Clinical trials: Medication Adherence
HIV Infections
Prospective Evaluation of Anti-retroviral Combinations for Treatment Naive, HIV Infected Persons in Resource-limited Settings
This study compared 3 different three-drug combinations in HIV infected individuals starting their first HIV treatment regimens.
- Trial name
- PEARLS (NCT00084136)
- Testing
- Atazanavir, Didanosine (enteric-coated), Efavirenz
- Where
- 42 sites in United States, Brazil and 7 more
- Volunteers
- 1,571 people
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV-1-infection
Population Effectiveness of Dolutegravir Implementation in Sub-Saharan Africa
This is a prospective observational cohort study enrolling participants in South Africa and Uganda who are prescribed an HIV treatment regimen containing lamivudine, tenofovir, and dolutegravir, which is known as TLD.
- Trial name
- DISCO (NCT04066036)
- Testing
- This is an observational study only.
- Where
- 2 sites in South Africa, Uganda
- Volunteers
- 999 people
- Sponsor
- Massachusetts General Hospital
HIV, AIDS
Care4Today v2.0 Application for Improving Adherence to HIV Medications
Although poor antiretroviral (ART) adherence in HIV does not mean a complete lack of therapeutic results, the benefit of ART increases as adherence improves.
- Trial name
- NCT02001064
- Testing
- Care4Today v2.0 mobile application + electronic monitoring of adherence
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Heart Failure
Study of Reminding to Improve Medication Adherence in Heart Failure
This study is being done to look at how people manage their heart failure. The investigators are testing two medication reminder systems and the investigators want to know which one people like better.
- Trial name
- Heart iRx (NCT01463267)
- Testing
- iPhone or pillbox, Non-reminding
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Kent State University
Diabetes Mellitus, Type 2, Hypertension
Motivational Interviewing (MI) Intervention to Improve Adherence
The purpose of this study is to examine the effectiveness of a telephone motivational interviewing intervention by pharmacy students in enhancing adherence to angiotensin converting enzyme inhibitors (ACEI)/ angiotensin receptor…
- Trial name
- MI (NCT03985098)
- Testing
- Motivational interviewing intervention arm
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Houston
Smokers
Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers
Little is known about the support needed to improve compliance with Chantix for smoking cessation. This is a two arm pilot study of African American smokers to provide varying levels of side effect management and compliance…
- Trial name
- NCT00781599
- Testing
- Chantix, Adherence Counseling, Standard Counseling
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Nikki Nollen, PhD, MA
Hypertension
Digital Health for Medication Adherence Among African Americans With Hypertension
The proposed Phase 1 project aims to develop and test Memento.HTN, an individually-tailored, culturally sensitive digital health intervention comprised of a provider platform and linked patient SMS (short message service) text…
- Trial name
- NCT05009004
- Testing
- text messages to support medication adherence
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Environment and Health Group, Inc.
Acne Vulgaris
Effect of Samples on Acne Treatment With Epiduo® Gel
The purpose of this study is to compare adherence to treatment and efficacy with Epiduo® Gel in patients with mild to moderate acne who receive a medication sample and instructions on proper application with their stock size…
- Trial name
- NCT01504204
- Testing
- Adapalene + benzoyl peroxide samples, Adapalene + benzoyl peroxide from standard tube
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wake Forest University
Obstructive Sleep Apnea
Mechanisms of Upper Airway Obstruction
The current study is designed to examine underlying mechanisms of action of lingual muscles in the maintenance of airway patency during sleep.
- Trial name
- DISE-CAD (NCT04322097)
- Testing
- Hypoglossal Nerve Stimulation
- Where
- United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Aging, Medication Adherence
Improving Hypertension Medication Adherence for Older Adults
This randomized controlled trial will assess the efficacy and scalability of a blood pressure technology system intervention. The investigators will enroll 224 older adults with hypertension to identify those who are nonadherent…
- Conditions
- Aging, Medication Adherence, Hypertension
- Trial name
- NCT05610059
- Testing
- Blood Pressure Technology System M, Blood Pressure Technology System E
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Arizona
Asthma
The Study is Enrolling Kids From 8 to 17 Years Old. The BreathSmart Device Attaches to the Inhaler to Measure Adherence.
Non-adherence to controller medication is a common problem in children with Asthma, resulting in overuse of reliever medication, increased asthma symptoms, more frequent Asthma attacks, and increased emergency room visits and…
- Trial name
- NCT03734861
- Testing
- BreatheSmart System, Standard of Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Connecticut Children's Medical Center
Smoking, Smoking Cessation
Evaluation of Treatments to Improve Smoking Cessation Medication Adherence
Many smokers fail to take their smoking cessation medication as recommended. This research is designed to identify treatments that improve the use of cessation medications and to determine whether an increase in medication use…
- Conditions
- Smoking, Smoking Cessation, Adherence, Nicotine Dependence
- Trial name
- Adherence (NCT01120704)
- Testing
- Short Term Combination Nicotine Replacement Therapy (patch + gum), Long Term Combination Nicotine Replacement Therapy (patch + gum), Intensive Maintenance Counseling
- Where
- United States
- Volunteers
- 544 people
- Sponsor
- University of Wisconsin, Madison
Kidney Transplant Recipients
Envarsus XR Compared to Immediate Release Tacrolimus
The purpose of this study is to compare once-daily tacrolimus extended-release (Envarsus XR®) to twice-daily immediate release tacrolimus to find out if people taking tacrolimus extended release (Envarsus XR®) report fewer side…
- Trial name
- SIMPLE (NCT03979365)
- Testing
- Envarsus XR, Tacrolimus twice daily
- Where
- 3 sites in United States
- Volunteers
- 261 people
- Sponsor
- Mayo Clinic
Schizophrenia, Schizoaffective Disorder
Development of a Mobile System for Self-management of Schizophrenia (SOS)
This 2-arm clinical trial piloted a mobile Self-Management of Schizophrenia (SOS) system that administers interventions targeting persistent symptoms of psychosis, social dysfunction, and medication adherence.
- Trial name
- NCT01969500
- Testing
- Mobile Application, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Uncontrolled Asthma, Young Adults
Medication Adherence With Telehealthcare Medication Therapy Management
Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an…
- Trial name
- MATCH (NCT03978936)
- Testing
- Medication Therapy Management (MTM) Video Telehealthcare, Electronic Adherence Self-Management (EAM)
- Where
- 21 sites in United States
- Volunteers
- 375 people
- Sponsor
- Johns Hopkins University
Medication Adherence, Medication Compliance
Connected Healthcare for Individuals Living at Home With Chronic Conditions
Managing and taking medications as prescribed can be a difficult task. This is especially true for older adults living at home with chronic conditions while managing multiple prescribed medications.
- Conditions
- Medication Adherence, Medication Compliance, Medication Nonadherence, Hypertension
- Trial name
- NCT04339296
- Testing
- Spencer
- Where
- Canada
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Alberta Health Services, Calgary
HIV, Medication Adherence
SteadyRx: Smartphone ART Adherence Intervention for Drug Users
Antiretroviral therapy (ART) increases life expectancy and quality of life for individuals infected with HIV, and can reduce the chance of HIV transmission, but a high degree of adherence to ART is required to achieve these…
- Trial name
- NCT02317614
- Testing
- SteadyRx
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
HIV Infections
Improving Treatment and Retention Adherence in Nontraditional Settings
This is a hybrid implementation-effectiveness study using both qualitative and quantitative methods. The research aims to examine whether providing a new, but approved, HIV once a month injection treatment…
- Trial name
- I-TRAINS (NCT04973254)
- Testing
- CAB-RPV LA, Standard treatment within an HIV clinic
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Boston Medical Center
Heart Failure
Values-Affirmation Intervention Targeting Medication Adherence in Older Adults With Heart Failure
Heart failure (HF) represents a significant public health concern. Medication non-adherence represents a modifiable contributor to costly hospital readmissions in older adults with HF.
- Trial name
- NCT05310877
- Testing
- Values-Affirmation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- The Miriam Hospital
Childhood Asthma
Asthma Link: A Real World Application of School Supervised Asthma Therapy
The goal of this study is to assess the feasibility of a clinical trial to evaluate the impact and process of deploying school-supervised asthma therapy in a real-world setting for children with poorly controlled asthma (aged…
- Trial name
- NCT04942379
- Testing
- Asthma Link, Enhanced Usual Care
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Massachusetts, Worcester