Clinical trials: MMN
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
sCD163 & CD19 as Candidate Biomarkers in CIDP and MMN
Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are characterized by progressive deterioration in muscle strength, loss of sensibility, diminished or absent reflexes and impaired…
- Trial name
- NCT02271724
- Testing
- Lumbar puncture, Blood sample
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- University of Aarhus
Growth and Development
fMRI Study to Investigate Hemodynamic Changes in Brain Resulting From Supplementation of Bacopa Monnieri Extract and Multiple Micronutrient Supplementation.
The study will aim to compare the effects of a beverage powder fortified with multiple micronutrients and Bacopa monnieri extract (test product) to a non-fortified isocaloric beverage powder (control product) on cognitive…
- Trial name
- NCT02345187
- Testing
- Beverage powder fortified with Bacopa Monnieri Extract and Multiple Micronutrient supplementation, Non-fortified isocaloric beverage powder
- Where
- India
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Multifocal Motor Neuropathy
Study of the Effectiveness of Intravenous Immune Globulin (10%) for the Treatment of Multifocal Motor Neuropathy
The purpose of the study is to evaluate the efficacy (effect on grip strength and disability) and safety/tolerability of IGIV, 10% in subjects with Multifocal Motor Neuropathy.
- Trial name
- NCT00666263
- Testing
- Immune Globulin Intravenous (human), 10%
- Where
- 17 sites in United States, Canada and 1 more
- Volunteers
- 50 people
- Sponsor
- Baxalta now part of Shire
Schizophrenia
A Single-Center, Double-Blind (DB) Study of MEM 3454 on P50 Sensory Gating and Mismatch Negativity in Schizophrenia Patients
The purpose of this study is to evaluate the effects of nicotinic alpha-7 MEM 3454 on P50 sensory gating in patients with Schizophrenia. The hypothesis is that MEM 3454 will normalize the P50 ratio.
- Trial name
- P50 (NCT00725855)
- Testing
- MEM 3454
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Memory Pharmaceuticals
Treatment-resistant Depression (TRD)
Auditory MMN EEG in TRD in Response to Ketamine
To develop and test a neurocomputational model of ketamine treatment response predictions in TRD.
- Trial name
- NCT05464264
- Testing
- Ketamine
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Multifocal Motor Neuropathy
HyQvia in Multifocal Motor Neuropathy
Subcutaneous immunoglobulin (SCIG) and recombinant human hyaluronidase (rHuPH20) will be tested in patient witch MMN and currently under maintenance treatment with IVIG for safety, tolerability and efficacy.
- Trial name
- HYMMNE (NCT02885259)
- Testing
- rHuPH20
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Multifocal Motor Neuropathy
A Clinical Study to Evaluate DNTH103 in Adults With Multifocal Motor Neuropathy
The purpose of this Phase 2 study is to evaluate the safety, tolerability, pharmacometrics, and efficacy of Claseprubart (DNTH103) in participants with multifocal motor neuropathy (MMN).
- Trial name
- MOMENTUM (NCT06537999)
- Testing
- Claseprubart
- Where
- 41 sites in United States, Canada and 13 more
- Volunteers
- 46 people
- Sponsor
- Dianthus Therapeutics
Healthy
Effects of Ketamine on ERP/EEG Measures in Healthy Volunteers
This is a Phase 0, Double-Blind, Randomized, Placebo-Controlled, Crossover Study to assess the changes in ERP Biomarkers in Healthy Volunteers before and after administration of a sub-anesthetic dose of ketamine.
- Trial name
- NCT04928703
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- ERP Biomarker Qualification Consortium
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy
Polyneuropathy, Impairments and Physical Activity - The PolyImPAct Study
The project aims to investigate the validity, and reliability of outcome measures of muscle strength, functioning (gait, balance, and fine motor skills), physical activity, and patient-reported outcome measures of functioning…
- Conditions
- Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Vasculitic Neuropathy, POEMS Syndrome, Multifocal Motor Neuropathy
- Trial name
- PolyImPAct (NCT06040567)
- Testing
- Validity and reliability of outcome measures in polyneuropathy, Healthy controls
- Where
- Denmark
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Multifocal Motor Neuropathy (MMN)
A Study of Purified Human Antibodies Administered Subcutaneously to Patients With Multifocal Motor Neuropathy (MMN)
The objective of this study is to assess efficacy, safety, and convenience of purified human antibodies administered under the skin in the treatment of MMN patients.
- Trial name
- NCT00701662
- Testing
- Vivaglobin
- Where
- 3 sites in Italy, Switzerland and 1 more
- Volunteers
- 8 people
- Sponsor
- CSL Behring
Schizophrenia
First Time in Human Study With GSK1018921
GSK1018921 is a new drug under development for the treatment of schizophrenia. GSK1018921 differs from other available drugs in its mode of action and it is assumed that it may have an effect in the treatment of so-called…
- Trial name
- NCT00527020
- Testing
- GSK1018921, Nicotine Lozenges
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
MMN
Predictive Factors of Long Term Outcome in MMN
The cornerstone treatment for multifocal motor neuropathy (MMN), a rare and disabling dysimmune neuropathy, is intravenous immunoglobulin (IVIg). The aim of this study is to identify prognostic factors of poor outcome.
- Trial name
- NCT04015934
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Central Hospital, Nancy, France
Sepsis-Associated Encephalopathy, Mismatch Negativity
The Dynamic Change of MMN in Patients With Sepsis Associated Encephalopathy
Sepsis-associated encephalopathy (SAE), is one of the most common organ dysfunction during the acute phase in sepsis and septic shock.
- Trial name
- NCT04870983
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Chinese Medical Association
Multifocal Motor Neuropathy (MMN), MMN
A Study to Assess the Efficacy and Safety of Empasiprubart Versus IVIg in Adults With Multifocal Motor Neuropathy
The main purpose of this study is to compare empasiprubart and IVIg in adult patients with MMN. The study consists of a double-blinded part A (empasiprubart, IVIg) and an open-label part B (empasiprubart).
- Trial name
- Empassion (NCT06742190)
- Testing
- Empasiprubart, IVIG (Intravenous Immunoglobulin)
- Where
- 109 sites in United States, Australia and 24 more
- Volunteers
- 154 people
- Sponsor
- argenx
Disorder of Consciousness, MMN
Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients
In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as…
- Conditions
- Disorder of Consciousness, MMN, Modification of Cognitive Status Indication, Anoxic Brain Damage
- Trial name
- VEG-TDCS (NCT04614792)
- Testing
- Transcranial direct current stimulation
- Where
- Israel
- Volunteers
- 16 people
- Sponsor
- Oded Meiron
Cognitive Dysfunction
GABA-glutamate Interactions and Psychosis
This study investigates the interactions between NMDA (N-Methyl-D-aspartic acid) antagonism and GABA (gamma-aminobutyric acid) system as it relates to cognitive function assessed by ERPs (event-related potentials) in healthy…
- Trial name
- NCT00611572
- Testing
- iomazenil
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Yale University
Multifocal Motor Neuropathy
Subcutaneous Immunoglobulin Treatment for Multifocal Motor Neuropathy
The purpose of this study is to evaluate the effect of subcutaneous administration of immunoglobulin compared to intravenous treatment, for multifocal motor neuropathy NB. ONLY RECRUITING FROM DENMARK
- Trial name
- NCT00268788
- Testing
- Subcutaneous immunoglobulin, Intravenous immunoglobulin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Schizophrenia
Event-Related Potential (ERP) Biomarkers in Subjects With Schizophrenia and Healthy Volunteer Subjects
This is an observational, non-interventional study that will recruit Healthy Volunteers (HV) and subjects with clinically confirmed Schizophrenia (SZ).
- Trial name
- NCT04025502
- Testing
- Event-Related Potentials (ERP) and Electroencephalogram (EEG) testing with the COGNISION® System
- Where
- 4 sites in United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- ERP Biomarker Qualification Consortium
Multifocal Motor Neuropathy (MMN), Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Do IgG Level Variations in CIDP and MMN Patients Following Initial Intravenous IVIg Treatment Correlate With Ultimate Dosing
CIDP and MMN are part of a group of chronic inflammatory conditions that affect the peripheral nervous system. In CIDP, there is chronic inflammation of the peripheral nerves and nerve roots leading to demyelination.
- Trial name
- digG (NCT04356781)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Walton Centre NHS Foundation Trust
Chronic Inflammatory Demyelinating Polyneuropathy, Multifocal Motor Neuropathy
Effect of Resistance and Aerobic Exercise in CIDP or MMN
Resistance and aerobic exercise has been shown to be effective for maintenance of muscle strength in patients with neuromuscular diseases. Exercise in CIDP and MMN is sparsely described.
- Trial name
- NCT02121678
- Testing
- Resistance training, Aerobic training
- Where
- 2 sites in Denmark
- Volunteers
- 23 people
- Sponsor
- University of Aarhus