Clinical trials: Medically Intractable Epilepsy
Epilepsy
P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
In up to 1 out of 3 patients with epilepsy, seizures continue to occur despite the use of one or more antiepileptic medications.
- Trial name
- NCT00524134
- Testing
- Carvedilol-CR
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Columbia University
Epilepsy
Non-Invasive Seizure Localization in Patients With Medically Refractory Localization Related Epilepsy: Synchronized MEG-EEG Recordings
This study will evaluate the magnetoencephalography (MEG) alone and together with electroencephalography (EEG) in non-invasive presurgical evaluation.
- Trial name
- NCT00071305
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Refractory Epilepsy, Deep Brain Stimulation
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection.
- Trial name
- NCT05493722
- Testing
- Physician-Selected Settings Stimulation, Optimized Settings Stimulation, DBS Setting Optimization
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Focal Epilepsy, Temporal Lobe Epilepsy
Spatial Scene Recognition Memory in Epilepsy Surgery
This study investigates the anatomical and physiological basis of spatial scene recognition memory in patients with temporal lobe epilepsy and temporal lobe lesions.
- Conditions
- Focal Epilepsy, Temporal Lobe Epilepsy, Medically Refractory Epilepsy, Memory Disorders
- Trial name
- NCT07580183
- Testing
- Virtual Tour Recognition Memory Task, Intracranial EEG Recording with Research Electrodes (Aim III only), MRI Neuroimaging and Neuropsychological Assessment (Aim I)
- Where
- 2 sites in United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Refractory Epilepsy
Evaluation of Onfi Conversion Therapy Replacing Clonazepam in Patients With Medically Refractory Epilepsy
The purpose of the study is to examine the clinical safety, tolerability, and efficacy of clobazam (Onfi) when it replaces the pre-existing clonazepam therapy in patients with refractory epilepsy.
- Trial name
- NCT01932502
- Testing
- clobazam (Onfi), Initial conversion and titration, Conversion schedule - Week 1
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Epilepsy
Cannabinoid Therapy for Pediatric Epilepsy
This is a Phase 1 trial to determine the tolerability and optimal dose of CBD rich cannabis extract as an adjunct treatment in children with severe drug resistant epilepsy due to Dravet Syndrome.
- Trial name
- NCT02983695
- Testing
- TIL-TC150
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Epilepsy, Lennox Gastaut Syndrome
RNS System LGS Feasibility Study
To generate preliminary safety and effectiveness data for brain-responsive neurostimulation of thalamocortical networks as an adjunctive therapy in reducing the frequency of generalized seizures in individuals 12 years of age or…
- Conditions
- Epilepsy, Lennox Gastaut Syndrome, Lennox-Gastaut Syndrome, Intractable, Seizures
- Trial name
- NCT05339126
- Testing
- RNS System
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- NeuroPace
Epilepsy, Seizure
Medium Chain Triglycerides as an Adjunct to the Modified Atkins Diet for Women With Catamenial Epilepsy
The modified Atkins diet (MAD) has been shown to be effective in treating intractable epilepsy. Approximately 55% of the patients started on the diet are women of childbearing age and women with epilepsy often have a pattern of…
- Conditions
- Epilepsy, Seizure, Catamenial Epilepsy, Medically Resistant Epilepsy
- Trial name
- NCT02426047
- Testing
- betaquik®
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Johns Hopkins University
Epilepsy
Controlled Randomized Vagus Nerve Stimulation (VNS) Therapy Versus Resection (CoRaVNStiR)
Background: There are a variety of treatment options for medically refractory medial temporal lobe epilepsy. Evidence from randomized trials indicates vagus nerve stimulation therapy can be used as a proven therapy for medically…
- Trial name
- CoRaVNStiR (NCT02089243)
- Testing
- Vagus nerve stimulation therapy, Resective surgery
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Epilepsy, Status Epilepticus
Repeated TMS at Low Frequencies to Reduce Seizure Occurrence
Perform non-invasive neuro-navigated repeated Transcranial Magnetic Stimulation (rTMS) at low frequencies (LF) with the intent to reduce the occurrence of seizures over time (long-term protocol).
- Conditions
- Epilepsy, Status Epilepticus, Epilepsia Partialis Continua, Epilepsia Partialis Continua, Refractory (Medically)
- Trial name
- NCT03154307
- Testing
- Low frequency repeated TMS (LF-rTMS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Baptist Health South Florida
Epilepsy, Idiopathic Generalized Epilepsy
RNS System NAUTILUS Study
To demonstrate that the RNS System for thalamic stimulation is safe and effective as an adjunctive therapy for the reduction of primary generalized seizures in individuals 12 years of age or older who have drug-resistant…
- Conditions
- Epilepsy, Idiopathic Generalized Epilepsy, Generalized Tonic Clonic Seizure
- Trial name
- NAUTILUS (NCT05147571)
- Testing
- Responsive stimulation
- Where
- 23 sites in United States
- Volunteers
- 100 people
- Sponsor
- NeuroPace
Epilepsy
Pilot Study to Evaluate MR-guided Laser Ablation of Focal Lesions in Patients With Medically Refractory Partial Epilepsy
To investigate whether MR-guided laser induced thermal therapy in patients diagnosed with focal lesional epilepsy using the Visualase Thermal Therapy System is both a feasible and safe minimally invasive technique for control of…
- Trial name
- NCT01703143
- Testing
- Laser ablation
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Mayo Clinic
Status Epilepticus, Seizure
Ketogenic Diet for Refractory Status Epilepticus
This research is being done to observe the safety, tolerability, side effects, and effectiveness of the ketogenic diet in people with continuous seizures (status epilepticus) being treated in a neurointensive care unit.
- Conditions
- Status Epilepticus, Seizure, Epilepsy, Refractory Status Epilepticus
- Trial name
- NCT01796574
- Testing
- Ketogenic diet
- Where
- 9 sites in United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Epilepsy, Seizure
Modified Atkins Diet Plus KetoCal for Adult Epilepsy
The modified Atkins diet (MAD) has been shown to be effective in treating children and adults with medically resistant seizures.
- Conditions
- Epilepsy, Seizure, Medically Resistant Epilepsy, Medically Resistant Seizures
- Trial name
- NCT01834482
- Testing
- Modified Atkins diet, KetoCal
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Cognition, Medically Intractable Epilepsy
Electrochemical and Electrophysiological Study
This study will utilize computerized algorithms in combination with real-time intracranial neurophysiological and neurochemical recordings and microstimulation to measure cognitive and affective behavior in humans.
- Trial name
- NCT05273970
- Testing
- Behavioral testing under intracranial monitoring
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Epilepsy
Brain Infusion of Muscimol to Treat Epilepsy
This study will examine the safety and effectiveness of infusing a chemical called muscimol into the brain to control seizures in patients with intractable epilepsy (frequent seizures that persist despite therapy).
- Trial name
- NCT00005925
- Testing
- Muscimol
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Sturge-Weber Syndrome
Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome
The purpose of this study is to determine the tolerability and optimal dose of cannabidiol (CBD) as an simultaneous treatment in children and young adults with Sturge-Weber syndrome (SWS) and drug resistant epilepsy.
- Trial name
- NCT02332655
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Anne Comi, MD
Medically Intractable Epilepsy
Personalizing Health Outcome in Epilepsy Now - An Introduction to Clinical Services
The assumption of the unpredictability of seizures may have an enormous impact on the perception of self-efficacy and may contribute more to a patient's poor quality-of-life than the actual seizures.
- Trial name
- PHOENICS (NCT01533649)
- Testing
- Andrews/Reiter approach to epilepsy, Relaxation/Meditation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Epilepsy
Efficacy of Omega-3 as Adjunctive Therapy for Medically Intractable Epilepsy: A Prospective Open-label Pilot Study
The purpose of this study is to determine whether omega-3 is effective in the treatment of medically intractable epilepsy as adjunctive therapy.
- Trial name
- NCT02899741
- Testing
- Omega-3
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Epilepsy
Clinical Trial of Light Therapy for Epilepsy
This study is designed to investigate whether light therapy may be an effective treatment for some people with epilepsy. Light treatment is already an established treatment for depression.
- Trial name
- NCT01028456
- Testing
- Light Therapy, 100 lux
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London