Clinical trials: Mechanical Ventilation Pressure High
Ventilatory Failure, Cardiac Failure
Non-invasive Monitoring of Mixed Venous Oxygen Saturation Using the Capnodynamic Method in Adults
The objective of this study is to compare the accuracy and correlation of the capnodynamic method for measuring mixed venous oxygen saturation (SvO2) with the standard reference method (pulmonary artery catheter), with the…
- Conditions
- Ventilatory Failure, Cardiac Failure, Mechanical Ventilation Pressure High
- Trial name
- CAPNO-SVO2 (NCT06632197)
- Volunteers
- 25 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
COVID-19, Mechanical Ventilation Pressure High
Different PEEP Settings of COVID-19 Induced ARDS
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March…
- Conditions
- COVID-19, Mechanical Ventilation Pressure High, Acute Respiratory Distress Syndrome
- Trial name
- NCT04359251
- Testing
- Gas exchanges at different PEEP, lung mechanics at different PEEP, Hemodynamics changes at different PEEP
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China
Tricuspid Regurgitation, Mechanical Ventilation Pressure High
Effect of PEEP on TRJV in Mechanically Intubated Pediatric Patients
Prospective observational cohort study within the Pediatric Intensive Care Unit (PICU). We will perform point-of-care-ultrasound (POCUS) to quantify tricuspid regurgitant jet velocity (TRJV) on mechanically ventilated (MV)…
- Conditions
- Tricuspid Regurgitation, Mechanical Ventilation Pressure High, Pediatric Respiratory Diseases
- Trial name
- NCT06229886
- Testing
- Application of positive-end-expiratory pressure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwell Health
ARDS, Human, Mechanical Ventilation Pressure High
Lung Protection in ARDS Using Neurally Adjusted Ventilatory Assist
The aim of this study is to investigate the use neurally adjusted ventilatory assist (NAVA) as lung protective strategy in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- NAVA (NCT03868982)
- Testing
- Neurally adjusted ventilatory assist
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Fu Jen Catholic University
Ards, Mechanical Ventilation Pressure High
Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.
Mortality of patients with COVID-19 associated acute respiratory distress syndrome (CARDS) treated with veno-venous extra-corporal membrane oxygenation (vv-ECMO) is increasing over time since the beginning of the COVID-19…
- Conditions
- Ards, Mechanical Ventilation Pressure High, Extracorporeal Membrane Oxygenation
- Trial name
- COMPLIECMO (NCT05341687)
- Testing
- No applicable
- Where
- France
- Volunteers
- 122 people
- Sponsor
- Central Hospital, Nancy, France
Lymphatic Insufficiency
Lymphatic Function During Mechanical Ventilation
This study wil examine the effect of altered intrathoracic pressure on lymphatic function, by investigating the lymphatic vessels in the lower limb during mechanical ventilation.
- Trial name
- LYMPH-UP (NCT05770752)
- Testing
- Elevated pressure ventilation
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Mechanical Ventilation Pressure High
Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation
This is a prospective randomized cross over study of healthy volunteers undergoing continuous positive airway pressure ventilation via a noninvasive ventilation (NIV) mask with and without the addition of nasal cannulas.
- Trial name
- NCT02743936
- Testing
- Nasal cannula, Non-invasive positive pressure ventilation
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
ARDS, COVID-19
Paradoxical Response to Chest Wall Loading in Mechanically Ventilated Patients
The purposes of our study are to: 1) determine the incidence of paradoxical response to chest wall loading in mechanically ventilated patients; 2) identify sub-populations in which it is most likely to occur (e.g., severe ARDS)…
- Conditions
- ARDS, COVID-19, Mechanical Ventilation Pressure High, Ventilator-Induced Lung Injury
- Trial name
- NCT06093958
- Testing
- Manual loading of the chest wall
- Where
- United States
- Sponsor
- HealthPartners Institute
Chronic Obstructive Pulmonary Disease
Closed Loop Ventilation With High Tidal Volumes and Safe Transpulmonary Pressure in COPD (COPD-SAFE)
This study evaluates the safety and efficacy of high tidal volumes generated by "Adapted Support Ventilation (ASV) mode' in mechanically ventilated severe COPD patients.
- Trial name
- COPD-SAFE (NCT04089111)
- Testing
- Minute volume target of 100%, Minute volume target to reach PaCO2 less than 45% (high tidal volume)
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Acute Respiratory Distress Syndrome
The EVLW for Set the Positive End Expiratory Pressure (PEEP) in the Acute Respiratory Distress Syndrome (ARDS)
ARDS is a severe pathology with high mortality and morbidity.Actual ventilatory management is clear for the set of the tidal volume and for the survey of the plateau pressure for the patients who require mechanical ventilation.
- Trial name
- NCT00714987
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Mechanical Ventilation Complication, Acute Respiratory Failure
Non-invasive Respiratory Monitoring During SBT
Spontaneous breathing trials (SBTs) assess readiness for extubation, yet the use of conventional parameters used to establish weaning success may be elusive, especially in high-risk patients.
- Conditions
- Mechanical Ventilation Complication, Acute Respiratory Failure, Re-intubation Rate
- Trial name
- NCT05295186
- Where
- 2 sites in Italy
- Volunteers
- 238 people
- Sponsor
- University of Bari
De Novo Hypoxemic Acute Respiratory Failure (hARF)
Impact on Mortality of a Strategy Including Continuous Positive Airway Pressure Plus High Flow Nasal Cannula Oxygen Therapy Versus High Flow Nasal Cannula Oxygen Therapy Alone in Patients With de Novo Acute Hypoxemic Respiratory Failure: a Prospective, Randomized Controlled Trial.
De novo hypoxemic acute respiratory failure (hARF) is one of the main causes of intensive care unit (ICU) admission. In de novo hARF, intubation is associated with a dramatic increase in mortality rate.
- Trial name
- HighCPAP (NCT06213168)
- Testing
- HFNC, CPAP and HFNC
- Where
- 29 sites in France
- Volunteers
- 1,084 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mechanical Ventilation Pressure High
Effect of Airseal System Valve-less Trocar on the Ventilatory Parameters During Robotic-assisted Radical Cystectomy
The aim of the investigators' study is to investigate if the use of the AirSeal insufflation system impairs ventilatory parameters of patients less than a conventional system in patients undergoing robot-assisted laparoscopic…
- Trial name
- NCT02506270
- Testing
- Airseal Trocar, conventional trocar
- Where
- Italy
- Volunteers
- 56 people
- Sponsor
- Regina Elena Cancer Institute
Weaning From Mechanical Ventilation, Extubation
T-piece Versus Pressure-support for the Spontaneous Breathing Trial
The main objective will be to compare the number of ventilator-free days within the 28 days following the first spontaneous breathing trial between strategies of extubation performing spontaneous breathing trials with T-piece…
- Trial name
- TiP-Ex (NCT04227639)
- Testing
- T-piece trial, Pressure-support trial
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Poitiers University Hospital
Caregiver, Mindfulness
Resourcefulness Training and Decentering on Self-Management in Caregivers of Technology Dependent Children
The investigators will conduct a randomized clinical trial pilot study to examine the effectiveness of a theoretically based intervention (called ReMind) encompassing two key components: (a) Resourcefulness Training for parent…
- Conditions
- Caregiver, Mindfulness, Mechanical Ventilation Pressure High, Gastrostomy
- Trial name
- NCT02993887
- Testing
- Resourcefulness Training, Mindfulness
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Type II Respiratory Failure, Hypercapnic Respiratory Failure
Post-Extubation High-Flow Nasal Cannula Versus Non-Invasive Ventilation in Type II Respiratory Failure
Acute hypercapnic respiratory failure is characterized by elevated arterial carbon dioxide levels and commonly occurs in patients with chronic respiratory diseases.
- Trial name
- NCT06918288
- Testing
- High-Flow Nasal Cannula (HFNC), Non-Invasive Ventilation (NIV)
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University
Coronavirus Disease 2019, ARDS
Prone Positioning in COVID-19 Patients
Prone positioning improves oxygenation in patients with ARDS (1-3). Patients with severe ARDS due to COVID-19 are candidates for prone position. It should be started within 36-48 h and maintained 1, 3).
- Conditions
- Coronavirus Disease 2019, ARDS, Mechanical Ventilation Pressure High
- Trial name
- NCT05150847
- Testing
- Oxygenation
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Tepecik Training and Research Hospital
Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP)
Dynamic Airway Resistance & ML: Guide Sputum Suction in Ventilated Patients
Research has shown that timely suctioning not only improves survival rates but also enhances the quality of life in ventilator-dependent patients.
- Conditions
- Mechanical Ventilation Pressure High, Ventilator-Associated Pneumonia (VAP), Respiratory Depression Neonatal
- Trial name
- NCT07375667
- Testing
- The dynamics of airway resistance, conventional suctioning
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Affiliated Hospital of Nantong University
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 6 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Mechanical Ventilation Pressure High
Recruitment Maneuver in General Anesthesia for Laparoscopic Cholecystectomy
This is a prospective non-randomized clinical trial evaluating the effect of the recruitment maneuver on static compliance in patients undergoing general anesthesia for laparoscopic cholecystectomy
- Trial name
- NCT06256029
- Testing
- Recruitment maneuver
- Where
- Serbia
- Volunteers
- 100 people
- Sponsor
- University of Novi Sad