Clinical trials: Malaria, Pregnancy
Intermittent Preventive Treatment, Placental Malaria
Sulphadoxine-Pyrimethamine for Intermittent Preventive Treatment of Malaria in Pregnancy in Uganda
The effectiveness of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy in malaria-endemic areas the effectiveness and efficacy of SP may be compromised by increased SP resistance.
- Trial name
- SP IPTp (NCT01184911)
- Testing
- Sulfadoxine-pyrimethamine
- Where
- Uganda
- Sponsor
- University of California, San Francisco
Malaria, Falciparum, HIV Infections
Prevention of Malaria During Pregnancy Using Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine: Malawi
In Malawi, the standard of care to prevent malaria during pregnancy at the time of the study was a two dose sulfadoxine-pyrimethamine intermittent protective treatment (SP IPT) regimen administered in the second and third…
- Trial name
- NCT00126906
- Testing
- Monthly sulfadoxine/pyrimethamine, 2-dose sulfadoxine/pyrimethamine
- Where
- Malawi
- Volunteers
- 700 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Pregnancy
Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women
Malaria in pregnancy is potentially fatal to both the mother and the foetus particularly in the primigravidae. Implementation of appropriate control and preventive measures is challenged by the fact that malaria infection in…
- Trial name
- NCT00131703
- Testing
- Amodiaquine, Sulphadoxine-pyrimethamine, Chloroquine
- Volunteers
- 900 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Malaria
Study of Pharmacokinetics and Pharmacodynamics of Artesunate in Pregnant Women in the Democratic Republic of Congo
The objective of this study is to assess the pharmacokinetics (PK) and pharmacodynamics (PD) of a standard dose of orally administered artesunate, in order to determine if the current adult dose (200 mg) is appropriate in…
- Trial name
- NCT00538382
- Testing
- Artesunate
- Where
- Democratic Republic of the Congo
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- NICHD Global Network for Women's and Children's Health
Malaria
Optimal Chemopreventive Regimens to Prevent Malaria and Improve Birth Outcomes in Uganda
This trial tests the hypothesis that intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) + dihydroartemisin-piperaquine (DP) will significantly reduce the risk of adverse birth outcomes…
- Trial name
- NCT04336189
- Testing
- Sulfadoxine-pyrimethamine (SP), Dihydroartemisinin-piperaquine (DP)
- Where
- Uganda
- Volunteers
- 2,757 people, healthy volunteers welcome
- Sponsor
- Grant Dorsey, M.D, Ph.D.
Malaria, Pregnancy, Malaria, Antepartum
Safety of Antimalarials in the FIRst trimEster
The SAFIRE study aims to find effective treatments with acceptable safety for malaria in early pregnancy, a particularly sensitive time for the adverse consequences of malaria in pregnancy for both mother and baby.
- Conditions
- Malaria, Pregnancy, Malaria, Antepartum, Malaria (Uncomplicated)
- Trial name
- SAFIRE (NCT06962319)
- Testing
- dihydroartemisinin-piperaquine (DP), Pyronaridine-artesunate (PA), Artemether-lumefantrine
- Where
- 3 sites in Burkina Faso, Kenya and 1 more
- Volunteers
- 1,510 people
- Sponsor
- Liverpool School of Tropical Medicine
Placental Malaria Infection, HIV Infections
Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia
Prevention of malaria in pregnancy is critical given the high incidence of malaria in Zambia and its serious impact on both maternal and infant survival.
- Conditions
- Placental Malaria Infection, HIV Infections, Stillbirth, Prematurity
- Trial name
- NCT00270530
- Testing
- Sulfadoxine-pyrimethamine (Fansidar)
- Where
- Zambia
- Volunteers
- 454 people
- Sponsor
- Center for International Health and Development
Malaria
Efficacy and Safety of Azithromycin and Artesunate in Pregnant Women
The purpose of this study is to compare the efficacy and safety of three treatment regimens for the prevention of malaria during pregnancy.
- Trial name
- NCT00287300
- Testing
- Sulfadoxine-Pyrimethamine, Azithromycin, Artesunate
- Where
- Malawi
- Volunteers
- 141 people
- Sponsor
- University of North Carolina
Pregnancy, Malaria
Efficacy of Intermittent Screening and Treatment or Intermittent Preventive Treatment (IPT) With Dihydroartemisinin-Piperaquine, Versus IPT With Sulfadoxine-Pyrimethamine for the Control of Malaria in Pregnancy in Kenya
Malaria in pregnancy (MiP) due to Plasmodium falciparum infection is a major cause of maternal morbidity and poor birth outcomes.
- Trial name
- STOP MiP KENYA (NCT01669941)
- Testing
- IPTp-SP, IPTp-DP, ISTp-DP
- Where
- 4 sites in Kenya
- Volunteers
- 1,546 people
- Sponsor
- Kenya Medical Research Institute
Malaria
ANC & Malaria Diagnostic in Pregnancy
The program's overall objective is to assess the impact of a package of interventions aimed at reducing malaria-related mortality and morbidity in pregnant women and newborns by ensuring access to a package of interventions…
- Trial name
- AQUAMOD (NCT01703884)
- Testing
- ASAQ
- Where
- Burkina Faso
- Volunteers
- 5,254 people
- Sponsor
- Centre Muraz
Malaria
Prevention of Malaria in HIV-uninfected Pregnant Women and Infants
This will be a double-blinded randomized controlled phase III trial of 782 HIV uninfected pregnant women and the children born to them.
- Trial name
- PROMOTE-BC3 (NCT02793622)
- Testing
- Monthly Sulfadoxine-Pyrimethamine (SP) During Pregnancy, Monthly Dihydroartemisinin-Piperaquine (DP) During Pregnancy
- Where
- Uganda
- Volunteers
- 782 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pregnancy, Malaria in Pregnancy
Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa
This study evaluates the efficacy and safety of monthly intermittent preventive treatment using dihydroartemisinin piperaquine (DP) alone or in combination with azithromycin (AZ) compared to sulphadoxine-pyrimethamine (SP) for…
- Conditions
- Pregnancy, Malaria in Pregnancy, Malaria
- Trial name
- IMPROVE (NCT03208179)
- Testing
- dihydroartemisinin-piperaquine, sulphadoxine-pyrimethamine, dihydroartemisinin-piperaquine plus azithromycin
- Where
- 7 sites in Kenya, Malawi and 1 more
- Volunteers
- 4,680 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Malaria
Efficacy of Artemisinin Combination Therapies for the Treatment of Uncomplicated P. Falciparum in Pregnancy in Brazil
Data on the burden of MIP in low transmission areas, such as Latin America, are very limited; there is even less information on the efficacy of case management of MiP.
- Trial name
- PAACT-PF (NCT01082731)
- Testing
- Artemether-Lumefantrine, Mefloquine- Artesunate
- Where
- 2 sites in Brazil
- Volunteers
- 6 people
- Sponsor
- Centers for Disease Control and Prevention
Malaria, Pregnancy Related
Pregnancy Registry in Mali
This registry will assess pregnancy outcomes through demographic surveillance and prospective data collection at a health facility in Kalifabougou, Mali.
- Trial name
- NCT06468319
- Where
- Mali
- Volunteers
- 9,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria, Pregnant
A Comparative Study of Azithromycin and S-P as Prophylaxis in Pregnant HIV+ Patients
Randomized controlled single blind prospective comparative study
- Conditions
- Malaria, Pregnant, HIV
- Trial name
- NCT02527005
- Testing
- Sulphadoxine-pyrimethamine, Azithromycin
- Where
- Nigeria
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Ibadan
Malaria
Comparison of Two Regimens of Artemether-lumefantrine for the Treatment of Malaria in Pregnancy
Malaria in pregnancy is a major cause of maternal and newborn morbidity and mortality in sub-Saharan Africa]. Effective antimalarial preventive and treatment regimens can significantly reduce malaria-related morbidity and…
- Trial name
- ALN5P (NCT01916954)
- Testing
- 3-day artemether-lumefantrine, 5-day artemether-lumefantrine
- Where
- Republic of the Congo
- Volunteers
- 96 people
- Sponsor
- University of Oxford
Malaria, Falciparum, Hookworm Infections
Iron Absorption and Utilization in Adolescents Infected With Malaria Parasites, Hookworms or Schistosoma
The aim of this study is to investigate the change in iron metabolism in relation to malaria and helminth infections using a stable isotope technique.
- Conditions
- Malaria, Falciparum, Hookworm Infections, Schistosoma Haematobium
- Trial name
- NCT01163877
- Testing
- Fe-57 orally, Fe-58 intravenously
- Where
- Côte d’Ivoire
- Volunteers
- 43 people
- Sponsor
- Swiss Federal Institute of Technology
Malaria in Pregnancy
Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)
In endemic settings Plasmodium falciparum (Pf) can sequester in the placenta resulting in low peripheral parasitemia and false negative malaria diagnosis in pregnant women.
- Trial name
- ULTRAPYRAPREG (NCT04783051)
- Testing
- Sulfadoxine pyrimethamine, Pyramax
- Where
- Democratic Republic of the Congo
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Kinshasa
Malaria
Monitoring Pregnant Women for Antimalarial Drug Resistance
Annually, malaria affects an estimated 229 million people, causing 409,000 deaths (WHO 2019) mostly in Africa. Despite a substantial decline in malaria-related maternal and child deaths in recent years, progress in controlling…
- Trial name
- MIRANDA (NCT05072613)
- Testing
- Malaria screening
- Where
- Democratic Republic of the Congo
- Volunteers
- 6,833 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Malaria in Pregnancy
Safe and Efficacious Artemisinin-based Combination Treatments for African Pregnant Women With Malaria
Malaria is the most important human parasitic disease and is responsible of high morbidity and mortality in resource-poor countries.
- Trial name
- PREGACT (NCT00852423)
- Testing
- Dihydroartemisinin-piperaquine, Artesunate-mefloquine, Artesunate-amodiaquine
- Where
- 7 sites in Burkina Faso, Ghana and 2 more
- Volunteers
- 3,428 people
- Sponsor
- Institute of Tropical Medicine, Belgium