Clinical trials: Male Contraception
Healthy
Evaluate the Pharmacokinetics and Gonadotropin Suppression of Nestorone®-Testosterone (NES/T) Combination Gel in Men
This is a prospective, randomized, double-blinded, two-center trial to evaluate the gonadotropin suppressive activity of transdermal treatment with a combined NES/T gel, or T gel alone, for 28 days.
- Trial name
- NCT02432261
- Testing
- Nestorone® /testosterone gel, Testosterone only gel
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Kimberly Myer
Healthy, Men
Study of Spermatogenesis Suppression With DMAU Alone or With LNG Versus Placebo Alone in Normal Men
This is a Phase IIa multicenter, double-blind, placebo-controlled study in healthy men to evaluate the spermatogenesis suppression after oral administration of Dimethandrolone Undecanoate (DMAU) alone or with Levonorgestrel (LNG)…
- Conditions
- Healthy, Men, Male Contraception
- Trial name
- NCT03455075
- Testing
- Dimethandrolone-Undecanoate, Levonorgestrel 0.03 MG
- Where
- 2 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Premier Research
Healthy Men, Male Contraception
28-Day Repeat-Dose, Dose Escalation Study of 11-β Methyl Nortestosterone Dodecylcarbonate (11β-MNTDC) in Healthy Men
This is a Phase I multicenter, double-blind, repeat dose, dose-escalating study, in healthy men to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of 11-β Methyl Nortestosterone Dodecylcarbonate…
- Trial name
- CCN014A (NCT03298373)
- Testing
- 11β-methyl-nortestosterone-dodecylcarbonate
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Premier Research
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Lack of Knowledge About Condoms and Birth Control, Adolescent Sexual Intercourse
An Evaluation of Virtual Student Health Center Among Incarcerated Juvenile Offenders
WestEd and its partners Efficacity and the Oregon Youth Authority (OYA), are conducting a randomized controlled trial of an innovative teen pregnancy prevention program, Healthy U, for youthful male offenders.
- Conditions
- Lack of Knowledge About Condoms and Birth Control, Adolescent Sexual Intercourse, Sexual Intercourse Without a Condom or Birth Control, Unplanned Pregnancies
- Trial name
- NCT04027010
- Testing
- "Healthy U" tablet application
- Where
- 2 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- WestEd
Male Contraception, Healthy Male Adults
A First in Human Study, Evaluating the Safety and Efficacy of ADAM™ 1.0
This study will evaluate the safety and feasibility of the ADAM System for implantation into the vas deferens in 25 healthy males at 3 sites. This is a prospective, non-randomized, open label interventional trial.
- Trial name
- NCT05134428
- Testing
- ADAM System
- Where
- 3 sites in Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Contraline, Inc
Hypogonadism, Contraception
The Effects of Testosterone on Prostate Tissue (ACYP-1)
The purpose of this research study is to understand the effects of testosterone on the prostate. This knowledge will be used to help in the development of a safe male hormonal contraceptive and may impact the development of…
- Trial name
- ACYP-1 (NCT00161486)
- Testing
- Testosterone gel, Acyline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Washington
CKD, Chronic Kidney Diseases
Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD)
This pilot study will assess the efficacy of a pregnancy and contraception education decision aid (DA) for patients with chronic kidney disease to support decisions about reproductive health, and will assess feasibility and…
- Trial name
- PACE-CKD (NCT06189807)
- Testing
- Decision aid, Standard handout
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan
Contraception, Hypogonadism
ORAL T-6: Oral Androgens in Man-6
We propose a study to determine the single-dose pharmacokinetics of these two novel formulations of testosterone in normal men with experimentally induced hypogonadism.
- Trial name
- ORAL-T-6 (NCT00663793)
- Testing
- Acyline, Testosterone, Finasteride
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Washington
Contraception
Hormonal Contraception in Healthy Young Men (P42306)(COMPLETED)(P06057)
Male volunteers receive a new hormonal contraceptive consisting of an implant releasing a hormone and hormone injections in order to investigate the suppressive effect on sperm production and reversibility of sperm production…
- Trial name
- NCT00403793
- Testing
- etonogestrel with testosterone undecanoate
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Contraception
Glycosphingolipid Inhibition and Spermatogenesis in Man: A Pilot Study (MIG 2)
The purpose of this research study is to help in the development of safe, effective and reversible male contraception. We are examining the impact of the drug Miglustat on sperm production in normal men.
- Trial name
- MIG-2 (NCT00194649)
- Testing
- Miglustat (Zavesca)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy
Contraception in Normal and Subnormal Men
Volunteers with normal and subnormal semen parameters receive a hormonal male contraceptive in order to investigate whether there are differences between normal and subnormal men in terms of suppressibility, rate of azoospermia…
- Trial name
- NCT00167141
- Testing
- injection of hormonal male contraceptive
- Where
- Germany
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Contraception
ACY-6 Oral Administration of Acyline
In this study, we propose oral dosing of GIPET enhanced oral acyline (MER-104) to determine if this potentially useful compound is safe and effective at suppression of gonadotropins after oral dosing in man.
- Trial name
- ACY-6 (NCT00471185)
- Testing
- Acyline
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Washington
Male Contraception
Open Label, Dose Escalation, Repeat Dose Study Evaluating YCT-529 in Healthy Males
This is a Phase 1b/2a open-label, dose escalation 3 part-study, 28-day, 90-day or 180 day repeat dose study of YCT-529 in healthy males who have decided to have a vasectomy and are waiting for the procedure and for men who have…
- Trial name
- NCT06542237
- Testing
- YCT-529
- Where
- New Zealand
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- YourChoice Therapeutics, Inc.
Blood Pressure
A Two-part Trial Assessing the Effects of 7α-methyl-19-nortestosterone (MENT) on Blood Pressure in Normal Men: an Open-label Pilot Study Followed by a Randomized, Double-blind, Placebo-controlled Study
This is a two-part trial assessing the effects of MENT on blood pressure. The first part of the trial is an open-label pilot study to verify the MENT gel formulation delivers appropriate drug levels.
- Trial name
- NCT00812630
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Population Council
Contraception
Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum
This study is being offered to all participants of the ACY-5 study as an optional addition to the male contraceptive study in which they participated. Participation is voluntary.
- Trial name
- IHOP-5 (NCT00156650)
- Testing
- Acyline, Testosterone Gel, Depo-Medroxyprogesterone
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Washington
Contraception, Hypogonadism
Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone
The purpose of this study is to test the how the body absorbs and processes new forms of oral testosterone. Information gained during the study may help develop better forms of testosterone therapy in the future.
- Trial name
- NCT00161421
- Testing
- Oral Testosterone, Leuprolide (Lupron), Dutasteride
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Washington
Contraception
Enhancing Male Participation in Interventions to Prevent Unintended Pregnancy
Globally, 41% of all pregnancies are unintended, increasing risk for maternal and infant morbidity and mortality. Most unintended pregnancies occur in the context of contraceptive non-use or failure.
- Trial name
- CHARM2 (NCT03514914)
- Testing
- The CHARM2 Intervention
- Where
- India
- Volunteers
- 2,402 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Contraception
Male Hormonal Contraceptive Development-ACY-5
The purpose of this research study is to help in the development of male contraception (birth control).
- Trial name
- ACY-5 (NCT00161447)
- Testing
- Acyline, Testosterone Gel, Depo-Medroxyprogesterone
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Healthy, Male Infertility
HOP-2A - Intratesticular Hormone Levels
The purpose of this investigational study is to find out what hormones are present in healthy male testicles using fine needle aspiration.
- Conditions
- Healthy, Male Infertility, Prostate Disease
- Trial name
- HOP-2A (NCT00756561)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington