Clinical trials: Malignant Biliary Obstruction
Biliary Obstruction, Pancreas Neoplasm
EUS-guided Choledochoduodenostomy for Primary Drainage of Malignant Distal Biliary Obstruction
A prospective single-centre pilot study investigating the feasibility and safety of EUS-guided choledochostomy as primary drainage strategy in patients with distal malignant biliary obstruction using a FCSEMS through LAMS to…
- Conditions
- Biliary Obstruction, Pancreas Neoplasm, Distal Cholangiocarcinoma
- Trial name
- SCORPION-II-p (NCT05595122)
- Testing
- EUS-CDS
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Malignant Bile Duct Obstruction
Sems Placement With and Without Biliary Sphincterectomy in Patients With Malignant Biliary Obstruction
Placement of biliary self expanding metal stent (SEMS) is indicated when malignant common bile duct obstruction is encountered [1].
- Trial name
- SEMS (NCT04805450)
- Testing
- ES before fully covered SEMS placement, no ES before fully covered SEMS placement
- Where
- Italy
- Volunteers
- 1,075 people
- Sponsor
- Istituto Clinico Humanitas
Acute Cholangitis, Biliary Tract Infection
Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis
Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis…
- Conditions
- Acute Cholangitis, Biliary Tract Infection, Biliary Obstruction, Choledocholithiasis
- Trial name
- NCT07407491
- Testing
- Gentamicin - single dose, Distilled water
- Where
- Malaysia
- Volunteers
- 172 people
- Sponsor
- National University of Malaysia
Periampullary Cancer, Biliary Obstruction
Preoperative Biliary Drainage in Patients With Operable Malignant Periampulary Tumors
The impact of preoperative biliary drainage (PBD) on morbidity and mortality associated with Pancreaticoduodenectomy (PD) in patients with peri-ampulary tumors is still controversial.
- Conditions
- Periampullary Cancer, Biliary Obstruction, Preoperative Biliary Drainage
- Trial name
- NCT04289831
- Testing
- Preoperative Biliary Drainage (PBD), Surgery
- Volunteers
- 150 people
- Sponsor
- University of Alexandria
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance
In a recently published meta-analysis (Sharaiha, Gastrointestinal Endoscopy, 2017), it is reported that percutaneous transhepatic biliary drainage (PTBD) is less clinical successful, causes more adverse events and needs more…
- Trial name
- NCT03541590
- Testing
- Percutaneous transhepatic biliary drainage
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Bile Duct Neoplasms, Gall Bladder Carcinoma
RADIO FREQUENCY ABLATION IN UNRESECTABLE MALIGNANT BILIARY OBSTRUCTION
Endoscopic retrograde cholangio pancreatography procedure will performed as per local standard procedure.After common bile duct cannulation,cholangiography will be performed (to confirm the stricture) followed by biliary…
- Trial name
- MBOP (NCT05320328)
- Testing
- Radio frequency ablation
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Biliary Neoplasms, Biliary Obstruction
Comparison of Drug Eluting Stent and Covered Metal Stent in Malignant Biliary Obstruction (MIRA III)
The purpose of this study is to compare the effectiveness and safety of Niti-S Mira-Cover III Biliary Stent with Comvi Biliary Covered Stent for the treatment of malignant biliary obstruction.
- Conditions
- Biliary Neoplasms, Biliary Obstruction, Pancreatic Neoplasms
- Trial name
- NCT02460432
- Testing
- Paclitaxel-eluting metal Stent, Covered Metal Stent
- Where
- 5 sites in South Korea
- Volunteers
- 106 people
- Sponsor
- Taewoong Medical Co., Ltd.
Interventional Radiology
The Impact of Puncture Angle on Total Fluoroscopy Time Reduction During Percutaneous Biliary Drainage
The purpose of this study is to retrospectively assess the importance of initial bile duct puncture angle on total fluoroscopy time and overall efficacy during ultrasound and fluoroscopy guided percutaneous transhepatic biliary…
- Trial name
- NCT04653987
- Testing
- Percutaneous biliary drainage
- Volunteers
- 130 people
- Sponsor
- Institut za Rehabilitaciju Sokobanjska Beograd
Bile Duct Obstruction, Pancreatic Cancer
Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction
The primary purpose is to compare patency of two different types of biliary metal stents, i.e. covered versus uncovered Nitinella metal stent. Secondary purposes are to determine frequency of complications in the two groups, e.g.
- Conditions
- Bile Duct Obstruction, Pancreatic Cancer, Gallbladder Cancer, Bile Duct Cancer
- Trial name
- NCT00280709
- Testing
- "Nitinella" ; SX-ELLA Stent Biliary (biliary metal stent)
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- University Hospital, Linkoeping
Cholangiocarcinoma, Gallbladder Carcinoma
Unilateral Stenting Versus Bilateral Stenting for Malignant Hilar Biliary Obstruction
The purpose of this study is to compare the clinical effectiveness and long-term outcomes between patients with malignant hilar biliary obstruction who are treated by unilateral or bilateral stenting.
- Conditions
- Cholangiocarcinoma, Gallbladder Carcinoma, Hepatocellular Carcinoma
- Trial name
- NCT02649712
- Testing
- biliary stent
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Xuzhou Central Hospital
Biliary Tract Neoplasms, Pancreatic Neoplasms
Malignant Obstruction ZILVER Against Routine Therapy (MOZART I)
This study compares the 6 mm nitinol Zilver biliary endoprostheses and the 10 mm nitinol Zilver biliary endoprostheses to the 10 mm Wallstent in appropriate patients in need of palliative treatment of malignant obstructive…
- Conditions
- Biliary Tract Neoplasms, Pancreatic Neoplasms, Jaundice, Obstructive
- Trial name
- NCT00196105
- Testing
- 6 mm Nitinol Zilver Stent, 10 mm Nitinol Zilver Stent, 10 mm Stainless Steel Wallstent
- Where
- United States
- Volunteers
- 241 people
- Sponsor
- Cook Group Incorporated
Klatskin Tumor
Single Versus Multiple Deployment of Metallic Stents for Inoperable Malignant Hilar Biliary Obstruction
In Bismuth II-IV hilar cholangiocarcinoma patients with a predicted survival of longer than 3 months, metallic stent performance is superior to plastic stenting for palliation with respect to outcomes and cost-effectiveness.
- Trial name
- NCT02166970
- Testing
- Metallic stent deployment in hilar obstruction
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Soon Chun Hyang University
Malignant Biliary Obstruction
Clinical Trial of Bile Etiology ,Proteomics and Metabonomics of Malignant Biliary Obstruction
To investigate bile culture and susceptibility test in patients with malignant biliary obstruction (MBO) or relation between bile, portal vein or vein culture and biliary infection.
- Trial name
- MBO-IR (NCT01073514)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Malignant Biliary Strictures
Covered Self-expandable Metal Stents for Palliation of Malignant Biliary Strictures: Evaluation of a New Type of Stent
self-expandable metal stents for palliation of malignant biliary strictures
- Trial name
- NCT01457105
- Testing
- Endoscopic retrograde cholangiography (ERC) (ComVi biliary stent)
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Catholic University of the Sacred Heart
Bile Duct Neoplasms Malignant
Stenting Malignant Jaundice for Quality of Life
Endoscopic stent insertion is considered the method of choice for palliation of malignant bile duct obstruction (MBDO). However, it can cause complications and requires periodic stent exchanges.
- Trial name
- NCT01459965
- Testing
- ERCP with 10 French biliary plastic stent placement, ERCP with 11.5 French biliary plastic stent
- Volunteers
- 164 people
- Sponsor
- Indiana University
Malignant Biliary Obstruction
Multihole Fully Covered Metallic Stents in the Management of Malignant Biliary Obstruction
multiholes fully covered metallic stents in the management of malignant biliary obstruction
- Trial name
- NCT05786326
- Testing
- group 1, group 2, group 3
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Zagazig University
Malignant Tumor
Efficacy of Partial Covered Double Bare Metal Stent Compared to Uncovered Double Bare Metal Stent in Malignant Biliary Obstruction
Previous studies indicated that covered stents are less likely to become occluded in comparison to bare stents. While the probability of occlusions caused by tumor in-growth is less in covered stents, they are more likely to…
- Trial name
- NCT02937246
- Testing
- SEMS(self-expandable metallic stent), Stenting by ERCP (endoscopic retrograde cholangiopancreatography)
- Where
- South Korea
- Volunteers
- 260 people
- Sponsor
- Yonsei University