Clinical trials: Malabsorption
Colitis Ulcerosa, Colitis Ulcerative
Magnesium in Gastrointestinal Disease
Individuals with gastrointestinal diseases - such as Crohn's disease, ulcerative colitis, ileostomy, or bile acid diarrhoea - are at increased risk of magnesium deficiency.
- Conditions
- Colitis Ulcerosa, Colitis Ulcerative, Crohns Disease, Morbus Crohn
- Trial name
- MAGIC (NCT07338565)
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Protein Malabsorption
Protein Digestion and Amino Acid Absorption in the Aging Gastrointestinal Tract
Rationale: Worldwide, the aging population is increasing. Aging is associated with loss of independence and increased risk of co-morbidity.
- Trial name
- AgingGut (NCT06553794)
- Testing
- Gastroscopy with duodenal mucosal tissue biopsies
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Premature Birth of Newborn, Intestinal Malabsorption
Study to Assess the Efficacy and Safety of NTRA-2112 on Intestinal Malabsorption in Preterm Infants
The study will evaluate the effect of NTRA-2112 on intestinal malabsorption in preterm infants.
- Trial name
- NCT02510560
- Testing
- NTRA-2112
- Where
- 50 sites in United States, Belgium and 8 more
- Volunteers
- 300 people
- Sponsor
- Elgan Pharma Ltd.
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Pancreatic Tumors, Diabetes
IMPact of AerobiC Exercise in Addition to Nutritional Treatment on Quality of Life After Pancreatectomy
The goal of this interventional study is to assess the impact of a 6-month unsupervised aerobic exercise program on the quality of life of patients undergoing partial or total pancreatectomy.
- Conditions
- Pancreatic Tumors, Diabetes, Malabsorption
- Trial name
- IMPACT (NCT06858631)
- Testing
- Physical Aerobic Exercise
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Lactose Intolerant, Lactose Malabsorption
Proper Dietary Management, Follow-up, and Lactase Enzyme Supplementation for Lactose Intolerance
Lactose intolerance (LI) is considered the clinical syndrome caused by lactose malabsorption (LM). It is possible to identify four causes of lactase deficiency defining four different types of LM: primary (genetic), secondary…
- Conditions
- Lactose Intolerant, Lactose Malabsorption, Lactose Intolerance
- Trial name
- NCT06773650
- Testing
- Completion of online survey
- Where
- Italy
- Volunteers
- 385 people
- Sponsor
- European Institute of Oncology
Parenteral Nutrition, Gastroparesis
Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction
Clear study hypothesis / research question It has already been proven that a prolonged negative energy balance during intensive care stay is an independent risk factor for mortality.
- Conditions
- Parenteral Nutrition, Gastroparesis, Gastrointestinal Dysfunction, Protein Deficiency
- Trial name
- ATTAINMENT (NCT06510348)
- Testing
- Supplemental Parenteral Nutrition (SPN)
- Where
- Romania
- Volunteers
- 164 people
- Sponsor
- Romanian Society for Enteral and Parenteral Nutrition
Protein Malabsorption
Changes in Plasma Amino Acid Appearance After Adding Bacillus Coagulans GBI-30, 6086 to Milk Protein Concentrate
The purpose of this study is to examine the pattern of plasma amino acid appearance after a two-week daily regimen of milk protein concentrate supplementation with and without the addition of Bacillus coagulans GBI-30, 6086 among…
- Trial name
- ABC (NCT05313178)
- Testing
- Bacillus Coagulans GBI-30, 6086
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Colorectal Neoplasms, Colorectal Cancer
Bile Acids and Microbiome in Early Colorectal Carcinogenesis
Currently colorectal cancer pathogenesis is mainly explained by the adenoma-carcinoma sequence theory that was proposed more than half a century ago.
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Colorectal Polyp, Microbiome
- Trial name
- NCT06502704
- Where
- Lithuania
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vilnius University
Intestinal Pseudo-Obstruction, Short Bowel Syndrome
Improved Quality of Life in Children With Intestinal Failure
Children with intestinal failure have a lack of tolerance for food in the intestine. The children are dependent on intravenous nutrition over a long period of time period to ensure growth and development.
- Conditions
- Intestinal Pseudo-Obstruction, Short Bowel Syndrome, Malabsorption Syndrome Autoimmune Enteropathy, Bacterial Overgrowth
- Trial name
- NCT04981262
- Testing
- Stimulance
- Where
- Norway
- Volunteers
- 56 people
- Sponsor
- Oslo University Hospital
Iron Deficiency Anemia of Pregnancy, Iron Malabsorption
Intravenous Iron for Iron-deficiency Anemia in Pregnancy: a Randomized Controlled Trial
Iron deficiency is the most common cause of anemia in pregnancy worldwide, and, when severe, can have serious consequences for mothers and babies.
- Trial name
- IVIDA (NCT03438227)
- Testing
- Iron dextran, Ferrous sulfate 325mg
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Protein Malabsorption
The Incorporation of Dietary Protein-Derived Amino Acids in Duodenal Epithelium
Rationale: Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion.This anabolic resistance may be related to decreased postprandial amino acid release in the circulation, due to greater amino…
- Trial name
- GutFeeding (NCT06091852)
- Testing
- Intrinsically labelled milk protein
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Carbohydrate Intolerance
Impact of Two Dietary Interventions on Simple Carbohydrate Intolerance
In this project we want to assess impact of dietary fructose as a simple sugar intolerance on abdominal pain and compare a low FODMAP diet versus an added sugar elimination diet effectiveness on symptoms but also impact on…
- Trial name
- NCT06057376
- Testing
- Low-FODMAP diet group (LFD), Low Sugar diet group (LAS)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Oregon Health and Science University
Bile Acid Malabsorption
Double-blind, Randomised Study of A3384 in BAM/BAD
The purpose of this trial is to determine the efficacy and safety of A3384 administered to patients with Bile Acid Malabsorption (BAM)/Bile Acid Diarrhoea (BAD).
- Trial name
- NCT02078856
- Testing
- A3384
- Where
- 3 sites in Sweden, United Kingdom
- Volunteers
- 19 people
- Sponsor
- Albireo
Malnutrition, Malabsorption
High Energy High Protein Peptide Feed Study
Oral nutritional supplements and enteral tube feeds are commonly used to meet the nutritional requirements of patients with disease-related malnutrition, or who require medical nutrition support for other reasons.
- Trial name
- NCT03140371
- Testing
- High energy high protein peptide feed study
- Where
- 10 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nutricia UK Ltd
Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea
Aldafermin (NGM282) for Chronic Diarrhea Due to Bile Acid Malabsorption (BAM)
This single-center, randomized, double-blind, placebo-controlled study is designed to compare effects of aldafermin, (NGM282), 1 mg, and placebo given daily by subcutaneous injection on bowel functions and hepatic synthesis and…
- Conditions
- Chronic Diarrhea, Irritable Bowel Syndrome With Diarrhea, Bile Acid Malabsorption, Bile Acid Diarrhea
- Trial name
- NCT05130047
- Testing
- Aldafermin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michael Camilleri, MD
Cystic Fibrosis, Gastrointestinal Dysfunction
Understanding Gut Symptoms in People With Cystic Fibrosis
Although chest infections affect wellbeing and survival in cystic fibrosis (CF), most people with CF also have difficulty digesting food and must take medication for this.
- Trial name
- GRAMPUS-CF SRC (NCT05934656)
- Testing
- Latent class analysis
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Nottingham
Fecal Incontinence, Bile Acid Malabsorption
A Study of Colesevelam in Fecal Incontinence
Compare the effects of a combination of colesevelam and clonidine to placebo on bowel symptoms in patients with urge or combined type of FI.
- Trial name
- NCT02628626
- Testing
- Colesevelam, Clonidine
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Mayo Clinic
Inflammation, Hypertriglyceridemia
Impact of Foods on Bile Acids, Metabolites, and Inflammation
Dietary incorporation of pulse crops may be an effective way to lower unhealthy elevations in serum bile acids. These elevations play a direct role in promoting obesity-related diseases estimated to be present in about one third…
- Conditions
- Inflammation, Hypertriglyceridemia, Metabolic Disease, Lipid Metabolism Disorder
- Trial name
- NCT05245357
- Testing
- Lentil, Control
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Montana State University
Primary Bile Acid Malabsorption, Secondary Bile Acid Malabsorption
Obeticholic Acid in Bile Acid Diarrhoea
The investigators propose to develop studies of obeticholic acid (OCA) in patients with bile acid diarrhoea. OCA is a semisynthetic bile acid, also known as 6αethylchenodeoxycholic acid or INT747,and is a potent farnesoid X…
- Conditions
- Primary Bile Acid Malabsorption, Secondary Bile Acid Malabsorption, Chronic Diarrhoea
- Trial name
- OBADIAH1 (NCT01585025)
- Testing
- Obeticholic acid
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College Healthcare NHS Trust