Clinical trials: Menopausal Complaints
Menopause
Trial to Compare the Effects of Tibolone (Livial®) and Continuous Combined Low-Dose Estradiol/Noresterone (Activelle®)
The present trial is undertaken to compare the effects of Tibolone with a low-dose HRT regimen.
- Trial name
- TOTAL (NCT00431093)
- Testing
- tibolone, low-dose estradiol/noresterone
- Volunteers
- 570 people
- Sponsor
- Organon and Co
Menopausal Complaints
Effect Of Transcutaneous Tibial Nerve Stimulation Technique Combined With Exercise on High Post-Void Residual Urine Volume in Post-Menopausal Women
Objective of the study is to explore effect of combining transcutaneous tibial nerve stimulation with exercise on high post-void residual urine volume in post-menopausal women.
- Trial name
- NCT07538895
- Testing
- Transcutaneous Tibial Nerve Stimulation Technique
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Sleep Disturbance
Bonafide Sleep Supplement for Menopausal Women With Sleep Complaints
This open-label study was designed to evaluate whether a daily dietary sleep supplement could improve sleep quality and related daytime well-being in menopausal women aged 40 to 65 with sleep complaints.
- Trial name
- NCT07839312
- Testing
- S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Cardiovascular Diseases, Endometrial Hyperplasia
Soy Estrogen Alternative Study (SEA)
To conduct a three-armed trial assessing the effect of soy phytoestrogens on menopausal complaints, plasma lipids and lipoproteins, vaginal bleeding and endometrial proliferation, and health related quality of life.
- Conditions
- Cardiovascular Diseases, Endometrial Hyperplasia, Heart Diseases, Menopausal Complaints
- Trial name
- NCT00000612
- Testing
- estrogens, conjugated, diet, soy proteins, dietary supplements
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aesthetic, Menopause
Post-Menopause Skin Rejuvenation Study
The post-menopausal state is marked by a sharp decline in estrogen, leading to significant structural and functional changes in the skin, including collagen loss, dryness, thinning, and reduced elasticity.
- Conditions
- Aesthetic, Menopause, Post-menopause, Injectables
- Trial name
- NCT07205744
- Testing
- Restylane SkinBoosters Vital, Sculptra Aesthetic
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Erevna Innovations Inc.
Planned RRSO
E2 and LDX for the Treatment of Cognitive Complaints After Oophorectomy
This project seeks to address cognitive disturbance, which is a frequent adverse sequelae of riskreducing bilateral salpingo-oophorectomy (RRSO) with or without post-procedure chemotherapy and adjunctive treatments.
- Trial name
- E2LDX (NCT01986764)
- Testing
- Lisdexamfetamine, Estradiol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cognitive Impairment, RRSO
IMProving Executive Function Study
This is a double-blind, placebo-controlled, crossover study testing whether Vyvanse (lisdexamfetamine; LDX) improves executive functioning (EF) in 100 postmenopausal women who report onset of EF difficulties after oophorectomy.
- Trial name
- IMPRES (NCT03187353)
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aromatherapy
The Effect of Aromatherapy to Women With Vasomotor Complaints on Menopausal Quality of Life and Vasomotor Symptoms
Evaluation of the effect of aromatherapy applied to women with vasomotor complaints on menopausal quality of life and vasomotor symptoms.
- Trial name
- Aromatherapy (NCT06035380)
- Testing
- mint oil group, rose oil group
- Where
- Cyprus
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Menopause, Menopausal Hormone Therapy
A Retrospective and Prospective Clinical Registry for Data Collection of Perimenopausal, Menopausal and Premature Ovarian Insufficiency Women
This study is designed as on observational, retrospective, and prospective clinical registry aimed at collecting comprehensive real-world data on women in perimenopause, menopause, and with premature ovarian insufficiency (POI)…
- Conditions
- Menopause, Menopausal Hormone Therapy, Menopause Surgical, Menopause Related Conditions
- Trial name
- NCT07606326
- Volunteers
- 5,000 people
- Sponsor
- IRCCS San Raffaele
Climacteric Symptoms
China Cimicifuga Trial of Climacteric Complaint Control
This study is designed to determine whether an extract of Cimicifuga Foetida L. is safe and efficacious to relieve the climacteric symptoms of Chinese women
- Trial name
- CCCCC (NCT00622986)
- Testing
- an extract of Cimicifuga Foetida L.
- Where
- 13 sites in China
- Volunteers
- 288 people
- Sponsor
- Shandong Luye Pharmaceutical Co., Ltd.
Healthy, Perimenopausal Depression
Multidimensional Determinants of Functional Health In Women Aged 45-60
The goal of this observational study is to learn about the multidimensional determinants of functional health in women aged 45 to 60 years.
- Conditions
- Healthy, Perimenopausal Depression, Menopausal Complaints, Bone Mineral Density
- Trial name
- NCT07667699
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Kartal City Hospital
Bone Diseases, Metabolic Syndrome X
Effect of Exercise and Phytoestrogen on Bone, Metabolic Syndrome Criteria and Complaints of the Early Menopause
The aim of the study is to compare the effect of a progressive, periodized exercise training designed to impact bone, CHD-risk-factors and menopausal complaints versus the combined effect of exercise and "phytoestrogen"…
- Conditions
- Bone Diseases, Metabolic Syndrome X, Coronary Disease
- Trial name
- NCT00663104
- Testing
- exercise, exercise + cimicifuga racemosa
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Menopausal Complaints, Vaginal Atrophy
Vaginal Estradiol vs Moisturizer to Improve Postmenopausal Vaginal Aging Symptoms and the Microbiome in Women Living With HIV
This is a research study about the effects of vaginal estradiol compared to moisturizer on vaginal symptoms of menopause and the microbiome in women with HIV.
- Conditions
- Menopausal Complaints, Vaginal Atrophy, Genitourinary Symptoms, HIV (Human Immunodeficiency Virus)
- Trial name
- NCT07526948
- Testing
- Vaginal estradiol tablets, Vaginal moisturizer
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Menopausal Complaints, Hypercholerolemia
Effects of Statins and Hormone Replacement Therapy in Coagulation Profile of Menopausal Women With Dyslipidemia
The goal of this study is to understand whether statin therapy, a common lipid-lowering therapy, may improve the coagulation profile of menopausal women with hypercholesterolemia undergoing hormone replacement therapy with oral…
- Conditions
- Menopausal Complaints, Hypercholerolemia, Coagulation Tests
- Trial name
- STAR-HRT (NCT07742488)
- Testing
- estroprogestins, Statin
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- University of Pisa
Perimenopause, Menopausal Complaints
Amygdala Insula Retraining in the Management of Perimenopause Symptoms
The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms.
- Trial name
- NCT07427459
- Testing
- Amygdala and Insula Retraining (AIR)
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Chronic Conditions Research Fund
Postmenopause, Menopausal Complaints
The Influence of Hormone Replacement Therapy and Supervised Exercise Training on Body Composition, Cardiovascular Risk and Insulin Sensitivity in Postmenopausal Women
This trial investigates whether supervised training in combination with hormonal substitution therapy has an impact on body composition, cardiovascular risk, risk for dementia, osteoporosis and insulin sensitivity in…
- Trial name
- OPERATE (NCT05831709)
- Testing
- Exercise program, Hormonal substitution therapy per SOC
- Where
- Belgium
- Volunteers
- 390 people
- Sponsor
- University Hospital, Ghent
Menopause
Klimadynon® in Comparison to Conjugated Oestrogens in Women Suffering From Menopausal Complaints
To investigate, relative to placebo and conjugated oestrogens, the efficacy, safety and tolerability of a 12 weeks peroral treatment twice daily with a cimicifuga racemosa extract corresponding to 20 mg, 75 mg or 150 mg plant…
- Trial name
- NCT02184364
- Testing
- Low dose of Klimadynon®, Medium dose of Klimadynon®, High dose of Klimadynon®
- Volunteers
- 161 people
- Sponsor
- Boehringer Ingelheim
Menopausal Symptoms in Breast Cancer Patients With Treatment-Induced Complaints
Cognitive Behavioral Therapy (CBT) and Physical Exercise for Climacteric Symptoms in Breast Cancer Patients Experiencing Treatment-Induced Menopause: a Multicenter Randomized Trial
Background: Breast cancer is the most common form of cancer among women in the Netherlands. Approximately 11,000 women are diagnosed with breast cancer annually, of whom about 30% are below 50 years of age.
- Trial name
- EVA project (NCT00582244)
- Testing
- CBT and relaxation, Physical activity, CBT and physical activity
- Volunteers
- 325 people
- Sponsor
- The Netherlands Cancer Institute
Postmenopausal Women
The Effect of Mindfulness Stress Reduction Program on Menopausal Complaints and Quality of Life
The study was conducted to determine the effect of the mindfulness stress reduction program (MBSR) applied to postmenopausal women on menopausal complaints and quality of life.
- Trial name
- NCT04762095
- Testing
- mindfulness stress reduction program
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- NURDİLAN SENER
Menopausal Complaints
Evaluation of the Relationship Between Mediterranean Diet and Menopausal Symptoms in Postmenopausal Women
This cross-sectional study aimed to evaluate the relationship between the frequency and severity of postmenopausal symptoms in women aged 45-65 years and the level of compliance with the Mediterranean diet, and the main question…
- Trial name
- NCT06755255
- Where
- Turkey (Türkiye)
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital