Clinical trials: Mammography, active
Breast Cancer
Clinical Effectiveness of CEM in Diagnosis of Additional Findings at Preoperative Breast Magnetic Resonance Imaging
In order to explain the value of adding CESM into the clinical pathway, and also to obtain the relevant clinical data to support future update of clinical guideline, we plan to evaluate the detection rate of CESM for additional…
- Trial name
- COMBO-I (NCT06475066)
- Testing
- contrast-enhanced spectral mammography
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Breast Cancer Screening, Artificial Intelligence (AI)
Screening Mammography: Single Reading by One Radiologist With AI vs. Double Reading by Two Radiologists (AI-BCSQ)
A randomized prospective study comparing the evaluation of mammography images in a breast cancer screening programme by a single radiologist with AI support versus standard double reading by two radiologists without AI support.
- Conditions
- Breast Cancer Screening, Artificial Intelligence (AI), Breast Cancer Screening and Diagnosis
- Trial name
- AI-BCSQ (NCT07075679)
- Testing
- Group with AI iCAD version 3, Group without AI
- Where
- Czechia
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Olomouc
Breast Cancer Female, Breast Cancer
Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania
This is a prospective clinical trial that will examine if contrast-enhanced mammography substantially improves breast cancer detection compared to mammography with tomosynthesis, with minimal increase in false-positives, in women…
- Conditions
- Breast Cancer Female, Breast Cancer, Breast Neoplasms, Neoplasms
- Trial name
- TOCEM (NCT04085510)
- Testing
- Contrast-enhanced mammogram
- Where
- 3 sites in United States
- Volunteers
- 1,647 people, healthy volunteers welcome
- Sponsor
- Wendie Berg
Breast Cancer
Non-inferiority Study of Contrast-enhanced Digital Mammography (CEDM) vs Magnetic Resonance Imaging (MRI) in Terms of Diagnostic Accuracy in Patients Undergoing Preoperative Staging of Established Invasive Breast Cancer
The general objective of the study is to verify the diagnostic accuracy of contrast-enhanced mammography (CEM) compared to breast magnetic resonance imaging in patients undergoing preoperative staging for breast neoformations…
- Trial name
- CEDM-VR (NCT07071272)
- Testing
- breast-MRI and CEM
- Where
- Italy
- Volunteers
- 216 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Mammography
Prospective Case Collection Study for New Mammography Technologies
To evaluate the safety and efficacy of the proposed investigational device and assess its clinical utility in breast cancer screening and diagnosis to support continuing technology development of the investigational technology.
- Trial name
- NCT05199701
- Testing
- Mammography
- Where
- 15 sites in United States
- Volunteers
- 7,500 people, healthy volunteers welcome
- Sponsor
- Hologic, Inc.
Breast Cancer
The C-MERIT Screening Cohort: Contrast-enhanced Mammography for Breast Cancer Screening and Risk Assessment in Women With Dense Breasts
To learn whether a new imaging technology, Contrast-Enhanced Mammography (CEM), compared to standard mammography, can better detect breast cancers in women with dense breasts
- Trial name
- NCT05667532
- Testing
- Contrast Enhanced Mammography
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
The Focus of This Study is to Identify How Different Approaches to Mammography Communication Affect Skepticism Toward Mammography Evidence
Evaluating Mammography Communication Approaches
This is a randomized online experiment testing different methods for communicating about the benefits and harms of breast cancer screening.
- Trial name
- NCT07228234
- Testing
- Harm/benefit language vs. outcomes that can happen, Breast cancer survivability information, No intervention
- Where
- United States
- Volunteers
- 1,900 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Breast Cancer
Added Value of Preoperative Contrast Enhanced Mammography in Staging of Malignant Breast Lesions
Patients diagnosed with breast cancer after routine assessment with digital mammography and ultrasound and scheduled for primary surgery are included in the trial.
- Trial name
- PROCEM (NCT04437602)
- Testing
- Contrast Enhanced Mammography (CEM)
- Where
- 3 sites in Sweden
- Volunteers
- 441 people
- Sponsor
- Region Halland
Breast Cancer
Community-led Navigation to Address Disparities in Mammography Among Native American Women
The goal of this study is to evaluate the effectiveness of an intervention to promote breast cancer screening mammography among women in one community on the Navajo Nation.
- Trial name
- NCT06957535
- Testing
- Navigation, TEAM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Breast Cancer
Individuals on Hormone Therapy Breast Cancer Screening Pilot
This investigation is a prospective breast cancer screening study open to all individuals on hormone therapy. Using a mixed methods approach, the study will 1) gather prospective quantitative breast imaging data in conjunction…
- Trial name
- NCT06383026
- Testing
- Breast Cancer Screening, Survey/Interview, Focus Group
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Breast Cancer Screening, Artificial Intelligence (AI)
A Trial Comparing Screening Mammography With and Without Assistance From Artificial Intelligence for Breast Cancer Detection and Recall Rates in Adult Patients
The goal of this clinical trial is to compare patient-centered outcomes when screening digital breast tomosynthesis (DBT) exams are interpreted with versus without a leading FDA-cleared artificial intelligence (AI)…
- Trial name
- NCT06934239
- Testing
- Artificial intelligence (AI) decision-support tool
- Where
- 6 sites in United States
- Volunteers
- 400,000 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Breast Cancer, Microcalcification
Imaging Quality and Potential Clinical Relevance of Phase Contrast Mammography In-vivo: a Single-center, Prospective Study
Conventional mammography, breast sonography and breast MRI have specific weaknesses. In particular, mammography has a low sensitivity for the detection of mammary carcinoma in patients with a dense breast.
- Conditions
- Breast Cancer, Microcalcification, Image
- Trial name
- NCT06489665
- Testing
- Experimental Intervention
- Where
- 2 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- University of Zurich
Breast Implant Revision
LTFU of PCL Breast Scaffolds Used in 2021-BRV-004
The objective of this study is to assess the long-term safety and performance of the PCL Breast Scaffold in women who previously underwent breast silicone implant revision and received the PCL Breast Scaffold combined with…
- Trial name
- NCT07383012
- Where
- Australia
- Volunteers
- 19 people
- Sponsor
- BellaSeno Pty Ltd
Breast Cancer Screening, Colon Cancer Screening
Bundled Cancer Screening and Genetic Services Navigation
The goal of this study is to test bundled familial cancer risk assessment + multicancer (colorectal + breast) vs. single (breast) cancer navigation, using a wait list control for colorectal cancer screening referral and…
- Conditions
- Breast Cancer Screening, Colon Cancer Screening, Genetics Predisposition
- Trial name
- NCT07228000
- Testing
- Breast cancer screening navigation, Multicancer screening navigation, Usual care genetics referral
- Where
- 2 sites in United States
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Cancer
Stockholm Mammography Risk Stratified Trial
SMART is a Phase III, randomised, non-blinded screening trial. Women who consent to participate in SMART are randomised to either individualised screening or screening according to the Swedish National Breast Cancer Screening…
- Trial name
- SMART (NCT06270355)
- Testing
- Risk based screening
- Volunteers
- 70,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Mammography Screening
Effect of Distraction Technique on Pain and Anxiety During Mammography
One of the non-medical interventions aimed at reducing sensitization is the cognitive-behavioral approach, in which the individual's attention is shifted from a painful stimulus to an external stimulus.
- Trial name
- NCT06682026
- Testing
- listening to music or chatting
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hitit University
Breast Carcinoma
Contrast-Enhanced Mammography for the Evaluation of Mammographic Microcalcifications
This clinical trial evaluates the added role of contrast-enhanced mammography (CEM), as well as imaging and blood biomarkers, for predicting the presence or absence of high-grade ductal carcinoma in situ (DCIS) or invasive cancer…
- Trial name
- NCT05046301
- Testing
- Biospecimen Collection, Contrast Agent, Contrast-Enhanced Mammography
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Optimising Mammography Screening Accuracy With Blood-based Biomarkers
The project aims to investigate whether breast cancer screening can be improved using blood tests, thereby reducing the number of unnecessary clinical mammographies.
- Trial name
- OPTIMA (NCT07049822)
- Where
- 2 sites in Denmark
- Volunteers
- 1,200 people
- Sponsor
- Vejle Hospital
Breast Carcinoma
An Imaging Technology, Contrast-Enhanced Mammography, in Predicting Breast Cancer
This clinical trial examines a new imaging technology, contrast-enhanced mammography, in predicting breast cancer. Contrast-enhanced mammography is similar to standard mammography, but it includes an intravenous (by vein)…
- Trial name
- NCT04871139
- Testing
- Biopsy, Contrast-Enhanced Mammography, Questionnaire Administration
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer Screening
Breast Cancer Screening: Digital Breast Tomosynthesis Versus Digital 2D Mammography
This study is a randomized, multicenter, multivendor, controlled, diagnostic superiority trial to compare digital breast tomosynthesis plus synthesized 2D mammograms (DBT+s2D) versus standard 2D full-field digital mammography…
- Trial name
- TOSYMA (NCT03377036)
- Testing
- DBT+s2D, 2D-FFDM
- Where
- 21 sites in Germany
- Volunteers
- 99,689 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster