Clinical trials: MINOCA
Myocardial Infarction With Nonobstructive Coronary Arteries
Etiologic Mechanisms, Myocardial Changes and Prognosis of Patients With MINOCA
This prospective trial will include 150 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). A thorough clinical, laboratory and imaging evaluation will be performed by novel biomarkers and modern…
- Trial name
- NCT04538924
- Testing
- extended clinical, laboratory and instrumental examination; treatment options comparison
- Where
- Lithuania
- Volunteers
- 150 people
- Sponsor
- Vilnius University Hospital Santaros Klinikos
Myocardial Infarction, MINOCA
Biomarkers of Inflammation and Endothelial Dysfunction in Patients With Myocardial Infarction With Non-obstructive Coronary Arteries
Around 10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA) which pathophysiology is often uncertain.
- Conditions
- Myocardial Infarction, MINOCA, Inflammation, Biomarkers
- Trial name
- IMACORN-INFLI (NCT06446895)
- Testing
- Coronariography
- Where
- Spain
- Volunteers
- 400 people
- Sponsor
- Hospital Universitario Getafe
Major Cardiovascular Events
Impact of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients Presented With MINOCA
This work was designed to explore the role of the triglyceride-glucose (TyG) index in the prediction of cardiovascular outcomes in Patients Presented with myocardial infarction with nonobstructive coronary arteries.
- Trial name
- NCT06066177
- Testing
- Triglyceride glucose index TyG
- Volunteers
- 100 people
- Sponsor
- Assiut University
Prevalence of Myocarditis in MINOCA Patients
Prevalence of Myocarditis in Patients Suspected Myocardial Infarction With Non-Obstructive Coronary Arteries
This study aims to determine the prevalence of myocarditis among patients suspected of having myocardial infarction with non-obstructive coronary arteries (MINOCA) and to analyze its clinical characteristics, diagnostic markers .
- Trial name
- NCT06966531
- Testing
- Coronary angiography
- Volunteers
- 148 people
- Sponsor
- Assiut University
Myocardial Infarction With Nonobstructive Coronary Arteries
The Prognostic Role of Indices of Sympathetic Nervous System Overdrive in MINOCA
Myocardial infarction with non-obstructive coronary arteries (MINOCA) occurs in 1-13% of all patients with acute myocardial infarction (AMI).
- Trial name
- PRISMA (NCT04681612)
- Testing
- MSNA, Heart Rate Variability, Blood Pressure Variability
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- Hippocration General Hospital
Cardiac Imaging Techniques, Cardiac Imaging
Role of Spectral CT in the Diagnosis of Myocarditis/MINOCA in Patients Undergoing cardioCT Investigations for Acute Chest Pain
It is a spontaneous, observational cross-sectional and single-center imaging (CT and MRI) study, coupled with clinical-laboratory data.
- Conditions
- Cardiac Imaging Techniques, Cardiac Imaging, Myocardial Disease, Myocarditis Acute
- Trial name
- NCT06804278
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome
Starring Optical Coherence Tomography During Percutaneous Coronary Intervention Guidance
The starring optical coherence tomography during percutaneous coronary intervention guidance (OCT-AGEM) registry aims to evaluate the clinical impact of intra-procedural optical coherence tomography (OCT) in coronary…
- Conditions
- Acute Coronary Syndromes (ACS), Chronic Coronary Syndrome, MINOCA, INOCA (Ischemia With Non Obstructive Coronary Artery Disease)
- Trial name
- OCT-AGEM (NCT07182799)
- Testing
- Plaque vulnerability assessment, Stent implantation optimization
- Where
- Italy
- Volunteers
- 3,200 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myocardial Infarction With Non-Obstructive Coronary Artery, Ischemia With Non-Obstructive Coronary Artery
Intracoronary Provocative Test With Acetylcholine in Patients With INOCA and MINOCA
Coronary vasomotor disorders, occurring both at microvascular and epicardial level, have been demonstrated as responsible for myocardial ischemia in a sizeable group of patients undergoing coronary angiography (CAG), with…
- Trial name
- Provoke (NCT05714319)
- Testing
- Data collection, Clinical follow-up
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Myocardial Infarction, Coronary Microvascular Dysfunction
Coronary Microvascular Dysfunction Assessments in Myocardial Infarction With Non-Obstructive Coronary Arteries
To compare clinical outcomes of myocardial infarction with non-obstructive coronary arteries (MINOCA) according to the coronary microvascular dysfunction (CMD), evaluated by optical coherence tomography (OCT), invasive and…
- Conditions
- Myocardial Infarction, Coronary Microvascular Dysfunction, Vasospasm, Coronary
- Trial name
- CMD-MINOCA (NCT05272618)
- Testing
- Intravascular imaging (OCT), Invasive physiologic assessment (FFR, CFR, IMR), or Non-invasive physiologic assessment (N-13 ammonia PET)
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Chonnam National University Hospital
Myocardial Infarction With Non-obstructive Coronary Arteries, Grow Stimulation Expressed Gene 2
Rapid Identification of MINOCA Based on Novel Biomarkers
Among the patients diagnosed as acute myocardial infarction by coronary angiography, 5%-25% of the patients did not find coronary artery obstructive lesions. These patients do not need PCI.
- Conditions
- Myocardial Infarction With Non-obstructive Coronary Arteries, Grow Stimulation Expressed Gene 2, Copeptin, Identification
- Trial name
- NCT04974320
- Testing
- blood biomarkers
- Where
- China
- Volunteers
- 2,616 people
- Sponsor
- Qilu Hospital of Shandong University
ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries
Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic
Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of…
- Conditions
- ANOCA, ANOCA - Angina With Non-obstructive Coronary Arteries, MINOCA, Microvascular Dysfunction
- Trial name
- CoroPhys-CZ (NCT07103317)
- Where
- Czechia
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Motol
Myocardial Infarction with Nonobstructive Coronary Arteries
Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3
The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR…
- Trial name
- SMINC-3 (NCT05426408)
- Testing
- Cardiac magnetic resonance imaging to study coronary microvascular dysfunction
- Where
- Sweden
- Volunteers
- 85 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome, Myocardial Infarction
Myocardial Infarction With Non-obstructive Coronary Arteries in Turkish Population
The objective of this study is to analyze the Demographics, Clinical Profiles, Management, in-Hospital and Long-Term Outcomes of Patients with Acute Coronary Syndrome Syndrome And Myocardial Infarction with Non-obstructive…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Diabetes Mellitus
- Trial name
- MINOCA-TR (NCT03364387)
- Where
- Turkey (Türkiye)
- Volunteers
- 16,026 people
- Sponsor
- Cardiovascular Academy Society, Turkey
Myocardial Infarction With Non-obstructive Coronary Arteries, Cardiac Shock Wave Therapy
Cardiac Shock Wave Therapy for the Treatment of Myocardial Infarction With Non-obstructive Coronary Arteries
Myocardial infarction with non-obstructive coronary arteries (MINOCA) accounts for 15% of all myocardial infarctions and its mortality rate approaches that of large vessel myocardial infarction, but there are currently no…
- Trial name
- NCT05935436
- Testing
- Cardiac Shock Wave Therapy
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Ya-Wei Xu
Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries
CMR in Myocardial Infarction with Nonobstructive Coronary Arteries
MINOCA is accompanied by a worse prognosis, which is related to the inability to clarify the etiology.CMR has been explicitly recommended by guidelines as an etiologic diagnostic tool for MINOCA.
- Conditions
- Cardiac Magnetic Resonance, Myocardial Infarction with Nonobstructive Coronary Arteries, Strain, Extracellular Volume
- Trial name
- NCT06502899
- Testing
- Cardiac MRI
- Where
- China
- Volunteers
- 387 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
MINOCA, STEMI
Retinal OCTA for Microvascular Dysfunction Evaluation and Outcome Prediction in MINOCA Patients
The aim of this study is to evaluate microvascular dysfunction through OCTA in MINOCA patients. In order to better understand the condition, OCTA will also be performed in two matched patient groups: healthy controls and ACS…
- Conditions
- MINOCA, STEMI, Normal
- Trial name
- REVEAL (NCT07055152)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Myocardial Infarction With Non-Obstructive Coronary Arteries
Prognostic Value of Precision Medicine in Patients With MINOCA (PROMISE Trial).
The aim of our study is to evaluate if the use of a precision-medicine approach with a specific therapy tailored on the underlying pathogenic mechanism will improve the quality-of-life in MINOCA patients.
- Trial name
- PROMISE (NCT05122780)
- Testing
- Coronary angiography, OCT imaging, Percutaneous coronary intervention (PCI):
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
MINOCA, Shortness of Breath
Determinants of Cardiorespiratory Fitness and Effects of HIIT in Patients With ANOCA Obstructive Coronary Artery Disease(ANOCA)
The main goal is to understand what causes reduced fitness in ANOCA and whether targeted exercise can help improve it. This study aims to better understand why patients with Angina and No Obstructive Coronary Artery Disease…
- Conditions
- MINOCA, Shortness of Breath, Atherosclerotic Heart Disease of Native Coronary Artery
- Trial name
- NCT07182955
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Virginia
Platelet Indices, White Blood Cell
Beyond Platelet Indices, WBC-to-MPV Ratio in Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) Correlate With Short-Term Rather Than In-Hospital Outcomes
This study aims to evaluate the role of platelet indices and the [White blood cell (WBC) /mean platelet volume (MPV)] ratio in correlation with angiographic profiles of patients diagnosed with myocardial infarction with…
- Conditions
- Platelet Indices, White Blood Cell, Mean Platelet Volume, Myocardial Infarction
- Trial name
- NCT07076732
- Testing
- Coronary Angiography, SYNTAX Score
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Sohag University
Myocardial Infarction With Non-obstructive Coronary Arteries
Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT
Myocardial infarction with non-obstructive coronary arteries" (MINOCA) occurs in 5-10% of all patients with AMI. There are neither any randomized clinical trials in MINOCA patients evaluating effects of secondary preventive…
- Trial name
- MINOCA-BAT (NCT03686696)
- Testing
- Beta blocker, ACEI, ARB
- Where
- 32 sites in Australia, New Zealand and 3 more
- Volunteers
- 198 people
- Sponsor
- Uppsala University