Clinical trials: Mediastinitis
Infective Endocarditis, Infection Related to Ventricular Assist Device
Retrospective Analysis of Nephrotoxicity During Daptomycin Versus Vancomycin Treatments in High Risk Patients
Acute kidney injury (AKI) is a frequent complication that occurs in 15 to 25% of patients after vascular surgery, and up to 40% of patients after cardiac surgery.
- Conditions
- Infective Endocarditis, Infection Related to Ventricular Assist Device, Infection Related to Vascular Prothesis, Surgical Site Infection
- Trial name
- DVN (NCT03961503)
- Testing
- Daptomycin (DAP) treatment, Vancomycin (VAN) treatment
- Where
- France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Sternal Wound Infection, Mediastinitis
Rapid Sternal Closure System (TALON)
The primary objective is to establish if the Rapid Sternal Closure System (RSCS) improves early postoperative recovery as manifested by decreased pain and improved pulmonary function.
- Trial name
- TALON (NCT00638014)
- Testing
- Rapid Sternal Closure System, Conventional wire closure
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Duke University
Mediastinitis, Coronary Artery Disease
Physiotherapy Exercises in Patients With Sternal Instability After Cardiovascular Surgery
Sternal instability caused by mediastinitis is one of the most feared complications for cardiac surgery team for generating large commitments and functional damages to patients.
- Conditions
- Mediastinitis, Coronary Artery Disease, Cardiovascular Infections
- Trial name
- NCT02513576
- Testing
- physiotherapy exercises
- Volunteers
- 30 people
- Sponsor
- Emilia Nozawa, PT PhD
Cardiovascular Disease, Surgical Site Infection
Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Cardiovascular Disease, Surgical Site Infection, Superficial Sternal Wound Infection, Mediastinitis
- Trial name
- NCT07507409
- Testing
- Knotless Barbed Sutures, Mesh-based Topical Skin Adhesive
- Volunteers
- 401 people
- Sponsor
- Unity Health Toronto
Children in Cardiac Intensive Care Requiring Surgery for Congenital Heart Disease
Antibiotics Distribution Study in Peripheral Compartments: Contribution of Microdialysis
Postoperative mediastinitis is an important cause of postoperative morbidity in children. The main objective of this study is to describe the distribution of cefazolin, using as surgical antibiotic prophylaxis, in the mediastinal…
- Trial name
- Antimidis (NCT07327502)
- Testing
- Microdialysis probe placement, Microdialysis and Plasma samples
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiac Valve Replacement Complication
Short Term Effect of Vitamin D Supplementation on the Clinical Outcomes in Patients Undergoing Valve Replacement Surgery
This study evaluates the effect of Vitamin D supplementation on ICU and hospital LOS in patients undergoing valve replacement surgery.
- Trial name
- NCT04085770
- Testing
- Alfacalcidol 1 MCG Oral Capsule
- Where
- Egypt
- Volunteers
- 86 people
- Sponsor
- Cairo University
Sternal Wound Infection, Sternal Non-union
Evaluation of Primary Plating in Sternotomy Patients for Osteosynthesis and Pain
The goal of this study is to evaluate sternal osteosynthesis, chest wall pain and return to normal activity in open heart surgery patients who had their breast bone closed either with wires or plates.
- Conditions
- Sternal Wound Infection, Sternal Non-union, Pain, Mediastinitis
- Trial name
- RESTORE (NCT00819286)
- Testing
- SternaLock Rigid Fixation Plates, wire (control)
- Where
- 6 sites in United States, Germany
- Volunteers
- 140 people
- Sponsor
- Zimmer Biomet
Mediastinitis
Delayed Primary Versus Late Secondary Wound Closure in Sternum Infections
Sternal osteomyelitis and poststernotomy mediastinitis is a severe and life-treating complication after the cardiac surgery. The incidence of sternal osteomyelitis ranges from 1% to 3% with a high mortality rate from 19% to 29% .
- Trial name
- NCT01473979
- Testing
- Surgical closure of the poststernotomy wound infection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Lausanne Hospitals
Soft Tissue Infections, Mediastinitis
Delafloxacin Plasma and Tissue Concentration in Patients With Skin, Soft Tissue, and Bone and Joint Infections.
The goal of this observational study is to measure how well the antibiotic delafloxacin penetrates into the blood and various body tissues in adult patients over 18 years old.
- Conditions
- Soft Tissue Infections, Mediastinitis, Osteomyelitis/Septic Arthritis, Prosthetic Joint Infection
- Trial name
- DELA-PLAT (NCT07426471)
- Testing
- delafloxacin
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele
Mediastinitis, Esophageal Neoplasms
Endoscopic-vacuum Assisted Closure of Intrathoracic Postsurgical Leaks
The purpose of this study is to determine the short and long term outcome of endoscopic vacuum assisted closure of intrathoracic postsurgical leaks.
- Conditions
- Mediastinitis, Esophageal Neoplasms, Anastomotic Leakage
- Trial name
- EVACoIL (NCT00876551)
- Testing
- Endoscopic vacuum assisted closure
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Hannover Medical School
Staphylococcus Aureus, Bacteremia
Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2)
This study will assess the efficacy of a single dose of V710 vaccine to prevent serious Staphylococcus aureus infections following elective cardiothoracic surgery.
- Conditions
- Staphylococcus Aureus, Bacteremia, Mediastinitis
- Trial name
- NCT00518687
- Testing
- V710
- Volunteers
- 8,031 people
- Sponsor
- Merck Sharp & Dohme LLC
Mediastinitis
Combined Air-plasma Flow and Nitric Oxide Therapy in Cardiac Surgery
In cardiovascular surgery, the most common and serious complication is postoperative wound infection. The most formidable wound complication is mediastinitis, the frequency of which varies from 1 to 3%.
- Trial name
- NCT04617353
- Testing
- NO-based treatment of sterno-mediastinitis, Treatment of sterno-mediastinitis
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Surgical Site Infection (SSI), Mediastinitis
Use of Platelet-Rich Plasma to Reduce Sternal Wound Complications After CABG With Median Sternotomy
The goal of this clinical trial is to learn whether applying autologous platelet-rich plasma (PRP) to the sternal wound during heart surgery improves wound healing and reduces complications after surgery.
- Conditions
- Surgical Site Infection (SSI), Mediastinitis, Delayed Wound Healing
- Trial name
- NCT07352020
- Testing
- Autologous Platelet-Rich Plasma (PRP) Application, Standard Sternal Wound Closure
- Where
- Pakistan
- Volunteers
- 98 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Mediastinitis
Infectious Mediastinitis Among the Strasbourg Universitary Hospital
Mediastinitis are rare but serious infections, with mortality rates varying from 6 to 30% according to the literature. They are essentially linked to surgical management (cardio-thoracic in particular), but some forms can be…
- Trial name
- MEDIASTINITIS (NCT05001308)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Fibrosing Mediastinitis, Pulmonary Hypertension
Study on the Treatment of Nonthrombotic Obstructive Pulmonary Hypertension
Through a randomized controlled trial (RCT) design, this study aiming to evaluated the efficacy and safety of rituximab lymph node injection combined with pulmonary vascular interventional therapy in treating fibrosing…
- Trial name
- ACCT-NOPH (NCT06980584)
- Testing
- Rituximab Lymph Node Injection Combined with Pulmonary Vascular Intervention, Pulmonary Vascular Interventional Therapy
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Chao Yang Hospital
Deep Sternal Infection, Diabete Mellitus
The Role of Inflammatory Biomarkers in Preventing Deep Sternal Wound Infections After Sternotomy
The goal of this observational study is to reveal blood biomarkers that will have prognostic significance in terms of the development of deep wound infection following sternotomy.
- Conditions
- Deep Sternal Infection, Diabete Mellitus, Mediastinitis
- Trial name
- NCT07376070
- Where
- 2 sites in Georgia
- Volunteers
- 30 people
- Sponsor
- Levan Nebieridze
Cardiovascular Disease, Healthcare Associated Infectious Disease
Optimizing Prevention of Healthcare-Acquired Infections After Cardiac Surgery (HAI)_2
The investigators will conduct qualitative interviews of hospital personnel regarding HAI prevention practices, and use coded data from these interviews to assist in developing standardized practices.
- Conditions
- Cardiovascular Disease, Healthcare Associated Infectious Disease, Sternal Superficial Wound Infection, Deep Sternal Infection
- Trial name
- NCT02073760
- Testing
- There is no intervention. The investigators are interviewing cardiac surgery staff with knowledge of infection prevention.
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Mediastinitis
Post-Surgical Mediastinitis Within the CHU Brugmann Hospital
Mediastinitis is an infectious complication that can occur after cardiac surgery. The incidence varies between 1 and 3% depending on the type of procedure and the patient's condition.
- Trial name
- NCT03922191
- Testing
- Data extraction from medical files
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- Pierre Wauthy
Surgery, Cardiac, Infection
Mediastinitis and Staphylococcus Aureus
Cardiac surgery with extracorporeal circulation (ECC) yields a deep immune system dysfunction that exposes patients to postoperative infectious complications.
- Trial name
- MEDIASTAPH (NCT03262558)
- Testing
- No intervention
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Rennes University Hospital
Coronary Artery Disease
Topical Vancomycin in Prevention of Methicillin-Resistant Staphylococcal Related Mediastinitis in Patients Receiving Coronary Artery Bypass Graft
Sternal or mediastinal infections after heart operation occurs infrequently but carries a high cost in money, morbidity, and mortality.
- Trial name
- NCT00711685
- Testing
- coronary artery bypass grafting via midline sternotomy
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Far Eastern Memorial Hospital