Clinical trials: MS
Violence, Recidivism
An Outcome Evaluation of the Project CHANGE-MS Violence Intervention Program
This is a prospective randomized control trial design to evaluate the effectiveness of a hospital based violence intervention program.
- Trial name
- NCT04567381
- Testing
- Enhanced Services, Treatment as Usual
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Medstar Health Research Institute
Stomach Diseases
Diagnosis of Gastric Lesions From Exhaled Breath and Saliva
The investigators study the feasibility of a novel method in oncology based on breath analysis with a nanosensors array for identifying gastric diseases.
- Trial name
- NCT01420588
- Where
- 2 sites in China, Latvia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis
Feasibility Study of Tolerogenic Fibroblasts in Patients With Refractory Multiple Sclerosis
Fibroblasts have demonstrated potent immune modulatory and therapeutic activity in the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis, as well as in other models of autoimmune and inflammatory…
- Trial name
- MSFibroblast (NCT05080270)
- Testing
- Tolerogenic Fibroblasts
- Where
- Mexico
- Volunteers
- 5 people
- Sponsor
- FibroBiologics
Multiple Sclerosis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of multiple sclerosis
- Trial name
- NCT05003388
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Multiple Sclerosis
Alternate Pre-med in Anti-Cluster of Differentiation 20 (CD20) Pilot Project
The purpose of this study is to assess and compare how well multiple sclerosis (MS) patients tolerate cetirizine versus diphenhydramine as a pre-medication before receiving anti-CD20 infusion therapy of ocrelizumab, ublituximab…
- Trial name
- NCT07472413
- Testing
- Cetirizine, Diphenhydramine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Miami
Multiple Sclerosis
Concentration of Ofatumumab in the Breast Milk of Lactating Women With Relapsing Forms of Multiple Sclerosis
This study will evaluate whether ofatumumab is excreted at quantifiable levels and at which concentrations in breast milk of lactating women with RMS).
- Trial name
- KATHAROS (NCT06444113)
- Testing
- Ofatunumab
- Where
- 15 sites in United States, Germany and 3 more
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Relapsing Remitting Multiple Sclerosis
Study to Evaluate the Usability and Value of Integrated Digital Solutions in Medical Care of Participants With Multiple Sclerosis
The main purpose of this study is to assess the usability and value of the multiple sclerosis (MS) care management platform in terms of improved monitoring of people with MS (pwMS) in clinical practice.
- Trial name
- ILLUMINATE (NCT05949580)
- Testing
- MS Care Platform (icobrain ms and icompanion ms)
- Where
- 7 sites in United States, Germany and 1 more
- Volunteers
- 500 people
- Sponsor
- Hoffmann-La Roche
Relapsing Remitting MS (RRMS), Secondary Progressive MS (SPMS)
BetaPlus Survey - Observational Study to Assess Drug Adherence in Patients With Multiple Sclerosis After Conversion to Betaferon® by Using Elements of the BetaPlus Program
This is an observational survey to assess the factors that influence adherence to Betaferon therapy in multiple sclerosis patients using elements of the BetaPlus support program, including the nurse support and auto-injectors.
- Trial name
- NCT01233245
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Where
- 15 sites in Czechia, France and 13 more
- Volunteers
- 1,077 people
- Sponsor
- Bayer
Infertility, Female
Rapid Detection Method for Microorganisms in the Lower Genital Tract
Mycoplasma, chlamydia, and gonococcal infection of the female lower genital tract can lead to infertility and various adverse pregnancy outcomes.
- Trial name
- NCT05678751
- Testing
- lower genital tract microorganisms detection using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Shenzhen Second People's Hospital
Prostate Carcinoma
Collection of Blood in Studying Metabolites in Patients With Prostate Cancer
This pilot research trial utilizes the collection of blood in studying metabolites in patients with prostate cancer. Metabolites are the small molecule products of cellular metabolism that are produced naturally in all living…
- Trial name
- NCT03485794
- Testing
- Biospecimen Collection, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
COPD
Breath Analysis in Chronic Obstructive Lung Disease (COPD)
To answer the question whether a disease specific profile of breath in patients with COPD can be detected by an untargeted metabolomic study using exhaled breath analysis by mass spectrometry.
- Trial name
- NCT02186639
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Multiple Sclerosis
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression
To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.
- Trial name
- TERIPET (NCT03368677)
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Turku University Hospital
Multiple Sclerosis
Multiple Sclerosis Rehabilitation Study
The effects of routine rehabilitation in MS patients versus no rehabilitation.
- Trial name
- NCT00202254
- Testing
- Physiotherapy, Occupational therapy, Speech pathology
- Volunteers
- 100 people
- Sponsor
- Melbourne Health
Multiple Sclerosis
Phase II Study of Teriflunomide as Adjunctive Therapy to Glatiramer Acetate in Subjects With Multiple Sclerosis
The primary objective was to estimate the tolerability and safety of 2 doses of Teriflunomide administered once daily for 24 weeks, compared to placebo, in patients with multiple sclerosis [MS] with relapses who were on a stable…
- Trial name
- NCT00475865
- Testing
- Teriflunomide, Glatiramer Acetate (GA)
- Where
- 6 sites in United States, Austria and 4 more
- Volunteers
- 123 people
- Sponsor
- Sanofi
Multiple Sclerosis
Treadmill Training in Chronic MS: Efficacy and Cost-effectiveness
The purpose of the study is to determine whether treadmill training is safe and beneficial in patients with walking difficulty because of multiple sclerosis.
- Trial name
- NCT00334100
- Testing
- Exercise
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Relapsing Multiple Sclerosis
Long-Term Safety and Efficacy Study of Peginterferon Beta-1a
The primary objective of this study is to evaluate the long-term safety and tolerability of peginterferon beta-1a (BIIB017) in participants originally treated in Study 105MS301 (NCT00906399) who continue peginterferon beta-1a…
- Trial name
- ATTAIN (NCT01332019)
- Testing
- peginterferon beta-1a
- Where
- 151 sites in United States, Belgium and 24 more
- Volunteers
- 1,077 people
- Sponsor
- Biogen
Multiple Sclerosis (Relapsing Remitting)
Safety and Efficacy of Fingolimod in MS Patients in China
To evaluate the safety and efficacy of fingolimod 0.5mg vs. placebo in MS patients in China
- Trial name
- NCT01941004
- Testing
- fingolimod
- Sponsor
- Novartis Pharmaceuticals
Relapsing-Remitting Multiple Sclerosis
Safety and Efficacy Study of Daclizumab High Yield Process (DAC HYP) to Treat Relapsing-Remitting Multiple Sclerosis
The primary objective of this study is to determine whether DAC HYP, when compared to placebo, is effective in reducing the rate of relapses between baseline and Week 52.
- Trial name
- SELECT (NCT00390221)
- Testing
- BIIB019 (Daclizumab High Yield Process)
- Where
- 56 sites in Czechia, Germany and 6 more
- Volunteers
- 621 people
- Sponsor
- Biogen
Carcinoma, Hepatocellular, Metabolic Syndrome
Liver Resection and Simultaneous Sleeve Gastrectomy for MS-HCC (LIRESS)
Hepatocellular carcinoma (HCC) related to metabolic syndrome (MS) as unique risk factor is gradually overpassing the more common viral and alcohol etiology, becoming a global health issue.
- Trial name
- LIRESS (NCT06060847)
- Testing
- Liver resection and simultaneous sleeve gastrectomy for HCC induced by metabolic syndrome, Liver resection for HCC induced by metabolic syndrome
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale V. Fazzi
Multiple Sclerosis, Urinary Bladder, Neurogenic
Urinary Disorders in Patients With Multiple Sclerosis: Invasive Vs Non-invasive Investigations.
The objective of the study is to describe the current status of MS patients with urinary disorders in Lebanon, and to demonstrate whether invasive investigations improve the management of these patients compared to an optimal…
- Conditions
- Multiple Sclerosis, Urinary Bladder, Neurogenic, Urodynamics
- Trial name
- NCT03336424
- Testing
- Non-invasive investigations, Invasive investigations
- Where
- Lebanon
- Volunteers
- 60 people
- Sponsor
- Saint-Joseph University