Clinical trials: Medication Management
Nitrous Oxide, Dentistry
Demand-Driven Method for Gas Delivery in a Dental Setting
This study compares two methods of gas delivery in a dental setting: 1) demand-driven (DD) and 2) free-flow (FF). Nitrous oxide and oxygen sedation (NOS) is a common form of minimal sedation for adult and paediatric patients…
- Conditions
- Nitrous Oxide, Dentistry, Drug Delivery System, Comfort
- Trial name
- NCT04305990
- Testing
- Demand-driven delivery method, Free-flow delivery method
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Schizophrenia and Related Disorders, Drug Administration Schedule
"Extended" (Alternate Day) Antipsychotic Dosing
The study wishes to examine whether "extended" antipsychotic treatment, in this case, antipsychotic treatment every other day, is as effective as daily treatment.
- Conditions
- Schizophrenia and Related Disorders, Drug Administration Schedule, Drug Therapy, Antipsychotic Agents
- Trial name
- NCT04478838
- Testing
- Risperidone, Olanzapine, paliperidone
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health
Type 2 Diabetes Mellitus
Drug-drug Interaction Study of Dapagliflozin With Voglibose in Japanese Type 2 Diabetes Mellitus Patients
The purpose of this study is to evaluate the pharmacokinetics of dapagliflozin when administered alone or in combination with voglibose in Japanese patients with type 2 diabetes by assessment of AUC and Cmax of dapagliflozin
- Trial name
- NCT01055652
- Testing
- Dapagliflozin
- Where
- 2 sites in Japan
- Volunteers
- 28 people
- Sponsor
- AstraZeneca
Pain, Acute
Analgesic Efficacy of Orally Administered VTS-K for Pain Management
A combination of ketamine and aspirin for the treatment of acute MSK pain in the ED would confer multimodal analgesia, with the contributions of aspirin and ketamine to an opioid sparing effect.
- Trial name
- NCT04702555
- Testing
- VTS-K
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Antonios Likourezos
Irritable Bowel Syndrome
Acupuncture/Moxibustion for Irritable Bowel Syndrome (IBS)
The objective of this study is to test the efficacy of a symptom management treatment strategy, namely, Acupuncture/Moxibustion (Acu/Moxa) to improve the symptoms associated with Irritable Bowel Syndrome (IBS) in persons between…
- Trial name
- Acu/MoxaIBS (NCT00945074)
- Testing
- Standard Acupuncture/Moxibustion (fixed protocol), Individualized Acupuncture/Moxibustion
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- New York University
Medication Adherence, Self Management
Medication Adherence Enhancement in Heart Transplant Recipients
Medication-related non-adherence increases the risk of rejections and associated graft loss after solid organ transplantation. A randomized controlled intervention will use adherence enhancing strategies out of a larger sample of…
- Conditions
- Medication Adherence, Self Management, Rejection
- Trial name
- NCT00843960
- Testing
- behavioral adaptation and symptom management
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Hannover Medical School
Metabolic Acidosis, Antiepileptic Drugs
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations
The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations
- Conditions
- Metabolic Acidosis, Antiepileptic Drugs, Craniotomy, Anesthesia Management
- Trial name
- NCT05940935
- Testing
- Arterial Blood Gas Base Deficit
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Trakya University
Hepatitis C, Chronic
A Retrospective Study of Real World Treatment Outcomes of Patients With Chronic Hepatitis C
This retrospective, observational study will assess the real world treatment out comes in the management of patients with chronic hepatitis C.
- Trial name
- NCT01705717
- Where
- Thailand
- Volunteers
- 49 people
- Sponsor
- Hoffmann-La Roche
Sickle Cell Disease
Optimizing the Management of Sickle Cell Patients on Hydroxyurea: The Value of Therapeutic Pharmacological Monitoring
Brief Summary: * A short description of the clinical study, including a brief statement of the clinical study's hypothesis, written in language intended for the lay public. Limit: 5000 characters.
- Trial name
- OPTIMDREP (NCT06464458)
- Testing
- management on hydroxyurea by therapeutic pharmacological monitoring
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
RSV Infection, Drug Drug Interaction
A Study to Evaluate the Drug-Drug Interaction of EDP-323 With Midazolam, Caffeine, and Rosuvastatin in Healthy Participants
The primary aim of this study is to assess the effect of EDP-323 on the pharmacokinetics and safety of midazolam, caffeine, and rosuvastatin in healthy adult participants.
- Trial name
- NCT06917508
- Testing
- EDP-323, Midazolam, Caffeine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Home Care, Pharmacists
Home Medication Reviews by Pharmacists in Ontario, Canada
RATIONALE: Several examples in the literature describe the types of medication management issues uncovered during the course of home-based medication reviews.
- Conditions
- Home Care, Pharmacists, Medication Therapy Management
- Trial name
- NCT02658604
- Testing
- Home medication review by a pharmacist
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Waterloo
Healthy
To Evaluate the PK, PD, Safety and Drug Tolerance of JW0302 in Healthy Volunteers
1. To evaluate the pharmacokinetic and pharmacodynamics characteristics after administration of Reference Drug or Test Drug in healthy volunteers under fasting conditions 2.
- Trial name
- NCT05784155
- Testing
- Test Drug(JW0302) or Reference Drug(C2206)
- Where
- South Korea
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- JW Pharmaceutical
Healthy Volunteers
A Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of Abiraterone Following Administration of Abiraterone Acetate Tablets in Healthy Adult Men
The purpose of this study is to evaluate the pharmacokinetics, safety, and potential for drug-drug interactions when a strong inhibitor of CYP3A4 (ie, ketoconazole) is co-administered with abiraterone acetate in healthy adult men.
- Trial name
- NCT01588782
- Testing
- Period 1: Abiraterone, Period 2: Abiraterone/Ketoconazole
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Cervical Radiculopathy
Conservative Therapy Versus Epidural Steroids for Cervical Radiculopathy
The main objective of this study is to determine whether interventional treatment (i.e. epidural steroids), conservative therapy, or the combination, is superior for cervical radiculopathy.
- Trial name
- NCT01144923
- Testing
- Gabapentin and/or Nortriptyline, Physical therapy, Epidural Steroid Injections (ESI), Combination treatment
- Where
- 2 sites in United States
- Volunteers
- 169 people
- Sponsor
- Johns Hopkins University
ADHD
Single and Combined Effects of Behavioral, Academic, and Medication Treatments for ADHD in the Classroom
This study is the first to systematically evaluate the efficacy of single and combined academic accommodation, behavioral treatment, and medication treatment in a large sample of children with ADHD.
- Trial name
- NCT05469386
- Testing
- Methylphenidate Hydrochloride ER, Behavioral classroom, General Classroom
- Where
- 2 sites in United States
- Volunteers
- 288 people
- Sponsor
- Florida International University
COPD, COPD Exacerbation
Nurse-led COPD Self-management Intervention
Introduction: Chronic Obstructive Pulmonary Disease (COPD) disease highest mortality and morbidity of respiratory diseases that third cause of death in the world and Turkey.
- Trial name
- NCT04459546
- Testing
- patient education, training booklet, 3 months tele health
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Pamukkale University
Healthy
Impact of Stress and Sleep Management on Emergency Professionals
The investigators hypothesize that a recovery management program could have an impact on emergency nurses and physicians by improving their sleep and reducing their psychological and physiological responses when dealing with…
- Trial name
- REST (NCT05251246)
- Testing
- recovery management program
- Where
- France
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Bipolar Disorder
A Safety and Efficacy Study of Ramelteon Tablets for Sublingual Administration (TAK-375SL) in the Maintenance Treatment of Bipolar 1 Disorder
To evaluate the efficacy and safety of once a day ramelteon tablets for sublingual administration (TAK-375SL) in the maintenance treatment of bipolar 1 disorder.
- Trial name
- NCT01685151
- Testing
- Ramelteon SL (Dose 1), Ramelteon SL (Dose 2)
- Sponsor
- Takeda
Healthy
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
The main purpose of the study is to see how safe the study drug AX-8 is and how well it is tolerated when administered at different dose levels in healthy participants.
- Trial name
- NCT04107441
- Testing
- AX-8 Part 1, AX-8 Part 2
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Axalbion SA
Major Depression
Efficacy of 18-Months of Antidepressive Medication Plus CBT or Dynamic or Supportive Psychotherapy for Recurrent Major Depression
Major Depressive Disorder affects approximately 16% of the adult population over the lifetime. Controlled studies indicate that short-term antidepressive medications or psychotherapy produce full remission in only about 46% of…
- Trial name
- NCT00220623
- Testing
- antidepressant medications, flexible drug choice, CBT, Psychodynamic or Supportive Psychotherapy
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
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