Clinical trials: Maternal Morbidity
Obstetrical Complications, Labor and Delivery Complication
Azithromycin Prophylaxis for PRElabor CEsarean DElivery Trial
This is a phase-III multi-center double-blind randomized controlled trial of 8,000 individuals undergoing a scheduled or prelabor cesarean delivery who are randomized to either adjunctive azithromycin prophylaxis or to placebo.
- Conditions
- Obstetrical Complications, Labor and Delivery Complication, Cesarean Delivery
- Trial name
- PRECEDE (NCT06605118)
- Testing
- Azithromycin Injection, Standard of Care Preoperative antibiotics
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Severe Maternal Morbidity, Maternal Death
The Effects of Medicaid Policy Interventions on Severe Maternal Morbidity
The goal of this study is to learn about the effects of Medicaid policy interventions on severe maternal morbidity (SMM) and mortality and maternal health. The main questions it aims to answer are: 1.
- Trial name
- NCT05678699
- Testing
- Medicaid healthcare quality interventions (incentive payment and obstetric bundled payment), Doula, Standard Care
- Where
- United States
- Volunteers
- 10,000,000 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Postpartum Hemorrhage
Oral Misoprostol Versus Intravenous Oxytocin in Preventing Blood Loss After Non-scheduled Cesarean Section
Postpartum hemorrhage (PPH) ranks among the leading causes of maternal morbidity and mortality, both in developed and developing countries.
- Trial name
- NCT00107874
- Testing
- misoprostol
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- University Hospital, Basel, Switzerland
Hypovolemic Shock, Hemorrhage
Non-Pneumatic Anti-Shock Garment for Obstetrical Hemorrhage: Zambia and Zimbabwe
This trial will address the question of whether early application of the Non-pneumatic Anti-Shock Garment (NASG) at the Satellite Health Facility (SHF) level before transport to a Referral Hospital (RH) will decrease maternal…
- Trial name
- NASG (NCT00488462)
- Testing
- non-pneumatic anti-shock garment
- Where
- 5 sites in Zambia, Zimbabwe
- Volunteers
- 887 people
- Sponsor
- University of California, San Francisco
Children Born After Assisted Reproductive Technologies, Health Status
Health Status of Children Born After Assisted Reproductive Technologies
The goal of this observational study is to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy, and to identify the connection with the health status of mothers…
- Conditions
- Children Born After Assisted Reproductive Technologies, Health Status, Child Development
- Trial name
- NCT06094998
- Testing
- hemogram examination
- Where
- Kazakhstan
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Kazakhstan's Medical University "KSPH"
Covid19, Breastfeeding, Exclusive
Exclusive Breastfeeding in Infants of Mothers Infected With Novel Coronavirus
COVID-19 pandemic emerges an issue for breastfeeding.Earlier in pandemic mothers who had COVID-19 were separated from their babies due to insufficient data but this approach was abandoned due to the lack of transmission via…
- Conditions
- Covid19, Breastfeeding, Exclusive, Newborn Morbidity
- Trial name
- NCT04925908
- Testing
- RT-PCR for SARS-Cov-2
- Where
- Turkey (Türkiye)
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Maternal Health, Infant Health
Using Advanced Data Systems to Improve Health in Early Life in Rural Nepal
The goal of this cluster randomized controlled trial is to study the effect of a mobile-phone based application used by pregnant women on maternal and newborn health indicators.
- Conditions
- Maternal Health, Infant Health, Institutional Delivery, Birth Preparedness and Complication Readiness
- Trial name
- CITH (NCT05697822)
- Testing
- Mobile Phone and Cloud-based Electronic Contact and Recording System
- Where
- Nepal
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Amit Arjyal
Maternal Heart Rate
Quantitative Assessment of Signal Loss in Cardiotocography Using External Recording
Signal loss in cardiotocography (CTG) recordings is numerous and frequent, whether due to artifacts in signal acquisition or confusion over inadvertent maternal heart rate recording, with various negative consequences for…
- Trial name
- RCFLoS (NCT06906744)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Postpartum Hemorrhage, Anemia
Misoprostol for the Prevention of Postpartum Hemorrhage in Rural Pakistan
This community-based trial will study misoprostol for the prevention of postpartum hemorrhage in rural Pakistan. Traditional birth attendants assisting home deliveries will administer study tablets (600 mcg oral misoprostol or…
- Trial name
- NCT00120237
- Testing
- Misoprostol
- Where
- Pakistan
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Maternal Death, Maternal Morbidity
BetterBirth: A Trial of the WHO Safe Childbirth Checklist Program
The purpose of this study is to measure the impact of a checklist-based childbirth safety program (the WHO Safe Childbirth Checklist Program) on reduction of severe maternal, fetal, and newborn harm in institutional deliveries in…
- Conditions
- Maternal Death, Maternal Morbidity, Stillbirth, Neonatal Death
- Trial name
- BetterBirth (NCT02148952)
- Testing
- WHO Safe Childbirth Checklist Program
- Where
- India
- Volunteers
- 157,689 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
covid19 Infection, Pregnancy Complications
Covid-19 in Pregnancy: a French Population-based Cohort of Women and Newborns
The purpose of this study is to characterize the incidence and clinical features of the maternal COVID 19 infection, as well as the associated morbidity of the mother and the child, in the French context
- Conditions
- covid19 Infection, Pregnancy Complications, Neonatal Complications
- Trial name
- Coropreg (NCT04463758)
- Testing
- An auto-questionnaire comprising three psychometric scales
- Where
- France
- Volunteers
- 6,015 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Decrease Maternal Morbidity
Transverse B-Lynch in Management of Placenta Accreta
Placenta accreta is considered a severe pregnancy complication that may be associated with massive and potentially life-threatening intrapartum and postpartum hemorrhage.
- Trial name
- NCT02943421
- Testing
- Transverse B-Lynch suture
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Fetal Growth Retardation, High-Risk Pregnancy
Routine Ultrasound Screening in the Third Trimester
Late intrauterine growth restriction is infrequently diagnosed with an overall sensitivity of 40 % in low-risk pregnancies. In addition, late intrauterine growth restriction may be associated with intrauterine death and poor…
- Trial name
- RECRET (NCT01594463)
- Testing
- ultrasound examination
- Where
- France
- Volunteers
- 3,760 people
- Sponsor
- University Hospital, Rouen
Integrated Community-based Intervention Package, Breastfeeding, Exclusive
An Integrated Community-based Intervention Package in Improving Maternal and Neonatal Health Outcomes
This study aims to improve maternal, neonatal and infant health outcomes through an integrated community-based intervention package in Jimma Zone, Southwest Ethiopia.
- Conditions
- Integrated Community-based Intervention Package, Breastfeeding, Exclusive, Morbidity;Newborn, Complementary Feeding
- Trial name
- ICBIP-MNH) (NCT05517577)
- Testing
- Behaviour Change Communication and Male involvement intervention
- Where
- Ethiopia
- Volunteers
- 624 people, healthy volunteers welcome
- Sponsor
- Jimma University
Maternal Mortality Disparities, Maternal Morbidity Disparities
Scaling up Maternal Health Equity Best Practices
This study works with prenatal and postnatal care providers in 12 Michigan counties to scale up best practices for maternal health equity.
- Trial name
- NCT06541951
- Testing
- Services as usual, Scale-up implementation approach
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Pregnancy Complications, Pregnancy, High Risk
Active Pregnancy Against COVID-19
Historically and traditionally, the recommendations related to physical exercise during pregnancy have been based more on moral or cultural issues than on scientific evidence.
- Conditions
- Pregnancy Complications, Pregnancy, High Risk, Pregnancy Induced Hypertension, Newborn Morbidity
- Trial name
- ACPREGCOV (NCT04563065)
- Testing
- Exercise program, Healthy lifestyle advise
- Where
- 2 sites in Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Hypertension in Pregnancy, Obstetrical Complications
Gestational Hypertension and Preeclampsia Blood Pressure (BP) Treatment Goals Less Than 140/90 vs. Less Than 160/110 mmHg: The GOALPOST Trial
This is a phase-III multi-center open-label randomized clinical trial of 4,120 individuals between 23 weeks, 0 days and 35 weeks, 6 days gestation with gestational hypertension or preeclampsia without severe features randomized…
- Trial name
- GOALPOST (NCT07746271)
- Testing
- Anti-hypertensive medication titrated to a BP goal of <140/90 mmHg, Usual Care: Anti-hypertensive medication for BP ≥160/110 mmHg titrated to a goal of < 160/110 mmHg
- Where
- 14 sites in United States
- Volunteers
- 4,120 people, healthy volunteers welcome
- Sponsor
- The George Washington University Biostatistics Center
Macrosomia, Induction of Labour
Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes.
A french study published in 2015 (DAME) showed a decrease of shoulder dystocia and an increase of spontaneous vaginal delivery when the non insulin-treated diabetes patients with large-for-date fetus were induced.
- Conditions
- Macrosomia, Induction of Labour, Non-insulin-dependent Diabetes
- Trial name
- NCT03355040
- Testing
- induction of labour
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Postpartum Hemorrhage, Postpartum Preeclampsia
Postpartum Video Education
This is a prospective, single-center, randomized control study to determine if video education at the time of postpartum discharge improves patient knowledge on the warning signs for the top three causes of severe maternal…
- Conditions
- Postpartum Hemorrhage, Postpartum Preeclampsia, Postpartum Sepsis, Postpartum Depression
- Trial name
- NCT05159726
- Testing
- Video Education
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yale University