Clinical trials: Malignant Biliary Stricture
Obstruction of Biliary Tree, Biliary Tract Cancer
Endoscopic Therapy of Malignant Bile Duct Strictures
Patients with malignant bile duct stenosis have poor prognosis and most of the patients are not good candidate for surgery at the time of diagnosis. Placement of the stent is the palliative care for these patients.
- Conditions
- Obstruction of Biliary Tree, Biliary Tract Cancer, Biliary Tract Neoplasms
- Trial name
- NCT01543607
- Testing
- Radiofrequency ablation catheter (Habib EndoHBP)
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Malignant Distal Biliary Stricture
Partially Covered and Uncovered Metal Stent for Malignant Distal Biliary Stricture
Endoscopic retrograde biliary drainage with a self-expandable metal stent (SEMS) has been used as a principle palliative method of distal biliary obstruction in patients with pancreaticobiliary cancers.
- Trial name
- NCT02178618
- Testing
- Deployment of Partially covered biliary self expandable metal stent, Deployment of uncovered biliary self expandable metal stent
- Where
- South Korea
- Sponsor
- Ajou University School of Medicine
Jaundice, Obstructive, Jaundice; Malignant
Microbiological Assessment of Bile in Patients Undergone to Endoscopic Retrograde Cholangiography (ERCP): the "Microbile Registry"
The study is a prospective evaluation of the microbial assessment in patients undergoing to ERC with naive papilla; the population includes all the indication to biliary drainage.
- Conditions
- Jaundice, Obstructive, Jaundice; Malignant, Choledocholithiasis, Biliary Stricture
- Trial name
- Microbile (NCT06115564)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Azienda Unità Sanitaria Locale della Romagna
Biliary Disease Tract, Biliary Stenosis
Supra-papillary Versus Trans-papillary Biliary Stenting in Malignant Peri-hilar Stenosis
This is a randomized controlled trial comparing patients with obstructive jaundice due to malignancies of the perihilar area of bile ducts and undergoing both preoperative and palliative biliary drainage.
- Conditions
- Biliary Disease Tract, Biliary Stenosis, Biliary Stents
- Trial name
- SupraBilS (NCT07325877)
- Testing
- ERCP with suprapapillary stent placement, ERCP with transpapillary stent placement
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Bile Duct Stricture, Bile Duct Cancer
PTFE Stents for Treatment of Malignant Biliary Strictures
In this randomized trial two two self-expanding metal stents (SEMS) for treatment of malignant biliary strictures are investigated.
- Conditions
- Bile Duct Stricture, Bile Duct Cancer, Pancreas Cancer
- Trial name
- NCT03763214
- Testing
- Stenting with PTFE-coated stent (HILZO)
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Johannes Vermehren
Liver Cancer, Bile Duct Cancer
Intra-luminal Radiofrequency Ablation for Inoperable Malignant Biliary Stenosis
Only a small proportion of patients with biliary obstruction caused by hepatopancreatobiliary malignancies are suitable for surgical resection.
- Conditions
- Liver Cancer, Bile Duct Cancer, Pancreatic Cancer
- Trial name
- NCT02841800
- Testing
- 'Intra-luminal radiofrequency ablation (Habib EndoHPB)
- Volunteers
- 5 people
- Sponsor
- National Taiwan University Hospital
Cholangiocarcinoma, Gallbladder Cancer, Pancreatic Cancer
Efficacy and Safety of Endobiliary Radiofrequency Ablation by Using a Novel RF Catheter (ELRA®) on Maintaining the Patency of Endobiliary Metal Drainage in Patients With Malignant Biliary Strictures : A Double-arm Comparable Study
Malignant obstructive jaundice is a common complication of advanced stage cholangiocarcinoma, gallbladder cancer, and pancreatic cancer.
- Trial name
- NCT02646514
- Testing
- Radiofrequency ablation with stenting, stenting
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Yonsei University
Stricture, Obstruction
Patency of a Prototype Large Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.
Plastic biliary stents which are a new larger size will remain free of obstructions for a longer period of time than currently used 10 French stents in cancer in the common bile duct.
- Conditions
- Stricture, Obstruction, Cancer
- Trial name
- NCT01590394
- Testing
- Large plastic biliary stent
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Biliary Stricture
Single-operator Digital Cholangioscopy for the Diagnosis of Malignant and Benign Biliary Strictures
Differentiation between malignant and benign biliary strictures can be challenging. Accurate differentiation of malignant biliary strictures from benign ones is crucial to guide management decisions.
- Trial name
- NCT03307382
- Testing
- SpyGlass DS Cholangioscopy
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Cholangiocellular Carcinoma, Pancreatic Cancer
Radiation Stent Versus Self-expanding Metallic Stents (SEMS) for Palliative Treatment of Malignant Biliary Stricture
Malignant biliary obstruction is a common clinical condition caused by various malignancies. Currently,biliary stent implantation guided either by fluoroscopy or endoscopy has become the most important methods for relieving…
- Conditions
- Cholangiocellular Carcinoma, Pancreatic Cancer, Gallbladder Cancer, Metastatic Carcinoma
- Trial name
- NCT01320241
- Testing
- self-expandable 125I radioactive seeds-loaded-stent, self-expandable biliary nitinol alloys stent
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Southeast University, China
Biliary Stricture
A Study of Endobiliary Radiofrequency Ablation in Malignant Biliary Obstructions
The purpose of this study is to assess the impact of temperature-sensitive radiofrequency ablation (RFA) immediately before biliary stent placement on duration of biliary stent patency and re-intervention free survival.
- Trial name
- NCT05826639
- Testing
- Temperature-sensitive radiofrequency ablation, No intervention
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Mayo Clinic
Malignant Biliary Obstruction
IRS(Irradiation Stent) vs. CS(Conventional Stent) Insertion in Inoperable Malignant Biliary Obstruction
Stenting the malignant biliary obstruction is considered to be the preferred palliation modality to relieve pruritus,cholangitis,pain and jaundice in patients without surgical indications of malignant biliary obstruction.An…
- Trial name
- IRCSMBO (NCT02001779)
- Testing
- Biliary SEMS loaded with 125I seeds, Conventional biliary SEMS
- Where
- China
- Volunteers
- 328 people
- Sponsor
- Zhongda Hospital
Biliary Stricture, Malignant Neoplasms
Efficacy and Safety of the Paclitaxel Eluting Covered Biliary Stent to the Common Covered Metallic Biliary Stent
Paclitaxel covered metal biliary stent is non-inferior to common covered metal biliary stent in their patency rate and safety at the 6 months after stenting.
- Trial name
- MIRAII (NCT01413386)
- Testing
- biliary stent
- Where
- 3 sites in South Korea
- Volunteers
- 74 people
- Sponsor
- Jong Taek, Lee
Cholangiocarcinoma, Ampullary Carcinoma
Endobiliary RFA for Unresectable Malignant Biliary Strictures
Only a small proportion of patients with cholangiocarcinoma or ampullary carcinoma are suitable for surgical resection. The endoscopic or percutaneous transhepatic biliary drainage is accepted approaches for the relief of…
- Trial name
- NCT01844245
- Testing
- Radiofrequency ablation (RFA)
- Where
- 6 sites in China
- Volunteers
- 174 people
- Sponsor
- Bing Hu
Malignant Biliary Obstruction
Evaluation of a New Metal Biliary Stent of 12-mm Diameter: a Case Control Study
Biliary stent allows the drainage of the bile ducts palliatively or preoperatively in the event of malignant biliary stenosis, and a biliary calibration in the event of benign stenosis.
- Trial name
- BIGDIAM (NCT04405752)
- Testing
- 12-mm metallic biliary stent, 10-mm metallic biliary stent
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Institut Paoli-Calmettes
Pancreatic Cancer, Cholangiocarcinoma
Endoscopic Biliary Radiofrequency Ablation of Malignant Distal Common Bile Duct Strictures
Malignant bile duct obstruction is a common sequela of pancreatic cancers or distal bile duct cancers, and its development can hinder the use of chemotherapy, decrease patient quality of life, and decrease survival.
- Trial name
- NCT01721174
- Testing
- SEMS only, EBRFA and SEMS
- Where
- Hong Kong
- Volunteers
- 42 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Neoplasms, Biliary Tract Neoplasms
Endoscopic Stenting of Gastrointestinal Cancer
Obstruction of the digestive tract is a frequent cause of morbidity in patients with gastrointestinal cancer.Palliative endoscopic treatment with self- expanding metal stents(SEMS)is an alternative to palliative surgery and other…
- Trial name
- NCT00422409
- Testing
- Endoscopic stenting
- Where
- 7 sites in Norway
- Volunteers
- 270 people
- Sponsor
- Ullevaal University Hospital
Malignant Biliary Obstruction, Malignant Biliary Stricture
Endoscopic Ultrasound Guided Hepaticogastrostomy With or Without Antegrade Stenting for Palliation of Malignant Distal Biliary Obstruction: Randomized Controlled Trial
The purpose of this study is to compare the efficacy and safety between EUS-HGAS and EUS-HGS. We hypothesized that EUS-HGAS provides lower recurrent biliary obstruction (RBO) rate but with a comparable safety profile to EUS-HGS.
- Trial name
- EASE-MBO (NCT07832045)
- Testing
- HGAS, HGS
- Where
- Taiwan
- Volunteers
- 88 people
- Sponsor
- National Taiwan University Hospital
Malignant Biliary Stricture
The Efficacy of Plastic Stent Anchoring to Reduce Migration of Metal Stent
The aim of this study is to demonstrate that the group with an additional plastic stent to anchor the fully covered self expandable metal stent (FCSEMS) in patients with malignant biliary stricture has less stent migration than…
- Trial name
- NCT03439020
- Testing
- Plastic stent anchoring, FCSEMS
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Biliary Disease, Common Bile Duct Calculi
Needle Knife Fistulotomy Versus Partial Ampullary Endoscopic Mucosal Resection for Difficult Biliary Cannulation
The aims of this study are to compare the needle knife fistulotomy (NKF) technique versus the partial ampullary endoscopic mucosal resection (PA-EMR) technique in patients with difficult biliary cannulation and to assess the…
- Conditions
- Biliary Disease, Common Bile Duct Calculi, Biliary Stricture, Malignant Hepatobiliary Neoplasm
- Trial name
- NCT05068739
- Testing
- PA-EMR, NKF
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Duzce University