute Diet- and Exercise-induced Changes in Energy Balance
This study is being conducted to learn more about the role of diet and exercise in regulating plasma triglyceride (fat) metabolism.
- Trial name
- DEV (NCT00830999)
- Testing
- Positive energy balance, Energy balance with exercise, Negative energy balance
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
NAFLD (Nonalcoholic Fatty Liver Disease)
Integrating Metabolic and Vascular Sensors to Monitor Cardiometabolic Disorders After Nutrition Interventions
It is a 12-week study. The participants will follow three different diets, and during each diet period, and the participants will wear our device, and blood samples will be collected.
- Trial name
- NCT06932289
- Testing
- Mediterranean diet (MED), high-fat/low carb diet (HF/LC), and low-fat diet (LF), The integrated sweat sensor and vascular sensor (wearable), continuous glucose monitor (CGM)
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- VA Greater Los Angeles Healthcare System
Shift Work
Measuring the Cardio-metabolic Response to Diet Quality Modification During Night Work.
The aim of this pilot study is to investigate the acute impact of diet quality modification during night work on 24-hr glucose variability (GV) and heart rate variability (HRV) in healthy free-living employees.
- Trial name
- NCT04182867
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- King's College London
Dietary Modification, Healthy
Acute Glycemic and Insulinemic Response of FOSSENCE™
Short chain fructooligosaccharide (FOS) is known as a prebiotic fiber/nutrient and has been documented to demonstrate different health benefits including glucose control, gut health, mineral absorption, weight and immunity.
- Trial name
- NCT03755232
- Testing
- scFOS, Control
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- TATA CHEMICALS LTD
Metabolic Response to Dietary Modification
NUtriGenomic Analysis in Twins
This is an intervention study in healthy adult twins with the aim to investigate the genetic determination of metabolic responses towards an isocaloric high carbohydrate, low fat diet versus an isocaloric low carbohydrate, high…
- Trial name
- NUGAT (NCT01631123)
- Testing
- Isocaloric high carbohydrate diet intervention, Isocaloric high fat diet intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Low Protein Dietary Intake, High Protein Dietary Intake
The Body's Response to Changes in Dietary Protein and Meal-Frequency In Men
the purpose of this study is to identify how the body responds to increased dietary protein (that includes pork and eggs) and meal-frequency in adult men.
- Trial name
- NCT01171716
- Testing
- Meal Patterning
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Purdue University
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Diet Modification, Insulin Resistance
Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans
Recent evidence suggests that hyperinsulinemia (i.e., elevated insulin levels) is the primary causative factor in obesity. Insulin promotes fat storage and prevents fat breakdown, suggesting that weight loss would be optimized if…
- Conditions
- Diet Modification, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT04309071
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes, Heart Diseases
PREDICT 2: Personalized Responses to Dietary Composition Trial 2
Foods in the human diet can affect the development of diseases over time, such as diabetes or heart disease. This is because the amount and types of foods in the diet eat can affect a person's weight, and because different foods…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- NCT03983733
- Testing
- Dietary Intervention
- Where
- United States
- Volunteers
- 1,139 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Metabolic Syndrome
Study the Role of Genetic Variation in the Determining Lipid Profile Response to Dietary Change
The purpose of this study is to determine whether plasma lipoproteins and lipid responsiveness to a dietary modification is influenced by CETP gene polymorphism.
- Trial name
- NCT00673023
- Testing
- Dietary experiments
- Volunteers
- 102 people
- Sponsor
- Tabriz University
Metabolic Flexibility
Metflex: The Effectiveness of a Dietary Intervention
This study is testing the effectiveness of a dietary intervention by means of measuring the change in RQ upon a hyperinsulinemic euglycemic clamp challenge and by means of measuring the kinetic responses of multiple PF markers…
- Trial name
- NCT02519127
- Testing
- Low glycaemic load diet, Western diet
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Brain Response to Dietary Interventions
In order to better understand how commonly used dietary interventions for obesity influence brain activity and in turn people's ability to adhere to their healthy nutrition plan, the investigators need to study how people's…
- Trial name
- BRDI (NCT02637271)
- Testing
- Low calorie total meal replacement, Low calorie typical diet
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Texas Tech University
Diabetes, Heart Diseases
Personalised Responses to Dietary Composition Trial
The foods we eat - our diet - can affect whether we develop diseases during our lives, such as diabetes or heart disease. This is because the amount and types of foods we eat can affect our weight, and because different foods are…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- PREDICT (NCT03479866)
- Testing
- Dietary intervention
- Where
- United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Vitamin D Deficiency
Nutritional Requirements for Vitamin D in Pregnant Women
Randomised, placebo-controlled dose-response intervention study with vitamin D3 in pregnant women.
- Trial name
- DMAT (NCT02506439)
- Testing
- 10 mcg Vitamin D3, 20 mcg Vitamin D3
- Where
- 2 sites in Ireland
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University College Cork
Metabolic Response to Dietary Modification
The CLOCK Study - A Human Dietary Intervention Study on Peripheral Circadian Clocks and Energy Metabolism
This human dietary intervention study with a cross-over design aims to investigate the effect of two different diurnal patterns of meal composition on peripheral circadian clocks and energy metabolism in healthy men.
- Trial name
- CLOCK (NCT02487576)
- Testing
- Carbohydrate-rich (HC), Fat-rich (HF)
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Endotoxemia, Intestinal Microbiota
Dietary Intervention to Reduce Metabolic Endotoxemia
The goal of this randomized clinical trial is to compare an antiinflammatory and environmentally friendly dietary strategy (AIA-D) designed based on the planetary health diet recommendations translated to the regional context and…
- Conditions
- Endotoxemia, Intestinal Microbiota, Dietary Habits, Clinical Trial
- Trial name
- NCT05776329
- Testing
- AIA-D, CONV-D
- Where
- 2 sites in Mexico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centro de Investigación en Alimentación y Desarrollo A.C.
Overweight and Obesity, Diabetes Mellitus, Type 2
Looking for Personalized Nutrition for Obesity/Type 2 Diabetes Mellitus Prevention
The objectives of this trial are to assess the effects of interactions between genetic factors and diet with various macronutrient intake on the metabolic disorders, obesity and type 2 diabetes risk, prevention, development and…
- Conditions
- Overweight and Obesity, Diabetes Mellitus, Type 2, Metabolic Syndrome, Genetic Predisposition
- Trial name
- NCT03792685
- Testing
- Normo-carbohydrate meal intake, High-carbohydrate meal intake, High-fat meal intake
- Where
- Poland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Type 1 Diabetes Mellitus
Guidelines for Post-exercise Dietary Intake in T1DM
The investigators hypothesise that manipulating the glycaemic index of the meal after exercise and before sleep will help prevent Type 1 diabetes individuals experiencing hypoglycaemia.
- Trial name
- NCT01794650
- Testing
- Meal composition
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Northumbria University
Diabetes, Heart Diseases
Personalized Responses to Dietary Composition Trial 3
The PREDICT 3 study will build on previous research in over 2,000 individuals to further refine machine learning models that predict individual responses to foods, with the aim of advancing precision nutrition science and…
- Conditions
- Diabetes, Heart Diseases, Diet Habit, Diet Modification
- Trial name
- NCT04735835
- Testing
- Dietary Intervention
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 250,000 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited